Patents Examined by Jyoti Nagpaul
  • Patent number: 10551395
    Abstract: Processing specimens in an automated histological staining system comprising robotically moving a slide carrier into a stainer of the system, the slide carrier carrying slides which respectively carry the specimens, and the specimens being at least partially embedded in paraffin. Liquids are automatically dispensed onto the slides according to a predetermined recipe for at least deparaffinizing, staining, and counterstaining the specimens. The slide carrier can be robotically moved out of the stainer after automatically dispensing the liquids. In some embodiments, a total of all liquid dispensed onto the slides after moving the slide carrier into the stainer and before moving the slide carrier out of the stainer has a greater volumetric concentration of polyol than of monohydric alcohol.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: February 4, 2020
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Heidi Barnett, Daniel Champion, Edward Durrant, Casey Kernag, Brian Howard Kram, Kristina Orosz, Melinda Polaske, Charles Weidner, Chad Wilkinson, Zofia Wosinska
  • Patent number: 10550368
    Abstract: Tissue processing devices are provided. The tissue processing devices can be used to process and transport tissue in a closed and continuous environment. The devices can be used for adipose tissue transfer, including autologous fat grafting.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 4, 2020
    Inventors: Kai-Roy Wang, Aaron Barere, Evan J. Friedman, Sangwook Park
  • Patent number: 10546482
    Abstract: A method for using a meter and a meter (10) adapted to determine an analyte concentration reading, the meter comprising a display (12) adapted to display information to a user of the meter, the display including information directed to a post-meal test-time alarm (22?) that is adapted to remind the user to obtain a post-meal analyte concentration reading, and at least one user input mechanism (15) adapted to allow the user to activate the post-meal test-time alarm.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 28, 2020
    Inventors: Barry D. Power, Jeffrey A. Culver
  • Patent number: 10542891
    Abstract: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: January 28, 2020
    Assignee: Cellview Imaging Inc.
    Inventor: Ralph Zuckerman
  • Patent number: 10537888
    Abstract: A centrifuge tube assembly includes an elongate tubular receptacle having upper and lower ends and a side wall that extends between the ends. A cap attached to the receptacle carries a common inlet/outlet port formed therethrough for communication with an interior chamber of the tubular receptacle. A liquid impermeable piston is longitudinally movable through the receptacle chamber and sealably interengages an interior wall of the receptacle. The piston separates upper and lower regions of the chamber, which respectively communicate with the inlet/outlet port and a pressure neutralizing vent. Biological products are introduced into and aspirated from the receptacle through the inlet/outlet port.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: January 21, 2020
    Inventor: Patrick Pennie
  • Patent number: 10539485
    Abstract: Devices and methods for yielding lymph nodes from fatty tissue, the device including a fenestrated sample chamber configured to receive a sample of fatty tissue having lymph nodes; a lockable gate switchable between a closed position that is locked and an open position; a pusher configured to push the sample against the gate when locked in the closed position to compress the tissue, and configured to push the compressed tissue out of the sample chamber when the gate is subsequently opened; and a cutting chamber aligned distal to the sample chamber for receiving compressed tissue from the sample chamber, the cutting chamber comprising sets of opposing through slots aligned to permit slicing of the compressed tissue into sections, thereby yielding lymph nodes from the fatty tissue.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: January 21, 2020
    Inventor: Oleg Ratner
  • Patent number: 10539560
    Abstract: A substrate for sample analysis is a substrate for sample analysis used for causing a binding reaction between an analyte and a ligand in a liquid sample, the substrate for sample analysis including: a base substrate having a rotation axis and a predetermined thickness; a chamber located in the base substrate for holding a liquid sample containing an analyte and a ligand immobilized on a surface of magnetic particles; and at least one magnet arranged at a position such that the magnetic particles are captured in the chamber by the magnet.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: January 21, 2020
    Inventors: Masayuki Saiki, Masahiro Johno, Fusatoshi Okamoto, Kazuya Kondoh
  • Patent number: 10527528
    Abstract: The present invention relates to systems and methods for tissue processing and analysis. Tissue chambers are configured to allow single-container chemical processing, imaging, and wax embedding of tissue samples in a single container without manipulation between steps. Tissue chambers with features to support the tissue sample and allow fluid flow between the tissue sample and the tissue chamber surface are disclosed. The features may be index matched to sample structures of interest or dissolvable in clearing solution to allow for in-chamber imaging with minimal distortion. Specialized tissue processing and wax removal apparatuses are also disclosed including for use with tissue chambers having frangible portions to permit ease of wax removal.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: January 7, 2020
    Inventors: Michael Levene, Richard Torres
