Patents Examined by Johnnie R. Brown
  • Patent number: 5243072
    Abstract: Betaine group-containing polysaccharides with recurring anhydroglucose units of the average, general formula ##STR1## are disclosed. In this formula the R.sup.1 groups are the same or different and represent methyl, ##STR2## in which n=2 or 3, m=0 to 10, p=0 to 10 and R.sup.2 is a hydrogen atom or the betaine group ##STR3## in which R.sup.3 and R.sup.4 are the same or different and represent an alkyl group with 1 to 4 carbon atoms and R.sup.5 is a divalent aliphatic hydrocarbon group with 1 to 10 carbon atoms, with the proviso that at least 0.5% of the R.sup.1 groups in the polysaccharide molecule represent the betaine group.Also disclosed is a method for the synthesis of these compounds and their use in cosmetic preparations, expecially for the care of the hair. In addition, novel compounds of the general formula ##STR4## are disclosed as intermediates in which the substituents R.sup.3, R.sup.4 and R.sup.5 have the above meaning.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: September 7, 1993
    Assignee: Th. Goldschmidt AG
    Inventors: Burghard Gruning, Klaus Hoffmann, Gotz Koerner, Hans-Joachim Kollmeier
  • Patent number: 5240835
    Abstract: Unsaturated esters can be converted into unsaturated polymerizable monomers using a biocatalyst derived from Corynebacterium oxydans. The method involves the step of reacting an unsaturated ester with an organic compound having a primary or secondary hydroxy group in a substantially organic environment in the presence of the noted biocatalyst. A transacylase has been isolated from the microorganism and at least partially purified.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: August 31, 1993
    Assignee: Genencor International, Inc.
    Inventors: Frank A. Pettrone, Patrick J. Grisdale, Gregory M. Whited, Theresa C. Paulson
  • Patent number: 5240717
    Abstract: A mannose isomerase having excellent properties for industrial use, such as high thermal stability and resistance to high substrate concentrations, can be produced by culturing a strain of Pseudomonas (sp. AM-9582), and extracting it from the cells of AM-9582. Mannose can be effectively produced from fructose of high concentrations using the enzyme.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: August 31, 1993
    Assignee: Amano Pharmaceutical Co., Ltd.
    Inventors: Yoshiyuki Takasaki, Takaichi Ohya
  • Patent number: 5240915
    Abstract: There are disclosed avermectin derivatives which are avermectin modified at the 3- and 4-positions. The 3-hydroxy and 4-keto, epoxide and hydroxy (hydroxymethyl) derivatives and the 4-oxo compound are prepared from the natural avermectin by moving the 3,4-double bond exocyclic at 4 and forming a 3-hydroxy group. Osmolation gave an .alpha.,.beta.-diol across the double bond and cleavage of the diol provided the 4-oxo compound. The 4-oxo compound is epoxidized with an ylide reagent. The compounds are useful as anthelmintic agents and compositions for that use using the compounds as the active ingredient thereof are also described.
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: August 31, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Avery Rosegay
  • Patent number: 5238597
    Abstract: Sucrosetricarboxylic acid can be prepared by oxidizing sucrose with oxygen, if desired in a mixture with inert gases, by means of a more effective catalyst than platinum/alumina.The product can be used in washing agents or as a food additive.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: August 24, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfram Fritsche-Lang, Ernst I. Leupold, Merten Schlingmann
  • Patent number: 5239064
    Abstract: A novel antibiotic complex, A59770, individual factors and derivatives thereof, are provided. The A59770 compounds are useful as pesticides, particularly as rodenticides. Further provided are methods for reducing a rodent population, rodenticidal compositions, and an A59770-producing Amycolatopsis orientalis culture.
    Type: Grant
    Filed: April 11, 1990
    Date of Patent: August 24, 1993
    Assignee: Eli Lilly and Company
    Inventors: Marvin M. Hoehn, Karl H. Michel, Raymond C. Yao
  • Patent number: 5236909
    Abstract: Octyl ethers and octadienyl ethers of glucose, sucrose, are disclosed. Compositions comprised of a mixture of octyl ethers of glucose and sucrose and those containing octadienyl ethers of sugar acids are also disclosed.
