Patents Examined by John W. Rollins
  • Patent number: 5674488
    Abstract: A method for lowering blood cholesterol levels which comprises administering to a human suffering from hypercholesterolemia an effective amount of a delta 5 hydrogenating enzyme over an extended period of time sufficient to effect a reduction of the blood cholesterol level of said human.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: October 7, 1997
    Inventor: John J. Reich
  • Patent number: 5674537
    Abstract: A microbiocidal solution for in vivo and in vitro treatment of microbial infections containing an electrolyzed saline solution having a content of regulated amounts of ozone and active chlorine species. The ozone content is 5 to 100 mg/L (milligram per liter) and the chlorine species content is 5 to 300 parts per million (ppm). The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1% or less saline to electrolysis under conditions sufficient to produce the active ingredients. The solution is used at an isotonic saline concentration and my be adjusted with hypertonic saline. The solution is used in vitro treatments of infected whole blood, blood cells or plasma to reduce contamination. The solution may also be administered to warm blooded animals, including humans by intravenous injection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 7, 1997
    Assignee: Medical Discoveries, Inc.
    Inventor: Robert E. Morrow
  • Patent number: 5674988
    Abstract: Novel azide groups containing sialosides and a process for their preparation is provided. The methods and resulting compounds may be of pharmaceutical interest for the inhibition of the influenza virus neuraminidase.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: October 7, 1997
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Subramamiam Sabesan
  • Patent number: 5670364
    Abstract: New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • Patent number: 5670486
    Abstract: New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • Patent number: 5670507
    Abstract: There is disclosed a method for reversing the multiple drug resistant (MDR) phenotype in tumors insensitive to hydrophobic chemotherapeutic drugs due to over expression of mdr-1, comprising administering an effective amount of a long chain amino alcohol compound. There is further disclosed a method for preventing the development of MDR during cancer chemotherapy treatments, comprising administering during cancer chemotherapy treatments an effective amount of a long chain amino alcohol compound.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: September 23, 1997
    Assignee: Cell Therapeutics, Inc.
    Inventors: Glenn C. Rice, Jack W. Singer
  • Patent number: 5670369
    Abstract: The invention includes an improved method for producing an aqueous solution of soluble collagen. The method comprises the steps of:(A) providing an aqueous ground slurry of insoluble collagen containing insoluble collagen at a first concentration and at a pH effective to obtain activity for a proteolytic enzyme added in step (B);(B) adding a proteolytic enzyme to said slurry;(C) reacting said slurry and enzyme at a temperature, T.sub.1, and for a time t.sub.1 effective for forming a slurry containing at least some soluble collagen;(D) diluting at least a portion of the slurry formed in step (C) with water to form a diluted slurry containing insoluble collagen at a second concentration; and(E) reacting said diluted slurry obtained in step (D) at a temperature, T.sub.2 and for a time t.sub.2, effective to produce a solution containing an increased amount of soluble collagen.
    Type: Grant
    Filed: June 25, 1996
    Date of Patent: September 23, 1997
    Assignee: Ranpak Corporation
    Inventors: David J. Fink, Kevin M. Virnelson
  • Patent number: 5665359
    Abstract: It has been discovered that the Chinese fruit known as shanzha, and extracts and purified component derived therefrom, can be administered orally to animals to reduce levels of cholesterol in the blood. The mechanism of action is believed to include the "up-regulation" of LDL receptors on cell surfaces and inhibition of transcription factors for sterol responsive genes. Examples demonstrate the isolation of active components and extracts, potential mechanisms of action in animals and cell culture, and conditions promoting retention of activity during storage.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: September 9, 1997
    Inventors: Walter Kwok Keung Ho, Hson-Mou Chang, Chi-Ming Lee
  • Patent number: 5665351
    Abstract: A method for controlling fungal diseases in turfgrasses using a Pseudomonas aureofaciens. The Pseudomonas aureofaciens is particularly useful in inhibiting dollar spot (Sclerotinia homoeocarpa) in turfgrasses. The method is environmentally safe and economical.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: September 9, 1997
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Muraleedharan G. Nair, Joseph M. Vargas, Jon F. Powell, Amitabh Chandra, Alvin Ronald Detweiler
  • Patent number: 5665576
    Abstract: A method for the production of taxanes such as taxol. The method includes inducing formation of callus cells by contacting an explant tissue with a liquid medium without complete submergence of the tissue in the medium. The callus cells formed are employed in a liquid suspension cell culture to produce one or more taxanes.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 9, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Paul M. Cino, Steven R. Schwarz, Dana L. Cazzulino
  • Patent number: 5665361
    Abstract: The freezing point of a food product subjected to freezing temperatures is increased by adding to the food product a juice obtained from berries of sea buckthorn or an aqueous extract obtained from sea buckthorn berry or leaf tissue. The food product containing the added sea buckthorn substance is then cooled to freeze the product.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: September 9, 1997
    Assignee: Nestec S.A.
