Patents Examined by John M. Kilcoyne
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Patent number: 4818526Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for mosquitos (Culicidae). The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: August 29, 1986Date of Patent: April 4, 1989Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
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Patent number: 4816248Abstract: Described are the uses of N,N-diethyl-m-toluamide having the structure: ##STR1## and the ethyl ester of 2-methyl-3-pentenoic acid having the structure: ##STR2## taken alone or in combination as attractions for mosquitos (Culicidae). The N,N-diethyl-m-toluamide and the ethyl ester of 2-methyl-3-pentenoic acid taken along or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: March 17, 1987Date of Patent: March 28, 1989Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
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Patent number: 4816485Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.Type: GrantFiled: March 30, 1987Date of Patent: March 28, 1989Assignee: Warner-Lambert CompanyInventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
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Patent number: 4810707Abstract: Method for the effective management of Herpes Simplex including the administration of an effective dosage of phenol, 4,4'-(2-pyridinyl methylene) bis diacetate (ester), in combination with a carrier, vitamins, or other therapeutic agents, and an effective dosage product comprising phenol, 4,4'-(2-pyridinyl methylene) bis,- diacetate (ester) for carrying out the method.Type: GrantFiled: March 29, 1988Date of Patent: March 7, 1989Assignee: Meditech Pharmaceuticals, Inc.Inventor: Joseph B. Michaelson
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Patent number: 4801446Abstract: Described are the uses of methyl-isoeugenol having the structure: ##STR1## n-dodecanol having the structure: ##STR2## and 1-(2-butenoyl)-2,6,6-trimethyl-1,3-cyclohexadiene having the structure: ##STR3## taken alone or taken in combination as attractants house flies (Musca domestica L. (Diptera:Muscidae)) and Stored Products Moths. The methyl-isoeugenol, n-dodecanol and 1-(2-butenoyl)-1,3-cyclohexadiene taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: November 14, 1986Date of Patent: January 31, 1989Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
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Patent number: 4801448Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for sand flies (Psychodidae), house flies and beetles (Coleoptera). The dimethyl disulfide itself is specifically useful as an attractant for house flies and the dibutyl succinate is specifically useful as an attractant for Coleoptera and Psychodidae. The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: June 27, 1986Date of Patent: January 31, 1989Assignees: International Flavors & Fragrances Inc., The University of FloridaInventors: Richard A. Wilson, Jerry F. Butler, Donald Whithycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
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Patent number: 4797285Abstract: A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.Type: GrantFiled: December 6, 1985Date of Patent: January 10, 1989Assignees: Yissum Research and Development Company of the Hebrew University of Jerusalem, Hadassah Medical OrganizationInventors: Yechezkel Barenholz, Alberto Gabizon
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Patent number: 4791136Abstract: Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.Type: GrantFiled: July 30, 1986Date of Patent: December 13, 1988Assignee: Burroughs Wellcome Co.Inventors: John F. Batchelor, Richard M. Hyde, David J. Livingstone
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Patent number: 4784667Abstract: This invention is directed to oxidation hair dye compositions and their use in the dyeing of human hair. The compositions consist essentially of precursors comprising 2,3-diamino-6-methoxy-pyridines and aromatic amines or diamines. The combination of oxidation dye precursors according to the invention gives bright, deep blue dye finishes having high stability to heat and light.Type: GrantFiled: October 7, 1985Date of Patent: November 15, 1988Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Norbert Maak, Peter Flemming, Dieter Schrader
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Patent number: 4774084Abstract: The use of compounds of formula I (in 2,3-threoconfiguration) ##STR1## wherein n is an integer from 5 to 9, R' and R" are equal or different, and are each selected from the group consisting of hydrogen, lower alkyl, or are together O (oxygen) or .dbd.CH.sub.2 (methylene), and R is lower alkyl, for the inhibition of pheromone mediated attraction between male and female of pest insects, particularly of the family Diprionidae; the use of compounds of the formula II (in 2,3-erythroconfiguration): ##STR2## wherein n is an integer from 5 to 9, R.sub.a ' is hydrogen, and R.sub.a " is lower alkyl, or R.sub.a ' and R.sub.a " together form methylene, and R.sub.a is lower alkyl, as an attractant for pest insects, preferably of the family Diprionidae.Type: GrantFiled: February 28, 1986Date of Patent: September 27, 1988Inventors: Hans G. Magnusson, Jan W. Lofqvist
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Patent number: 4772468Abstract: The invention provides a pharmaceutical composition for filling into bone cavities comprising an agueous paste formed from powdered calcium phosphate and an antibacterial substance, if necessary together with one or more binders. The antibacterial substance is preferably taurolidine and the calcium phosphate is preferably .beta.-tricalcium phosphate.Type: GrantFiled: October 7, 1987Date of Patent: September 20, 1988Assignee: ED Geistlich Sohne AG fur Chemische IndustrieInventor: Rolf W. Pfirrmann
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Patent number: 4772593Abstract: The invention discloses a method of treating swine dysentery by the administration of an animal feed composition containing an effective amount of an alkoxysilane compound such as 3-(triethoxysilyl)propyloctadecyldimethyl ammonium chloride.Type: GrantFiled: July 1, 1985Date of Patent: September 20, 1988Assignee: The Dow Chemical CompanyInventors: Joseph W. Whalen, Edward E. Flagg
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Patent number: 4769241Abstract: Perfluorocarbon emulsion formulations are oxygenated prior to use by means of a portable oxygenation system. The blood substitute is in a closed container or bag. An oxygen-containing gas is introduced into the bag from a separate container. The bag is continuously agitated for a sufficient time to increase the pO.sub.2 of the perfluorocarbon emulsion formulations to a desired pressure, e.g., to at least 600 mmHg. In one embodiment, the system used for oxygenation of the perfluorocarbon emulsion formulations comprises a small tank for gas having an inlet port and an outlet port fitted with shut-off valves. The outlet port is adapted to be connected to a filter which, in turn, is adapted to be connected to the inlet port of a three-way valve. The primary outlet of the three-way valve is adapted to mount a hypodermic needle which is adapted to be pushed through a rubber septum in a port of the bag to communicate with the interior of the bag.Type: GrantFiled: September 23, 1986Date of Patent: September 6, 1988Assignee: Alpha Therapeutic CorporationInventors: Charles M. Heldebrant, Kim C. Crowe, George R. Groveman, Charles H. Davis, Jr.
