Patents Examined by Karen Carlson
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Patent number: 9657322Abstract: The invention relates to the field of poly-and oligosaccharides and their nutritional effects. In particular, it relates to the application of ?-glucanotransferases in methods for preparing dietary fibers, including prebiotic oligosaccharides, and to novel oligosaccharides obtainable thereby. Provided is a method for producing a mixture of gluco-oligosaccharides having one or more consecutive (?1?6) glucosidic linkages and one or more consecutive (?1?4) glucosidic linkages, comprising contacting a poly- and/or oligosaccharide substrate comprising at least two (?1?4) linked D-glucose units with an ?-glucanotransferase capable of cleaving (?1?4) glucosidic linkages and making new (?1?4) and (?1?6) glucosidic linkages. Also provided are (isolated) gluco-oligosaccharides obtainable thereby, and their application in nutritional and cosmetic compositions.Type: GrantFiled: May 10, 2010Date of Patent: May 23, 2017Assignee: RIJKSUNIVERSITEIT GRONINGENInventors: Lubbert Dijkhuizen, Marc Jos Elise Cornelis van der Maarel, Johannis Paulus Kamerling, Reinder Johannes Leemhuis, Slavko Kralj, Justyna Malgorzata Dobruchowska
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Patent number: 9200039Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.Type: GrantFiled: March 14, 2014Date of Patent: December 1, 2015Assignee: SYMIC IP, LLCInventors: Alyssa Panitch, John Eric Paderi, Shaili Sharma, Katherine Allison Stuart, Nelda Marie Vazquez-Portalatin
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Patent number: 8877471Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.Type: GrantFiled: May 1, 2013Date of Patent: November 4, 2014Assignee: Novozymes A/SInventors: Leonardo De Maria, Carsten Andersen, Lars Kobberoee Skov, Mikael Blom Soerensen
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Patent number: 8383766Abstract: The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5?-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.Type: GrantFiled: August 15, 2007Date of Patent: February 26, 2013Assignee: Sangamo BioSciences, Inc.Inventors: Qiang Liu, Edward Rebar, Andrew C. Jamieson
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Patent number: 8299013Abstract: Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form.Type: GrantFiled: February 16, 2007Date of Patent: October 30, 2012Assignee: Wake Forest University Health SciencesInventor: Mark E. Van Dyke
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Patent number: 8247369Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: GrantFiled: July 25, 2011Date of Patent: August 21, 2012Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl M. Defontes
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Patent number: 8236543Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.Type: GrantFiled: September 27, 2010Date of Patent: August 7, 2012Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
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Patent number: 8236526Abstract: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.Type: GrantFiled: December 22, 2009Date of Patent: August 7, 2012Assignee: JNC CorporationInventors: Satoshi Inouye, Yuiko Sahara
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Patent number: 8227402Abstract: The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.Type: GrantFiled: November 13, 2009Date of Patent: July 24, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: Tapas Das Gupta, Ananda Chakrabarty
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Patent number: 8221743Abstract: The present invention relates to the use of isolated polypeptides as coccidiostats and/or histomonastats. An example of a polypeptide of the invention is the so-called L12 protein from Bacillus licheniformis ATCC 14580.Type: GrantFiled: December 13, 2007Date of Patent: July 17, 2012Assignee: Novozymes A/SInventors: Gilbert Weber, Jiri Broz
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Patent number: 8216806Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.Type: GrantFiled: July 25, 2011Date of Patent: July 10, 2012Assignee: Syngenta Participations AGInventors: Eric Chen, Cheryl Stacy
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Patent number: 8202696Abstract: The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein.Type: GrantFiled: May 15, 2003Date of Patent: June 19, 2012Assignee: Max-Planck-Gessellschaft zur Forderung der Wissenschaften E.V.Inventors: Susann Schweiger, Hans-Hilger Ropers, Jennifer Winter, Sybille Krauss, Vanessa Suckow, Rainer Schneider, Alexander Trockenbacher, John Foerster
