Patents Examined by Jyoti Nagpaul
  • Patent number: 11686740
    Abstract: The present disclosure is directed to opposables including a body having a plurality of cavities disposed therein. Each cavity can be designed to contain one or more reagents, liquids, or fluids which may be applied to a specimen-bearing surface. In some embodiments, the cavities include one or more reagent chambers, the reagent chambers can have one or more seals such that the reagents, liquids, or fluids contained therein may be stored and released to the specimen-bearing surface.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: June 27, 2023
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Christopher Lawrence Donat, Timothy James Keller
  • Patent number: 11686738
    Abstract: Methods, systems, and compositions featuring a solid, dissolvable reagent composition for delivering the reagent, such as an antibody, probe, chromogen, etc., to a sample. The present invention also features methods of producing said compositions, and automated systems featuring the use of the solid, dissolvable reagent compositions. The solid, dissolvable reagent composition may comprise a water-soluble polymer film, such as a polyvinyl alcohol film, infused with the reagent, wherein when applied to the sample, the water-soluble polymer film with reagent contacts the sample (e.g., tissue) and dissolves.
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: June 27, 2023
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Anisha Anand, Crystal L. Stephens, Natcha Suriyavirun
  • Patent number: 11680943
    Abstract: An electric field stirring apparatus, in which a droplet as a liquid disposed between a first electrode and a second electrode disposed to face each other is vibrated and stirred by an electric field generated between the first electrode and the second electrode, the second electrode having a groove formed along a first direction on an electrode surface facing the first electrode, includes a movement mechanism that reciprocally moves the first electrode relative to the second electrode in a second direction intersecting the first direction in a state in which the first electrode and the second electrode face each other during a period in which the electric field is generated.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: June 20, 2023
    Inventors: Taro Aoki, Tadashi Sato, Yoichi Suzuki, Junya Enomoto
  • Patent number: 11679386
    Abstract: An analytical toilet comprising: a bowl for collecting feces from a user; a comminutor that comminutes at least a portion of the feces; a processing fluid driver that causes a processing fluid to mix with and transport at least a portion of the comminuted feces to an analytical station in the toilet; a separator that separates a sample of the at least a portion of the comminuted feces to be analyzed; and a wash fluid driver that causes a wash fluid to wash the feces out of the bowl.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: June 20, 2023
    Assignee: Medic, Inc.
    Inventors: David R. Hall, David Crismon, K. Jeffrey Campbell, Joshua Larsen, Anthony E. Pullen
  • Patent number: 11674970
    Abstract: An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: June 13, 2023
    Inventors: Yuto Kazama, Masahiko Iijima, Sakuichiro Adachi
  • Patent number: 11667979
    Abstract: A disease screening device (100) comprising a substrate (101) and a sonication chamber (102) formed on the substrate (101). The sonication chamber (102) is provided with an ultrasonic transducer (105) which generates ultrasonic waves to lyse cells in a sample fluid within the sonication chamber (102). The device (100) comprises a reagent chamber (111) formed on the substrate (101) for receiving a liquid PCR reagent. The device (100) comprises a controller (23) which controls the ultrasonic transducer (105) and a heating arrangement (128) which is provided on the substrate (101). The device (100) further comprises a detection apparatus which detects the presence of an infectious disease, such as COVID-19 disease.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: June 6, 2023
    Assignee: Shaheen Innovations Holding Limited
    Inventors: Imad Lahoud, Mohammed Alshaiba Saleh Ghannam Almazrouei, Sajid Bhatti, Jeff Machovec, Clement Lamoureux
  • Patent number: 11667884
    Abstract: The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The present disclosure further provides methods of using the bead beating system to extract nucleic acids from cells containing the nucleic acids.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 6, 2023
    Assignee: Safeguard Biosystems Holdings Ltd.
    Inventors: Holger Klapproth, Nicolaas Smit
  • Patent number: 11668725
    Abstract: A digital slide scanning apparatus slide rack carousel allows continuous loading and unloading of slide racks into the carousel while the digital slide scanning apparatus is simultaneously digitizing glass slides. The slide rack carousel includes a base having an interior portion of its upper surface at an angle. The slide rack carousel also includes plural rack spacers extending upward from the base and adjacent rack spacers define a rack slot. Each rack spacer also includes a rack stopper on each side such that adjacent rack spacers have rack stoppers facing each other. The rack stoppers prevent a slide rack from moving further toward the center of the carousel than desired.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: June 6, 2023
    Assignee: Leica Biosystems Imaging, Inc.
    Inventors: Nicholas Newberg, Prentash Djelosevic
  • Patent number: 11649427
    Abstract: A portable apparatus useful for collection and processing of human biological material, such as adipose or cancellous bone material, to prepare a concentrated product (e.g., stromal vascular fraction). The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a pellet well for collecting concentrate product in the form of a pellet phase from centrifuge processing. The pellet well is accessible only from above when the apparatus is in an access orientation. Collected pellet phase material may be removed from the pellet well by direct aspiration, without suspending the material in a suspension liquid within the container. Access ports may be configured for access only from above the container. The apparatus may include a tissue collector disposed in the disuse retention volume to engage and collect collagen or other stringy tissue.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 16, 2023
    Assignee: GID Bio, Inc.
