Patents Examined by James W. Rogers
  • Patent number: 11400172
    Abstract: The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: August 2, 2022
    Assignee: GE HEALTHCARE AS
    Inventors: Mikkel Jacob Thaning, Andreas Richard Meijer
  • Patent number: 11400159
    Abstract: The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: August 2, 2022
    Assignee: Amryt Endo, Inc.
    Inventors: Roni Mamluk, Moshe Tzabari, Karen Marom, Paul Salama, Irina Weinstein
  • Patent number: 11389538
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: July 19, 2022
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Patent number: 11384088
    Abstract: The present invention relates to compounds that are useful as radiopharmaceuticals and radioimaging agents which bear a radionuclide-chelating agent. These coordinated compounds are useful in radiotherapy and diagnostic imaging. The invention also relates to methods of diagnosis, prognosis and therapy utilising the non-coordinated and radiolabelled compounds of the invention.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: July 12, 2022
    Assignee: Clarity Pharmaceuticals Ltd
    Inventors: Nicholas Alan Zia, Paul Stephen Donnelly
  • Patent number: 11359044
    Abstract: The present disclosure discloses preparation and application of a novel multifunctional nanocomposite material with new photosensitizer, and belongs to the technical field of photodynamic therapy and the field of biomedicine. The photosensitizer multifunctional nanocomposite material provided by the present disclosure is prepared by self-assembly of cercosporin and an acid-sensitive copolymer multifunctional material with liver tumor cell targeting ability and traceability, wherein the acid-sensitive copolymer multifunctional material can be a copolymer of poly(N,N-dimethylaminoethyl methacrylate) and poly-3-azido-2-hydroxypropyl methacrylate covalently linked by galactose-modified rhodamine B.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 14, 2022
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Jian Yin, Jing Hu, Zhou Ye, Yijian Rao
  • Patent number: 11357872
    Abstract: Imaging based detection of changes in extracellular neurotransmitter concentration in living tissue is achieved using novel nanotube-based sensors. The sensors are functionalized, neurocompatible single-walled carbon nanotubes (SWNT) comprising an adsorbed neurotransmitter analyte selective polynucleotide.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: June 14, 2022
    Assignee: The Regents of the University of California
    Inventors: Markita P. Del Carpio Landry, Linda A. Wilbrecht, Jackson Travis Del Bonis-O'Donnell, Abraham G. Beyene
  • Patent number: 11331278
    Abstract: A hydrophobic topical skin composition is disclosed. The composition includes greater than 50% w/w of the composition of a continuous hydrophobic carrier, 5-24% w/w of one or more volatile silicone fluids, and 0.1 to 5% w/w of the composition of a plurality of taxane nanoparticles, wherein the mean particle size (number) of the taxane nanoparticles is from 0.1 microns to 1.5 microns, and wherein the taxane nanoparticles are crystalline nanoparticles or a combination of amorphous and crystalline nanoparticles.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 17, 2022
    Assignee: DFB SORIA, LLC
    Inventors: Keith Johnson, Robert Lathrop, Meidong Yang, Holly Maulhardt, Roland Franke
  • Patent number: 11324853
    Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: May 10, 2022
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Craig Wiltsey, Nikhita Mansukhani, Jeffrey Groom, II, Kate Rielly, Changcheng You, Danny Concagh
  • Patent number: 11311648
    Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for controlling the movement of bodily fluid within a patient, among many other uses.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 26, 2022
    Assignee: MEDTRONIC VASCULAR, INC.
