Patents Examined by Jacqueline Brazin
  • Patent number: 9950323
    Abstract: A device includes a first structure with a sheet layer with a plurality of discrete through-holes and a second structure coupled to the first structure. At least a portion of a first surface of the sheet layer of the first structure is exposed from the second structure. A top portion of the sheet layer, including the exposed portion of the first surface of the sheet layer, includes fluorocarbon. The second structure includes a material of a higher surface tension than the top of the sheet layer. A second surface of the sheet layer, opposite to the first surface of the sheet layer, is embedded in the second structure. The second structure extends at least partially into the plurality of discrete through-holes of the first structure.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: April 24, 2018
    Assignee: CURIOX BIOSYSTEMS PTE LTD.
    Inventors: Namyong Kim, Eng Seng Lim, Siah Chong Cheong
  • Patent number: 9952187
    Abstract: The invention relates to an optical sensor element, comprising indicators, selected from luminescence-active means that are of the same type or different, and indicator protectors, and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: April 24, 2018
    Assignee: Hamilton Bonaduz AG
    Inventors: Dirk Schoenfuss, Claudius-Michael Ortega Schulte
  • Patent number: 9926208
    Abstract: Water containing one or more solvents miscible in the water is heated to its boiling point. Air is introduced into the vapor mixture of steam and the miscible solvent at an air-to-steam volumetric ratio that is sufficient to get good transfer of the miscible solvent from the steam to air and provides an equilibrium temperature of the steam-air mixture compatible with operations of the heat exchanger. The mixture of gases is then rapidly cooled to condense the steam into water so that a substantial portion of the miscible solvent remains volatilized in the air. The air and condensed steam fractions are separated.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 27, 2018
    Inventor: Daniel Oberle
  • Patent number: 9926553
    Abstract: A fluid sample extraction device is disclosed comprising a housing defining an internal fluid passage having a distal open end and a proximal open end and a porous medium within the fluid passage, between the distal open end and proximal open end. The porous medium, which may be glass, is configured to allow fluid flow in the fluid passage to flow around the porous medium, toward the proximal open end of the housing, when fluid is drawn from the distal open end toward the proximal open end, and to allow fluid in the fluid passage to flow toward the distal open end of the housing, through the porous medium when the fluid is forced toward the distal open end. The porous medium is also configured to capture nucleic acids in the porous medium from the fluid when fluid is forced through the porous medium. Devices and kits are also disclosed.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: March 27, 2018
    Assignee: Biomeme, Inc.
    Inventors: Marc Dominic DeJohn, Jesse Wilson van Westrienen
  • Patent number: 9895665
    Abstract: Spin columns that include a poly(acid) membrane separation matrix are provided. Also provided are kits that include the subject devices, as well as methods of using the devices, e.g., in sample preparation (such as protein purification) protocols.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: February 20, 2018
    Assignee: Takara Bio USA, Inc.
    Inventors: George G. Jokhadze, Sayantan Mitra
  • Patent number: 9885652
    Abstract: A multi-well plate reader including an emitter assembly having a plurality of emitters and a receptor assembly including a plurality of receptors separated by at least one spacer element such that a multi-well plate can be inserted between the emitter assembly and the receptor assembly. The emitters and receptors are paired and arranged in parallel arrays such that electromagnetic radiation can be transmitted through each well of the multi-well plate to a corresponding receptor to determine the opacity of the biological material contained within the well. Each well of the multi-well plate can be evaluated by a different emitter receptor pair allowing the entire multi-well plate to be efficiently monitored at a high throughput.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: February 6, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: Jason A. Papin, Paul A. Jensen
  • Patent number: 9874521
    Abstract: A detection plate includes a track region having a bottom surface having a groove provided therein, and a well apart from the track region. The well has a bottom surface. The bottom surfaces of the track region and the well are disposed substantially on a plane. This detection plate detects a specimen rapidly and highly accurately with a simple structure.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: January 23, 2018
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventor: Kenji Nagatomi
  • Patent number: 9867692
    Abstract: The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for grafting to a patient. In applying the method and/or in using the device, donor tissue is harvested, subjected to a cell dissociation treatment, cells suitable for grafting back to a patient are collected and dispersed in a solution that is suitable for immediate dispersion over the recipient graft site.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 16, 2018
    Assignee: Avita Medical Ltd.
