Patents Examined by Jeffrey Snay
  • Patent number: 7045023
    Abstract: Various rubbers, thermoplastic elastomers, and plastics can be cleaned with an acid (inorganic or organic) or a salt thereof to extend the useful life of the material. A desired end use for the material is a vehicle wiper blade. Alkyl or aromatic sulfonic acids are desired due to their ability to clean and regenerate a used wiper blade as well as to reduce streaking. Residual alkyl or aromatic sulfonic acid left on the blade can help to retard later build-up of oil and dirt on the blade.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: May 16, 2006
    Assignee: Bandon Corporation
    Inventor: Ronald A. Kramer
  • Patent number: 6927064
    Abstract: A fertility determining system employing hormone level measuring apparatus on selected days in a menstrual cycle to determine the levels of analytes, i.e., estrone-3-glucuronide (“E3G”) and luteinizing hormone (“LH”), in early morning urine. The fertility/infertility signalling algorithm relies upon data characterizing the user earlier in that menstrual cycle, and also upon her analyte pattern in past recent cycles. At a point in a menstrual cycle which is user-dependent, the early morning E3G urine level is compared against the lower E3G level earlier in the cycle. The beginning of the fertile period is signalled when a sufficient E3G increase occurs. The end of the fertile period (and, correspondingly, the reestablishment of a period requiring no contraception) is signalled a period after the LH surge. In the absence of an LH surge in any subject, the end of the fertile phase is signalled a period of time following the peak of the E3G urinary metabolite of estradiol.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: August 9, 2005
    Assignee: Inverness Medical Switzerland GmbH
    Inventors: Michael Catt, Carole R. Cunningham, Paul H. C. Mundill, Michael E Prior, Stewart Wilson, Zhi G. Zhang
  • Patent number: 6887430
    Abstract: A total reflection cell has a total reflection prism on at least one surface thereof. A mixed solution containing a gold colloid labelled antibody which is adsorbed on a gold colloid is stored in the total reflection cell, and a sample solution containing an antigen causing antigen-antibody reaction with the antibody is added thereto for forming a gold colloid labelled immune complex. A measuring beam is introduced into the total reflection prism from an incident optical system at an angle ? of incidence causing total reflection and an outgoing beam from the total reflection prism is received by a measuring optical system, thereby measuring absorption by the gold colloid labelled immune complex and carrying out qualification and determination of the antigen.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: May 3, 2005
    Assignee: Kyoto Dai-Ichi Kagaku Co., Ltd.
    Inventors: Xiaoming Dou, Yoshinori Yamaguchi, Harumi Uenoyama
  • Patent number: 6830732
    Abstract: The invention relates to a new multiwell filtration plate for high throughput applications in nucleic acid technology, preferably in a 96-well or 384-well format, consisting of two individual parts, which are firmly and tightly connected together. The upper part of the plate is a sample holder 1 for holding a sample to be filtered. The lower part of the plate is an outlet part with a filter insert for receiving a sample from the sample holder part and filtering the, sample through the filter insert.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: December 14, 2004
    Assignees: Invitek GmbH, AHN Biotechnologie GmbH
    Inventors: Hans-Jürgen Hoffman, Timo Hillebrand, Peter Bendzko
  • Patent number: 6818453
    Abstract: The invention pertains to a non-fluorescent label which is suitable for making a charge-transfer fluorescent probe having a donor-bridge-acceptor structure, characterized in that the label comprises a maleimide moiety and the donor-bridge-acceptor structure, wherein the bridge is a group which leads to an all-trans orbital coupling of the donor and the acceptor, and the donor-bridge-acceptor structure has a higher energy charge-transfer emissive state than at least one non-emissive state of part of the label comprising the maleimide moiety, which non-emissive state must have a higher energy than the charge-transfer emissive state of the donor-bridge-acceptor structure after coupling of the maleimide moiety to a suitable system.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: November 16, 2004
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Johannes W. Hofstraat, Jan W. Verhoeven, Marijn Goes
  • Patent number: 6812030
    Abstract: A system and method high throughput sample preparation and analysis using column chromatography. Each port in a plurality of ports has a port input that interfaces with a first fluid source and a port output. A fluidic circuit is coupled to each port output and to a second fluid source, the fluidic circuit for controlling fluid flow from the plurality of ports and the second fluid source. The fluidic circuit is also coupled to a plurality of chromatography columns. An interface to an analyzer receives output from at least one of the plurality of chromatography columns. The plurality of chromatography columns is moved relative to the analyzer via a translation stage, such that sample output from one of the plurality of chromatography columns can be selectively presented to the analyzer.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: November 2, 2004
    Assignee: BioTrove, Inc.
