Patents Examined by Johnnie R. Brown
  • Patent number: 5346890
    Abstract: An antioxidant substance which is a green leaf component in a green plant, comprising a component which is substantially insoluble in n-hexane but soluble in an aqueous ethanol solution having a water content of 0 to 80% by volume. The substance has an antioxidant activity as potent as or more potent than .alpha.-tocopherol, and is useful as an antioxidant for use in the field of foods, and medicines. Particularly, the antioxidant substance can be used for maintaining the freshness and quality of foods or storage thereof. The substance can be blended with cosmetics for skin and hair and are useful for the prevention of spots, freckles, chapping and sunburn.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: September 13, 1994
    Assignee: Yoshihide Hagiwara
    Inventors: Yoshihide Hagiwara, Hideaki Hagiwara
  • Patent number: 5344924
    Abstract: A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of:1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base;2) heating the mixture to a temperature sufficient to allow the mixture to react;3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced;4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture;5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally,6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.
    Type: Grant
    Filed: April 6, 1993
    Date of Patent: September 6, 1994
    Assignee: Greenwich Pharmaceuticals, Incorporated
    Inventor: Sudershan K. Arora
  • Patent number: 5344823
    Abstract: A new antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: September 6, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kin S. Lam, Leonard A. McDonald, Jacqueline Mattei, Salvatore Forenza, James A. Matson
  • Patent number: 5342931
    Abstract: A process for purifying DNA comprising 1) binding the DNA to a hydrated silica in the presence of water or physiological buffers in which the hydrated silica is prepared by refluxing silicon dioxide in sodium hydroxide or potassium hydroxide at a molar ratio of about 2:1 to 10:1 for at least about 48 hours, 2) separating and washing hydrated silica and the DNA bound thereto, and eluting the DNA from the hydrated silica in a heated physiological buffer or in heated water.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: August 30, 1994
    Assignee: Becton, Dickinson and Company
    Inventors: Daniel L. Woodard, Adriann J. Howard, James A. Down
  • Patent number: 5340932
    Abstract: A process for the synthesis of a new N-acetylated Heparin derivative is disclosed which includes a reaction of a N-desulfated Heparin with acetic anhydride. The new compound so obtained and pharmaceutical compositions containing it, exhibit antithrombotic and fibrinolytic properties with low anticoagulant activity.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: August 23, 1994
    Assignee: Ajorca S.A.
    Inventors: Fernando Fussi, Victor Diaz, Ricardo H. Domanico, Esteban P. Fuentes
  • Patent number: 5338728
    Abstract: Disclosed are novel pradimicin compounds which possess antifungal activity and, preferably, improved water solubility. The compounds of the invention are prepared by modifying the 4'-amino or 4'-alkylamino moieties of known pradimicin compounds.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: August 16, 1994
    Assignee: Bristol-Myers Squibb
    Inventors: Hajime Kamachi, Minoru Hirano, Shinji Masuyoshi
  • Patent number: 5338838
    Abstract: An antioxidant substance which is a green leaf component in a green plant, comprising a component which is substantially insoluble in n-hexane but soluble in an aqueous ethanol solution having a water content of 0 to 80% by volume. The substance has an antioxidant activity as potent as or more potent than .alpha.-tocopherol, and is useful as an antioxidant for use in the field of foods, and medicines. Particularly, the antioxidant substance can be used for maintaining the freshness and quality of foods or storage thereof. The substance can be blended with cosmetics for skin and hair and are useful for the prevention of spots, freckles, chapping and sunburning.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: August 16, 1994
    Assignee: Yoshihide Hagiwara
    Inventors: Yoshihide Hagiwara, Hideaki Hagiwara
  • Patent number: 5338418
    Abstract: A process for the production of hydroxocobalamin that eliminates cyanocobalamin as an intermediate. Co-enzyme-type vitamin B.sub.12 is first absorbed to a divinylbenzene/styrene resin which is washed with warm water and then eluted with a solution containing at least 25% of a lower alcohol. The eluate is then irradiated with a light that causes the conversion of coenzyme-type vitamin B.sub.12 to hydroxocobalamin. Finally, the solution of hydroxocobalamin is treated with alumina or silica which binds the impurities leaving behind the highly purified hydroxocobalamin in the flow-through.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: August 16, 1994
    Assignee: Nippon Oil Co., Ltd.
    Inventors: Takayuki Hirayama, Takashi Kiyota
  • Patent number: 5332809
    Abstract: The present invention is directed to total and partial esters of gellan in which the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols, and salts of said partial esters with inorganic or organic bases, and compositions containing the same.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: July 26, 1994
    Assignee: Fidia S.p.A.
    Inventors: Francesco Della Valle, Vittorio Crescenzi, Lanfranco Callegaro
  • Patent number: 5332812
    Abstract: A solid phase substrate which yields soluble labeled products upon hydrolysis by a glycosaminoglycan endoglycosidase and methods of producing said substrate are comprised in the present invention. The solid phase substrate comprises glycosaminoglycan bearing labeled substances bound to amino groups. The labeled glycosaminoglycan substrate is reductively aminated at its reducing terminal end to produce an amine-terminus. The substrate is further coupled to an amino-reactive solid matrix through its amine-terminus.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: July 26, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventors: Garth L. Nicolson, Motowo Nakajima, Tatsuro Irimura
  • Patent number: 5332845
    Abstract: Novel phosphorylating reagents are provided which are useful in DNA synthesis and purification procedures. The reagents are substituted phosphines which are particularly useful in the phosphorylation of nucleoside and solid supported oligonucleotides at the 5'-hydroxyl position. Phosphorylation using these reagents is easily and accurately monitored colorimetrically.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: July 26, 1994
    Assignee: Chiron Corporation
    Inventors: Michael S. Ureda, Thomas Horn
  • Patent number: 5330977
    Abstract: The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ;n is 12 or 14;R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy.The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: July 19, 1994
    Assignee: The Wellcome Foundation Limited
    Inventors: Ezio Tubaro, Giovanni Cavallo
  • Patent number: 5328832
    Abstract: A transparent and stable aqueous solution of a substrate for a determination of lipase, comprising triglyceride uniformly solubilized therein, a method for determination of lipase activity in a sample, employing the aqueous solution, and a process for the manufacture of a lyophilized product capable of forming the aqueous solution are disclosed. A process for the manufacture of a transparent and stable aqueous solution of triglyceride is also disclosed.
    Type: Grant
    Filed: September 25, 1991
    Date of Patent: July 12, 1994
    Assignee: Iatron Laboratories, Inc.
    Inventors: Iyoko Miki, Hiroyuki Tsubota, Toshio Tsuchiko, Hisashi Ochi
  • Patent number: 5329000
    Abstract: A process for purifying DNA in which the DNA is bound to silicon tetrahydrazide in the presence of less than 2M chaotrope, low salt buffers, or water. The DNA is then eluted with low salt buffer or by heating in water.
    Type: Grant
    Filed: October 31, 1991
    Date of Patent: July 12, 1994
    Assignee: Becton, Dickinson and Company
    Inventors: Daniel L. Woodard, Adriann J. Howard
  • Patent number: 5326867
    Abstract: The present invention relates to intermediates, pradimic acids and pradimic acid amides of the formula (II) ##STR1## wherein R is OH or NH.sub.2 ; R.sup.1 is hydrogen or a group of the formula ##STR2## with the proviso that when R is OH, R.sup.1 is not hydrogen; Y is OH or NR.sup.2 R.sup.3 ; R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, C.sub.1-5 alkyl, or an amino protecting group; R.sup.4 is hydrogen, hydroxy protecting group, or .beta.-D-xylosyl. The invention relates also to novel processes for the preparation of pradimic acids and pradimic acid amides, as well as novel pradimicin derivatives prepared therefrom.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: July 5, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Satsuki Okuyama, Takaaki Okita, Hajime Kamachi
  • Patent number: 5322840
    Abstract: The object of the present invention is the administration of a substance which contains, as active principle, an adenosine substituted on N.sup.6 of formula I ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each represents hydrogen or ##STR2## for the treatment of hyperlipemia and/or hypertriglyceridemia.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: June 21, 1994
    Assignee: Centre d'Etudes Experimentales et Cliniques de Physiobiologie, de Pharmacologie et d'Eutonologie (Cepbepe)
    Inventors: Genevieve Laborit, Camille Wermuth
  • Patent number: 5321013
    Abstract: Pharmaceutical compositions in the form of stable sucralfate suspensions free of suspending agents, wherein the sucralfate is present in the form of a gel having self-suspending properties and is suspended in an aqueous carbohydrate solution in a quantity of between 1 and 40% of sucralfate by weight.Said gel has a surface area exceeding 200 m.sup.2 /g and is prepared by dissolving powdered sucralfate in an HCl solution and then precipitating it with an NaOH solution added to a pH of between 4 and 4.5.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: June 14, 1994
    Assignee: Lisapharma SpA
    Inventors: Giorgio G. Z. Zagnoli, Ubaldo Conte, Paolo Colombo, Carla Caramella
  • Patent number: 5321011
    Abstract: A phytohormone for inducing root hair curling and root nodulation in the roots of leguminous plants particularly in the absence of nitrogen-fixing bacteria. The phytohormone comprises a pentasaccharide having a fatty acid condensed on the non-reducing end. A method for treating the roots of leguminous plants for inducing root hair curling and root nodulation is also disclosed.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: June 14, 1994
    Assignee: The University of Tennessee Research Corporation
    Inventors: Gary Stacey, Russell W. Carlson, Herman Spaink
  • Patent number: 5321131
    Abstract: Disclosed are compounds consisting of a plurality of nucleosides which are covalently linked by at least one aminoalkylphosphoramidate linkage of the formula ##STR1## wherein n=2 to 6 and Nu.sub.1 and Nu.sub.2 represent nucleoside phosphates.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: June 14, 1994
    Assignee: Hybridon, Inc.
    Inventors: Sudhir Agrawal, Jinyan Tang
  • Patent number: 5319079
    Abstract: Method for substituting a substitution compound for the hydrogen of a support bound primary hydroxyl group. The support bound primary hydroxyl group is treated in an organic, substantially anhydrous solvent in the presence of a tertiary amine base and the substitution compound.The substitution compound has a positive moiety and a negative moiety. The positive moiety is selected from the group consisting of trityl, pixyl, and derivatives thereof.The reagent is selected from the group consisting of tetraalkylammonium salts, inorganic salts, and mixtures thereof. Each reagent has a cation and an anion moiety.The cation moiety of the reagent is more electropositive than the positive moiety of the substitution compound. This relationship enables the reagent to attract the negative moiety of the substitution compound.
    Type: Grant
    Filed: May 28, 1991
    Date of Patent: June 7, 1994
    Assignee: Beckman Instruments, Inc.
    Inventors: Paramesewara M. Reddy, Serge L. Beaucage, Jang Rampal