Patents Examined by Joseph M. Conrad
  • Patent number: 5653990
    Abstract: There is provided an ester compound represented by the formula I: ##STR1## wherein R.sub.1 is a methyl group or a hydrogen atom; R.sub.2 is a C.sub.1-6 haloalkyl group; and R.sub.3 is a pyrethroid acid residue, an agent for controlling noxious organisms containing the same as active ingredient and an intermediate for producing the same.
    Type: Grant
    Filed: June 21, 1995
    Date of Patent: August 5, 1997
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tomonori Iwasaki, Kazunori Tsushima, Takashi Furukawa, Takao Ishiwatari, Toru Tsuchiya, Mikako Nakamachi
  • Patent number: 5627211
    Abstract: Compounds of formula (I), and salts and prodrugs thereof wherein X, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7 and R.sup.8 are defined herein, are tachykinin receptor antagonists.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: May 6, 1997
    Assignee: Merck Sharp & Dohme Limited
    Inventor: Martin R. Teall
  • Patent number: 5618841
    Abstract: A composition for improving the anti-microbial activity of mammalian iodophor teat dips is disclosed, which includes an iodophor concentrate an organic acid buffer having an antimicrobial acid within the pKa range of from approximately 2.0 to 6.0, preferably within the pKa range of from approximately 3.0 to 5.0. Antimicrobial acids for use as the organic acid buffer include lactic acid, malic acid, mandelic acid, formic acid, glycolic acid, benzoic acid and combinations thereof.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: April 8, 1997
    Inventor: Robert Kross
  • Patent number: 5616786
    Abstract: A method of obtaining optically active anhydrous phenylalanine crystals from an aqueous solution containing optically active phenylalanine, which involves crystallizing and precipitating optically active phenylalanine from an optically active phenylalanine super-saturated solution at a temperature, T, wherein the super-saturated solution is required to have an osmotic pressure .pi. (mOsm/kg.H.sub.2 O) which is related to said temperature T in accordance with the following formula (I):.pi..gtoreq.10,500-450T+4.4T.sup.2 (I),wherein the method provides anhydrous crystals having excellent handleability.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: April 1, 1997
    Assignee: Ajinomoto Co., Inc.
    Inventors: Takeru Sato, Chiaki Sano
  • Patent number: 5605932
    Abstract: Compounds of Formula 1 bind opioid receptors: which binds to the opioid receptor: ##STR1##
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: February 25, 1997
    Assignee: Chiron Corporation
    Inventors: Simon Ng, Robert L. Warne, Ronald N. Zuckermann, Eric J. Martin, Reyna J. Simon
  • Patent number: 5602278
    Abstract: This invention relates to compounds which are N-oxides and derivatives of chlorambucil and which, under certain conditions, (1) are stable in hypoxic and oxic cells, (2) are toxic in cells having varying degrees of hypoxia, and (3) show little toxicity to oxic cells. These compounds have the general formula set out below and are used to treat tumorous cells: ##STR1## wherein R is an alkyl, aryl, or derivatives thereof, such as CH.sub.3 OCH.sub.2 CH.sub.2 --; CH.sub.3 CH.sub.2 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 OCH.sub.2 CH.sub.2 --; C.sub.6 H.sub.5 CH.sub.2 --; CH.sub.3 (CH.sub.2).sub.3 OCH.sub.2 CH.sub.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: February 11, 1997
    Inventor: Lynn Kirkpatrick
  • Patent number: 5583126
    Abstract: The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to prevent or reduce the consequent progressive necrosis of tissue associated with such ischemia. This effect is achieved by administering DHEA or DHEA derivatives to a patient as soon as possible after the injury. The present invention is further directed to methods for preventing or reducing bacterial translocation or adult respiratory distress syndrome in a patient. Similarly, bacterial translocation and adult respiratory distress syndrome are prevented or reduced by administering DHEA or DHEA derivatives to a patient. Suitable derivatives of DHEA include, among others, 16.alpha.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: December 10, 1996
    Assignee: University of Utah Research Foundation
    Inventors: Raymond A. Daynes, Barbara A. Araneo
  • Patent number: 5580542
    Abstract: Disclosed is an acetyltransferase activity measuring agent which contains an arylamine derivative. As the arylamine derivative, sodium p-aminohippurate can be used preferably. Use of the acetyltransferase activity measuring agent of this invention permits a simple and safe diagnosis of the progress of the pathema of nephritis, which is accompanied by a mesangial proliferative lesion, or renal insufficiency. Furthermore, the scattering of measured values is small, thereby assuring an accurate diagnosis.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 3, 1996
    Assignee: Kureha Kagaku Kogyo K.K.