    Inventors: Alfred Jann, Rolv Lundheim, Peter Niederberger, Michel Richard
  • Patent number: 5663209
    Abstract: The present invention reveals the isolation, purification and characterization from the creosote bush Larrea tridentata of compounds of the structural formula: ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of HO--, CH.sub.3 O-- and CH.sub.3 (C.dbd.O)O--, provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not each HO-- simultaneously. Each compound is a derivative of 1,4-bis-(3,4-dihydroxyphenyl)-2,3-dimethylbutane (nordihydroquaiaretic acid, NDGA). In addition, NDGA and each derivative can be used in a method to suppress Tat transactivation of a lentivirus, including the HIV virus, in a cell by administering NDGA or a derivative of NDGA to the cell.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: September 2, 1997
    Assignee: The Johns Hopkins University
    Inventors: Ru Chih C. Huang, John N. Gnabre
  • Patent number: 5662889
    Abstract: Oral compositions for use in the mouth are provided which contain a DNA-sodium salt obtained preferably from sturgeon milt. The compositions are useful, for example, as mouth wash and toothpaste formulations.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: September 2, 1997
    Assignee: PharmecCompany
    Inventors: Yuri Petrovich Vainberg, Elli Nicoltevna Kaplina, Ideya Grigorievna Anosova
  • Patent number: 5662902
    Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: Genencor International, Inc.
    Inventors: Ernest W. Boyer, Robert L. Charles
  • Patent number: 5661020
    Abstract: Disclosed are pharmaceutical compositions containing low diol polyethylene glycol, covalently attached to superoxide and dismutase process of making the compositions. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: August 26, 1997
    Assignee: Sanofi
    Inventors: Robert A. Snow, David L. Ladd, Denton W. Hoyer
  • Patent number: 5660831
    Abstract: A method is described for obtaining an extract from the flowers of Salvia officinalis. The extraction process is performed preferably at a temperature of less than 50.degree. C. A preferred extraction agent is supercritical CO.sub.2. The extract thus obtained can be processed, if desired, with the addition of suitable thinners or fillers, in order to obtain a medicament. Medicaments containing the extract of Salvia officinalis flowers can be used to control high blood-pressure, circulatory problems and incomplete cicatrization of wounds.
    Type: Grant
    Filed: July 24, 1995
    Date of Patent: August 26, 1997
    Assignee: Heilmittebetrieb Isernhagen GmbH
    Inventor: Max Reinhard
  • Patent number: 5660832
    Abstract: Pesticide-poor concentrates of active components of plants are obtained in that in a first step plants or parts thereof, which may be charged in fresh or dried state, are extracted with at least one polar solvent at a measured pH-value in the range from 3.2 to 9.8 in such a way, that in the obtained primary extract are contained mainly the desired plant components, accompanied by undesired plant components, accompanying substances and pesticides, in a second step said primary extract is contacted with adsorber resin(s) in such a way, that on one hand the desired plant components are adsorbed thereon, and on the other hand the solution with the undesired plant components, the accompanying substances and pesticides are separated from the charged resin, in a third step the desired plant components are desorbed from said resin with at least one solvent, and in a fourth step the solvent(s) is (are) removed either partially or completely, and by this way a concentrate of active components is obtained.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: August 26, 1997
    Assignee: Emil Flachsmann AG
    Inventors: Rudolf Steiner, Renato Colombi
  • Patent number: 5660830
    Abstract: Counter-irritants produce a slight irritation, as on an area of the skin, in order to relieve more serious inflammation elsewhere. Peppers, members of the Capsicum species, are a source of counter-irritants. The Scoville rating for a pepper provides a measure of the counter-irritant content of a given pepper. This invention provides for the solubilizing and recovery of the counter-irritants contained within peppers, having Scoville ratings of from 30,000 to 250,000, in the common capsaicin containing ethyl alcohol extract from the same specific peppers. The synergisitic pain relieving benefits of the counter-irritants in combination with the capsaicin provides superior pain relief for many hours after an application.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: August 26, 1997
    Inventor: Cleve Richard Anderson
  • Patent number: 5658794
    Abstract: A method for controlling fungal diseases in turfgrasses using a Pseudomonas aureofaciens. The Pseudomonas aureofaciens is particularly useful in inhibiting dollar spot (Sclerotinia homoeocarpa) in turfgrasses. The method is environmentally safe and economical.
    Type: Grant
    Filed: December 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Muraleedharan G. Nair, Joseph M. Vargas, Jon F. Powell, Amitabh Chandra, Alvin Ronald Detweiler
  • Patent number: 5658915
    Abstract: An antibacterial agent characterized by containing a polyelectrolyte complex prepared by reacting a cationic polymer containing N.sup.+ atoms in repeating units thereof and an anionic polymer containing --COO.sup.-, --SO.sub.3.sup.-, or --PO.sub.3.sup.- groups in repeating units thereof, and an antibacterial material carrying the above polyelectrolyte complex on a carrier.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: August 19, 1997
    Assignee: Iatron Laboratories, Inc.
    Inventors: Koji Abe, Mitsunao Tanaka, Satoshi Inaba, Masaharu Akimoto