  • Patent number: 10525468
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: January 7, 2020
    Assignee: Cepheid
    Inventors: Douglas B. Dority, Ronald Chang
  • Patent number: 10527192
    Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 7, 2020
    Assignee: Talis Biomedical Corporation
    Inventors: Thomas H. Cauley, III, John Dixon
  • Patent number: 10519410
    Abstract: A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 31, 2019
    Assignee: Emulate, Inc
    Inventors: Christopher David Hinojosa, Guy Robert Thompson, II, Joshua Gomes, Jacob Freake, Doug Sabin
  • Patent number: 10507077
    Abstract: A tissue marking system for marking a tissue sample includes at least one container and at least one ink stored in the container. The at least one ink may include a plurality of inks each of a different colored and may be sterile or non-sterile. The ink has a viscosity of from 85 ku to 115 ku such that when applied to a tissue surface having adjacent tissue margins, the ink does not migrate onto an adjacent tissue surface.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: December 17, 2019
    Inventors: Michael J. Phillips, Janet L. F. Phillips
  • Patent number: 10494627
    Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: December 3, 2019
    Assignee: General Electric Company
    Inventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
  • Patent number: 10495654
    Abstract: Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 3, 2019
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Tim Keller, Matthew Mette, Christine Tse, Glen Ward, Chad Wilkinson
  • Patent number: 10488307
    Abstract: Provided herein are systems, devices, and methods for improved treatment of tissue, such as brain tissue. The improved treatment described herein can result in improved tissue penetration of various compounds and chemicals, such as stains and immunohistochemistry reagents. For example, provided herein is a pressurizing device that may include a chamber body having an opening in one of a top and a sidewall of the body, and may also include a chamber lid covering the opening and releasably coupled to the chamber body proximate the opening. The chamber lid and chamber body form an air-tight cavity. The pressurizing device may also have an inlet passing through one of the chamber body and the chamber lid and into the air-tight cavity. The device may also include a retainer coupled inside the air-tight cavity and configured to releasably couple to at least one tissue sample receptacles.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: November 26, 2019
    Assignee: Dignity Health
    Inventors: Roberto Fiorelli, Gurpaul Singh Sidhu
  • Patent number: 10481150
    Abstract: A microfluidic device, method and kit for assaying and/or culturing cells are provided.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: November 19, 2019
    Inventors: Craig Simmons, Oleg Chebotarev
  • Patent number: 10472603
    Abstract: Systems, devices, and methods of the present disclosure assist with management of tubes and hoses during surgical procedures. The systems, devices, and methods provide for the proper opening and closing of tubes to facilitate performance of steps in a surgical procedure. Systems, devices, and methods of the present disclosure control fluid delivery to and from a medical device, including devices for tissue processing and cleaning.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: November 12, 2019
    Assignee: LifeCell Corporation
    Inventors: Evan Friedman, Israel James Jessop, Kai-Roy Wang, Aaron Barere, Brendan P. Collins, Derek Hugger, Christopher Labak, Scott Woodruff
  • Patent number: 10457912
    Abstract: Disclosed herein are systems, devices and methods for processing tissue, such as autologous tissue. Implementations of a Stromal Vascular Fraction (SVF) system are described that can isolate and wash harvested cells contained within various tissues, such as isolate and wash stem cells from fat tissue. The SVF system can minimize the handling and transferring of tissue and fluids, including minimizing the number of human interventions and manipulations required throughout processing. The SVF system can ensure sterility of processed tissue and harvested cells, as well as significantly reduce cost and time associated with the processing.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 29, 2019
    Inventors: Philip J. Simpson, David G. Matsuura, Darryl D'Lima, Daniel Kincade
  • Patent number: 10451528
    Abstract: The present disclosure describes a closed apparatus for collection, filtration and concentration of biological samples, such as fecal material. The sample is collected with an integrated sample collection device which introduces the sample into a transport liquid in a sample collection tube which couples to a filter unit coupled to a processing tube containing a processing liquid. The apparatus may be introduced into a centrifuge for centrifugal filtration.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: October 22, 2019
    Assignee: Alpha-Tec Systems, Inc.
    Inventors: Richard O. Williams, Mark Williams, John Kempke
  • Patent number: 10449539
    Abstract: A fluid-containing cartridge for a tissue processing apparatus includes a body defining a plurality of discrete fluid passageways, and a plurality of fluid-containing wells that are disposed on the body, wherein each fluid passageway of the body defines a fluid path between one of the fluid-containing wells and a fluid exit port that is configured to dispense fluid onto a laboratory slide.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: October 22, 2019
    Inventors: Preyas Shah, Sahil Shah, Eli Endres, Joseph Lessard