Patents Examined by John Kight, III
  • Patent number: 6110480
    Abstract: The present invention teaches method for culturing nematode pesticidal compositions, to produce at a high yield, and generate biotic compositions that are effective as insecticides with high pesticidal activity and preventive effects.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: August 29, 2000
    Assignee: Development Center for Biotechnology
    Inventors: Linag-Kuang Chu, Chiao Po Lin, Chien-Ming Shih, Tsae Yueh Lee, Tai-Sen Soong
  • Patent number: 5843916
    Abstract: A method of inhibiting the proliferation of cells, particularly cancerous cells, by contacting the cells with a phosphorothioate derivative of a cAMP modified at either or both the C-6 and C-8 positions of the adenine moiety, and pharmaceutical compositions therefor.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: December 1, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Yoon Sang Cho-Chung, Bernd Jastorff, Hans-Gottfried Genieser
  • Patent number: 5756721
    Abstract: A steam-stripping process suitable for the removal of impurities from polysaccharides, including soluble starch hydrolysates, is disclosed herein. This process may be used in combination with other purification processes, such as ultrafiltration, ion exchange, treatment with activated carbon, as well as bleaching process. Soluble starch hydrolysates may also be purified by a combination of ultrafiltration or activated carbon treatment and bleaching. In these processes, the polysaccharide or the soluble starch hydrolysate produced is bland in flavor, free of off-odor, optionally, lighter or white in color and suitable for use in systems requiring these characteristics.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: May 26, 1998
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: James Eden, James Kasica, Leo Walsh, Morton W. Rutenberg, Norman Lacourse, Daniel Solarek, Timothy G. Koubek
  • Patent number: 5659021
    Abstract: Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: August 19, 1997
    Assignee: The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
    Inventor: Elie Abushanab
  • Patent number: 5591836
    Abstract: Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation to the diet, or incorporated into food compositions.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: January 7, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Adam W. Mazur, Stanislaw Pikul, Bruce P. Daggy
  • Patent number: 5583206
    Abstract: In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: December 10, 1996
    Assignee: Sterling Winthrop
    Inventors: Robert A. Snow, David L. Ladd, John L. Toner
  • Patent number: 5576306
    Abstract: Water-soluble, high-viscosity grade cellulose ether compositions are useful for the reduction of serum lipid levels, particularly total serum cholesterol, serum triglycerides, and low-density lipoprotein (LDL) levels and/or attenuate the postprandial rise of blood glucose levels in animals. The pharmaceutical uses of compositions for reducing cholesterol levels additionally include the treatment of diabetes and/or hypercholesterolemia, with avoidance of many of the undesirable side effects associated with other forms of treatment. The composition may be in the form of a prehydrated ingestible composition, such as a gelatin, or a comestible, such as a cookie. In addition, the compositions of the present invention are palatable to the patient, thereby enhancing patient compliance with the regimen.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: November 19, 1996
    Assignees: Dow Chemical Company, Board of Regents Acting for and on Behalf of the University of Michigan
    Inventors: Jennifer B. Dressman, Christos Reppas, Stephen W. Tobey, Cynthia W. Sowle
  • Patent number: 5567685
    Abstract: A method for producing a substantially stable water-soluble polysaccharide conjugate of a polyene antibiotic is described. The method comprises the following steps: (a) activating the polysaccharide to a dialdehyde by periodate oxidation; (b) purifying the dialdehyde from interfering anions and by-products; (c) coupling the polyene to the purified dialdehyde by Schiff base formation to form the conjugate; and (d) purifying the conjugate. In a preferred embodiment, the conjugate of step (c) is reduced to an amine conjugate by a reducing agent prior to purification. Also described are imine and amine polysaccaride conjugates of the polyene Nystatin.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: October 22, 1996
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Galina Linden, Abraham J. Domb, Itzhack Polacheck, Shimon Benita
  • Patent number: 5550155
    Abstract: Monofucosylated and monosialyated derivatives of the compound .beta.Gal(1-4).beta.GlcNAc(1-3).beta.Gal(1-4).beta.GlcNAc-OR, where R is hydrogen, a saccharide, an oligosaccharide or an aglycon moiety have been found to be useful in modulating a cell-mediated immune inflammatory response in mammals.
