Patents Examined by Jennifer C Sawyer
  • Patent number: 11072686
    Abstract: An integrated process for manufacturing polyethyleneamine compounds selected from the group of polyethyleneamines and hydroxyethylethyleneamines is provided.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: July 27, 2021
    Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Rens Veneman, Antoon Jacob Berend Ten Kate, Michiel Jozef Thomas Raaijmakers, Slavisa Jovic, Rolf Krister Edvinsson, Eike Nicolas Kantzer, Karl Fredrik Lake, Ina Ehlers, Hendrik Van Dam
  • Patent number: 11066354
    Abstract: The invention relates to a process for the preparation of a compound represented by formula (I) wherein X is selected from the group consisting of —H, -halogen, linear or branched C1-C7 alkyl group, linear or branched C1-C5 alkoxy group, —NO2 and —CN and Y is a linear or branched C1-C7 alkyl group, comprising the steps of: 10 a) reacting a compound represented by formula (II) with a compound represented by (III) to obtain an intermediate product, wherein X is as defined with respect to formula (I), wherein Z is H, CH3 or C2H5, b) reacting the intermediate product of step a) with a compound represented by Y2SO4 (IV) wherein Y is as defined with respect to formula (I) to obtain a salt and c) hydrolyzing the salt of step b) to obtain the compound of formula (I).
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: July 20, 2021
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Prashant Sukumar Shinge, Jaiprakash Brijlal Sainani
  • Patent number: 11059773
    Abstract: The present invention discloses a type-B crystal form of fenolamine, a preparation method thereof, and a composition and use thereof, more particularly a type-B crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-B fenolamine crystal form in solid state; a method for preparing the solid of type-B crystal form; and use of the solid of the type-B fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 13, 2021
    Assignees: INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES, SHIJIAZHUANG YILING PHARMACEUTICAL CO., LTD.
    Inventors: Yang Lv, Shiying Yang, Gengtao Liu, Dan Zhang, Xiuqi Bao, Ping Xie
  • Patent number: 11046637
    Abstract: The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention.
    Type: Grant
    Filed: July 20, 2019
    Date of Patent: June 29, 2021
    Inventors: Hongjun Du, Wenting Wu
  • Patent number: 11045439
    Abstract: Pentacyclic triterpene weight loss agents are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the weight loss agents, or pharmaceutically acceptable salts or prodrugs thereof, in combination with one or more pharmaceutically acceptable excipients. The pharmaceutical formulations can be administered to a pre-obese, obese, or morbidly obese patient to induce weight loss, reduce body fat, reduce food intake, improve glucose homeostasis, prevent obesity, or a combination thereof. The weight loss agents can also be co-administered with leptin or a leptin analog.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: June 29, 2021
    Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, THE GENERAL HOSPITAL CORPORATION
    Inventors: Umut Ozcan, Joseph Majzoub, Ralph Mazitschek
  • Patent number: 11021434
    Abstract: The present invention relates to a process for preparing ethyleneamines and/or alkanolamines, comprising the following steps: 1) reacting MEG with ammonia in the presence of hydrogen and an amination catalyst; 2) removing hydrogen and ammonia from the reaction output from stage 1, wherein the removal of hydrogen and ammonia in stage 2 comprises the following steps: 2-1) separating the reaction output from stage 1 into a gaseous phase comprising ammonia and hydrogen, and a liquid phase comprising ethyleneamines and/or alkanolamines, 2-2) passing the gaseous phase from stage 2-1) through one or more condensers to obtain one or more liquid phases in which ammonia has been enriched, and a gaseous phase in which hydrogen has been enriched, 2-3) contacting the gaseous phase from stage 2-2) with MEG so as to obtain a liquid phase comprising MEG and ammonia and a gaseous phase comprising hydrogen and optionally ammonia.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: June 1, 2021
    Inventor: Hermann Luyken
  • Patent number: 11021431
    Abstract: A method for producing a cinnamic acid ester derivative includes reacting a cinnamic acid derivative compound represented by the formula (1), wherein the symbols are as defined in the description, with an alcohol compound represented by the formula: R6OH, wherein the symbol is as defined in the description, in the presence of a strong acid resin catalyst without using a solvent. As the cinnamic acid derivative compound, cinnamic acid, ferulic acid, and caffeic acid are preferred, and as the alcohol compound, methanol, ethanol, propanol, butanol, pentanol, hexanol, ethylene glycol, glycerol, phenethyl alcohol, and a monosaccharide are preferred.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: June 1, 2021
    Assignee: TOHOKU UNIVERSITY
    Inventors: Naomi Kitakawa, Kousuke Hiromori, Yusuke Miwa
  • Patent number: 11013760
    Abstract: Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 25, 2021
    Assignee: SEALIFE PHARMA GMBH
    Inventors: Alexander Pretsch, Michael Nagl, Christoph Wiesner, Ralph Hollaus, Miroslav Genov
  • Patent number: 11008279
    Abstract: Provided is a method for purifying 1,5-pentanediamine comprising: providing 1,5-pentanediamine to be purified and treating the 1,5-pentanediamine to be purified by a reduction reaction to obtain purified 1,5-pentanediamine. Meanwhile, further provided is 1,5-pentanediamine prepared by the method. The purification method has a concise process and a simple operation, and is suitable for industrial production, and can significantly improve the quality of 1,5-pentanediamine.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: May 18, 2021
    Assignees: CATHAY BIOTECH INC., CIBT AMERICA INC.