    Inventors: Craig Wiltsey, Nikhita Mansukhani, Jeffrey Groom, II, Kate Rielly, Changcheng You, Danny Concagh
  • Patent number: 11304964
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: April 19, 2022
    Assignee: Lauren Sciences LLC
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Patent number: 11285226
    Abstract: The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERR?) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: March 29, 2022
    Assignees: Daegu-Gyeongbuk Medical Innovation Foundation, KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL, Kyungpook National University Industry-Academic Cooperation Foundation
    Inventors: Sung Yeoun Hwang, Sung Jin Cho, Jina Kim, Jungwook Chin, Hayoung Hwang, In-Kyu Lee, Yong-Hyun Jeon, Jaetae Lee, Jae-Han Jeon, Sang Wook Kim
  • Patent number: 11279784
    Abstract: The present disclosure provides purified forms of iobenguane and preparations of a precursor to iobenguane, such as a polymer, the polymer comprising a monomer of formula (I) or a pharmaceutically acceptable salt thereof, the preparation comprising leachable tin at a level of 0 ppm to 850 ppm.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: March 22, 2022
    Assignee: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
    Inventors: Jason Moss, Machinani Rao
  • Patent number: 11249073
    Abstract: The present disclosure provides metal-containing (MC) semiconducting (SC) Pdots (MC-SC-Pdots) with beneficial functionalities in both cellular imaging and manipulation, among other applications. The Pdots comprise at least one nanoparticle comprising at least one metal, and a semiconducting polymer associated with the nanoparticle.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Daniel T. Chiu, Wei Sun, Jiangbo Yu, Changfeng Wu
  • Patent number: 11197818
    Abstract: Aqueous nanoemulsions of carbamato-functional organopolysiloxanes prepared using a polyoxyethylene emulsifier having an HLB greater than 15 and at least 40 oxyethylene moieties and having a D50 particle size ?100 nm are transparent, stable, and useful in cosmetic compositions, particularly hair care compositions.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: December 14, 2021
    Assignee: WACKER CHEMIE AG
    Inventors: Christof Brehm, Gerhard Beer, Werner Limmer
  • Patent number: 11191714
    Abstract: A robust sunscreen composition is disclosed herein comprising a water soluble polymer and a water insoluble film former providing a synergistic effect in SPF retention and critical wavelength after immersion in water, salt water, and chlorinated water. The water soluble polymer comprises poloxamer 338 (and) PPG-12/SMDI copolymer, poloxamer 407 (and) PPG-12/SMDI copolymer, or a combination thereof.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: December 7, 2021
    Assignee: EDGEWELL PERSONAL CARE BRANDS, LLC
    Inventors: Geng Li, James SaNogueira
  • Patent number: 11191704
    Abstract: The subject matter of the present invention is a cosmetic or pharmaceutical composition for controlled moisturizing and release of active molecule(s), comprising at least one emulsifier having an enzyme cleavable bound, at least one emollient, at least one polar solvent, and water, forming together a macroscopically homogenous liquid crystals emulsion. In some embodiments of the invention, the composition also includes at least one ingredient having a cosmetic or pharmaceutical activity.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: December 7, 2021
    Assignee: AMANTIN EXPERTS
    Inventors: Elisabeth Briand, Jean-Baptiste Dumas Milne Edwards, Jacques Delort
  • Patent number: 11186553
    Abstract: The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small excess of free chelator. The method uses a solid phase-bound scavenger chelator to remove excess lanthanide metal ions, prior to the addition of a defined excess chelator. Also provided is a method of preparation of MRI contrast agents, together with solid-phase bound chelator meglumine salts useful in the methods.
    Type: Grant
    Filed: November 27, 2015
    Date of Patent: November 30, 2021
    Assignee: GE HEALTHCARE AS
    Inventors: Mikkel Jacob Thaning, Andreas Richard Meijer
  • Patent number: 11135173
    Abstract: A prolonged release multiple unit dosage form, preferably pellets, of cysteamine, cystamine or a pharmaceutically acceptable salt thereof, preferably cysteamine bitartrate, with a non gastro-resistant coating is described. The dosage form is particularly indicated for the administration to patients once or twice a day and it can be used also for pediatric administration.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 5, 2021
    Assignee: RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A.
    Inventors: Andrea Gazzaniga, Matteo Cerea, Alessandra Maroni, Marco Barchielli
  • Patent number: 11134684
    Abstract: A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: October 5, 2021
    Assignee: Purdue Research Foundation
    Inventors: Jeffrey P. Youngblood, Philippe H. Sellenet
  • Patent number: 11116855
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 14, 2021
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb