Patents Examined by K. Weddington
  • Patent number: 5464623
    Abstract: Insecticidal pellet compositions of N-hydrocarboyl phosphoroamidothioates and phosphoroamidodithioates are provided. These compositions have improved odor control, thermal stability, attrition resistance, bulk density and handling characteristics over the powdered forms of the insecticides. Methods are provided for making such pellets, and in particular, an extrusion method is provided in which the dry insecticidal composition is mixed with from 3-25% of a solvent to form a consistency of damp sandy loam and then extruded.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: November 7, 1995
    Assignee: Chevron Research Company
    Inventors: Jimmy H. Chan, Rodrick I. Satre, James H. Trusler, Sadanand G. Memula
  • Patent number: 5461042
    Abstract: The present invention provides an improved compositions and methods for regulating the immune response, for ameliorating effects of stress, and for avoiding untoward effects of chemotherapy or exposure to irradiation by administration of androstenediol (AED) and androstenetriol (AET). The improved means of regulating immune response can be utilized in treating infectious diseases and immune diseases such as diabetes and chronic fatigue syndrome, both diseases now considered to be immune response related syndromes.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: October 24, 1995
    Inventor: Roger M. Loria
  • Patent number: 5457120
    Abstract: The present invention provides a method of inhibiting gastric acid secretion in mammals by administering a 5-HT1A agonist compound or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 29, 1994
    Date of Patent: October 10, 1995
    Assignee: Eli Lilly and Company
    Inventors: Jaswant S. Gidda, John M. Schaus
  • Patent number: 5446061
    Abstract: A method of lowering serum cholesterol levels, comprising administering an effective amount of a compound having the formula ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, --H, --OH, halo, --OC.sub.1 -C.sub.17 alkyl, --OC.sub.3 -C.sub.6 cycloalkyl, --O(CO)C.sub.1 -C.sub.17 alkyl, --O(CO) aryl, --O(CO)O aryl, or --OSO.sub.2 -(n-butyl or n-pentyl);R.sup.3 is ##STR2## and R.sup.4 is --H, methyl, ethyl, propyl, ethenyl or ethynyl; or a pharmaceutically acceptable salt or solvate thereof, to an animal in need of lower cholesterol levels.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: August 29, 1995
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Timothy A. Grese
  • Patent number: 5443849
    Abstract: A sporicidal composition characterized in that it comprises iodine bromide in aqueous solution at a pH of less than 7.
    Type: Grant
    Filed: August 19, 1992
    Date of Patent: August 22, 1995
    Assignee: Diversey Corporation
    Inventor: Michael P. Corby
  • Patent number: 5441748
    Abstract: An aqueous agent for disintegrating gallstones containing an alkali metal carbonate such as sodium or potassium hydrogen carbonate and optionally N-acetylcysteine.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: August 15, 1995
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventor: Akihito Moyiyasu
  • Patent number: 5441962
    Abstract: The use of isoquinolinone derivatives as an antiarteriosclerosis agent and antihyperlipoproteinemics. The derivatives are of the formula ##STR1## wherein R.sub.1 is hydrogen or a C.sub.1 -C.sub.6 alkyl group and R.sub.2 is a C.sub.1 -C.sub.6 alkyl group or the pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: August 15, 1995
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Motoharu Hasegawa, Kohji Shirai, Kiyohiko Matsumoto, Yasuhiko Suzuki, Isao Takahasi, Yuuiti Takarada, Mitsuyo Saito, Kumiko Yamamoto, Yositaka Takayama, Tsutomu Komazawa, Toshiji Sugai
  • Patent number: 5436269
    Abstract: A drug for hepatic diseases, particularly an ameliorant for hepatic functions and a drug for hepatitis, containing docosahexaenoic acid or a derivative thereof (DHA) as an active ingredient. The DHA as the active drug ingredient, though also taking part in the metabolism of cholesterol formed in vivo and exuding into the plasma, mainly metabolizes that cholesterol specifically which is accumulated in hepatic microsomes as a result of hypometabolism or dysbolism to thereby bring about the recovery of flexibility of a microsome lipid membrane, thus enhancing the enzymatic activity, and to significantly reduce a triglyceride, thus being prospective as an ameliorant for hepatic functions in treating fatty liver, hepatic cirrhosis, etc. The invention also provides a drug for hepatitis, which can inhibit the induction of hepatitis which is one of the factor causative of chronic hepatitis, hepatocirrhosis, hepatocellular carcinoma, hepatic insufficiency, etc.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: July 25, 1995
    Assignee: Sagami Chemical Research Center
    Inventors: Kazunaga Yazawa, Tomohito Hamasaki, Hirofumi Taki, Kiyosi Kondo, Mitihiro Sugano, Ikuo Ikeda
  • Patent number: 5433959
    Abstract: The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: July 18, 1995
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tadashi Makino, Tetsuro Tabata, Shin-ichiro Hirai
  • Patent number: 5434185
    Abstract: Aurintricarboxylic acid has potent anti-angiogenic activity and may be used for new therapeutic approaches for diseases of neovascularization including the treatment of solid tumors, diabetic retinopathy and arthritis, among others.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: July 18, 1995
    Assignee: The University of Kentucky Research Foundation
    Inventors: Delwood C. Collins, Antonio Gagliardi, Anjan Bhattacharyya
  • Patent number: 5432160
    Abstract: A nutrient composition such as infusions and nutrient preparations, which contains .beta.-alanyl-L-glutamine.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: July 11, 1995
    Assignee: Kyowa Hakko Kohyo Co., Ltd.