    Type: Grant
    Filed: March 26, 1991
    Date of Patent: August 17, 1993
    Assignees: Henkel Research Corporation, Zucker-Aktiengesellschaft Uelzen-Braunschweig
    Inventors: Bert Gruber, Kenneth J. Weese, Hans-Peter Mueller, Karlheinz Hill, Arno Behr, James R. Tucker
  • Patent number: 5237016
    Abstract: This invention concerns methods and means for covalent attachment of oligonucleotides to solid supports substantially at their 5'-ends. According to the invention thiol-oligonucleotides are attached to bromoacetyl-derivatized polyacrylamide supports, or conversely, bromoacetyl-oligonucleotides are immobilized on thiol-polyacrylamide supports.In a further aspect, this invention relates to bromoacetyl-oligonucleotides that may be immobilized on thiol-polyacrylamide solid supports, thiol-oligonucleotides immobilized on bromoacetyl-derivatized polyacrylamide supports as well as to methods for capture of nucleic acids by oligonucleotides attached to polyacrylamide solid supports, either by direct capture or in sandwich hybridization formats.
    Type: Grant
    Filed: January 5, 1989
    Date of Patent: August 17, 1993
    Assignee: Siska Diagnostics, Inc.
    Inventors: Soumitra S. Ghosh, Eoin D. Fahy
  • Patent number: 5234913
    Abstract: Synergistic combinations of nucleoside derivatives, pharmaceutical formulations containing said combinations and use of the combinations in the treatment of retroviral infections are disclosed.
    Type: Grant
    Filed: March 5, 1992
    Date of Patent: August 10, 1993
    Assignee: Burroughs Wellcome Co.
    Inventors: Phillip A. Furman, Jr., George R. Painter, III
  • Patent number: 5232830
    Abstract: Novel methods and compositions for detecting a member of a ligand pair on solid supports having intrinsic fluorescence are disclosed. A target member of a ligand pair is contacted with a capture member of a ligand pair, wherein the capture member is immobilized on a solid support having intrinsic fluorescence, and the contacted pair is in association with a colorimetric reporter, then the solid support is irradiated the solid support, and the resultant fluorescence is determined. Preferably, methods include hybridization assays of nucleic acid sequences on such solid supports. The extent of detecting a member of a ligand pair, preferably a nucleic acid sequence, is determined using a method or technique described throughout this document as fluorescent quenching. Methods and compositions pertaining to solid supports having their intrinsic or natural fluorescence quenched or masked are also described herein. The present invention has utility in detection assays for a member of a ligand pair.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: August 3, 1993
    Assignee: MicroProbe Corporation
    Inventor: Jeffrey Van Ness
  • Patent number: 5233031
    Abstract: The present invention provides a series of cytotoxic phosphoramidate analogs of 5-fluoro-2'-deoxyuridine of the general formula (I): ##STR1## wherein R.sup.1 is H, F or (C.sub.1 -C.sub.4)alkyl; R.sup.2 is CH.sub.2 CH.sub.2 X wherein X is Cl, Br, I or p-toluenesulfonyl; R.sup.3 is (C.sub.1 -C.sub.4)alkyl or CH.sub.2 CH.sub.2 X wherein X is Cl, Br, I or p-toluenesulfonyl; or wherein R.sup.2 and R.sup.3, taken together with the N atom, can be a 5- or 6-membered heterocyclic ring which is aliphatic or aliphatic interrupted by a ring oxygen or a second ring nitrogen; R.sup.4 is H, one equivalent of a pharmaceutically-acceptable cation or (4,4,6-trimethyltetrahydro-1,3-oxazin-2-yl)ethyl, and the pharmaceutically-acceptable salts thereof.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: August 3, 1993
    Assignee: University of Rochester
    Inventors: Richard F. Borch, Kristin M. Fries
  • Patent number: 5233032
    Abstract: Polygalactomannans containing a hydroxybutyl ether substituent and a hydrophobic substituent can be used in the fracturing of subterranean formations.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: August 3, 1993
    Assignee: Stein, Hall & Co., Inc.
    Inventors: George M. Zody, Michael E. Morgan
  • Patent number: 5231174
    Abstract: The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'.beta.-D-nucleosides and their derivatives where the base moiety has .beta.-stereochemistry but is transposed from the normal 1'-position to the 2'-position and the carbohydrate moiety has the D-configuration at the 4'-position. These compounds are resistant towards hydrolytic cleavage of the glycosidic bond and are resistant to enzymatic deamination. They have potential in the treatment or prophylaxis of viral infections, particularly retroviral infections and especially AIDS.
    Type: Grant
    Filed: February 27, 1992
    Date of Patent: July 27, 1993
    Assignee: University of Iowa Research Foundation
    Inventor: Vasu Nair
  • Patent number: 5231177
    Abstract: Sodium N-acetylneuraminate trihydrate herein provided is represented by the following formula: ##STR1## The sodium N-acetylneuraminate trihydrate can be prepared, for instance, according to a method which comprises the steps of: dissolving sodium N-acetylneuraminate in water or in a mixture of water and an organic solvent; allowing the resulting solution to stand; precipitating and separating the resulting crystals of sodium N-acetylneuraminate.trihydrate; and then drying the separated crystals. The sodium N-acetylneuraminate trihydrate has very low hygroscopicity and hence can be handled without any difficulty in the form of powder.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: July 27, 1993
    Assignee: Mect Corporation
    Inventors: Kinichi Saito, Hideo Mizu, Naokazu Sugiyama, Shikoh Minagawa, Motoaki Goto, Kenji Abiko
  • Patent number: 5231086
    Abstract: This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
    Type: Grant
    Filed: January 14, 1992
    Date of Patent: July 27, 1993
    Assignee: Item Development Aktiebolag
    Inventor: Alf Sollevi
  • Patent number: 5231175
    Abstract: A process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a transition metal or lanthanide compound.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: July 27, 1993
    Assignee: American Cyanamid Company
    Inventors: Kenneth E. Green, David M. Blum, Michael P. Trova
  • Patent number: 5229505
    Abstract: The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially in the central nervous system as analgesics, anticonvulsants, antiepileptics, anxiolytics, antidepressants and neuroprotectors, and in the cardiovascular system as antiarrhythmics, antihypertensives and platelet aggregation inhibitors.
    Type: Grant
    Filed: February 7, 1992
    Date of Patent: July 20, 1993
    Assignee: LABORATOIRES UPSA
    Inventors: Nicole Bru-Magniez, Timur Gungor, Jean-Marie Teulon
  • Patent number: 5229415
    Abstract: Avermectin compounds are substituted at the 4", 4' or 13-postion hydroxy group with an alkylthioalkyl group and are optionally substituted at the other reactive positions of the avermectin molecule. The compounds are prepared by reacting protected avermectins, avermectin monosaccharides or avermectin aglycones with dialkylsulfoxides. The compounds are potent antiparasitic agents and compositions for such uses are also disclosed.
    Type: Grant
    Filed: March 24, 1992
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Bruce O. Linn, Helmut Mrozik
  • Patent number: 5229370
    Abstract: A complex of branched beta cyclodextrin and steroid is formed by mixing a steroid and a branched beta cyclodextrin together in water for a period of about 4 to 24 hours under ambient conditions. The solubility of the steroid is increased about 95 times by employing the complex.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: July 20, 1993
    Inventor: Robert N. Ammeraal
  • Patent number: 5229371
    Abstract: This invention relates to novel elsamicin A derivatives having an alkylidene group on the 3' and 4'-OH group or a tetrahydropyranyl group on the 4'-OH group, a process for producing said elsamicin A derivatives, antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: July 20, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Soichiro Toda, Haruhiro Yamashita, Takayuki Naito, Yuji Nishiyama