Patents Examined by John Kight, III
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Patent number: 6110480Abstract: The present invention teaches method for culturing nematode pesticidal compositions, to produce at a high yield, and generate biotic compositions that are effective as insecticides with high pesticidal activity and preventive effects.Type: GrantFiled: October 21, 1997Date of Patent: August 29, 2000Assignee: Development Center for BiotechnologyInventors: Linag-Kuang Chu, Chiao Po Lin, Chien-Ming Shih, Tsae Yueh Lee, Tai-Sen Soong
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Patent number: 5843916Abstract: A method of inhibiting the proliferation of cells, particularly cancerous cells, by contacting the cells with a phosphorothioate derivative of a cAMP modified at either or both the C-6 and C-8 positions of the adenine moiety, and pharmaceutical compositions therefor.Type: GrantFiled: April 8, 1994Date of Patent: December 1, 1998Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Yoon Sang Cho-Chung, Bernd Jastorff, Hans-Gottfried Genieser
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Patent number: 5756721Abstract: A steam-stripping process suitable for the removal of impurities from polysaccharides, including soluble starch hydrolysates, is disclosed herein. This process may be used in combination with other purification processes, such as ultrafiltration, ion exchange, treatment with activated carbon, as well as bleaching process. Soluble starch hydrolysates may also be purified by a combination of ultrafiltration or activated carbon treatment and bleaching. In these processes, the polysaccharide or the soluble starch hydrolysate produced is bland in flavor, free of off-odor, optionally, lighter or white in color and suitable for use in systems requiring these characteristics.Type: GrantFiled: August 29, 1994Date of Patent: May 26, 1998Assignee: National Starch and Chemical Investment Holding CorporationInventors: James Eden, James Kasica, Leo Walsh, Morton W. Rutenberg, Norman Lacourse, Daniel Solarek, Timothy G. Koubek
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Patent number: 5659021Abstract: Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.Type: GrantFiled: July 25, 1994Date of Patent: August 19, 1997Assignee: The Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventor: Elie Abushanab
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Patent number: 5591836Abstract: Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation to the diet, or incorporated into food compositions.Type: GrantFiled: October 7, 1993Date of Patent: January 7, 1997Assignee: The Procter & Gamble CompanyInventors: Adam W. Mazur, Stanislaw Pikul, Bruce P. Daggy
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Patent number: 5583206Abstract: In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.Type: GrantFiled: November 28, 1994Date of Patent: December 10, 1996Assignee: Sterling WinthropInventors: Robert A. Snow, David L. Ladd, John L. Toner
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Patent number: 5576306Abstract: Water-soluble, high-viscosity grade cellulose ether compositions are useful for the reduction of serum lipid levels, particularly total serum cholesterol, serum triglycerides, and low-density lipoprotein (LDL) levels and/or attenuate the postprandial rise of blood glucose levels in animals. The pharmaceutical uses of compositions for reducing cholesterol levels additionally include the treatment of diabetes and/or hypercholesterolemia, with avoidance of many of the undesirable side effects associated with other forms of treatment. The composition may be in the form of a prehydrated ingestible composition, such as a gelatin, or a comestible, such as a cookie. In addition, the compositions of the present invention are palatable to the patient, thereby enhancing patient compliance with the regimen.Type: GrantFiled: December 9, 1994Date of Patent: November 19, 1996Assignees: Dow Chemical Company, Board of Regents Acting for and on Behalf of the University of MichiganInventors: Jennifer B. Dressman, Christos Reppas, Stephen W. Tobey, Cynthia W. Sowle
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Patent number: 5567685Abstract: A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccaride conjugates of the polyene Nystatin.Type: GrantFiled: August 16, 1994Date of Patent: October 22, 1996Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Galina Linden, Abraham J. Domb, Itzhack Polacheck, Shimon Benita