    Inventors: Takahiro Hara, Yoshiharu Yokoo
  • Patent number: 5430066
    Abstract: Animal feed or human food which contains added conjugated linoleic acids (CLA) can enhance growth and prevent anorexia and weight loss due to immune stimulation (e.g., endotoxin exposure) and the adverse effects of catabolic hormones (i.e., IL-1). Methods of treatment using CLA also are disclosed.
    Type: Grant
    Filed: April 29, 1992
    Date of Patent: July 4, 1995
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mark E. Cook, Michael W. Pariza
  • Patent number: 5428072
    Abstract: A method of enhancing weight gain and feed efficiency in an animal which comprises administering to the animal a safe and effective amount of a conjugated linoleic acid.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: June 27, 1995
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mark E. Cook, Michael W. Pariza
  • Patent number: 5422357
    Abstract: Oxatomide reduces the number of cough attacks and also prolongs the time between each attack. The effect is dose-related.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: June 6, 1995
    Assignee: Farkemo S.r.l.
    Inventor: Piercarlo Braga
  • Patent number: 5420163
    Abstract: A method of systemically controlling endoparasites and ectoparasites of warm-blooded animals by orally or percutaneously administering to the animal a parasiticidally effective amount of an acyl urea compound.
    Type: Grant
    Filed: August 3, 1992
    Date of Patent: May 30, 1995
    Assignee: Ciba-Geigy
    Inventors: Michael F. Potter, George L. Rotramel, Andrew J. Caruso, David T. Chou, Paul A. Cain
  • Patent number: 5418252
    Abstract: A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidino and piperidino, a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: May 23, 1995
    Assignee: Eli Lilly and Company
    Inventor: Daniel C. Williams
  • Patent number: 5416115
    Abstract: The present invention pertains to reducing milk fat levels optionally to enhancing overall milk yields in ruminants by administration of trans-fatty acids, trans-fatty acid salts, amides, and triglycerides containing trans-fatty acid substituents. The invention also pertains to a method of identifying those trans-fatty acids, trans-fatty acid salts, amides, and triglycerides containing trans-fatty acid substituents which reduce milk fat levels and may also enhance milk yields, and designing ruminant diets containing such trans-fatty acids, salts, or triglycerides.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: May 16, 1995
    Assignee: University of Maryland, Dept. of Animal Sciences
    Inventors: Richard A. Erdman, Beverly B. Teter, Mark Keeney, Joseph Sampugna
  • Patent number: 5414014
    Abstract: The present invention provides methods of using compositions containing local anesthetic compounds for facilitating the removal of sucking arthropods from the skin of a mammal; for reducing inflammation associated with a bite of a sucking arthropod; for limiting infection from a sucking arthropod; and for enhancing the facilitated removal of sucking arthropods from the skin of a mammal.
    Type: Grant
    Filed: April 8, 1993
    Date of Patent: May 9, 1995
    Assignee: Innova Biomed, Inc.
    Inventors: Linda H. Schneider, Randall B. Murphy
  • Patent number: 5407958
    Abstract: Therapeutic and preventive compositions that treat dull, dry and rough skin, improve skin smoothness and elasticity, diminish fine lines and wrinkles, prevent acne and promote renewed skin vibrance. The compositions include an alpha hydroxy acid and a preservative.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: April 18, 1995
    Assignee: BeautiControl Cosmetics, Inc.
    Inventors: Jinger L. Heath, Clifton R. Sanders, John H. Murphy, Rhonda Atkins
  • Patent number: 5403592
    Abstract: A composition comprised of at least one surface active phospholipid, hyaluronic acid or a water soluble salt thereof in saline solution for use as a lubricant, in particular, for physiological use such as the lubrication of joints. The composition can be used to reduce the coefficient of kinetic friction between surfaces in contact with each other, particularly load-bearing surfaces.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: April 4, 1995
    Assignee: MacNaught Pty Limited
    Inventor: Brian A. Hills