Patents Examined by John W. Rollins
  • Patent number: 5620962
    Abstract: Disclosed are topical anti-inflammatory compositions containing 0.1% to 10% by weight of a monogalactosyl dieicosapentaenoyl glycerol having esterified eicosapentaenoic acid residues (MGDG-EPA); anti-inflammatory compositions are formulated using a purified microalgal lipid preparation containing 30% to 100% by weight of MGDG-EPA; methods of making the microalgal lipid preparation; methods of treating inflammation by administering the topical anti-inflammatory compositions to a subject in need thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 15, 1997
    Inventor: Rodner R. Winget
  • Patent number: 5620871
    Abstract: The present invention relates to a process for preparing indigestible polysaccharides and to the corresponding hydrogenated products. This process essentially consists in carrying out an enzymatic hydrolysis of at least one dextrin and/or one polyglucose using at least one saccharifying enzyme and at least one enzyme which hydrolyzes the 1-6 bonds of amylopectin.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: April 15, 1997
    Assignee: Roquette Ferres
    Inventor: Jean-Jacques Caboche
  • Patent number: 5620964
    Abstract: A composition for treating and/or inhibiting gastric and duodenal ulcers, comprising an oligosaccharide selected from the group consisting of Formula I ##STR1## or a mixture thereof; wherein:X is independently OH or NHAc;Y is independently H, or an amino acid or a peptide of 2-100, preferably 2-20, amino acids; andW, W', and W" are each independently H or ##STR2## where Z is independently H or a pharmaceutically acceptable cation; and P is independently H or ##STR3## where Z is defined as above; wherein at least one of W, W' or W" is an .alpha.-N-acetylneuraminic acid moiety, andwherein W' and W" are not simultaneously .alpha.-N-acetylneuraminic acid moietywith the proviso that the compound of Formula II is not NAN .alpha.(2.fwdarw.3)Gal .beta.1-4 Glu or NAN .alpha.(2.fwdarw.6)Gal .beta.1-4 Glu; and a kit for detecting the presence of Helicobacter pylori comprising at least one compound of the Formula I or II, are described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 15, 1997
    Assignee: Neose Technologies, Inc.
    Inventors: Stephen Roth, Edward J. McGuire, Dennis H. Langer
  • Patent number: 5620885
    Abstract: The present invention is to methods of obtaining plant-derived compositions that-inhibit apoptosis, the compositions obtained thereby, compositions comprising the composition, and methods of use thereof.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: April 15, 1997
    Assignee: LXR Biotechnology Inc.
    Inventors: Ian C. Bathurst, John D. Bradley, L. David Tomei, Philip J. Barr
  • Patent number: 5618537
    Abstract: Plant-based medicament having tonicising action on smooth muscular organs which are atonic or have decreased tone. The medicament contains Iberis amara, preferably Iberis amara totalis (flowers, seeds, leaves, stalk and roots), in particular as a plant extract or its constituents, optionally together with one or more other constituents selected from the group consisting of Menthae piperitae, Matricariae, Carvi fructus, Melissae folium and Liquiritiae radix, as the sole carrier(s) of the activity. Methods of treating patients comprising administering the medicaments.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: April 8, 1997
    Assignee: Steigerwald Arzneimittelwerk GmbH
    Inventor: Samuel N. Okpanyi
  • Patent number: 5618538
    Abstract: Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of drying plant matter to preserve their taxane content and facilitate their extraction is disclosed. In addition, methods of extracting and purifying taxol and other taxanes from ornamental cultivars using a series of organic and aqueous solvents and normal phase chromatography columns are also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 8, 1997
    Assignee: The University of Mississippi
    Inventors: Hala N. ElSohly, Edward M. Croom, Jr., Mahmoud A. ElSohly, James D. McChesney
  • Patent number: 5616324
    Abstract: A synergistic mixture particularly suitable for the treatment of animals whic consists of at least two of the group consisting of DL.Phenylalanine, Ruta Graveolans and Corydali Bulbosa together with a carrier to make up a required volume, the mixture having a pro-inflammatory effect which accelerates the healing process of inflammation. It is preferred that there is provided mixture of DL.Phenylalanine with one product selected from the group of Ruta Graveolans and Corydalis Bulbosa. In a specific form, the mixture also includes Nicotinic Acid.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 1, 1997
    Inventors: Antoinette Foster, Don Foster
  • Patent number: 5616458
    Abstract: The present invention provides for the use of Tripterygium wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase-2 induction and inflammatory processes such as the production of prostaglandin E.sub.2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 1, 1997
    Assignee: Board of Regents, University of TX System
    Inventors: Peter E. Lipsky, Xue-Lian Tao, Jian Cai, William J. Kovacs, Nancy J. Olsen
  • Patent number: 5614197
    Abstract: The invention provides new methods and products for use in photoprotection from ultraviolet radiation. The products include extracts from ferns of the genus Polypodium mixed in prepartions for topical application and oral administration. The preparations have both photoprotective and antioxidant properties. The topical formulations may also include physical and/or chemical sunscreen agents and/or cosmetic agents.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: March 25, 1997
    Assignee: Industrial Farmaceutica Cantabria, S.A.
