Patents Examined by Jyoti Nagpaul
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Patent number: 11639886Abstract: The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative.Type: GrantFiled: June 1, 2020Date of Patent: May 2, 2023Assignee: Ventana Medical Systems, Inc.Inventors: Daniel Bauer, David Chafin, Michael Otter
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Patent number: 11635356Abstract: A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.Type: GrantFiled: June 24, 2020Date of Patent: April 25, 2023Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Kenneth Heng-Chong Ng, Mark Brian Dockrill, Peter Toogood, Martin Limon, Daniel Dobrogorsky, Mark Wilcock, Greg Boyes, Brendyn Rodgers, Stephen John Bagnato, Ashan Chiranga Perera
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Patent number: 11619569Abstract: In one embodiment, a tissue planing assembly includes a base frame, a plurality of disassemblable components assembled to the base frame and having a ready configuration, a sample conveyor, a blade assembly configured to be coupled to the base frame, a control unit communicatively coupled to the sample conveyor, and one or more component sensors communicatively coupled to the control unit. The plurality of disassemblable components is configured to support a tissue sample. The sample conveyor is configured to convey the tissue sample through the blade assembly. The one or more components sensors are configured to output a signal indicative of at least one of the plurality of disassemblable components missing from the ready configuration, wherein the control unit prohibits operation of the sample conveyor when at least one of the plurality of disassemblable components is missing from the ready configuration.Type: GrantFiled: November 11, 2021Date of Patent: April 4, 2023Assignee: Community Blood CenterInventors: Shawn Aaron Hunter, Robert Hoskins, Gregory S. Lucous
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Patent number: 11614387Abstract: Automated system configured to perform and methods for performing one or more slide processing operations on slides bearing biological samples. The system and methods enable high sample throughput while also minimizing or limiting the potential for cross-contamination of slides. The automated systems can include features that facilitate consistency, controllability of processing time, and/or processing temperature.Type: GrantFiled: August 21, 2020Date of Patent: March 28, 2023Assignee: Ventana Medical Systems, Inc.Inventors: Kayla Capps, Henning Groll, Brian Howard Kram, Matthew Mette, Ali Mousavi, Christine Tse, Glen Ward, Daniel O'Connor, Troy Paluszcyk, Benjamin David Randall, Ken Stumpe
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Patent number: 11592365Abstract: A smear preparing apparatus that operates under selectable operation modes, may include: a smearing unit that prepares smeared slides by smearing samples onto slides; a staining unit that is capable of housing the smeared slides and that performs staining processing by accommodating a staining solution used to stain the samples on the housed smeared slides; a fluid circuit that supplies the staining solution to the staining unit; and a controller that controls the supplying of the staining solution to the staining unit depending on a selected one of the operation modes.Type: GrantFiled: June 25, 2020Date of Patent: February 28, 2023Assignee: SYSMEX CORPORATIONInventors: Junya Ikuta, Masaharu Shibata, Noriyuki Nakanishi, Mitsuo Yamasaki, Yuji Takano, Ken Nishikawa
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Patent number: 11592369Abstract: A tissue processing station includes a housing and a first heated plate that is either disposed on or forms a first horizontally oriented surface of the housing. The first heated plate is configured to either (i) contain water, or (ii) receive a dish containing water. The tissue processing station may also include a vertically-oriented heated well for heating slides. A second heated plate is either disposed on or forms an angled surface of the housing for supporting one or more laboratory slides. The angled surface is angled relative to the first horizontally oriented surface. A third heated plate is either disposed on or forms a second horizontally oriented surface of the housing for supporting one or more laboratory slides. The first and second horizontally oriented surfaces are defined at different elevations on the housing. The angled surface extends between the two horizontally oriented surfaces.Type: GrantFiled: May 10, 2021Date of Patent: February 28, 2023Assignee: Rushabh Instruments, LLCInventors: Preyas Shah, Sahil Shah, Joseph Lessard, Alyicia Marie Rios, Joshua T. Greenlee, Olivia Grabowski
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Patent number: 11573242Abstract: Systems and methods that enable automated spray deposition of biological specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen deposition systems and methods of generating high-quality, reproducible specimen-bearing microscope slides in automated processing systems.Type: GrantFiled: May 23, 2022Date of Patent: February 7, 2023Assignees: NanoCytomics, LLC, Northwestern UniversityInventors: Jarema Czarnecki, Justin Derbas, Sergey Rozhok, Hariharan Subramanian, Parvathi Viswanathan