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Patent number: 4765979Abstract: A molluscicide composition is provided which is highly effective and environmentally safe. The composition includes a carrier compound, an attractant, and a molluscicide agent. The attractant consists of metaldehyde and the molluscicide agent consists of atomized powdered elemental aluminum. Wheat, barley, oats, corn and mill-run bran are used as the carrier compounds. In a preferred form of the invention, a preservative, a dispersing agent and water are added to enhance the preparation and stability of the composition. The composition may be applied in meal, pellet, cake or slurry form. It is highly effective in killing terrestrial molluscs (slugs and snails) while avoiding the environmental and efficacy problems of other molluscicide compositions, including those using metaldehyde as the sole molluscicide agent.Type: GrantFiled: March 11, 1986Date of Patent: August 23, 1988Inventor: James W. Nielsen
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Patent number: 4764366Abstract: Novel lower alkyl esters of iodo-trans-2-methylcyclohexanecarboxylic acid are useful to attract the Mediterranean Fruit Fly, "Medfly," for prolonged periods of time. The esters are competitive in attraction with the current "standard" attractant, Trimedlure, but are much more persistent. The esters may be economically produced and possess the dual properties required for effective use in Medfly control programs.Type: GrantFiled: April 27, 1987Date of Patent: August 16, 1988Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Terrence P. McGovern, Roy T. Cunningham
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Patent number: 4762720Abstract: Novel process for liposome compositions capable to retain larger amount of drugs with a small amount of phospholipid and to provide, therefore, safer medications of various drugs, which comprises dispersing freeze-dried MLV or SUV in an aqueous medium in the presence of both an active ingredient and a divalent cation to regenerate LUV or LOV entrapping said active ingredient.Type: GrantFiled: September 19, 1985Date of Patent: August 9, 1988Assignee: Shionogi & Co., Ltd.Inventor: Hiroaki Jizomoto
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Patent number: 4761280Abstract: Certain esters of 4(and 5)-chloro-trans-2-methylcyclohexanecarboxylic acid act in a dual and advantageous capacity when added to the Mediterranean fruit fly attractant, trimedlure. They greatly reduce or eliminate crystallization of the solid trimedlure isomers that occurs on storage or use during cool weather and they significantly extend the attractive activity of trimedlure.Type: GrantFiled: September 8, 1986Date of Patent: August 2, 1988Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Terrence P. McGovern, Barbara A. Leonhardt, Roy T. Cunningham
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Patent number: 4759931Abstract: Liquid iodophors are provided containing as surface-active agent a product of the formula RO--(C.sub.3 H.sub.6 O).sub.m --(C.sub.2 H.sub.4 O).sub.n --CH.sub.2 COOM, wherein RO is the residue of an alcohol of at least 8 carbon atoms or of an alkylphenol of at least 10 carbon atoms which is substantially free of olefinic unsaturation, m is a number having an average value of 0-10, n is a number having an average value of 2-20 and M is hydrogen or a monovalent cation. Preferably the iodophors contain at least 20% of iodine. The novel iodophors are prepared by dissolving at room temperature the desired amount of iodine in the surface-active agent.Type: GrantFiled: April 10, 1984Date of Patent: July 26, 1988Assignee: 501 Stamicarbon B.V.Inventor: Nicolaas A. I. van Paassen
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Patent number: 4756910Abstract: A liposome preparation entrapping adriamycin as the effective component, whose constitutional lipids are phosphatidylcholine, cholesterol, and sulfatide in a specific molar ratio.Type: GrantFiled: November 25, 1986Date of Patent: July 12, 1988Assignee: Kabushiki Kaisha Vitamin KenkyusyoInventors: Kunio Yagi, Nakao Kojma, Makoto Takano
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Patent number: 4757075Abstract: A method of reducing serum levels of uric acid which comprises administration of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone or its pharmaceutically acceptable salts is described herein.Type: GrantFiled: October 14, 1986Date of Patent: July 12, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventor: Steven R. Wagner