Patents Examined by Jan M. Ludlow
  • Patent number: 8071056
    Abstract: The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: December 6, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Mark A. Burns, Brian N. Johnson, Michael Chen
  • Patent number: 8007742
    Abstract: A digester-evaporator for partially digesting a sample and for evaporating the solvent after partial digestion. The digester includes at least one reaction coil; a heating element arranged along a portion of the reaction coil; at least a portion of the reaction coil proximate to its output being preheated by the heating element to a degree sufficient to convert a partially digested sample into vapor; a collector spoon with carrier water for collecting sample vapor; and an evaporator portion including an evaporation chamber including a substantially vertically-oriented tube The collector spoon is arranged in the top of the substantially vertically-oriented tube, and a gas supply tube for supplying a preheated gas provided in a top of the substantially vertically-oriented tube so as to create a cyclonic gas flow into the chamber and carry the sample to a container area in a bottom portion of the chamber.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: August 30, 2011
    Assignee: United States of America as represented by the Secretary of Commerce
    Inventors: Stephen E. Long, David M. Bunk, Mariana Arce-Osuna
  • Patent number: 8007745
    Abstract: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample prior to analysis. More specifically, the device in accordance with an embodiment of the present invention includes a plurality of wells in fluid communication with a an outlet or drainage opening containing a three dimensional structure comprising a plurality of sorptive particles entrapped in a porous polymer matrix so as to form a device capable of carrying out solid phase extraction. In a preferred embodiment, the wells are configured so as to prevent a sample carrier present in the wells from clogging the outlet when subjected to a driving force such as vacuum.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: August 30, 2011
    Assignee: Millipore Corporation
    Inventors: Phillip Clark, Chris A. Scott, Marc Emerick, William Kopaciewicz, Donald B. Rising
  • Patent number: 7998411
    Abstract: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: August 16, 2011
    Assignee: ABAXIS, Inc.
    Inventors: Anne R. Kopf-Sill, Carol T. Schembri
  • Patent number: 7998746
    Abstract: Chips that include one or more particle manipulation mechanisms, or force transduction elements, provided at specific locations to manipulate and localize particles proximal the substrate surface. In one embodiment, individually addressable magnetic control mechanisms such as electric coils are provided at specific locations to create a magnetic field to attract magnetic particles, such a magnetic or magnetizable beads, to those specific locations. In another embodiment, electrostatic control mechanisms such as electrodes are provided to attract and manipulate electrically charged micro-particles. A location may include a crater or well formed in the substrate, or it may include an element on the surface of the substrate. In some embodiments, one or more sensors are located proximal specific locations, e.g., specific craters, so as to analyze specific conditions at each location. In other embodiments, multiple locations share one or more sensors.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: August 16, 2011
    Inventors: Robert Otillar, David Storek, Christer Johansson
  • Patent number: 7988934
    Abstract: Relates to a carrier (1) for positioning objects (5), which are oriented in the Z direction of a coordinate system, in relation to laboratory articles. Z rods (12) comprise a Z guide (43), on a cage (10) carrying the individual drive wheel (17), on which the Z rod (12) is guided in the Z direction. Each drive wheel (17) comprises a section (41), which is tailored to the cross-section of the profiled rod (18) of the Z drive of the carrier (1), individually driven by a motor, on which the drive wheel (17) is seated so it is not rotatable and is displaceable by sliding in the Y direction. The carrier (1) is characterized in that the attack faces (40) of the profiled rods (18) for driving a drive wheel are larger than the attack faces of a profiled rod having a square cross-section but having equally large radius.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: August 2, 2011
    Assignee: Tecan Trading AG
    Inventor: Johannes Balmer
  • Patent number: 7985593
    Abstract: Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: July 26, 2011
    Assignee: Dow Global Technologies LLC
    Inventors: David T. Gillespie, Colin Li Pi Shan, Lonnie G. Hazlitt, Alexander W. DeGroot, Peter B. Arnoudse, Charles Allen Williams
  • Patent number: 7977114
    Abstract: Embodiments of the invention feature methods and apparatus for the efficient utilization of detectors and other components. The apparatus comprises a pump for receiving and propelling one or more samples in a fluid path. The apparatus further comprises a valve element in fluid communication with the pump for receiving the samples from the pump and directing the sample along one fluid path selected from a group. The group comprises a delay path comprising a delay volume, and a chromatography assembly having at least one chromatography column. The apparatus further comprises a detector or grouping of detectors in fluid communication with the delay path and the chromatography assembly for detecting compounds of interest to allow a single detector or single grouping of detectors to receive samples from the two fluid paths.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: July 12, 2011
    Assignee: Waters Technologies Corporation
    Inventors: Michael Swartz, Charles H. Fraiser, Patricia Ann Fowler, Michael D. Jones
  • Patent number: 7955865
    Abstract: Apparatus for dispensing droplets of reagent onto samples includes a probe tip to which droplets of reagent can adhere. The apparatus advances the probe tip toward a sample until a droplet of reagent touches the sample and is pulled off from the probe tip. A sensor detects that the droplet has been pulled off from the probe tip and halts the advance of the probe tip before the probe tip touches the sample. Such apparatus may be used to automatically dispense small volumes of reagent onto fragile samples.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: June 7, 2011
    Assignee: The University of British Columbia
    Inventors: Andrea Marziali, Diponkar Banerjee, Jason Donald Thompson, Kurtis Dan Guggenheimer, Jared Raymond Slobodan, Roy Alexander Belak, David Keddie Brown
  • Patent number: 7951611
    Abstract: A card or insert having a plurality of recesses for a sample preparation device, the card containing cast-in-place composite and/or non-filled structures which are useful as sorptive or reactive media or for size-based separations. Any particular card size or configuration can be used, and the inclusion of a large amount of adsorptive particles in polymer is achieved while still maintaining the membrane three dimensional structure. In a first preferred embodiment, the composite structures comprise particles entrapped within a porous polymeric substrate, and are cast in-place into a plurality of recesses in an insert for a multi-well sample preparation device, thereby providing an effective platform for high throughput micromass handling.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: May 31, 2011
