Patents Examined by Jyoti Nagpaul
  • Patent number: 11366125
    Abstract: Examples described herein also provide a substrate conveyance system. The substrate conveyance system may include a conveyor surface to convey a number of substrates, and a number of apertures defined in the conveyor surface between the substrates as positioned on the conveyor surface. The location of the apertures is based on a location at which at least one reagent module dispenses a reagent.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: June 21, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Jeffrey A. Nielsen, Christie Dudenhoefer
  • Patent number: 11365213
    Abstract: Disclosed are a composition for clearing spheroids, a method for clearing spheroids using same, and a kit comprising same. The composition for clearing spheroids can clear the spheroids in a convenient and rapid manner and thus may be usefully used for imaging of spheroids and in identifying the causes of various diseases, treating the diseases, and predicting the therapeutic effects and toxicity of drugs. In addition, the composition may be used in combination with various medical devices, and in particular, can be prepared as a kit and usefully used as an in vitro medical diagnostic device.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: June 21, 2022
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Ki-Suk Kim, Sun Hyun Park
  • Patent number: 11366127
    Abstract: A testing system according to one or more embodiments may include: a smear preparing apparatus that prepares a smear slide by smearing a sample on a glass slide; a smear transporting apparatus that transports the smear slide; a controller; and a display part. The controller may cause the display part to display a selection screen on which one or more of the smear preparing apparatus and the smear transporting apparatus can be selected. Based on a selection on the selection screen, the one or more of the smear preparing apparatus and the smear transporting apparatus selected on the selection screen may run respective start operations.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: June 21, 2022
    Inventors: Ken Nishikawa, Tetsuya Oda, Hidetaka Hayama
  • Patent number: 11360007
    Abstract: The present invention addresses an object to provide an embedding apparatus capable of removing an embedding material such as paraffin and solids such as debris of a tissue fragment adhered to a tweezers holder hole easily.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: June 14, 2022
    Inventors: Masahisa Mimura, Yoshiaki Nakazawa, Mitsuaki Narita
  • Patent number: 11346782
    Abstract: A tomographic imaging method which includes the steps of activating fluorescence in a surface layer of a protein-marked or fluorescent dye-marked biological tissue sample not emitting fluorescence or only emitting specific fluorescence to acquire an activated surface of biological tissue sample; performing fluorescence excitation on the acquired surface biological tissue sample, and imaging the fluorescence to acquire a fluorescence image of the surface layer; cutting off the surface layer; exposing an inactivated new surface layer after cutting the surface layer; repeatedly performing activating, imaging and cutting off steps for the new surface layer to repeat tomographic imaging in such a manner till acquiring a two-dimensional image of each layer of the biological tissue sample; and overlapping the two-dimensional images to acquire a complete three-dimensional image of the biological tissue sample, thus acquiring three-dimensional structure information of the entire sample.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 31, 2022
    Assignee: Huazhong University of Science and Technology
    Inventors: Shaoqun Zeng, Qingming Luo, Hanqing Xiong, Wenyan Guo, Xiaohua Lv
  • Patent number: 11344164
    Abstract: An analytical toilet is disclosed. The toilet includes a bowl for receiving excreta, a mechanism that uses a consumable for analyzing a sample of excreta, a storage structure for storing the consumable, a sensor that detects at least one property of the consumable, and a processor that generates an alert when the property is outside a predetermined parameter. The property the sensor detects can be used to determine at least one of the identity of the consumable, the quantity or supply of the consumable, or a property related to the suitability of the consumable.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: May 31, 2022
    Assignee: Medic, Inc.