    Inventors: Bingbing Qin, Charlie Liu, Shanshi Guo, Benliang Hou, Xiucai Liu
  • Patent number: 11006629
    Abstract: The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: May 18, 2021
    Assignee: ARMIS BIOPHARMA, INC.
    Inventors: Ed Neas, Scott Noblitt
  • Patent number: 11000050
    Abstract: The invention relates to bird feed comprising synthetic capsaicinoids for prohylactic use or treatment of salmonella infection.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: May 11, 2021
    Assignee: AXICHEM AB
    Inventor: Torsten Helsing
  • Patent number: 10995058
    Abstract: A process for preparing hydroxyethyl ethylene amines and/or ethylene urea derivatives thereof includes reacting monoethylene glycol with an amine-functional compound having at least two —NH— units, of which at least one is selected from the group of primary amine groups and cyclic secondary amine groups, in the presence of a carbon oxide-delivering agent. The amine-functional compound includes at least one —NH—CH2-CH2-NH— unit, wherein one or more —NH—CH2-CH2-NH— units in the amine-functional compound may be present in the form of piperazine moieties or ethylene urea moieties. The molar ratio of amine-functional compound to monoethylene glycol is in the range of 0.2:1 to 1.5:1 and the molar ratio of carbon oxide-delivering agent to —NH—CH2-CH2-NH— units in the amine-functional compound is at least 0.5:1. The process allows the conversion of monoethylene glycol into ethanol amines in the absence of metals-containing catalysts and without using ammonia.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 4, 2021
    Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Eike Nicolas Kantzer, Karl Fredrik Lake, Antoon Jacob Berend Ten Kate, Michiel Jozef Thomas Raaijmakers, Rens Veneman, Ina Ehlers, Michael Bertil Einar Sarning, Hendrik Van Dam, Rolf Krister Edvinsson
  • Patent number: 10995081
    Abstract: A compound represented by Formula (1): The compound can be used as insecticides.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 4, 2021
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba
  • Patent number: 10995057
    Abstract: The present invention relates to a process for hydrogenating nitriles with hydrogen in the presence of a ZrO2-supported ruthenium catalyst.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 4, 2021
    Assignee: BASF SE
    Inventors: Christian Eidamshaus, Thomas Krug, Johann-Peter Melder, Joerg Pastre, Regine Helga Bebensee, Stephanie Jaegli
  • Patent number: 10988437
    Abstract: The invention relates to bis(aniline) compounds containing multiple arylethynyl, alkylethynyl, ethynyl groups or their combinations, processes of making such compounds and materials comprising such compounds. Such, bis(aniline) compounds preferably comprise multiple phenylethynyl (PE) groups, i.e. 2-4 PE moieties. Such compounds are useful monomers for the preparation of polyimides, polyamides and poly(amide-imides) whose post-fabrication crosslinking chemistry (i.e. reaction temperature) can be controlled by the number of PE per repeat unit as well as finding utility in thermosetting matrix resins, 3D printable resins, and as high-carbon-content precursors to carbon-carbon composites.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: April 27, 2021
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, Zhenning Yu
  • Patent number: 10961401
    Abstract: The invention relates to benzophenone-terminated quaternary ammonium compounds, processes for preparing benzophenone-terminated quaternary ammonium compounds, environmentally friendly antimicrobial formulations of said quaternary ammonium compounds and their use as durable antimicrobial surface coatings for surfaces.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 30, 2021
    Assignee: Nano Safe Coatings Incorporated
    Inventors: Lukasz Porosa, Amanda Mocella, Gideon Wolfaardt, Daniel Foucher
  • Patent number: 10947185
    Abstract: Disclosed is a crystal form of dezocine. The X-ray powder diffraction (XRD) pattern thereof is determined using Cu/K-?1 and has diffraction peaks at the 2? value of 9.1±0.2 and 12.2±0.2, with the height % of these diffraction peaks greater than 20. Also disclosed are a preparation method for the crystal form, a pharmaceutical composition and use thereof. The crystal form of dezocine has good solubility, the preparation method has simple operations, good reproducibility, suitability for industrial production and the like.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: March 16, 2021
    Assignee: Yangtze River Pharmaceutical Group Co., Ltd.
    Inventors: Jingren Xu, Wei Cai, Haoyu Xu, Ying Xu, Zhichao Xiao, Shiwei Yao
  • Patent number: 10927067
    Abstract: The present invention specifically relates to novel salt and crystalline form of haloacetic acid and its process of preparation. The invention more particularly relates to novel crystalline form dichloroacetate tromethamine salt and its process of preparation. The present invention more specifically relates to the dichloroacetate tromethamine salt, its process and its use for the treatment of various diseases and/or disorders.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: February 23, 2021
    Inventors: Sarin Parayil, Anil Roy
  • Patent number: 10927068
    Abstract: Processes for preparing acetylated amphetamine derivatives and, in particular, processes for preparing L-lysine-D-amphetamine dimesylate from D-amphetamine salts.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: February 23, 2021
    Assignee: SpecGX LLC
    Inventors: Brian Orr, Kevin Roesch, Joel McClenaghan
  • Patent number: 10919831
    Abstract: A method for producing an aqueous equilibrium peroxylactic acid solution by reaction mixing lactic acid, hydrogen peroxide, water, one or more optional acid catalysts and one or more optional sequestering agents in a vessel over a period of time while maintaining the temperature of the solution at a temperature below about 100° C. The aqueous equilibrium peroxylactic acid solution can be used for reducing the bacterial count on a protein food product during processing.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: February 16, 2021
    Assignee: Zee Company, Inc.
    Inventors: Robert C. Bullard, Jonathon R. Bullard, James A. Faller, A. Rider Barnum