    Type: Grant
    Filed: October 14, 1994
    Date of Patent: August 27, 1996
    Assignee: Alberta Research Council
    Inventors: Mohammed A. Kashem, Andre P. Venot, Richard Smith
  • Patent number: 5550115
    Abstract: A composition in dry form which can easily undergo dry blending and milling contains biologically active materials and a solid surfactant composed of a combination of an alkyl polyglycoside and an inert carrier selected from the group consisting of silica, talc, a zeolite, magnesium aluminum silicate, calcium sulfate, magnesium carbonate, magnesium oxide, aluminum oxide.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: August 27, 1996
    Assignee: Henkel Corporation
    Inventors: Roger H. Garst, Jane C. Mueninghoff, Matthew C. Schwan
  • Patent number: 5547945
    Abstract: A remitting agent for nephrotic syndrome and hepatopathy symptoms is provided that which comprises water-soluble polysaccharides having poly-D-galacturonic acid as an effective constituent; polysaccharides having the following characteristic properties which are extractable from Tanjin with water or an aqueous solvent:A. Sugar content: 60 to 100%.(1) Sugar composition:40 to 80% of uronic acid (composed almost entirely of D-galacturonic acid) and10 to 30% of neutral sugars(2) Neutral sugar composition:0 to 15% of rhamnose0 to 15% of glucose25 to 55% of galactose30 to 60% of arabinose0 to 15% of mannoseB. Molecular weight: 150,000 to 300,000; the invention also provides a process for producing the above-described polysaccharides which comprises allowing an aqueous extract of Tanjin to pass through a porous polymeric resin, followed by purification through gel filtration chromatography.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: August 20, 1996
    Assignee: JCR Pharmaceuticals Co., Ltd.
    Inventors: Guoji Ye, Jun-ichi Kajihara, Sei Kirihara, Kazuo Kato, Hiroko Abe
  • Patent number: 5545535
    Abstract: The invention relates to a method of analyzing a sample thought to contain bacteria using an aqueous solution comprising one or more fluorescent dyes: a fluorescent dye of formula I, a fluorescent dye of formula II, a fluorescent dye of formula III, and a fluorescent dye of formula IV. Each of the dyes differ each from the other in their affinity for nucleic acids and in their spectral response to different types of bacteria in the sample. The first three dyes are nucleic acid stains and the fourth dye is a fluorescent reagent that binds selectively to cell surface components. The fluorescent dyes of formula I are highly membrane-permeant cyanine dye derivatives and label all bacteria, whether live or dead, whether Gram positive or Gram negative. The dyes of formula II label only live Gram positive bacteria and label all dead bacteria, whether Gram positive or negative. The dyes of formula II bind to nucleic acids preferentially with respect to the dyes of formula I.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: August 13, 1996
    Assignee: Molecular Probes, Inc.
    Inventors: Bruce L. Roth, Paul J. Millard, Stephen T. Yue, K. Sam Wells, Richard P. Haugland
  • Patent number: 5543512
    Abstract: The invention concerns a process for preparing saccharide monomers comprising at least one polymerizable acrylate or methacrylate group whereby the saccharide used in the process is selected from mono-, di- and tri-saccharides, in particular from non-reducing mono-, di- and tri-saccharides. The process comprises reacting the saccharide in an aqueous medium with an esterifying reagent containing the polymerizable acrylate or methacrylate group in the presence of a base while maintaining the pH of the reaction medium to a value within the range of 7 to 11 during the entire reaction time. The invention furthermore concerns saccharide monomers comprising at least one polymerizable acrylate or methacrylate group with a controlled degree of substitution.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: August 6, 1996
    Assignee: Beghin-Say
    Inventors: Julio Mentech, Isabelle Betremieux, Bruno Legger
  • Patent number: 5543299
    Abstract: The invention relates to polymeric compositions useful in analyte determination. The compositions contain a polymer, a reagent system for analyte determination, and an extender. The last component alleviates tackiness in the composition, and thus reduces damage in preparation of test apparatus. Mica is the particularly preferred extender.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: August 6, 1996
    Assignee: Boehringer Mannheim Corporation
    Inventors: Eric Diebold, Myron Rapkin, Abol Azhar, Arthur Usmani
  • Patent number: 5543298
    Abstract: The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I) wherein either n is 1 or 2, R.sup.1 is --OR.sup.4 or --NR.sup.5 R.sup.6 ; R.sup.2 is H, --OR.sup.4, alkyl (1-6C), --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --, to form a ring by binding to the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H, alkyl (1-6C) or --OR.sup.4 (if R.sup.2 is different from --OR.sup.4); with R.sup.4 being H or alkyl (1-6C); R.sup.5 being H, alkyl (1-6C), --CH.sub.2 COOH, --C.sub.6 H.sub.5 COOH or --C.sub.6 H.sub.5 SO.sub.3 H; and R.sup.6 is H, alkyl (1-6C) or --CH.sub.2 COOH; or n is 1, R.sup.1 is --OR.sup.4, R.sup.2 is --CH.sub.2 --O--, in order to form a ring by bonding of O with the phenyl substituent, at meta with respect to R.sup.1 ; and R.sup.3 is H or --OR.sup.4.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: August 6, 1996
    Assignee: Oxis International S.A.
