Patents Examined by Jennifer A Berrios
  • Physically and chemically stable oral suspensions of givinostat
    Patent number: 10688047
    Abstract: Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 23, 2020
    Assignee: ITALFARMACO SPA
    Inventors: Giuseppe Colombo, Roberta Artico, Paolo Mascagni, Maria Valmen Monzani, Silvia Puccianti
  • Topical gel for alleviating food cravings and method of making same
    Patent number: 10688042
    Abstract: A gel for topical application for alleviating food cravings is disclosed, which includes the steps of: periodically applying a gel topically to a user's skin, wherein said gel comprises: about 45.0 percent by weight of deionized water; about 10.0 percent by weight of benzyl alcohol; about 40.0 percent by weight of ethyl alcohol; about 0.2 percent by weight of tocopherol acetate; about 0.15 percent by weight of docosahexaenoic acid (DHA); about 1.15 percent by weight of resveratrol; about 1.0 percent by weight of a cross-linked polyacrylic acid copolymer; about 0.1 percent by weight of ethylenediaminetetraacetic acid (EDTA); about 200 ?L of lemon essential oil; and, from about 100 ?L to 200 ?L of triethanolamine.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: June 23, 2020
    Inventor: Antonino Cavallaro
  • UV-protective compositions and their use
    Patent number: 10675229
    Abstract: Disclosed are compositions comprising inorganic UV-absorbing agents and the use of such compositions, in particular for protecting a subject or the surface of an inanimate object against a harmful effect of ultraviolet radiation.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: June 9, 2020
    Assignee: LANDA LABS (2012) LTD.
    Inventors: Benzion Landa, Sagi Abramovich, Snir Dor
  • Drug delivery devices and methods of making and using same
    Patent number: 10653822
    Abstract: The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.
    Type: Grant
    Filed: August 11, 2018
    Date of Patent: May 19, 2020
    Assignee: THE ADMINSTRATORS OF THE TULANE EDUCATIONAL FUND
    Inventors: Diane A. Blake, Vijay T. John, Ramesh Ayyala, Thiruselvam Ponnusamy
  • Process for cosmetic treatment of keratin materials
    Patent number: 10646428
    Abstract: The invention relates to a cosmetic treatment process, in particular for caring for or making up keratin materials, comprising the following steps: a) a step of applying, to the keratin materials, a cosmetic composition comprising a compound comprising at least 2 maleimide groups; b) a step of applying a cosmetic composition comprising a compound comprising at least 2 furfuryl groups. The invention also relates to a kit comprising the two compositions, enabling said process to be carried out. The invention also relates to copolymers furfuryl (meth)acrylate, specifically (meth)acrylamide, and addition monomer chosen from polyethylene glycol (meth)acrylates and polydimethylsiloxanes with mono(meth)acryloyloxy end group.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 12, 2020
    Assignee: L'OREAL
    Inventors: Gwenaëlle Jegou, Philippe Barbarat, Gérard Malle
  • Oral baclofen solutions
    Patent number: 10610502
    Abstract: The present disclosure relates to aqueous oral solutions comprising baclofen. In one embodiment, the aqueous oral solutions comprise a buffer comprising citric acid, a salt of citric acid, or any combination thereof, and are stored at from about 2° C. to about 8° C. The present disclosure also relates to buffer free aqueous oral solutions comprising baclofen. Additionally, the present disclosure relates to an assay for determining the amount of an impurity, 4-(3-carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-chlorophenyl)butanoic acid, in a baclofen containing solution, and to methods of treatment using such aqueous oral solutions.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: April 7, 2020
    Assignee: Metacel Pharmaceuticals, LLC
    Inventors: Thomas Jeffrey Bryant, H. Greg Thomas
  • Skin tightening compositions
    Patent number: 10588848
    Abstract: The present disclosure relates to cosmetic compositions that provide immediate skin-tightening and long-lasting improvements to the skin for the treatment of, for example, eye bags, facial wrinkles, and other age-related skin imperfections. The compositions comprise: (a) a first film former sodium silicate; (b) a second film former; (c) at least one polyvalent silicate; (d) at least one anionic associative polymeric thickener; (e) a third film former VP/VA Copolymer; (f) at least two plasticizer; (g) at least one treated or non treated iron oxide pigments; and (h) optionally at least one cosmetic powder.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: March 17, 2020
    Assignee: L'OREAL
    Inventors: Mariana Montoya, Angelike A. Galdi, Susan Halpern Chirch, Hubert Tunchiao Lam
  • Barrier patch of a foamed film and methods of improving skin appearance
    Patent number: 10576023
    Abstract: A beauty care product is provided. The beauty care product has a multi-layered barrier patch with a non-foamed first layer and a foamed second layer. The non-foamed first layer has a non-foamed polymer film with a first surface and a thickness from 5 microns to 250 microns. The foamed second layer has a foamed polymer film comprising a Mean Void Volume Percentage from 45% to 80% and a thickness of from 10 microns to 250 microns. The beauty care product also has a cosmetic composition with an effective amount of a skin active agent and a pressure sensitive adhesive.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: March 3, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Emily Charlotte Boswell, Elizabeth Anne Wilder, Michael Remus
  • Dry powder Vancomycin compositions and associated methods
    Patent number: 10561608
    Abstract: Dry powder vancomycin compositions and methods for administering and preparing such compositions are provided.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: February 18, 2020
    Assignee: Savara Inc.