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Patent number: 8202707Abstract: The present invention relates to a continuous method of producing a mash extract by decoction mashing, said method comprising: a. mixing a first malt enzyme source with an aqueous liquid to obtain an aqueous malt enzyme suspension; b. separately, mixing a second enzyme source with one or more starch-containing adjuncts to obtain a decoction suspension while maintaining temperature conditions that do not cause significant gelatinization of the starch; c. subjecting the decoction suspension to a first heat treatment at 60-85° C. to simultaneously partially gelatinize and enzymatically degrade the starch; d. subjecting the decoction suspension to a second heat treatment at a higher temperature than the first heat treatment to gelatinize the starch at an increased rate and to a higher extent; e. combining the heated decoction suspension obtained from the second heat treatment with the aqueous malt enzyme suspension from step a. to obtain a mash; f. maintaining the mash at 35-85° C. for at least minutes; and g.Type: GrantFiled: May 14, 2007Date of Patent: June 19, 2012Assignee: Heineken Supply Chain B.V.Inventor: Hendrikus Mulder
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Patent number: 8197808Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.Type: GrantFiled: December 27, 2006Date of Patent: June 12, 2012Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Amihay Freeman, Noa Hadar
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Patent number: 8198230Abstract: The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell via receptor-mediated endocytosis. According to the invention, novel synthetic mimics of cell surface receptors have been designed and methods for use of the same are disclosed.Type: GrantFiled: January 7, 2011Date of Patent: June 12, 2012Assignee: The Penn State Research FoundationInventor: Blake R. Peterson
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Patent number: 8198409Abstract: A mutant of the polypeptide Protein A, wherein immunoglobulin binding properties can be altered by changing temperature under the conditions of pH 5-9, below 60° C. The use of the mutant Protein A include the use thereof as a ligand coupled to an affinity chromatography support for the purification of immunoglobulins by affinity chromatography, wherein the immunoglobulins is eluted by changing temperature and thereby the conformation of the mutant Protein A.Type: GrantFiled: May 18, 2008Date of Patent: June 12, 2012Assignee: Nomadic Bioscience Co., Ltd.Inventor: Satoshi Sato
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Patent number: 8198047Abstract: The invention concerns recombinant gelatins with unevenly distributed RGD motifs that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.Type: GrantFiled: February 21, 2008Date of Patent: June 12, 2012Assignee: Fujifilm Manufacturing Europe B.V.Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
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Patent number: 8193314Abstract: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes and methods for evaluating phenotypic diversity.Type: GrantFiled: July 10, 2008Date of Patent: June 5, 2012Assignee: Massachusetts Institute of TechnologyInventors: Gregory Stephanopoulos, Daniel Klein-Marcuschamer
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Patent number: 8193160Abstract: In Magnaporthe species and other plant pathogenic fungal species, the appressoriu, (infection structure) is responsible for breaching the host plant cell wall and gaining entry into the host tissues. Magnaporthe ABC3 protein is an MDR transporter that plays an important role during host penetration and also is involved in regulating fungal response to intracellular oxidative stress. The insertional mutant abc3?, in which the ABC3 efflux pump function is blocked, lacks functional appressoria and is therefore incapable of causing disease in host plants. This invention provides the abc3 nucleic acid (gene) and ABC3 protein from Magnaporthe or from Aspergillus, Ustilago or Fusarium and describes methods for reducing plant pathogenicity for important rice pathogens.Type: GrantFiled: March 14, 2007Date of Patent: June 5, 2012Assignee: Temasek Life Sciences LaboratoryInventors: Naweed Isaak Naqvi, Chuan Bao Sun
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Patent number: 8183022Abstract: Embodiments of the invention relate, for example, to methods for reducing the load of organic acids and glycerol in water recycled to the fermentation process. Organic acids and glycerol produced during ethanol fermentation are used as a replacement for carbohydrates for propagation of yeast. The yeast may be sold as a feed product or used in subsequent fermentation.Type: GrantFiled: October 31, 2008Date of Patent: May 22, 2012Assignee: Archer Daniels Midland CompanyInventor: Gadi Steiner