    Inventors: David R. Hall, Scott Skousen, Scott R. Cleere
  • Patent number: 11338286
    Abstract: A substrate for use in manufacture of a production master plate for production of a detection disc for carrying samples in an apparatus for detection of microscopic objects in a fluid, the substrate having a channel and separate focus structure, wherein the focus structure is a groove.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: May 24, 2022
    Assignee: Q-LINEA AB
    Inventors: Jonas Sven Peter Jarvius, Jan Grawe
  • Patent number: 11340147
    Abstract: Disclosed herein are a sonic homogenizing module (100, 200, 300) and a biological sample preparation system (500) containing the same. The sonic homogenizing module (100, 200, 300) comprises a rod made of a magnetic material (120, 220, 320); a piezoelectric conductor (130, 230,330); a driver (140, 340); and a sleeve-coupling member (110, 210, 310) having a first portion defining a space (112, 212, 312) for coupling with a gripper module of a biological sample preparation system, and for accommodating the piezoelectric conductor and the driver therein; and a second portion having a conduit (114, 214, 314) for receiving the rod therethrough; wherein the driver (140, 340) is electrically coupled with the piezoelectric conductor (130, 230,330) and is configured to drive the piezoelectric conductor (130, 230, 330) to generate a sonic vibration at a frequency of 100 KHz-1 MHz.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 24, 2022
    Inventor: Chun-Chao Wang
  • Patent number: 11333586
    Abstract: A smear staining machine and a smearing control method and device thereof. The viscosity of the test sample is used for guiding the configuration of at least on smearing parameter. Since the viscosity of the test sample presents multiple influences of many effecting parameters, it is more suitable for presenting the characteristics of the test sample. Therefore, better smearing effect could be acquired by referring the viscosity of the test sample to get the smearing parameter.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: May 17, 2022
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Bin Jiang, Tao Shen, Shubin Xue
  • Patent number: 11300581
    Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: April 12, 2022
    Inventors: Christopher Procyshyn, Marcin Cichy
  • Patent number: 11293844
    Abstract: A tissue processing apparatus for processing biological tissue. The tissue processing apparatus includes: an extraction device configured to, when connected to a reagent receptacle, take reagent out from the reagent receptacle for use by the tissue processing apparatus; a tag reader configured to read information from a machine-readable tag.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: April 5, 2022
    Inventors: Daniel Peter Robinson, Michael James Forshaw, David John Chan, Mark Baker, David McNulty, Marc Neill Murphy
  • Patent number: 11287355
    Abstract: A smear preparing apparatus may include: a staining unit including staining tanks that are configured to receive glass slides smeared with samples and to accommodate a staining solution used to stain the samples smeared on the glass slides; a transfer unit that holds the glass slides and transfers the glass slides to the staining unit; a fluid circuit that supplies the staining solution to each of the staining tanks in the staining unit; and a controller that determines a staining tank used for staining processing among the staining tanks in response to a manipulation by a user.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: March 29, 2022
    Inventors: Junya Ikuta, Masaharu Shibata, Noriyuki Nakanishi, Mitsuo Yamasaki, Yuji Takano, Ken Nishikawa
  • Patent number: 11286447
    Abstract: Devices and methods for the efficient disaggregation of tissue samples, separating the tissue into individual intact cells or small aggregates of cells for analysis. A device may include a chamber to receive fluid and a tissue specimen containing more than one cell to be disaggregated. The chamber may include an opening and an agitator in fluid contact with the fluid and the tissue specimen. The agitator may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The device may include an electrical energy source electrically coupled to the micromotor to rotate the impeller sufficient to disaggregate the one or more individual cells from the tissue specimen and in a manner which does not lyse the one or more individual cells.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: March 29, 2022
    Inventors: Mark Brown, Robert Doebler, Gary Fife Blackburn
  • Patent number: 11280708
    Abstract: Provided herein are systems, devices, and methods for improved treatment of tissue, such as brain tissue. The improved treatment described herein can result in improved tissue penetration of various compounds and chemicals, such as stains and immunohistochemistry reagents. For example, provided herein is a pressurizing device that may include a chamber body having an opening in one of a top and a sidewall of the body, and may also include a chamber lid covering the opening and releasably coupled to the chamber body proximate the opening. The chamber lid and chamber body form an air-tight cavity. The pressurizing device may also have an inlet passing through one of the chamber body and the chamber lid and into the air-tight cavity. The device may also include a retainer coupled inside the air-tight cavity and configured to releasably couple to at least one tissue sample receptacles.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: March 22, 2022
    Assignee: Dignity Health
    Inventors: Roberto Fiorelli, Gurpaul Singh Sidhu
  • Patent number: 11278883
    Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 22, 2022
    Assignees: Roche Diagnostics Hematology, Inc., Roche Diagnostics Operations, Inc.