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Patent number: 5550155Abstract: Monofucosylated and monosialyated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR, where R is hydrogen, a saccharide, an oligosaccharide or an aglycon moiety have been found to be useful in modulating a cell-mediated immune inflammatory response in mammals.Type: GrantFiled: October 14, 1994Date of Patent: August 27, 1996Assignee: Alberta Research CouncilInventors: Mohammed A. Kashem, Andre P. Venot, Richard Smith
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Patent number: 5550115Abstract: A composition in dry form which can easily undergo dry blending and milling contains biologically active materials and a solid surfactant composed of a combination of an alkyl polyglycoside and an inert carrier selected from the group consisting of silica, talc, a zeolite, magnesium aluminum silicate, calcium sulfate, magnesium carbonate, magnesium oxide, aluminum oxide.Type: GrantFiled: May 26, 1995Date of Patent: August 27, 1996Assignee: Henkel CorporationInventors: Roger H. Garst, Jane C. Mueninghoff, Matthew C. Schwan
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Patent number: 5547945Abstract: A remitting agent for nephrotic syndrome and hepatopathy symptoms is provided that which comprises water-soluble polysaccharides having poly-D-galacturonic acid as an effective constituent; polysaccharides having the following characteristic properties which are extractable from Tanjin with water or an aqueous solvent:A. Sugar content: 60 to 100%.(1) Sugar composition:40 to 80% of uronic acid (composed almost entirely of D-galacturonic acid) and10 to 30% of neutral sugars(2) Neutral sugar composition:0 to 15% of rhamnose0 to 15% of glucose25 to 55% of galactose30 to 60% of arabinose0 to 15% of mannoseB. Molecular weight: 150,000 to 300,000; the invention also provides a process for producing the above-described polysaccharides which comprises allowing an aqueous extract of Tanjin to pass through a porous polymeric resin, followed by purification through gel filtration chromatography.Type: GrantFiled: July 7, 1994Date of Patent: August 20, 1996Assignee: JCR Pharmaceuticals Co., Ltd.Inventors: Guoji Ye, Jun-ichi Kajihara, Sei Kirihara, Kazuo Kato, Hiroko Abe
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Patent number: 5545535Abstract: The invention relates to a method of analyzing a sample thought to contain bacteria using an aqueous solution comprising one or more fluorescent dyes: a fluorescent dye of formula I, a fluorescent dye of formula II, a fluorescent dye of formula III, and a fluorescent dye of formula IV. Each of the dyes differ each from the other in their affinity for nucleic acids and in their spectral response to different types of bacteria in the sample. The first three dyes are nucleic acid stains and the fourth dye is a fluorescent reagent that binds selectively to cell surface components. The fluorescent dyes of formula I are highly membrane-permeant cyanine dye derivatives and label all bacteria, whether live or dead, whether Gram positive or Gram negative. The dyes of formula II label only live Gram positive bacteria and label all dead bacteria, whether Gram positive or negative. The dyes of formula II bind to nucleic acids preferentially with respect to the dyes of formula I.Type: GrantFiled: November 1, 1993Date of Patent: August 13, 1996Assignee: Molecular Probes, Inc.Inventors: Bruce L. Roth, Paul J. Millard, Stephen T. Yue, K. Sam Wells, Richard P. Haugland
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Patent number: 5543298Abstract: The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I) wherein either n is 1 or 2, R.sup.1 is --OR.sup.4 or --NR.sup.5 R.sup.6 ; R.sup.2 is H, --OR.sup.4, alkyl (1-6C), --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --, to form a ring by binding to the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H, alkyl (1-6C) or --OR.sup.4 (if R.sup.2 is different from --OR.sup.4); with R.sup.4 being H or alkyl (1-6C); R.sup.5 being H, alkyl (1-6C), --CH.sub.2 COOH, --C.sub.6 H.sub.5 COOH or --C.sub.6 H.sub.5 SO.sub.3 H; and R.sup.6 is H, alkyl (1-6C) or --CH.sub.2 COOH; or n is 1, R.sup.1 is --OR.sup.4, R.sup.2 is --CH.sub.2 --O--, in order to form a ring by bonding of O with the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H or --OR.sup.4.Type: GrantFiled: June 6, 1994Date of Patent: August 6, 1996Assignee: Oxis International S.A.Inventors: Jinzhu Xu, Jean-Claude Y. Yadan, Marc E. Moutet, Jean R. Chaudiere
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Patent number: 5543299Abstract: The invention relates to polymeric compositions useful in analyte determination. The compositions contain a polymer, a reagent system for analyte determination, and an extender. The last component alleviates tackiness in the composition, and thus reduces damage in preparation of test apparatus. Mica is the particularly preferred extender.Type: GrantFiled: January 5, 1995Date of Patent: August 6, 1996Assignee: Boehringer Mannheim CorporationInventors: Eric Diebold, Myron Rapkin, Abol Azhar, Arthur Usmani