    Inventors: Madhukar A. Pathak, Salvador Gonzalez, Thomas B. Fitzpatrick
  • Patent number: 5614196
    Abstract: A method of preparing a substance capable of deterring gypsy moths and gypsy moth larvae is disclosed. Green ash foliage are placed in contact with methanol for a period of time sufficient to extract methanol-soluble compounds from the foliage. The foliage-methanol mixture is filtered, and the filtrate is concentrated. The concentrated filtrate is then contacted with ethyl acetate for a period of time sufficient to extract ethyl acetate-soluble compounds from the concentrated filtrate.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: March 25, 1997
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dale M. Norris, Ingrid Markovic
  • Patent number: 5612202
    Abstract: Starch containing amylopectin is hydrolyzed with an alpha-amylase, preferably derived from Bacillus stearothermophilus, under conditions which cause a non-random cleavage of the starch molecules to yield fragments (molecules) having similar size and branching characteristics and a molecular weight range from about 20,000 to about 50,000 daltons are made. All of the desired molecules have (.alpha.1,6) linkages. The hydrolysate is treated to enrich the concentration of the desired fragments and the enriched portion can be processed further to make a maltodextrin having a D.E. of less than about 8.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: March 18, 1997
    Assignee: Enzyme Bio-Systems Ltd.
    Inventor: Phillip J. Brumm
  • Patent number: 5612039
    Abstract: A composition for dietary supplementation includes the following three compositions: The first composition is Germander (Teucrium Chamaedrys Herba), Camelia Tea (Camelia Thea Folia), and Spirulina (Spirulina Maxima); the second composition is Garcinia Gambogia, dry extract (Garcinia Cambogia Fructuse), Brown Algae, dry extract (Fucus Vesicolosus), and Germander (Teucrium Chamaedrys Herba); the third composition is Garcinia Gambogia, dry extract (Garcinia Cambogia Fructuse), Brown Algae, dry extract (Fucus Vesicolosus), and Orthosiphon, dry extract (Orthosiphon Stamineus Folia), respectively. Additionally, there is a fourth composition including Common Bean (Phaseolus Vulgaris Fructus), Garcinia Cambogia, dry extract (Garcinia Cambogia Fructus), Pineapple, dry extract (Ananas Sativus Stipites), Gymnema Sylvestre, dry extract (Gymnema Sylvestre Folia), and Chromium Dinicotinate (Chromium).