    Inventors: Ertan Ergezen, Stephen Conroy, Rijk Edwin Oosterbroek, Claudio Cherubini
  • Patent number: 11280709
    Abstract: A coverslipping machine (1) is embodied to be connected to an electrical power grid in order to be supplied with electrical energy as an electrical load; and removes specimen slides (4), having samples present thereon, from a specimen slide magazine (5) and respectively carries out a coverslipping process in which a mounting medium (7) and then a coverslip (8) are applied onto each specimen slide (4); and deposits the coverslipped specimen slides (4) in the specimen slide magazine (5) or in a further specimen slide magazine (55). The coverslipping machine (1) has an electrical energy reservoir (12) and an electronic control apparatus (13).
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 22, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Benjamin Siehl, Markus Sharpe, Markus Wittmann
  • Patent number: 11280710
    Abstract: A tape for collecting tissue samples in a manner compatible with imaging in a transmission electron microscopy (TEM) system, includes a tape substrate having two side walls forming a trough. The trough is defined by a bottom surface of the tape substrate and internal surfaces of the side walls, with an open side therebetween. A support film is attached to a top surface of the tape substrate, and a plurality of apertures is spaced at predetermined locations along the length of the tape substrate, each aperture being covered by the support film. The tape includes a stacked configuration in which the tape substrate is wound in layers, the bottom surfaces of the side walls in one layer being in contact with the support film in an immediately adjacent layer. The apertures in the second layer are aligned within the trough of the first layer, between the side walls.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: March 22, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: David Grant Colburn Hildebrand, Brett Jesse Graham, Wei-Chung Allen Lee
  • Patent number: 11274352
    Abstract: A disease screening device (100) comprising a substrate (101) and a sonication chamber (102) formed on the substrate (101). The sonication chamber (102) is provided with an ultrasonic transducer (105) which generates ultrasonic waves to lyse cells in a sample fluid within the sonication chamber (102). The device (100) comprises a reagent chamber (111) formed on the substrate (101) for receiving a liquid PCR reagent. The device (100) comprises a controller (23) which controls the ultrasonic transducer (105) and a heating arrangement (128) which is provided on the substrate (101). The device (100) further comprises a detection apparatus which detects the presence of an infectious disease, such as COVID-19 disease.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: March 15, 2022
    Assignee: Shaheen Innovations Holding Limited
    Inventors: Imad Lahoud, Mohammed Alshaiba Saleh Ghannam Almazrouei, Sajid Bhatti, Jeff Machovec, Clement Lamoureux
  • Patent number: 11266382
    Abstract: A flag, or marker for identifying the locations of a plurality of tissue cassettes containing mounted Formalin Fixed Paraffin Embedded (FFPE) tissue specimens once removed from a tissue cassette/block storage system. The invention comprises a rectangular cuboid body member having front, rear, left, right, top, and bottom surfaces which substantially approximates the shape of a predefined number of tissue cassette/blocks, with a recessed area with grooves to accept one tissue index marker card for recording the patient's case information, or other relevant information. When multiples of the present invention are used within a tissue cassette/block storage system, they point to locations where pluralities of tissue cassette/blocks should be returned, and provides a support structure for neighboring tissue cassette/blocks within the storage location from becoming askew or damaged within the tissue cassette/block storage system.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 8, 2022
    Inventor: Brian L. Branton
  • Patent number: 11262279
    Abstract: A specimen for analyzing the shape of an antistatic antifouling layer and a method for preparing the same are provided. The specimen includes Pt coated on an antistatic antifouling layer comprising a conductive polymer formed on a polymer substrate, so that a contrast difference between the polymer substrate layer and the antistatic antifouling layer is caused by the diffusion of Pt by means of the conductive polymer and the dyeing effect of the antifouling layer. Accordingly, it is possible to clearly distinguish the shape of the antistatic antifouling layer formed on the polymer substrate by using TEM.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 1, 2022
    Inventors: Bo Ri Lee, Byung Su Park