    Inventors: John Lord, Jaakko Taneli Jouhikainen, Herman E. Snyder, Pravin Soni, Mei-Chang Kuo
  • Highly penetrative nanocarriers for treatment of CNS disease
    Patent number: 10555911
    Abstract: Brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery (CED) have been developed. In the preferred embodiment, these are loaded with FDA-approved compounds, identified through library screening to target brain cancer stem cells (BSCSs). The particles are formed by emulsifying a polymer-drug solution, then removing solvent and centrifuging at a first force to remove the larger particles, then collecting the smaller particles using a second higher force to sediment the smaller particles having a diameter of less than 100 nm, more preferably less than 90 nanometers average diameter, able to penetrate brain interstitial spaces.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: February 11, 2020
    Assignee: Yale University
    Inventors: Jiangbing Zhou, Toral R. Patel, Joseph M. Piepmeier, William Mark Saltzman
  • Dermatological adhesive agent, patch material, and method for producing dermatological adhesive agent
    Patent number: 10556038
    Abstract: Provided are a dermal adhesive composed of a radiation-curable resin and capable of reducing stuffiness that causes rash or itch, a patch including the dermal adhesive, and a method for producing the dermal adhesive. Also provided is a porous membranous dermal adhesive formed through irradiation of a radiation-curable resin with radiation rays. Further provided is a patch including a base sheet and the dermal adhesive disposed on the base sheet. Still further provided is a method for producing a porous membranous dermal adhesive, the method including applying a dermal adhesive composition containing a radiation-curable resin to an adherend so as to form a porous membranous dermal adhesive, and irradiating the dermal adhesive composition with radiation rays.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: February 11, 2020
    Assignee: ALCARE CO., LTD
    Inventors: Ryota Watanabe, Wataru Okuyama
  • Redox signaling gel formulation
    Patent number: 10543230
    Abstract: Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8° C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: January 28, 2020
    Assignee: RDG HOLDING, INC.
    Inventors: Andrew Hoover, James Pack
  • Personal care composition and method of making the same
    Patent number: 10537515
    Abstract: Personal care compositions that include bioactive ingredients derived from achachairu and methods of making the same. The bioactive compositions (ingredients) of the present invention may be free of or substantially free of benzophenones and/or protein, and may exhibit anti-inflammatory, anti-oxidant, anti-aging, and/or anti-protein loss properties. The achachairu ingredient may be in the form of a serum fraction and/or an extract. The personal care compositions are formulated for topical use on skin and/or hair.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: January 21, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Rosemarie Osborne, Lisa Ann Mullins, Michael Koganov
  • Stable liquid formulations of melphalan
    Patent number: 10537520
    Abstract: The present invention relates to stable, liquid parenteral formulations of Melphalan or pharmaceutically acceptable salts thereof. Further this invention also describes process of preparing such formulations.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: January 21, 2020
    Assignee: LEIUTIS PHARMACEUTICALS PVT. LTD.
    Inventors: Kocherlakota Chandrashekhar, Banda Nagaraju
  • Barrier patch of a foamed film and methods of improving skin appearance
    Patent number: 10537498
    Abstract: A beauty care product is provided. The beauty care product has a multi-layered barrier patch with a non-foamed first layer and a foamed second layer. The non-foamed first layer has a non-foamed polymer film with a first surface and a thickness from 5 microns to 250 microns. The foamed second layer has a foamed polymer film comprising a Mean Void Volume Percentage from 45% to 80% and a thickness of from 10 microns to 250 microns. The beauty care product also has a cosmetic composition with an effective amount of a skin active agent and a pressure sensitive adhesive.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: January 21, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Emily Charlotte Boswell, Elizabeth Anne Wilder, Michael Remus
  • Volumizing mascara compositions
    Patent number: 10532010
    Abstract: The present invention relates generally to mascara compositions that impart volume to the eyelashes while maintaining a smooth texture and high shine.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: January 14, 2020
    Assignee: Avon Products, Inc.
    Inventors: Collette Fava Bekisz, Rahul A. Ranade
  • Infection fighting drug eluting device
    Patent number: 10518004
    Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: December 31, 2019
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Mary M. Byron, David R. Wulfman, Angelo Fruci, Adam McGraw, Danielle Frankson, Gregory J. Sherwood, Joseph T. Delaney, Jr., Adeniyi O. Aremu
  • Method to prepare a cream product
    Patent number: 10517801
    Abstract: A method to prepare a cream product includes separately preparing an exclusively aqueous phase and a mixed fatty/aqueous phase, and assembling and emulsify the exclusively aqueous phase and the mixed fatty/aqueous phase.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: December 31, 2019
    Assignee: BAKEL S.R.L.
    Inventor: Raffaella Gregoris
  • Skin care compositions
    Patent number: 10507174
    Abstract: Provided are skin care compositions that are useful as SPF and UV absorption boosters in formulations containing inorganic metal oxides. The compositions comprise (a) (a) copolymer particles; (b) voided latex particles; (c) inorganic metal oxide particles; and (d) one or more dermatologically acceptable carriers. Also provided are methods of protecting skin from UVA and UVB damage comprising topically administering such compositions to the skin, and methods of boosting the SPF or UV absorption of a sunscreen composition containing inorganic metal oxide particles comprising including such copolymer particles and voided latex particles in the composition.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: December 17, 2019
    Assignee: Rohm and Haas Company
    Inventors: Kinjalbahen Joshi, Fanwen Zeng, Beth Cooper
  • Drug delivery system
    Patent number: 10500381
    Abstract: The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: December 10, 2019
    Assignee: BAYER OY
    Inventors: Heikki Lyytikäinen, Harri Jukarainen