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: March 18, 1997
    Assignee: Nini E. Policappelli
    Inventors: Nini E. Policappelli, Rafaele Garzone, Claudio Russo
  • Patent number: 5612038
    Abstract: Product with lipolytic activity and its method preparation.The present invention relates to a process for preparing a sea-weed based product with lipolytic activity. Said process consists of subjecting sea-weed to the following stages:a) rehydration of previously lyophilized sea-weed to the original level of humidity with demineralized water,b) lixiviation in semi-fluid bed of the rehydrated sea-weed,c) elimination from the extraction juice of the macromolecules and particles which are greater in size than 0.22 micron,d) concentration of the organic elements by eliminating the minerals.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: March 18, 1997
    Assignee: Codif Inernational SA
    Inventors: Jean Gedouin, Romuald Vallee
  • Patent number: 5609873
    Abstract: The invention relates to a cosmetic or dermatological composition, as well as a cell culture medium. This composition and this medium contain an ecdysteroid, an ecdysteroid derivative or a plant or animal extract containing it. This composition is aimed notably to give to skin a smoother and softer appearance, to strengthen the water barrier function of skin, and to strengthen the cohesion of the cells of the epidermis. This composition may also be used for improving the hair appearance. The cell medium may be used advantageously for the mass culture of keratinocytes.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: March 11, 1997
    Assignee: LVMH Recherche
    Inventors: Alain Meybeck, Fr ed eric Bonte, G erard Redziniak
  • Patent number: 5609875
    Abstract: Cosmetic skin whitening compositions based on the combination of plant extracts and alpha-, beta-hydroxy or keto acids, amides, ammonium salts, other inorganic salts and esters of these. The compositions may also contain one or more of UVA filters, UVB filters, derivatives of vitamin E, Vitamin C or its derivatives. The compositions may contain conventional additives. A preferred plant extract is that of licorice (Glycyrrhiza Glabra) and of related plant species. Such compositions also prevent to a large extent formation of skin spots.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: March 11, 1997
    Assignee: Fischer Pharmaceuticals Ltd.
    Inventor: Nira Hadas
  • Patent number: 5609874
    Abstract: This invention relates to a method and means for the treatment of a viral infection and for reducing the rate of decrease in CD4 lymphocyte counts in a subject having a viral infection. It relates, in particular, to a use of an extract of corms of the family Hypoxidaceae in the preparation of a medicament for the treatment of a viral infection; to the use of the said extract in the preparation of a medicament for reducing the rate of decrease of CD4 lymphocyte counts in a subject with a viral infection; to a method of treating a viral infection, to a method of reducing the rate of decrease in CD4 lymphocyte counts in a subject having a viral infection; to a medicament for the treatment of a viral infection, and to a medicament for reducing the rate of CD4 lymphocyte counts in a subject having a viral infection.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: March 11, 1997
    Assignee: Virostat (NA) NVQ
    Inventors: Roelof W. Liebenberg, Petrus B. Kruger, Patrick J. D. Bouic, Carl F. De Vos Albrecht
  • Patent number: 5610189
    Abstract: A disinfecting composition comprising stable aqueous solutions of (a) a blend of biocidally active terpenes, (b) one or more biocidally active surfactants, (c) one or more proton donor type biocides, and (d) a salt of mono, di or trihydroxy aliphatic or aromatic acid wherein the blend of biocidally active terpenes is tea tree oil.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: March 11, 1997
    Inventor: Reginald K. Whiteley
  • Patent number: 5610179
    Abstract: A method of treating or preventing babesiosis is described which is based on the administration of a tellurium compound. The preferred tellurium compound is ammonium trichloro (O,O'-dioxoethylene tellurate).
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: March 11, 1997
    Inventors: Benjamin Sredni, Michael Albeck
  • Patent number: 5610060
    Abstract: An isolated bacterium of the genus Helicobacter, characterized by the 16S ribosomal RNA encoding nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1 is provided. An isolated nucleic acid having the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1 is provided. Such a nucleic acid can be used for diagnosis of infection with H. hepaticus. A nucleic acid of the present invention in a vector suitable for expression of the nucleic acid is also provided. The vector can be in a host suitable for expressing the nucleic acid. A purified antigen specific for H. hepaticus is provided. A method of making an animal model for chronic Helicobacter infection is also provided.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: March 11, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jerrold M. Ward, James G. Fox, Michael J. Collins, Jr., Peter L. Gorelick, Raoul E. Benveniste, Joseph G. Tully, Matthew A. Gonda, Bruce J. Paster, Floyd E. Dewhirst, III
  • Patent number: 5607673
    Abstract: In HIV infected individuals, certain clinical and biological markers are used to assess the progression or regression of the disease. From the plant, Uvaria bevistipitata of the Annonaceae family, a substantially pure extract was derived. This extract was administered to 268 HIV infected patients in a clinical trail in Zaire Africa and dramatic results were obtained. The extract was also submitted to a laboratory for in vitro analysis. when tested against the HIV reverse transcriptase enzyme, the extract tested 96.7% active. In further laboratory analysis, against HIV-.sub.IIB, it demonstrated efficacy at doses that showed no cytotoxic effects.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: March 4, 1997
    Assignee: C.S.S.A.H.A., Inc.
    Inventor: Constantin M. Bashengezi