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Patent number: 5543512Abstract: The invention concerns a process for preparing saccharide monomers comprising at least one polymerizable acrylate or methacrylate group whereby the saccharide used in the process is selected from mono-, di- and tri-saccharides, in particular from non-reducing mono-, di- and tri-saccharides. The process comprises reacting the saccharide in an aqueous medium with an esterifying reagent containing the polymerizable acrylate or methacrylate group in the presence of a base while maintaining the pH of the reaction medium to a value within the range of 7 to 11 during the entire reaction time. The invention furthermore concerns saccharide monomers comprising at least one polymerizable acrylate or methacrylate group with a controlled degree of substitution.Type: GrantFiled: January 26, 1995Date of Patent: August 6, 1996Assignee: Beghin-SayInventors: Julio Mentech, Isabelle Betremieux, Bruno Legger
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Patent number: 5541316Abstract: A process for the production of polycarboxylic acids or salts thereof from polysaccharides by oxidation with nitrogen dioxide/dinitrogen tetroxide with at least partial conversion of the primary alcohol groups of the polysaccharides into carboxyl groups and optionally at least partial neutralization of the carboxylic acid groups formed is provided. The oxidation reaction is carried out in a closed reaction system in the presence of oxygen under pressures of 2 bar to 10 bar and at a temperature above room temperature. Nitrogen dioxide/dinitrogen tetroxide is used in such quantities that, in the event of a theoretically complete shift of the equilibrium onto the nitrogen dioxide side, the nitrogen dioxide is present in quantities of at most 2 mole equivalents, based on the content of monomer unit of the polysaccharide containing one primary alcohol group.Type: GrantFiled: July 28, 1994Date of Patent: July 30, 1996Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Konrad Engelskirchen, Herbert Fischer, Hans-Wilhelm Verholt
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Patent number: 5534501Abstract: Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by a hydrophobic layer of fatty acids bound to the matrix by covalent bonds and capable of interacting with lipidic or amphiphilic compounds. The invention also concerns a composition for use as a fat substitute and a process for the preparation of such particles.Type: GrantFiled: June 7, 1995Date of Patent: July 9, 1996Assignee: A Et S BiovecteursInventors: Daniel Samain, Joelle Gibilaro
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Patent number: 5525719Abstract: This invention is directed to processes for producing high purity N-protected-2'-O-methyl-5'-dimethoxytrityl-3' ribonucleoside methoxy, N,N-diisopropyl phosphoramidites (group 1), and N-protected-2'-O-methyl-5'-dimethoxytrityl-3'-ribonucleoside ethoxy, N,N-diisopropyl phosphoramidites (group 2). This invention is further directed to the process for producing high purity 2'-O-methyl-5'-dimethoxytrityl-inosine (structure IX; group 3), and 2'-O-methyl-5'-dimethoxytrityl-inosine-3'-cyanoethyl, N,N-diisopropyl phosphoramidite (structure Xa; group 3). This invention is also directed to the process for producing high purity N-protected-3'-O-methyl-5'-dimethoxytrityl ribonucleosides (group 6), and N-protected-3'-O-methyl-5'-dimethoxytrityl-2'-ribonucleoside cyanoethyl, N,N-diisopropyl phosporamidites (group 7).Type: GrantFiled: May 24, 1993Date of Patent: June 11, 1996Assignee: Chemgenes CorporationInventors: Saresh C. Srivastava, Syed K. Raza
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Patent number: 5480955Abstract: An aliphatic spray polyurea elastomer is disclosed. The elastomer comprises an (A) and (B) component. The (A) component includes an aliphatic isocyanate. The (B) component includes an amine terminated polyoxyalkylene polyol and an amine terminated aliphatic chain extender.Type: GrantFiled: September 7, 1993Date of Patent: January 2, 1996Assignee: Huntsman CorporationInventor: Dudley J. Primeaux, II
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Patent number: RE35524Abstract: Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.Type: GrantFiled: April 19, 1994Date of Patent: June 3, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Mark G. Saulnier, Peter D. Senter, John F. Kadow