    Assignee: Millipore Corporation
    Inventors: William Kopaciewicz, Cheryl Brucato
  • Patent number: 7947512
    Abstract: The invention relates to a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, and aims at providing a dispensing cylinder, a large capacity dispensing device, and a method of using a large capacity dispensing device, with high quantitativity and capable of suppressing the scale of the device and efficiently utilizing working space, despite the relatively large volumes of fluid handled. The construction comprises: a small diameter section, a large diameter section which communicates with the small diameter section and is capable of holding fluids, a sliding section provided in a slidable manner within the large diameter section which enables fluid to be sucked and discharged to and from the large diameter section through the small diameter section, and a connection section which connects the sliding section in a detachable manner to a suction and discharge mechanism which drives the sliding section.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: May 24, 2011
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Yoshinao Hirahara
  • Patent number: 7923252
    Abstract: A droplet forming flow cytometer system (1) allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal (10) within the nozzle volume (3) and directly coupled to the sheath fluid. The nozzle container (27) continuously converges so as to amplify unidirectional oscillations (11) which are transmitted as pressure waves through the nozzle volume (3) to the nozzle exit so as to form droplets from the fluid jet. A variation in substance concentration is achieved through a movable substance introduction port (9) which is positioned within a convergence zone (32) to vary the relative concentration of substance to sheath fluid while still maintaining optimal laminar flow conditions. This variation may be automatically controlled through a sensor and controller configuration.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: April 12, 2011
    Assignee: University of Washington
    Inventor: Ger Van den Engh
  • Patent number: 7910371
    Abstract: A method of monitoring residual treating agent in treated water wherein fluorescent tracers are used to determine the concentration of treating agent in the water at two different treating agent dosages and the difference in the measured concentrations of the fluorescent tracer at the respective doses are correlated with the residual concentration of the treating agent. The fluorescence response at the different treating agent dosages is used to determine whether the system is overdosed or underdosed on a continuous basis and to control treating agent dose accordingly.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: March 22, 2011
    Assignee: Nalco Company
    Inventor: Brian S. Johnson
  • Patent number: 7910373
    Abstract: An ultra-fast response, high sensitivity structure for optical detection of low concentrations of hydrogen gas, comprising: a substrate; a water-doped WO3 layer coated on the substrate; and a palladium layer coated on the water-doped WO3 layer.
    Type: Grant
    Filed: May 5, 2001
    Date of Patent: March 22, 2011
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: Ping Liu, C. Edwin Tracy, J. Roland Pitts, Se-Hee Lee
  • Patent number: 7892848
    Abstract: The present invention pertains to a method of ion chromatography wherein a specialized electrodeionization (EDI) apparatus is used for (1) the preparation of a pure acid or pure base for use as an eluent in a chromatographic separation column and/or (2) for ion suppression (or neutralization) of the acid or base after it has been used to elute ions from a chromatographic separation column. Methods for trace ion removal, acid and base neutralization, and ion suppression using a specialized EDI apparatus are also described. The methods described herein allow for the ion suppression of samples containing chloride, nitrate, and other electrochemically active anions, without causing damage to the suppressor.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: February 22, 2011
    Assignee: Trovion Singapore Pte. Ltd., Co.
    Inventor: John M. Riviello
  • Patent number: 7842246
    Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: November 30, 2010
    Assignee: Meso Scale Technologies, LLC
    Inventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
  • Patent number: 7833480
    Abstract: Apparatus or systems which employ luminescence-quenching to produce a signal indicative of oxygen concentration.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: November 16, 2010
    Assignee: RIC Investments, Inc.
    Inventors: Perry R. Blazewicz, Leslie E. Mace, Jerry R. Apperson
  • Patent number: 7815863
    Abstract: An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle portion is reinforced to prevent flexing, and a prefabricated trough along the edge of the land surface prevents introduction of the adhesive into the region for analysis. The cartridge has a stopper having a dual sealing mechanism, which seals the test chamber inlet between the vestibule and the test chamber, and the mouth of the vestibule so that when the stopper is in place, the test chamber is closed to the admission of air or other contaminants. The vestibule is similarly closed against escape of the overflow from the test chamber. The stopper is composed of a single elastomer. An improved locking mechanism has two flexible walls on either side of the handhold that locks into their respective keepers on the cartridge to provide a secure lock.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: October 19, 2010
    Assignee: Veridex, LLC
    Inventors: Michael Kagan, Galla Chandra Rao, Jerry Prohaska, Tor Alden
  • Patent number: 7807466
    Abstract: Fat content is analyzed by extraction in a filtration vessel having a porous hydrophilic and oleophobic filter.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: October 5, 2010
    Assignee: Foss Analytical AB
    Inventors: Michael Arthur Kitcherside, Margaret Joan Kitcherside
  • Patent number: 7776273
    Abstract: The present invention generally discloses an extraction system that provides a locale for fluid processing and extraction on a post-microcapture transfer film. The extraction system includes a transfer film carrier and an extraction device forming a reservoir. The extraction system selectively excludes regions of the transfer film from the reservoir to advantageously reduce contamination due to matter adhered to the transfer film by non-specific transfer.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: August 17, 2010
    Assignee: Life Technologies Corporation
    Inventors: Thomas M. Baer, Robert H. Reamey, Keith E. Moravick, David F. Head, Bruce J. Richardson, Derrick A. Richardson