Patents Examined by Jacqueline Brazin
  • Patent number: 10576190
    Abstract: The present technology discloses a cost-effective, single use bag or container for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, O2, CO2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: March 3, 2020
    Assignee: FreMon Scientific, Inc.
    Inventor: Menachem Shavit
  • Patent number: 10564097
    Abstract: Techniques for forming nanoribbon or bulk graphene-based SPR sensors are provided. In one aspect, a method of forming a graphene-based SPR sensor is provided which includes the steps of: depositing graphene onto a substrate, wherein the substrate comprises a dielectric layer on a conductive layer, and wherein the graphene is deposited onto the dielectric layer; and patterning the graphene into multiple, evenly spaced graphene strips, wherein each of the graphene strips has a width of from about 50 nanometers to about 5 micrometers, and ranges therebetween, and wherein the graphene strips are separated from one another by a distance of from about 5 nanometers to about 50 micrometers, and ranges therebetween. Alternatively, bulk graphene may be employed and the dielectric layer is used to form periodic regions of differing permittivity. A testing apparatus and method of analyzing a sample using the present SPR sensors are also provided.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: February 18, 2020
    Assignee: International Business Machines Corporation
    Inventors: Phaedon Avouris, Damon B. Farmer, Yilei Li, Hugen Yan
  • Patent number: 10562669
    Abstract: A support that comprises a plate having a first side and a second side opposed to the first side. The plate has a sample section including bottle-receiving members defined in the first side and configured for holding the bottles in a fixed position relative to the plate, and first conduit-receiving openings extending from the first side to the second side for receiving conduits extending from the bottles. The plate has a manifold section including second conduit-receiving openings extending from the first side to the second side for receiving the conduits. The plate has a channel section including channels defined in the second side and extending between the first conduit-receiving openings and the second conduit-receiving openings for receiving the conduits therein. The support may be used for example on a shaker. A method for retaining bottles and conduits connected to the bottles is also discussed.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 18, 2020
    Assignee: LALLEMAND INC.
    Inventors: Richard Monckton, Sean Covalla
  • Patent number: 10562029
    Abstract: An apparatus, in particular a microfluid apparatus, includes a chamber for extracting a fluid. The chamber has a wall with an opening. The opening is sealed by a sealing mechanism that is impermeable to specified substances. The apparatus further includes a membrane that contacts the outside of the wall, in a region of an outside of the wall which adjoins the opening, and covers the opening.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 18, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Sven Zinober, Yvonne Beyl, Daniel Czurratis
  • Patent number: 10557812
    Abstract: The present disclosure is directed to a gas sensor that includes an active sensor area that is exposed to an environment for detection of elements. The gas sensor may be an air quality sensor that can be fixed in position or carried by a user. The gas sensor includes a heater formed above chamber. The gas sensor includes an active sensor layer above the heater that forms the active sensor area. The gas sensor can include a passive conductive layer, such as a hotplate that further conducts and distributes heat from the heater to the active sensor area. The heater can include a plurality of extensions. The heater can also include a first conductive layer and a second conductive layer on the first conductive layer where the second conductive layer includes a plurality of openings to increase an amount of heat and to more evenly distribute heat from the heater to the active sensor area.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: February 11, 2020
    Inventors: Olivier Le Neel, Alexandre Le Roch, Ayoub Lahlalia, Ravi Shankar
  • Patent number: 10549271
    Abstract: A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: February 4, 2020
    Inventors: Mark Brian Dockrill, Anthony Favaloro, Kenneth Heng-Chong Ng, Martin Limon, Peter Toogood, Stephen John Bagnato
  • Patent number: 10549280
    Abstract: [Problem to be solved] A sample storage tube having the seal function to the tube body is provided by integral molding and the airtightness is secured in the sample storage tube. [Solution] The sample storage tube 100 comprise a first molded portion 210 and a second molded portion 220 by the integral molding. The first molded portion 210 is molded as the base figure of the tube body. The second molded portion 220 includes at least the opening edge portion which contacts the lid 300 and closes the opening. The first molded portion 210 is molded by the first material such as polypropylene, the second molded portion 220 is molded by the second material such as TPE which is suitable for the seal object to secure the airtightness between the opening and the lid 300. This second molded portion providing the seal function is molded onto the opening edge of the tube body by the integral molding.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: February 4, 2020
    Inventor: Shinichiro Kakuda
  • Patent number: 10537892
    Abstract: Disclosed herein are devices and techniques for providing for enhanced fluid mixing in a sample vial. A plunger head may be removably housed inside of a cap that is attached to a container; the cap may have an opening allowing a shaft, e.g., a probe or sipper shaft, to be inserted into the cap and into the plunger head. The shaft may be used to push the plunger head free of the cap, and then to reciprocate the plunger head within the container to mix the content. Withdrawal of the shaft may then cause the plunger head to disengage from the shaft and remain in the container.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: James Christopher Blake, Umberto Ulmanella, Bradley Kent Drews, Michael Dai Wang, Stephen Wayne Clark, Michael Adalbert Niziolek
  • Patent number: 10527582
    Abstract: Separation methods based on electrophoresis or chromatography that use a stationary phase including fibril cellulose.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: January 7, 2020
    Inventors: Marko Lauraeus, Antti Laukkanen
  • Patent number: 10520432
    Abstract: Embodiments described are generally directed to a test sample apparatus. The test sample apparatus generally comprises a holder base arranged that accommodates a tablet or cell phone. The apparatus has a hood that is placed over a portion of the tablets illuminating touchscreen such that the illuminating touchscreen provides light that can be collected by the hood. There is a chamber integrated with the hood adapted to accommodate a chemically activated test strip. The chemically activated test strip is illuminated when the hood collects light from the illuminating touchscreen. A lens in the hood interposed between the camera and the test strip enables the camera to focus on a portion of the chemically activated test strip when the hood is placed over the portion of the illuminating touchscreen.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: December 31, 2019
    Inventor: Donald Channing Cooper
  • Patent number: 10501235
    Abstract: A biological sample containment system and a label for a container that includes a first layer having a first readable information portion and a second layer removably attached to the first layer, the second layer having a second readable information portion, is disclosed. In one embodiment, the first layer and the second layer of the label are both formed of a thermosensitive material. In one embodiment, at least a part of the first readable information portion is identical to at least a part of the second readable information portion. The label of the present disclosure allows a portion of the label having readable information to be removed and adhered to a patient record, for example, while a portion of the label having identical readable information remains on the container.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: December 10, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Eric John Provencher, Craig Owen Russ, Bo Yon Lillian Yoo
  • Patent number: 10481125
    Abstract: To a biomolecule measuring apparatus, a semiconductor sensor for detecting ions generated by a reaction between a biomolecular sample and a reagent is set. The semiconductor sensor has a plurality of cells which are arranged on a semiconductor substrate, and each of which detects ions, and a plurality of readout wires. Each of the plurality of cells has an ISFET which has a floating gate and which detects ions, a first MOSFET M2 for amplifying an output from the ISFET, and a second MOSFET M3 which selectively transmits an output from the first MOSFET to a corresponding readout wire R1. Each of the plurality of cells is provided with a third MOSFET M1 which generates hot electrons in the ISFET and which injects a charge to the floating gate of the ISFET. Here, the second MOSFET and the third MOSFET are separately controlled.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: November 19, 2019
    Inventors: Takayuki Kawahara, Yoshimitsu Yanagawa, Naoshi Itabashi, Riichiro Takemura
  • Patent number: 10471196
    Abstract: A fluid cassette, for example, a blood treatment cassette having a cassette body embodied as a hard part and, optionally, a film which is connected to the hard part and at least partially covers the hard part, wherein the hard part comprises at least one first alignment device, and a second alignment device which are optionally arranged at first and second opposite sides of the fluid cassette or are attached thereon. The disclosure relates in addition to a blood treatment apparatus.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: November 12, 2019
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventor: Martin Lauer
  • Patent number: 10451613
    Abstract: A progressive compression driven flow cartridge for analyzing liquids is coupled with convenient sampling methods for different applications. A one-step device provides for direct sample collection upon a sample pad annexed to the cartridge. The sample pad can deliver sample to the test strips, while saving a portion of the sample pad for further laboratory confirmation use. If the sample collecting pad is not suitable to collect the sample, such as the case of biological substances inside the human body, such as within the nose or throat, a two-step device can include a long-arm swab applicator and a specialized chamber in which some amount of liquid can dissolve biological substances as specimen. The specimen can then be transferred onto the cartridge, either by application to the sample pad, or into the device through a sample window. Each method provides a qualitative analysis much faster than traditional rapid diagnostic devices.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: October 22, 2019
    Inventors: Naishu Wang, Michael Chang Chien
  • Patent number: 10441950
    Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 15, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 10436681
    Abstract: Methods and apparatus for transmitting acoustic energy to a liquid sample within a vessel are described. The acoustic energy may have a peak incident power to enhance cooling of the sample.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: October 8, 2019
    Assignee: Covaris, Inc.
    Inventor: James A. Laugharn, Jr.
  • Patent number: 10427155
    Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 1, 2019
    Assignee: Illumina, Inc.
    Inventors: Alex Aravanis, Boyan Boyanov, M. Shane Bowen, Dale Buermann, Alexander Hsiao, Behnam Javanmardi, Tarun Khurana, Poorya Sabounchi, Hai Quang Tran
  • Patent number: 10421073
    Abstract: The invention relates to a covering device (10), in particular a lid, for covering reaction vessels (50), in particular PCR plates, microtiter plates, and the like, comprising: a substantially flat main body (14) having an inside (34) and an outside (12), at least one planar sealing element (36) arranged on the main body (14) and connected to the main body, wherein the at least one sealing element (36) is arranged on the inside (34) of the main body (14), an edge segment (16), which runs along the periphery of the main body and extends from the outside (12) in the direction of the inside (34) and beyond the inside, and at least one spring element (22, 24) arranged on the main body (14) or on the sealing element (36), which at least one spring element is designed in such a way that the at least one spring element supports the covering device (10) on a surface (54) of a reaction vessel (50) to be covered facing the covering device (10) in the relaxed state of the at least one spring element and that an intermed
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: September 24, 2019
    Inventors: Eduard Woizenko, Sandro Sferlazza
  • Patent number: 10413904
    Abstract: The invention relates to kits and components thereof used in the conduct of solid-phase binding assays.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: September 17, 2019
    Assignee: Meso Scale Technologies
    Inventors: Yihong Claire Lu, Pankaj Oberoi
  • Patent number: 10412927
    Abstract: The present invention concerns a device for improved hygienic monitoring of individually ventilated caging (IVC) rack systems for laboratory animals and method for contamination-free removal of biological samples from unwanted organisms from the IVC-rack system. The device allows the performance of sampling operations on a ventilated shelving system in a safe and effective manner, without interfering with the ventilation air flow. The method of the invention allows the removal and transfer of the biological sample from inside the IVC-rack in a contamination-free manner by enabling a safe transfer of the sample from inside the IVC-rack system to any further processing procedure for analysis of the biological sample outside the IVC-rack system. It is also an object of the present invention to provide a device which is adapted to be used also on existing ventilated shelving systems, allowing the refitting of existing IVC-rack systems.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: September 17, 2019
    Inventors: Markus Brielmeier, Wolfgang Nagel, Julia Zorn, Alfredo Campiotti, II, Gianpaolo Milite, Carmelo Di Martino