Patents Examined by Jennifer Kolb
  • Patent number: 6669980
    Abstract: A method for spray-coating a medical device by using a nozzle apparatus having a chamber that is connected to at least one opening for dispensing a coating formulation. Such method comprises (a) grounding the surface of the medical device that is to be coated and (b) applying a coating formulation, which comprises a polymeric material and a solvent, by (1) providing the nozzle apparatus comprising a chamber connected to at least one opening for dispensing the coating formulation; (2) placing the coating formulation into the chamber; (3) electrically charging the coating formulation; (4) creating droplets of the electrically charged coating formulation; and (5) depositing the droplets of coating formulation onto the grounded surface to form a coating on the surface.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: December 30, 2003
    Assignee: SciMed Life Systems, Inc.
    Inventor: Henrik Hansen
  • Patent number: 6663913
    Abstract: The invention generally provides a method of coating a material, the method including the following steps: (a) forming a generally elongate coating structure (15), the coating structure having an internal cavity (17) extending at least substantially along its length, and wherein the internal cavity of the coating structure is capable of receiving a core material (21); (b) inserting a core material (21) into the internal cavity (17) of the coating structure (15); (c) compressing the coating structure at a first location (44) along its length so as generally to form a seal at that location; and (d) compressing the coating structure at a second location along its length (45).
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: December 16, 2003
    Assignee: Scientec Research Pty. Ltd.
    Inventors: Michael Francis O'Donoghue, James Allan Morris
  • Patent number: 6660323
    Abstract: The present invention is a method for treating a cattail blossom. A cattail blossom is soaked in a thinned adhesive mixture. When dry, the resulting treated blossom does not burst and can be used for a very long period of time as a decorative item.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: December 9, 2003
    Inventor: Ronald Earl Rush
  • Patent number: 6656517
    Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a therapeutic, diagnostic or hydrophilic top coat, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of a hydrophilic compound, a grafting component, and salt, wherein the polymerized grafting component contains uncrosslinked domains. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device coated with a polymeric primer or without a primer, or to a stent.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: December 2, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Eugene T. Michal, Christopher J. Buchko, Stephen J. Bigus
  • Patent number: 6652903
    Abstract: A method for metering active ingredient in powder form onto a predetermined area is characterized in that the active ingredient is transferred as electrically charged powder to a roll with the opposite charge, the active ingredient transferred to the roll is transferred to a two-dimensional substrate with an electric charge opposite to the active ingredient, the active ingredient transferred to the substrate is fixed by means of a heat treatment.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: November 25, 2003
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Walter Muller
  • Patent number: 6645547
    Abstract: The present invention is a method and device, which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical coating to an implantable medical device, for example a stent. Disclosed is a device for use with a stent deployed on a catheter balloon. The device is configured to apply a medical coating of a desired thickness to the surface of a stent only. This is done by use of a drop-on-demand ink-jet printing system in association with an optical scanning device. The device is further configured so as to, if necessary, apply a plurality of layered coats, each layered coat being of a different coating material, and if appropriate, different thickness. The section of the housing in which the stent is held during the coating procedure is detachable from the housing base. The detachable housing section may be easily cleaned and re-sterilized or simply disposed of.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: November 11, 2003
    Assignee: Labcoat Ltd.
    Inventors: Avraham Shekalim, Ascher Shmulewitz
  • Patent number: 6638568
    Abstract: A method of curing cracks in a ceramic shaped body made from ceramic magnet materials or ceramic superconductor materials, in which a filling material which melts at a lower temperature than the material of the shaped body or is flowable at a lower temperature than the material of the shaped body is applied to the surface of the shaped body at least in the area of a crack and/or is introduced into at least one crack, in which the shaped body with the filling material is heated to and maintained at a temperature at which the material of the shaped body does not yet melt or is not yet flowable, but at which the filling material is in at least partially molten and flowable state at least until the fused filling material can penetrate at least partially into the crack, in which the filling material consists of non-metallic or essentially of non-metallic compounds and is at least partially crystallized, and in which the shaped body with the filling material is cooled, wherein the thermal crystallization conditions
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: October 28, 2003
    Assignee: Nexans Superconductors GmbH
    Inventors: Michael Baecker, Joachim Bock, Herbert C. Freyhardt, Andreas Leenders, Heribert Walter, Martin Ullrich
  • Patent number: 6635305
    Abstract: A process for coating at least a portion of a face of a siliceous substrate with a silicon containing layer, the process includes at least the following steps: a treatment step, in which at least the portion of the face of the siliceous substrate is treated with a composition containing at least one biocide, and at least the portion of the face of the siliceous substrate is reacted with a reactive composition for forming a silicon containing layer chemically bound to the siliceous substrate.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: October 21, 2003
    Assignee: ICT Coating N.V.