    Inventors: William W. Cimino, Ramon Llull, Adam J. Katz
  • Patent number: 11639886
    Abstract: The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: May 2, 2023
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Daniel Bauer, David Chafin, Michael Otter
  • Patent number: 11635356
    Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: April 25, 2023
    Inventors: Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
  • Patent number: 11619569
    Abstract: In one embodiment, a tissue planing assembly includes a base frame, a plurality of disassemblable components assembled to the base frame and having a ready configuration, a sample conveyor, a blade assembly configured to be coupled to the base frame, a control unit communicatively coupled to the sample conveyor, and one or more component sensors communicatively coupled to the control unit. The plurality of disassemblable components is configured to support a tissue sample. The sample conveyor is configured to convey the tissue sample through the blade assembly. The one or more components sensors are configured to output a signal indicative of at least one of the plurality of disassemblable components missing from the ready configuration, wherein the control unit prohibits operation of the sample conveyor when at least one of the plurality of disassemblable components is missing from the ready configuration.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: April 4, 2023
    Assignee: Community Blood Center
    Inventors: Shawn Aaron Hunter, Robert Hoskins, Gregory S. Lucous
  • Patent number: 11614387
    Abstract: Automated system configured to perform and methods for performing one or more slide processing operations on slides bearing biological samples. The system and methods enable high sample throughput while also minimizing or limiting the potential for cross-contamination of slides. The automated systems can include features that facilitate consistency, controllability of processing time, and/or processing temperature.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: March 28, 2023
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Kayla Capps, Henning Groll, Brian Howard Kram, Matthew Mette, Ali Mousavi, Christine Tse, Glen Ward, Daniel O'Connor, Troy Paluszcyk, Benjamin David Randall, Ken Stumpe
  • Patent number: 11592365
    Abstract: A smear preparing apparatus that operates under selectable operation modes, may include: a smearing unit that prepares smeared slides by smearing samples onto slides; a staining unit that is capable of housing the smeared slides and that performs staining processing by accommodating a staining solution used to stain the samples on the housed smeared slides; a fluid circuit that supplies the staining solution to the staining unit; and a controller that controls the supplying of the staining solution to the staining unit depending on a selected one of the operation modes.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: February 28, 2023
    Inventors: Junya Ikuta, Masaharu Shibata, Noriyuki Nakanishi, Mitsuo Yamasaki, Yuji Takano, Ken Nishikawa
  • Patent number: 11592369
    Abstract: A tissue processing station includes a housing and a first heated plate that is either disposed on or forms a first horizontally oriented surface of the housing. The first heated plate is configured to either (i) contain water, or (ii) receive a dish containing water. The tissue processing station may also include a vertically-oriented heated well for heating slides. A second heated plate is either disposed on or forms an angled surface of the housing for supporting one or more laboratory slides. The angled surface is angled relative to the first horizontally oriented surface. A third heated plate is either disposed on or forms a second horizontally oriented surface of the housing for supporting one or more laboratory slides. The first and second horizontally oriented surfaces are defined at different elevations on the housing. The angled surface extends between the two horizontally oriented surfaces.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: February 28, 2023
    Assignee: Rushabh Instruments, LLC
    Inventors: Preyas Shah, Sahil Shah, Joseph Lessard, Alyicia Marie Rios, Joshua T. Greenlee, Olivia Grabowski
  • Patent number: 11573242
    Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: February 7, 2023
    Assignees: NanoCytomics, LLC, Northwestern University
    Inventors: Jarema Czarnecki, Justin Derbas, Sergey Rozhok, Hariharan Subramanian, Parvathi Viswanathan
  • Patent number: 11570983
    Abstract: According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm×30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane includi
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: February 7, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Kuniyuki Kaminaga, Ryuta Takegami, Kazuhiro Hasegawa, Yusuke Mochizuki
  • Patent number: 11566212
    Abstract: The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: January 31, 2023
    Inventors: Paul Bigliardi, Zhiping Wang, Ruige Wu, Massimo Alberti, Bo Wu, Mei Bigliardi-Qi, Sriram Gopu, Srinivas Ramasamy, Yuri Hebert Dancik
  • Patent number: 11555765
    Abstract: The present invention relates to systems and methods for tissue processing and analysis. Tissue chambers are configured to allow single-container chemical processing, imaging, and wax embedding of tissue samples in a single container without manipulation between steps. Tissue chambers with features to support the tissue sample and allow fluid flow between the tissue sample and the tissue chamber surface are disclosed. The features may be index matched to sample structures of interest or dissolvable in clearing solution to allow for in-chamber imaging with minimal distortion. Specialized tissue processing and wax removal apparatuses are also disclosed including for use with tissue chambers having frangible portions to permit ease of wax removal.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: January 17, 2023
    Inventors: Michael Levene, Richard Torres
  • Patent number: 11555819
    Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: January 17, 2023
    Assignee: MIE UNIVERSITY
    Inventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura