Patents Examined by Kagnew H. Gebreyesus
  • Patent number: 11497209
    Abstract: The present disclosure relates to a synthetic Túngara frog foam composition. The synthetic Túngara frog foam composition comprises six synthetically synthesized ranaspumin proteins (RSN-1 to RSN-6) wherein only the active segments of the RSN proteins are synthesized and six synthetically synthesized polysaccharides comprising four tetrasaccharides, a heptasaccharide and a nonasaccharide. Multiple novel applications of the foam are described.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: November 15, 2022
    Assignee: 1283581 BC LTD
    Inventor: Robert Scott McKinley
  • Patent number: 11492608
    Abstract: The invention relates to archaeal pyrrolysyl tRNA synthetases lacking a nuclear localization signal and/or comprising a nuclear export signal. The invention also relates to polynucleotides encoding said pyrrolysyl tRNA synthetases, eukaryotic cells comprising said polynucleotide and tRNA acylated by the pyrrolysyl tRNA synthetase or a polynucleotide encoding such tRNA, methods utilizing said cells for preparing polypeptides comprising unnatural amino acid residues, and kits useful in said methods.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: November 8, 2022
    Assignee: European Molecular Biology Laboratory
    Inventors: Edward Lemke, Ivana Nikic, Gemma Estrada Girona, Christine Köhler
  • Patent number: 11471514
    Abstract: A composition includes two exogenous enzymes from animals for consumption by human beings to prevent, treat and/or alleviate veisalgia and/or symptoms associated therewith arising from or caused by consumption or spontaneous production of alcohol through a dual-enzyme based breakdown of the alcohol, wherein a first enzyme of the two exogenous enzymes is capable of converting alcohol into a first metabolite while a second enzyme thereof is capable of converting the first metabolite into a second metabolite which is excretable to systemic circulation after an oxidation reaction of the alcohol in the presence of the two exogenous enzymes and NAD+/NADH, and wherein the first enzyme to the second enzyme is in a molar ratio of 1:3-51 in the composition in order to avoid an elevation in the level of the first metabolite in the human being.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: October 18, 2022
    Assignee: ALCOLEAR LIMITED
    Inventors: Bing Lou Wong, Sek Lun Law
  • Patent number: 11467166
    Abstract: Compositions and methods for detecting molecule-molecule interactions are provided. The methods employ a prokaryotic ubiquitin-like protein (Pup) and a Pup ligase that is coupled to one of the molecules. When the Pup ligase is brought to proximity to the other molecule by virtue of the molecule-molecule interaction, the Pup ligase can conjugate the Pup to a lysine residue on the other molecule. As such conjugation can be easily detected, this method allows easy identification of the molecule-molecule interaction.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: October 11, 2022
    Assignee: ShanghaiTech University
    Inventors: Min Zhuang, Haopeng Wang, Qiang Liu
  • Patent number: 11453902
    Abstract: A cell lysate or cell-free protein synthesis system comprising recombinant translational proteins and uses thereof are provided.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: September 27, 2022
    Assignee: The Regents of the University of California
    Inventors: Cheemeng Tan, Luis Eduardo Contreras Llano, Conary Meyer, Fernando Villarreal
  • Patent number: 11453692
    Abstract: Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: September 27, 2022
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Xiaodan Yu
  • Patent number: 11447809
    Abstract: The disclosure provides amino acid sequence variants of orthogonal aminoacyl-tRNA synthetases (AARSs) having increased activity and selectivity compared to previous AARSs, and methods of producing the same.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: September 20, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, David Irby Bryson, Jr.
  • Patent number: 11447759
    Abstract: The invention relates to a polypeptide having hemicellulase activity which comprises the amino acid sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, 6, 11, 16, 21, 26, 31, 36, 41, 46, 51, 56, 61, 66 or 71, SEQ ID NO: 4, 9, 14, 19, 24, 29, 34, 39, 44, 49, 54, 59, 64, 69 or 74, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72 or the variant polynucleotide encodes a polypeptide that has at least 75% sequence identity with the sequence set out in SEQ ID NO: 2, 7, 12, 17, 22, 27, 32, 37, 42, 47, 52, 57, 62, 67 or 72.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: September 20, 2022
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alrik Pieter Los, Rene Marcel De Jong, Maaike Appeldoorn
  • Patent number: 11441170
    Abstract: A kit for preparing a nucleic acid sample for analysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) is provided, the kit comprising: a lyophilized enzyme composition comprising: micrococcal nuclease; nuclease P1; and bacterial alkaline phosphatase (BAP); and a digestion buffer. Also provided are enzyme compositions and methods of use for rapid, efficient preparation of a nucleic acid sample for analysis by LC-MS/MS, without the need for denaturation of the sample.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: September 13, 2022
    Assignee: University of Cincinnati
    Inventors: Robert Ross, Patrick A. Limbach, Balasubrahmanyam Addepalli, Manasses Jora
  • Patent number: 11439166
    Abstract: This document relates to ground meat replicas, and more particularly to plant-based products that mimic ground meat, including the fibrousness, heterogeneity in texture, beefy flavor, and red-to-brown color transition during cooking of ground meat.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: September 13, 2022
    Assignee: Impossible Foods Inc.
    Inventors: Ranjani Varadan, Sergey Solomatin, Celeste Holz-Schietinger, Elysia Cohn, Ariel Klapholz-Brown, Jennifer Woan-Yi Shiu, Aniket Kale, Jessica Karr, Rachel Fraser
  • Patent number: 11434491
    Abstract: Provided herein are, inter alia, compositions and methods for manipulation of genomes of living organisms.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of California
    Inventors: Jin Chen, Luke Gilbert, James Nunez, Jonathan Weissman
  • Patent number: 11421218
    Abstract: The present invention provides methods of increasing the efficiency of genome editing.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: August 23, 2022
    Assignees: Dana-Farber Cancer Institute, Inc., Oregon Health & Science University
    Inventors: Alan D'Andrea, Markus Grompe
  • Patent number: 11408007
    Abstract: Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (GMO) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. Safeguards with low escape frequency prevent the rise of mutants escaping defined media and limit growth in the wild. Robust safeguards retain wild-type levels of fitness while also maintaining containment in diverse growth conditions.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: August 9, 2022
    Assignee: YALE UNIVERSITY
    Inventors: Farren J. Isaacs, Ryan Gallagher, Jaymin Patel, Alexis Rovner
  • Patent number: 11408005
    Abstract: Provided herein is a system for inducible expression of a chimeric antigen receptor in cells, such as mammalian cells.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 9, 2022
    Assignee: Seattle Children's Hospital
    Inventors: Michael C. Jensen, Tracy Ooi, Jia Wei
  • Patent number: 11406107
    Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: August 9, 2022
    Assignees: Bayer CropScience LP, Spogen Biotech Inc.
    Inventors: Damian Curtis, Brian Thompson
  • Patent number: 11401515
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 2, 2022
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • Patent number: 11389516
    Abstract: The present invention relates to a composition comprising the UNE-L domain of leucyl-tRNA synthetase as an effective ingredient for increasing muscle. More particularly, the UNE-L domain of LRS according to the present invention, which is a region that controls activity of Vps34, activates mTORC1 involved in protein synthesis and increases myocyte differentiation and muscle fiber regeneration, thus finding useful application in muscle augmentation.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: July 19, 2022
    Assignees: Gachon University of Industry-Academic Cooperation Foundation, Gil Medical Center
    Inventors: Mee Sup Yoon, Jie Chen, Kook Son, Cheol Soo Choi, Sunghoon Kim, Jung Min Han
  • Patent number: 11390890
    Abstract: Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: July 19, 2022
    Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Chaoguang Tian, Jingen Li, Chuannan Long, Tao Sun, Liangcai Lin, Jing Xu, Qian Liu, Jingxiao Ji, Wenliang Sun, Yanhe Ma
  • Patent number: 11384350
    Abstract: Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: July 12, 2022
    Assignee: The Regents of the University of California
    Inventors: Yvonne Y. Chen, Patrick Ho
  • Patent number: 11384348
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: July 12, 2022
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Frits Goedegebuur, Lilia Maria Babe, Rie Mejldal, Harm Mulder, Anja Hemmingsen Kellett-Smith, Richard R Bott, Miles Christopher Scotcher