    Inventors: Jinzhu Xu, Jean-Claude Y. Yadan, Marc E. Moutet, Jean R. Chaudiere
  • Patent number: 5541316
    Abstract: A process for the production of polycarboxylic acids or salts thereof from polysaccharides by oxidation with nitrogen dioxide/dinitrogen tetroxide with at least partial conversion of the primary alcohol groups of the polysaccharides into carboxyl groups and optionally at least partial neutralization of the carboxylic acid groups formed is provided. The oxidation reaction is carried out in a closed reaction system in the presence of oxygen under pressures of 2 bar to 10 bar and at a temperature above room temperature. Nitrogen dioxide/dinitrogen tetroxide is used in such quantities that, in the event of a theoretically complete shift of the equilibrium onto the nitrogen dioxide side, the nitrogen dioxide is present in quantities of at most 2 mole equivalents, based on the content of monomer unit of the polysaccharide containing one primary alcohol group.
    Type: Grant
    Filed: July 28, 1994
    Date of Patent: July 30, 1996
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Konrad Engelskirchen, Herbert Fischer, Hans-Wilhelm Verholt
  • Patent number: 5534501
    Abstract: Particle for use especially as a fat substitute, characterized in that it includes an insoluble hydrophile matrix, surrounded by a hydrophobic layer of fatty acids bound to the matrix by covalent bonds and capable of interacting with lipidic or amphiphilic compounds. The invention also concerns a composition for use as a fat substitute and a process for the preparation of such particles.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 9, 1996
    Assignee: A Et S Biovecteurs
    Inventors: Daniel Samain, Joelle Gibilaro
  • Patent number: 5525719
    Abstract: This invention is directed to processes for producing high purity N-protected-2'-O-methyl-5'-dimethoxytrityl-3' ribonucleoside methoxy, N,N-diisopropyl phosphoramidites (group 1), and N-protected-2'-O-methyl-5'-dimethoxytrityl-3'-ribonucleoside ethoxy, N,N-diisopropyl phosphoramidites (group 2). This invention is further directed to the process for producing high purity 2'-O-methyl-5'-dimethoxytrityl-inosine (structure IX; group 3), and 2'-O-methyl-5'-dimethoxytrityl-inosine-3'-cyanoethyl, N,N-diisopropyl phosphoramidite (structure Xa; group 3). This invention is also directed to the process for producing high purity N-protected-3'-O-methyl-5'-dimethoxytrityl ribonucleosides (group 6), and N-protected-3'-O-methyl-5'-dimethoxytrityl-2'-ribonucleoside cyanoethyl, N,N-diisopropyl phosporamidites (group 7).
    Type: Grant
    Filed: May 24, 1993
    Date of Patent: June 11, 1996
    Assignee: Chemgenes Corporation
    Inventors: Saresh C. Srivastava, Syed K. Raza
  • Patent number: 5480955
    Abstract: An aliphatic spray polyurea elastomer is disclosed. The elastomer comprises an (A) and (B) component. The (A) component includes an aliphatic isocyanate. The (B) component includes an amine terminated polyoxyalkylene polyol and an amine terminated aliphatic chain extender.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: January 2, 1996
    Assignee: Huntsman Corporation
    Inventor: Dudley J. Primeaux, II
  • Patent number: RE35524
    Abstract: Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: June 3, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark G. Saulnier, Peter D. Senter, John F. Kadow