    Inventors: Can Ozbal, Ian W. Hunter, John Linton
  • Patent number: 6808931
    Abstract: A method for the determination of hexavalent chromium (CrVI) in environmental and industrial hygiene samples is provided. Based on the chemical properties of chromium species in aqueous solutions, a simple, fast, sensitive, and economical field method has been developed and evaluated for the determination of hexavalent chromium (CrVI). Using ultrasonic extraction in combination with a strong anion exchange solid phase extraction (SAE-SPE) technique, the filtration, preconcentration, and isolation of CrVI in the presence of other chromium species and interferents was achieved.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: October 26, 2004
    Assignee: The United States of America as represented by the Secretary of Health and Human Services
    Inventors: Jin Wang, Kevin Ashley
  • Patent number: 6805843
    Abstract: A slide glass rack for use in a centrifugal apparatus has a slide glass accommodating concave that opens upward, and a flange provided on an upper outer peripheral surface of the rack. A centrifugal apparatus that uses the slide glass rack comprises a rotor, wherein the rotor is formed at a peripheral edge thereof with an inclined face extending upward obliquely with a predetermined angle, the inclined face being formed with a rectangular hole through which a slide glass rack is inserted, the flange of the rack is supported by the peripheral edges of the rectangular hole.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: October 19, 2004
    Assignee: Tomy Kogyo Co., Ltd
    Inventors: Sadashi Tsukui, Masami Arakawa
  • Patent number: 6777244
    Abstract: A compact sensor for detection of chemical and/or biological compounds in low concentration. The sensor comprises electromagnetic microcavities. The agent to be detected passes the microcavities, is absorbed and/or absorbed by the microcavities, and modifies the electromagnetic field inside the microcavities. After the agent has been adsorbed and/or absorbed, a probe beam is applied to the microcavities. The change of electromagnetic field is detected by the detector, and the frequency of the probe beam at which the resonance is observed, is indicative of a particular agent being present. A method for detecting chemical and/or biological compounds using the sensor.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: August 17, 2004
    Assignee: HRL Laboratories, LLC
    Inventors: David M. Pepper, Daniel Sievenpiper
  • Patent number: 6762054
    Abstract: In order to improve the reliability of the measurement by judging the precision of a measured value and judging the effectiveness of the measurement based on a result of the precision judgment, the optical characteristic of a reagent solution is previously measured in measuring the concentration of a specific component in a sample solution. Consequently, the precision of the concentration measurement is ensured based on the degree of degradation of the reagent solution.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: July 13, 2004
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventor: Tatsurou Kawamura
  • Patent number: 6759247
    Abstract: In analyzing radiation from a sample, single-quanta counting can be used to advantage especially at low levels of radiation energy, e.g. in the detection of fluorescent radiation. Preferred detection techniques include methods in which (i) fluorescence-stimulating radiation is intensity-modulated in accordance with a preselected code, (ii) wherein it is the fluorescent radiation which is intensity-modulated with the preselected code, and (iii) wherein modulation with a preselected code is applied to a sample to influence a property which functionally affects emitted fluorescent radiation. For registration of the signals from a sensing element of a single-photon detector, time of arrival is recorded, optionally in conjunction with registration of time intervals. Advantageously, in the interest of minimizing the number of pulses missed due to close temporal spacing of pulses, D-triggers can be included in counting circuitry.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: July 6, 2004
    Assignee: The Research Foundation of State University of New York
    Inventors: Serge Luryi, Vera Gorfinkel, Mikhail Gouzman
  • Patent number: 6716637
    Abstract: This invention relates a chemiluminescent gas analyzer for determining a concentration of a gaseous component (G1) in a sample gas mixture (2). The analyzer comprises a measuring chamber (3), an ozonizer (4) with ozone generating devices (44) for producing ozone-containing gas (G2), input conduits (24, 23) for delivering the ozone-containing gas and said gas mixture into the chamber and an outlet (18). A detector (7) receives radiation (E) emitted as a consequence of a reaction between the gaseous component and the ozone-containing gas. Said analyzer further comprises a flow delay device (41) in or upstream the input conduit for said ozone-containing gas and downstream from the ozone generating devices (44) of the ozonizer. The flow delay device has a delay volume (VD) causing a predetermined delay time (T) for the flow of the ozone-containing gas from said ozonizer to said measuring chamber (3).
    Type: Grant
    Filed: March 20, 2002
    Date of Patent: April 6, 2004
    Assignee: Instrumentarium Corp.