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Patent number: 11570983Abstract: According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm×30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane includiType: GrantFiled: December 27, 2019Date of Patent: February 7, 2023Assignee: FUJIFILM CorporationInventors: Kuniyuki Kaminaga, Ryuta Takegami, Kazuhiro Hasegawa, Yusuke Mochizuki
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Patent number: 11566212Abstract: The present disclosure describes a microfluidic chip for culturing and in vitro testing of 3D organotypic cultures. The tests may be performed directly on the organotypic culture in the microfluidic chip. The microfluidic chip includes at least one microfluidic unit which includes two fluidic compartments, such as upper and lower, separated by a permeable supporting structure, one or more access opening for the fluidic compartments, and a set of lids interchangeable with a set of insets. The permeable support structure serves as a support for the organotypic culture. The upper and lower compartments may include inlets and outlets which allow fluids to be perfused into the lower compartment and fluids to be perfused into the upper compartment. The access opening may be closed with a lid or accommodate an inset.Type: GrantFiled: August 10, 2017Date of Patent: January 31, 2023Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Paul Bigliardi, Zhiping Wang, Ruige Wu, Massimo Alberti, Bo Wu, Mei Bigliardi-Qi, Sriram Gopu, Srinivas Ramasamy, Yuri Hebert Dancik
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Patent number: 11555765Abstract: The present invention relates to systems and methods for tissue processing and analysis. Tissue chambers are configured to allow single-container chemical processing, imaging, and wax embedding of tissue samples in a single container without manipulation between steps. Tissue chambers with features to support the tissue sample and allow fluid flow between the tissue sample and the tissue chamber surface are disclosed. The features may be index matched to sample structures of interest or dissolvable in clearing solution to allow for in-chamber imaging with minimal distortion. Specialized tissue processing and wax removal apparatuses are also disclosed including for use with tissue chambers having frangible portions to permit ease of wax removal.Type: GrantFiled: January 6, 2020Date of Patent: January 17, 2023Assignee: APPLIKATE TECHNOLOGIES LLCInventors: Michael Levene, Richard Torres
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Patent number: 11555819Abstract: A cancer test device (1) is provided with: an application unit (40) for applying a staining agent (45), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit (10) for imaging the group of living cells having the staining agent (45) applied thereto; and a determination unit (52) for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.Type: GrantFiled: May 18, 2017Date of Patent: January 17, 2023Assignee: MIE UNIVERSITYInventors: Akira Mizoguchi, Koji Tanaka, Naoyuki Katayama, Tetsuya Nosaka, Kyosuke Tanaka, Shujie Wang, Aika Kaito, Kousyoku Sai, Kazushi Kimura
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Patent number: 11549956Abstract: Assay system including assay apparatus and handheld single use assay devices for ElectroMagnetic Radiation (EMR) examination of a specimen. The assay devices include a housing, a specimen slide for elevation from an initial lowermost specimen introduction position to a final uppermost specimen examination position and a built-in liquid reagent dispensing arrangement for dispensing liquid reagent on the specimen slide. The assay apparatus automatically actuates an assay device and includes an imaging arrangement for obtaining specimen images.Type: GrantFiled: October 27, 2020Date of Patent: January 10, 2023Assignee: GYNTOOLS LTDInventors: Nimrod Lev, Menachem Lev-Sagie, Tal Shlomovitz, Zohar Horowitz Limor
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Patent number: 11543405Abstract: An environmental sampling and assay system, having a coupon storage assembly, storing coupons; an environment sampling assembly, the sampling assembly mixing an environmental sample with a liquid to create a sample-liquid, bearing the environmental sample; a coupon moving assembly; a coupon wetting assembly for automatically wetting a coupon with the sample-liquid; a coupon perceiving device; a data input, adapted to receive a signal; and a data processing and control assembly, controlling the environmental sampling system, the coupon moving assembly, the wetting assembly and the coupon perceiving device. Further, the coupon moving assembly can retrieve a coupon from the coupon storage assembly and move it in a linear manner to the coupon wetting assembly.Type: GrantFiled: June 1, 2020Date of Patent: January 3, 2023Assignee: CBRN INTERNATIONAL, LTD.Inventors: Elric Saaski, Robert Fay Livingston, Duane M. Fox