    Inventors: Chikau Onodera, Hiromi Yoshihara, Mikiro Yanaka
  • Patent number: 5543563
    Abstract: Alkyl derivatives of trazodone endowed with pharmacological activity, pharmaceutical compositions containing them, process for preparing them and intermediate compounds useful in their preparation.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: August 6, 1996
    Assignee: Istituto Ricerca Francesco Angelini S.p.A.
    Inventor: Leandro Baiocchi
  • Patent number: 5543426
    Abstract: 3,7-disubstituted indole derivatives of formula I ##STR1## wherein R.sub.1, R.sub.2, n, X, Y and Z are as defined in the description, are useful for the treatment of psychiatric disorders.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: August 6, 1996
    Assignee: Sandoz Ltd.
    Inventors: Arnold K. Dixon, Rudolf K. A. Giger
  • Patent number: 5536868
    Abstract: Compounds of Formula 1 bind to the opioid receptors: ##STR1## wherein R.sub.1 is a group of the formula ##STR2## where W is --(CH.sub.2).sub.a -- (where a is 0, 1, or 2), --O--, --NH--, --S--, --SO--, or --SO.sub.2 --, and Ar is phenyl, phenyl-alkyl, phenyl substituted with 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups, and n is 0, 1, 2, 3, or 4;R.sub.2 and R.sub.3 are each independently H, lower alkyl, or ##STR3## where X is H, OH, lower alkyl, or lower alkoxy, and p is 0, 1, 2, or 3; R.sub.4 is ##STR4## where m is 0, 1, 2, or 3, and R is 1-3 halo, nitro, lower alkyl, hydroxy, amino, alkylamino, dialkylamino, and/or hydroxy-lower alkyl groups;R.sub.5 is cycloalkyl, bicycloalkyl, or tricycloalkyl; andR.sub.6, R.sub.7, R.sub.8, and R.sub.9 are each independently H or lower alkyl.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: July 16, 1996
    Assignee: Chiron Corporation
    Inventors: Simon Ng, Robert L. Warne, Ronald N. Zuckermann, Eric J. Martin, Reyna J. Simon
  • Patent number: 5536869
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof which comprises treating (trimethylsilyl)acetylene sequentially with n-butyllithium and 4-formylmorpholine followed by acid hydrolysis to give 3-(trimethylsilyl)-2-propynal; treating 3-(trimethylsilyl)-2-propynal with lithium bis(trimethylsilyl)amide to give in situ N,3-bis(trimethylsilyl)-2-propyn-1-imine; condensation of N,3-bis(trimethylsilyl)-2-propyn-1-imine with lithium t-butyl acetate to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate; treating (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate- with p-toluenesulfonic acid to give (.+-.)1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate, mono p-toluenesulfonic acid salt, treatment of resulting salt with ethanol in the presence of p-toluenesulfonic acid to give (.+-.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: July 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. McLaughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • Patent number: 5536864
    Abstract: The reaction between methanol, carbon monoxide and oxygen for preparing dimethyl carbonate, in the presence of cuprous chloride as the catalyst, is carried out in a special reactor constituted by two parallel, vertical tubes, at the base of one of which the fresh gas and the recycle gas are fed; the reaction products are separated by partially condensing the recirculate vapors.
    Type: Grant
    Filed: December 27, 1994
    Date of Patent: July 16, 1996
    Assignee: Enichem Synthesis S.p.A.
    Inventors: Giancarlo Paret, Gianni Donati, Maurizio Ghirardini
  • Patent number: 5532015
    Abstract: A process for quickly and reproducibly obtaining .alpha.-L-aspartyl-L-phenylalanine methyl ester with controlled water content is disclosed. Wet crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester obtained by crystallization are subjected to a drying step to adjust the water content to not more than 5 wt %, and subsequently a gas adjusted to a temperature of C. and relative humidity of 20-90 RH % is contacted with the dried crystals to control water content.