    Inventor: Kurt Weckstrom
  • Patent number: 6713307
    Abstract: The present invention provides a real-time luminescent piezoelectric detector capable of sensing the presence of biological and chemical agents. This detector includes a free-standing thin film that is driven by a frequency driver to produce light emitted from an edge of the thin film. A surface layer sensitive to the biological or chemical agent to be detected is disposed on the surface of the thin film. In the presence of the biological or chemical agent to be detected, the light emitted from the edge of the thin film structure is altered. A processor capable of determining the presence and/or concentration of the biological or chemical agent in question based on the altered emitted light receives an output representative of the emitted light and outputs the status of the presence and/or concentration of the biological or chemical agent in question.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: March 30, 2004
    Assignee: R&DM Foundation
    Inventor: Robert Mays, Jr.
  • Patent number: 6709634
    Abstract: An automatic analytical instrument comprising a plurality of specimen tubes to store specimens, a plurality of storage tubes to store a part of the specimens contained in the specimen tubes by dispensing, a first dispensing unit to dispense the specimens contained in the specimen tubes into the storage tubes, a first turning table to hold a plurality of the storage tubes and transfer them by revolution, a plurality of analytical tubes to store a part of the specimens contained in the storage tubes by dispensing, a second dispensing unit to dispense the specimens contained in the storage tubes into the analytical tubes, a second turning table to hold a plurality of the analytical tubes and transfer them by revolution, an analytical unit to analyze the specimens contained in the analytical tubes, a transfer unit to transfer the analytical tubes held in the second turning table to the analytical unit, an delivering unit to deliver the analytical tubes after analysis is completed, a tube supply unit to supply the
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: March 23, 2004
    Assignees: Sysmex Corporation, Ryusyo Industrial Co., Ltd.
    Inventors: Satoru Okada, Tadahiro Takami, Motoki Koyama, Katsushi Yano, Koichi Miyake
  • Patent number: 6706528
    Abstract: The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: March 16, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert E. London, Pieter Otten, Louis A. Levy
  • Patent number: 6699717
    Abstract: The present invention relates to a transition metal-ligand complex that shows changes in its luminescence lifetime characteristic and/or luminescence intensity as a function of the polarity and/or hydrogen bonding properties of its environment, and a sensor, probe, system and method based on the complex for detecting the presence, amount or concentration of a polar solvent in a medium.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: March 2, 2004
    Assignees: The University of Maryland Baltimore County, The University of Maryland Biotechnology Institute
    Inventors: Govind Rao, Qing Chang, Joseph R. Lakowicz, Zakir Murtaza
  • Patent number: 6699719
    Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Multiplexed assays using the surface detector array device of the present invention are disclosed, as are automated methods for making the surface detector array device that enable formation of arrays wherein the composition of the individual, addressable bilayer regions is unrestricted.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: March 2, 2004
    Assignee: Proteomic Systems, Inc.
    Inventors: Miki (Vikky) Yamazaki, Morrison Ulman, Luat T. Nguyen, Steven G. Boxer, John T. Groves
  • Patent number: 6692697
    Abstract: A versatile flow cell front-end (104) for storing and delivering reagents, test samples, and other transportable materials within an optically-based integrated sensor device (100), where management of those materials is controlled via electrical connections (110, 114) within the optically-based integrated sensor device is disclosed, including an inlet chamber (118) formed within the flow cell, a sensing chamber (116) formed within the flow cell, an electrical interface (114) formed within the flow cell, a conduit (122) adjoining the inlet and sensing chambers, another conduit (124) adapted to dispose of fluid in the sensing chamber, and a fluidic control member (126) instantiated along the conduit and responsively coupled to the electrical interface.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: February 17, 2004
    Assignee: Texas Instruments Incorporated
    Inventors: Jose L. Melendez, Jerome L. Elkind
  • Patent number: 6692967
    Abstract: A method, compositions and kit are set forth for detecting blood stains. A reactant solution includes fluorescin solubilized (reduced) in acetic acid in ethanol. The solution may be buffered to a pH of approximately 9. After spraying the reactant solution on the suspected area an oxidizer is applied to promote the fluorescin to fluorescein reaction with the blood. The reacted fluorescein is then detected through luminescence for capture by photography.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: February 17, 2004
    Inventors: John Di Benedetto, Kevin Kyle, Terry Boan, Charlene Marie
  • Patent number: 6689318
    Abstract: The apparatus for analysis of physiological fluids of the invention contains equipment for automatic introduction of reference fluids to a sample aggregate inlet of the apparatus. The apparatus also contains equipment for analyzing the samples.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: February 10, 2004
    Assignee: Radiometer Medical A/S
    Inventors: Allan Spork, Bent Pedersen, Niels Fremming, Kristian Jacob Hvidtfeldt