    Inventors: Fiona M. Wood, Marie L. Stoner
  • Patent number: 9855557
    Abstract: Devices and methods for manual and high-throughput protein crystal growth and growth of other biological and organic crystals. A microplate includes a plurality of cells and a frame that defines the cells in the microplate. In each cell there is at least one well open at top. Each well in a cell may be enclosed at bottom, or it may be open at bottom, in which case the well bottom may be sealed by a separate part, which may be, e.g., a separate film or plate (e.g., of plastic, glass or metal) or a molded part.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: January 2, 2018
    Assignee: MITEGEN, LLC
    Inventors: Robert E. Thorne, Benjamin Apker, Robert Newman
  • Patent number: 9839913
    Abstract: A container for storing a histological sample comprises a container housing having an open top end and a bottom end defining a container interior. The container interior is configured to hold a fluid and receive the sample. A removable lid encloses the open top end. A container insert engages the container housing so as to substantially inhibit leaking of the fluid from the container. The insert includes an aperture configured to permit a sample holder containing the sample passage therethrough so as to enable depositing of the sample within the fluid in the container.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: December 12, 2017
    Inventor: Maria Lotosky-Compton
  • Patent number: 9829486
    Abstract: A sensor device includes a flow path and a metal layer disposed in the flow path. The flow path is configured to allow a sample containing analytes to flow and to allow a carrier to be disposed therein. The carrier has acceptors that are fixed on a surface thereof and specifically bound with the analytes for producing aggregates. The flow path includes an aggregate trapping section at which the analytes locally concentrate to the section. This sensor device has high detection sensitivity with a simple structure.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 28, 2017
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Yusuke Kitagawa, Kiyoshi Hashimotodani, Susumu Fukushima
  • Patent number: 9802194
    Abstract: A separation container includes a separation tube receiving a sample therein, a first sedimentation part connected to an end portion of the tube, a particle in the sample being deposited by a centrifugal or agitating force, and a separating part provided in the tube and including at least one separating layer which selectively opens and closes the tube.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: October 31, 2017
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Young-Ho Cho, Yoon-Tae Kang
  • Patent number: 9791376
    Abstract: An optical sensor includes an input part, a fixing part, and a determining part. The input part is provided on the upper side of the sensor. The fixing part on which a carrier is disposed is provided below the input part. The carrier has an acceptor that reacts with an analyte contained in the sample and is fixed on the carrier. The determining part includes a first metal layer, a second metal layer, and a hollow area. The first metal layer is configured to receive an electromagnetic wave. The second metal layer faces the first metal layer. The hollow area is sandwiched between the first metal layer and the second metal layer. The input part, the fixing part, and the hollow area form a part of a passage where the sample flows from the input part to the hollow area.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: October 17, 2017
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Yusuke Kitagawa, Kiyoshi Hashimotodani
  • Patent number: 9669167
    Abstract: A multifunctional glucose monitoring system and method of measuring glucose level, determining insulin dosage, and indicating insulin dosage on a syringe is disclosed. The multifunctional glucose monitoring system includes standard functionality with respect to acquiring a blood glucose reading. However, in addition, the multifunctional glucose monitoring system includes a dosage algorithm for calculating an insulin dosage based on the blood glucose reading and any other useful parameters, and includes a built-in marking device for marking the calculated dosage level on the barrel of an insulin syringe that is installed in the body of the multifunctional glucose monitoring system. A method includes the steps of measuring the glucose level, determining an insulin dosage, and indicating the insulin dosage on a syringe.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: June 6, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Artis Lockhart, Lawrence Monahan
  • Patent number: 9649633