    Inventor: Gino Sirejacob
  • Patent number: 6632470
    Abstract: A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: October 14, 2003
    Assignee: Percardia
    Inventors: Marco Morra, Clara Cassinelli, Linda Lee Cahalan, Patrick T. Cahalan
  • Patent number: 6627246
    Abstract: This invention provides an improved process for coating medical and surgical devices and the like using super-critical fluids.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: September 30, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Deepak B. Mehta, Michael Corbo
  • Patent number: 6623785
    Abstract: An apparatus and method for manufacturing a pharmaceutical dose which dispenses a variable selectable quantity of at least one pharmaceutical onto a pharmaceutical receiving medium. The quantity of the dispensed pharmaceutical(s) are controllably dispensed to customize each pharmaceutical dose to suit the needs of a particular user. The apparatus is coupled by an external telecommunication network to a remote signal source for receiving pharmaceutical quantity and type data for custom manufacturing a pharmaceutical dose. In one aspect, a replaceable cartridge contains a reservoir carrying at least one pharmaceutical component and a fluid drop generator which is mountable in the fluid dispenser. The reservoir may contain a number of separate compartments, each carrying different pharmaceutical component.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: September 23, 2003
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventor: Winthrop D. Childers
  • Patent number: 6623786
    Abstract: A method of modifying the surface characteristics of a polymeric hydrogel, and a polymer article formed therefrom, without causing substantial swelling or distortion or the hydrogel. A preferred method includes photoinitating of the surface of the article with a benzophenone and grafting a macromer having a number-average molecular weight greater than 1000 in the presence of UV irradiation. The preferred article is a siloxane-containing hydrogel, especially a soft contact lens.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: September 23, 2003
    Assignee: Novartis AG
    Inventors: Richard Carlton Baron, Qin Liu
  • Patent number: 6610350
    Abstract: A method of modifying a surface of an ophthalmic lens, includes the steps of: generating plasma at an atmospheric pressure between electrodes of a plasma generating device; and blowing the plasma from the plasma generating device by introducing a gas between the electrodes. The ophthalmic lens, which is located outside the plasma generating device, is irradiated with the plasma blown out from the plasma generating device to modify the surface of the ophthalmic lens to form a final ophthalmic lens product.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: August 26, 2003
    Assignee: Menicon Co., Ltd.
    Inventors: Hiroaki Suzuki, Yuuji Gotou, Kazuhiko Nakada
  • Patent number: 6599558
    Abstract: A metal, glass or ceramics surface is treated to enhance its compatibility with biological material such as blood or blood related products. Treatment involves covalently bonding to the surface by means of a catalyst functional molecules each of has at least one alkoxysilane group which can form at least one first covalent bond by reaction with the oxide or hydroxide of said surface and at least one other group which can participate in free-radical polymerisation. Free-radical polymerisation from said functional molecules is then effected to build bio-compatible and/or hydrophilic polymer chains. The compatibility of the metal surface with biological material may be further improved by bonding bio-active molecules, such as heparin or heparin derived molecules to the polymer chains. Suitable metal surfaces are those of medical devices such as heat exchangers, coronary and peripheral stents and guide wires used in angioplasty.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: July 29, 2003
    Assignee: Polybiomed Limited
    Inventors: Kadam Gayad Al-Lamee, Yousef Samih Taktak
  • Patent number: 6596338
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 22, 2003
    Assignee: Howmedica Osteonics Corp.
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Patent number: 6592949
    Abstract: A method of marking a plastics surface comprises at least the following steps: a) applying a composition comprising at least one coloring component to a plastics surface, b) irradiating the plastics surface with light from a light source.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: July 15, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Polke, Michael Schäfer, Martin Welz, Manfred Reimann
  • Patent number: 6592930
    Abstract: A method and a device involving an electric iris diaphragm/shutter are disclosed for controlling particle transfer of electrically charged medication powder particles from a source to a defined target area, of a substrate. Spatial distribution of particles onto the target area is achieved by an electro-dynamic field technique (320) applied to the distribution and deposition of particles in a dose forming process. An electric iris diaphragm/shutter (130) is located between a particle generator (110) and the substrate (140) such that all particles must pass the iris diaphragm for being transferred to the substrate. By adjusting amplitude and frequency of a superimposed AC potential (136) charged particles will oscillate in the created AC field such that only small light particles will emerge from the iris diaphragm/shutter for further transfer in the dose forming process.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: July 15, 2003
    Assignee: Microdrug AG
    Inventor: Thomas Nilsson
  • Patent number: 6589590
    Abstract: A method of making artificial bone comprises providing a membrane of collagen with solutions of calcium ions and of phosphate ions on opposite sides of the membrane. The calcium ions and phosphate ions diffuse through the membrane and precipitate as a hydroxyapatite material. Control of ionic concentrations ensures that precipitation takes place within the fibrils of the membrane. The result is an artificial bone material comprising a matrix of collagen and a hydroxyapatite material deposited within the matrix.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: July 8, 2003
    Assignee: Isis Innovation Limited
    Inventors: Jan Tadeusz Czernuszka, Alison Christina Lawson, Alasdair Hamish Robert Wallace Simpson
  • Patent number: 6589595
    Abstract: A method of preventing tar, asphalt and related material from sticking to paving equipment involves spraying a release agent concentrate diluted with water contemporaneously with spraying, utilizing a carbonator pump capable of about 1 gallon per minute pumping rate at about 200 psi, an appropriately-sized motor, a pushbutton momentary contact switch, a timing relay capable of switching the motor on and running it for about 1-2 minutes, a spray gun and appropriately-sized nozzle, appropriate fittings and hoses, and such optional ancillary devices as solenoid valves, particulate screens and freeze protection. The major advantages of the instant invention are that it is simple and economical to build, very robust, and is capable of delivering a good spray pattern at relatively high concentrations of viscous release agents.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: July 8, 2003
    Assignee: Chemtek, Inc.
    Inventor: Michael Gates Kinnaird
  • Patent number: 6589591
    Abstract: A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices depending on the types of infections related to each device. The combination of different antimicrobial substances has a synergistic effect against certain bacteria and fungi. An antimicrobial agent can be used to treat a non-metallic medical device by mixing the antimicrobial agent with an acid solution and glycerol and exposing the non-metallic medical device to the resulting mixture such that an enough of the antimicrobial agent binds to a portion of the non-metallic medical device to inhibit the growth of bacterial and fungal organisms.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: July 8, 2003
    Assignee: Baylor College of Medicine
    Inventors: Mohammad David Mansouri, Rabih O. Darouiche