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Patent number: 11543408Abstract: The present invention is related to the field of bio/chemical sampling, sensing, assays and applications. Particularly, the present invention is related to how to make the sampling/sensing/assay become simple to use, fast to results, highly sensitive, easy to use, using tiny sample volume (e.g. 0.5 uL or less), operated by a person without any professionals, reading by mobile-phone, or low cost, or a combination of them.Type: GrantFiled: October 15, 2019Date of Patent: January 3, 2023Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding
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Patent number: 11532392Abstract: A method for using a meter and a meter (10) adapted to determine an analyte concentration reading, the meter comprising a display (12) adapted to display information to a user of the meter, the display including information directed to a post-meal test-time alarm (22?) that is adapted to remind the user to obtain a post-meal analyte concentration reading, and at least one user input mechanism (15) adapted to allow the user to activate the post-meal test-time alarm.Type: GrantFiled: December 22, 2020Date of Patent: December 20, 2022Assignee: Ascensia Diabetes Care Holdings AGInventors: Barry D. Power, Jeffrey A. Culver
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Patent number: 11519925Abstract: A digital slide scanning apparatus includes a safety light curtain that operates to disable the motor that rotates the carousel when the presence of an object (e.g., the fingers of an operator) is detected within a predetermined area of the carousel. The light curtain also operates to disable the motor that rotates the carousel when an improperly positioned glass slide or slide rack is detected. The digital slide scanning apparatus also includes a multi-color status indicator for each rack slot that indicates the rack slot location of an improperly positioned glass slide or slide rack.Type: GrantFiled: January 15, 2021Date of Patent: December 6, 2022Assignee: Leica Biosystems Imaging, Inc.Inventor: Nicholas Newberg
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Patent number: 11510660Abstract: A sample container for use in imaging includes a bottom portion and a wall portion extending upwardly from the bottom portion. The lid overlies the cavity when in the closed position, and a plurality of latches are coupled to the lid and extend substantially orthogonally from the lid. A plurality of recesses are coupled to the wall portion, each recess of the plurality of recesses being adapted and configured to receive one of the plurality of latches. A first alignment structure is within the cavity and is adapted and configured to align a sample lengthwise and widthwise within the cavity such that the sample is aligned relative to an imaging system when the sample container is engaged with the imaging system. A second alignment structure is at least partially within the cavity, and is adapted and configured to align the sample height wise within the cavity.Type: GrantFiled: August 15, 2019Date of Patent: November 29, 2022Assignee: Leica Biosystems Richmond, Inc.Inventors: Bruce A. Goeckner, Heather Renko-Breed, Randy Shanahan
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Patent number: 11493411Abstract: The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.Type: GrantFiled: December 19, 2018Date of Patent: November 8, 2022Assignee: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Zbigniew Mioduszewski, Aaron Ridgway, Matthew King, Blake Hellard
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Patent number: 11480502Abstract: Disclosed are compositions, methods, and kits for clearing tissue that preserve cellular morphology, reporter fluorescence, and epitope labeling which allow for quantitative phenotypic analysis of intact organs. The compositions include, for example, a compound of formula R1—C(X)—NR2R3, wherein R1 is alkyl, haloalkyl, hydroxyalkyl, amino, or alkylamino, X is O or S, and R2 and R3 are independently H, alkyl, or hydroxyalkyl, a salt thereof, or a combination thereof, and at least one non-ionic density gradient medium. Also disclosed are methods for clearing tissue comprising positioning a tissue in a tissue clearing composition and allowing a tissue clearing composition to permeate the tissue. Further disclosed are methods for visualizing tissue characteristics which involve fixing a tissue, staining the tissue, positioning the tissue in the tissue clearing composition and allowing the tissue clearing composition to permeate the tissue, and imaging the tissue utilizing a microscope or tissue scanning device.Type: GrantFiled: August 29, 2017Date of Patent: October 25, 2022Assignee: United States of America, as represented by the Secretary, Department of Heatlth and Human ServiceInventors: Ronald N. Germain, Weizhe Li, Michael Y. Gerner
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Patent number: 11474007Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.Type: GrantFiled: September 1, 2019Date of Patent: October 18, 2022Inventors: James D. Anderson, Jr., John Glenn Edelen, Manish Giri, Michael A. Marra, III, Sam Norasak