    Abstract: A device for fractionation of a fluid containing particles and extraction of a particle-lean volume and a particle-rich volume, including: a cylindrical reservoir including an inlet orifice to supply the reservoir with fluid in a pumping direction from first to second ends of the reservoir; a fractionation body extending along a central axis of the reservoir, an upstream end positioned in vertical alignment above the inlet orifice, a cross section of the fractionation body reducing sharply at its downstream end; the fractionation body defining, with the reservoir, a first passage opening at the downstream end onto a recirculation zone with a geometric singularity; and an extraction mechanism downstream of the fractionation body to separate and extract the lean and rich volumes, including a partition delimiting an extraction volume configured, as fluid circulates in the pumping direction, to receive the particle-lean phase formed in the recirculation zone.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: May 16, 2017
    Assignees: Commissariat à l'énergie atomique et aux énergies alternatives, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Julien Marchalot, Jean-Luc Achard, Yves Fouillet
  • Patent number: 9599596
    Abstract: The invention relates to an optical sensor element, comprising indicators (2), selected from luminescence-active means that are of the same type or different, and indicator protectors (1), and to a sensor, comprising at least one such sensor element, an energy source that excites the luminescence emission of the indicators, and a detector unit, wherein the sensor element or sensor is suitable for detecting molecular oxygen in a gaseous or liquid medium and/or for determining the molecular oxygen content of a gaseous or liquid medium and at least one layer of the sensor element bearing the indicator protectors is designed in such a way that the diffusion rate of the molecular oxygen formed on the indicator protectors by means of the reduction of strong oxidants back into the medium is greater than the diffusion rate of molecular oxygen from the medium in the direction of the at-least-one layer bearing the indicator molecules.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: March 21, 2017
    Assignee: Hamilton Bonaduz AG
    Inventors: Dirk Schoenfuss, Claudius-Michael Ortega Schulte
  • Patent number: 9541477
    Abstract: A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. Additionally, in some embodiments a second elongate tubular body is provided which telescopingly receives at least a portion of the first elongate tubular body. In other embodiments, a support member is provided for engaging the filter membrane and positioning the filter membrane at a midpoint of the elongate tubular body during centrifuging.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: January 10, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSTITY IN THE CITY OF NEW YORK
    Inventors: Anjali Saqi, Keith Yeager
  • Patent number: 9533136
    Abstract: The present application provides a device and methods of making and using these devices. The devices comprise porous caps and porous vents made from sintered porous polymeric media comprising plastic particles, elastomeric particles or a combination thereof. These devices are used with medical devices or components thereof to provide ease of use, resistance to infection, sterilization and venting.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 3, 2017
    Assignee: Porex Corporation
    Inventors: William G. Midgette, GuoQiang Mao, Avi Robbins, Jack Chan
  • Patent number: 9527059
    Abstract: A field kit for collecting analytical samples has one or more dynamic fabric phase sorptive extraction (DFPSE) devices and/or fabric phase sorptive extraction (FPSE) devices and a plurality of containers for storing and transporting the DFPSEs and/or FPSEs that were used for sampling. The field kit has media for documenting information concerning the site, quantity, date, and/or other pertinent information concerning the sampling. Samples can be maintained within the kit for any required period of storage. Sampling can be done once or a plurality of times, such that an initial analysis can be carried out and analysis can be repeated using a portion of a FPSE or with a redundant FPSE that has been stored. The DFPSE device is a sampling device including a plurality of FPSEs, such that a number of different types of analytes can be sampled in different layers of the DFPSE. At least one external surface layer of the DFPSE is a barrier FPSE that restricts solids from underlying layers.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: December 27, 2016
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Abuzar Kabir, Kenneth G. Furton
  • Patent number: 9500646
    Abstract: The present invention relates to a cartridge for sensor for detecting the concentrations of one or more components in a sample. The cartridge for sensor for detecting one or more components in a sample of the present invention not only enables quantitative measurement of one or more components in a sample by one time sample injection but also facilitates mass-production with low cost owing to the simple structure and easiness in preparation and carry. Therefore, the cartridge of the present invention can be effectively used as the biosensor cartridge for field measurement.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: November 22, 2016
    Inventors: Kyujeong Song, Seung Hyun Jung, Moon Hee Choi, In Seok Jeong, Junhee Han, Geun Sig Cha