    Type: Grant
    Filed: November 21, 1994
    Date of Patent: July 2, 1996
    Assignee: Ajinomoto Co., Inc.
    Inventors: Atsuhiko Hirano, Satoshi Yamahara, Takehiko Kataoka, Shinichi Kishimoto
  • Patent number: 5532360
    Abstract: A method for handling and stabilizing a (2-alkyl)-acryloyl isocyanate represented by the formula (1) ##STR1## is disclosed, which comprises the steps of: reacting an azomethine compound represented by formula (2) ##STR2## with the (2-alkyl)-acryloyl isocyanate of formula (1) to obtain the reaction product of formula (3) ##STR3## and dissolving said reaction product into a solvent to regenerate the (2-alkyl)-acryloyl isocyanate of formula (1); the identity of said solvent and R-groups being defined herein.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: July 2, 1996
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Noriyuki Tsuboniwa, Satoshi Urano, Otohiko Tsuge, Taizo Hatta
  • Patent number: 5530155
    Abstract: Addition of a reaction mixture obtained by the mineral acid hydrolysis of at least one side flow generated from the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester to a crystallization slurry containing L-phenylalanine while maintaining the pH of the slurry at 3-8 by adding aqueous alkali affords crystallized L-phenylalanine having a low water content in a high yield.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: June 25, 1996
    Assignee: Ajinomoto Co., Inc.
    Inventors: Toyoto Hijiya, Chiaki Mochizuki, Tadashi Takemoto, Kazutaka Nagashima
  • Patent number: 5530014
    Abstract: The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are suitable as active compounds in medicaments on account of their property of being selective modulators of calcium channel-dependent potassium channels.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: June 25, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor De Vry
  • Patent number: 5523457
    Abstract: This invention relates to a retinoid mpound of formula I ##STR1## in which Y is --CO--NH--, --CR.sup.2 .dbd.CR.sup.3 --, --CO--O--, --O--CO--, --C(.dbd.S)--NH--, --C.tbd.C--, --O--CH.sub.2 --, --CH.sub.2 --O--, or --CH.sub.2 --CH.sub.2 --;A is --(CH.sub.2).sub.t -- or a bond;Q is phenyl optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, or --CO.sub.2 R.sup.4 ;R.sup.1 is --CO.sub.2 Z, --CONHR.sup.5, C.sub.1-6 alkyl, --CH.sub.2 OH, or --CHO;R.sup.2, R.sup.3, R.sup.4, R.sup.5, and Z are independently hydrogen or C.sub.1-6 alkyl;t is one to six.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 4, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Starrett, Jr., Muzammil M. Mansuri, David R. Tortolani
  • Patent number: 5523458
    Abstract: Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: June 4, 1996
    Assignee: Takasago International Corporation
    Inventors: Tetsuro Yamasaki, Hidenori Kumobayashi, Noboru Sayo, Toshiyuki Murayama, Noboru Sano, Takero Ishizaki
  • Patent number: 5523471
    Abstract: The present invention relates to a process for the preparation of ether-sulphonates of high purity, substantially free from extraneous salts, of the general formula IR.sup.1 --[O--(CR.sup.2 R.sup.2 R.sup.2' --CR.sup.5 R.sup.5' SO.sub.3 MIin whichR.sup.2 to R.sup.5, R.sup.2+ to R.sup.5', M, x and y are defined as given in claim 1 by reacting a compound of the general formula IIR.sup.1 --[O--(CR.sup.2 R.sup.2+ --CR.sup.3 R.sup.3').sub.x ].sub.y --OHIIwith a compound of the general formula IIIHO--CR.sup.4 R.sup.4' CR.sup.5 R.sup.5' --SO.sub.3 M IIIin the presence of a compound of the general formula IVMOH IVfollowed by neutralization of the compound of the general formula IV with an acid, characterized in that the acid employed is a compound of the general formula VR.sup.1 --[O--(CR.sup.2 R.sup.2' --CR.sup.3 R.sup.3').sub.x ].sub.y --OCR.sup.4 R.sup.4' CR.sup.5 R.sup.5' SO.sub.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: June 4, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Delpy, Fritz Engelhardt, Ralf Zerrer, Dirk Buhring