Patents Examined by Karen Carlson
  • Patent number: 9657322
    Abstract: The invention relates to the field of poly-and oligosaccharides and their nutritional effects. In particular, it relates to the application of ?-glucanotransferases in methods for preparing dietary fibers, including prebiotic oligosaccharides, and to novel oligosaccharides obtainable thereby. Provided is a method for producing a mixture of gluco-oligosaccharides having one or more consecutive (?1?6) glucosidic linkages and one or more consecutive (?1?4) glucosidic linkages, comprising contacting a poly- and/or oligosaccharide substrate comprising at least two (?1?4) linked D-glucose units with an ?-glucanotransferase capable of cleaving (?1?4) glucosidic linkages and making new (?1?4) and (?1?6) glucosidic linkages. Also provided are (isolated) gluco-oligosaccharides obtainable thereby, and their application in nutritional and cosmetic compositions.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: May 23, 2017
    Assignee: RIJKSUNIVERSITEIT GRONINGEN
    Inventors: Lubbert Dijkhuizen, Marc Jos Elise Cornelis van der Maarel, Johannis Paulus Kamerling, Reinder Johannes Leemhuis, Slavko Kralj, Justyna Malgorzata Dobruchowska
  • Patent number: 9200039
    Abstract: This disclosure provides extracellular matrix-binding synthetic peptidoglycans comprised of one or more synthetic peptides conjugated to a glycan and methods of their use.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 1, 2015
    Assignee: SYMIC IP, LLC
    Inventors: Alyssa Panitch, John Eric Paderi, Shaili Sharma, Katherine Allison Stuart, Nelda Marie Vazquez-Portalatin
  • Patent number: 8877471
    Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g. in animal feed and animal feed additives.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: November 4, 2014
    Assignee: Novozymes A/S
    Inventors: Leonardo De Maria, Carsten Andersen, Lars Kobberoee Skov, Mikael Blom Soerensen
  • Patent number: 8383766
    Abstract: The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5?-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: February 26, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Qiang Liu, Edward Rebar, Andrew C. Jamieson
  • Patent number: 8299013
    Abstract: Disclosed are optimized keratin preparations for use in medical applications. Methods to produce optimized keratin preparations are provided for use in biomedical applications, particularly for the treatment of bleeding, and for the treatment of wounds. Also disclosed are surgical or paramedic aids comprising a substrate with keratin preparations provided thereon, and kits comprising keratin derivatives packaged in sterile form.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: October 30, 2012
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Patent number: 8247369
    Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: August 21, 2012
    Assignee: Syngenta Participations AG
    Inventors: Eric Chen, Cheryl M. Defontes
  • Patent number: 8236543
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: August 7, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Patent number: 8236526
    Abstract: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: August 7, 2012
    Assignee: JNC Corporation
    Inventors: Satoshi Inouye, Yuiko Sahara
  • Patent number: 8227402
    Abstract: The present invention relates to compositions comprising peptides that may be variants, derivatives and structural equivalents of cupredoxins that inhibit the development of premalignant lesions in mammalian cells, tissues and animals. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The present invention further relates to compositions that may comprise cupredoxin(s), and/or variants, derivatives or structural equivalents of cupredoxins, that retain the ability to inhibit the development of premalignant lesions in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 24, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Tapas Das Gupta, Ananda Chakrabarty
  • Patent number: 8221743
    Abstract: The present invention relates to the use of isolated polypeptides as coccidiostats and/or histomonastats. An example of a polypeptide of the invention is the so-called L12 protein from Bacillus licheniformis ATCC 14580.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: July 17, 2012
    Assignee: Novozymes A/S
    Inventors: Gilbert Weber, Jiri Broz
  • Patent number: 8216806
    Abstract: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is thus designed. The coding sequence of the modified Cry3A toxin may be transformed into a host cell and the host cell grown under conditions that allow the host cell to produce the modified Cry3A toxin. The host cell may be a plant cell and the plant may be comprised in a transgenic plant. Thus, the transgenic plant may be used to produce the modified Cry3A toxin.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: July 10, 2012
    Assignee: Syngenta Participations AG
    Inventors: Eric Chen, Cheryl Stacy
  • Patent number: 8202696
    Abstract: The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: June 19, 2012
    Assignee: Max-Planck-Gessellschaft zur Forderung der Wissenschaften E.V.
    Inventors: Susann Schweiger, Hans-Hilger Ropers, Jennifer Winter, Sybille Krauss, Vanessa Suckow, Rainer Schneider, Alexander Trockenbacher, John Foerster
  • Patent number: 8202707
    Abstract: The present invention relates to a continuous method of producing a mash extract by decoction mashing, said method comprising: a. mixing a first malt enzyme source with an aqueous liquid to obtain an aqueous malt enzyme suspension; b. separately, mixing a second enzyme source with one or more starch-containing adjuncts to obtain a decoction suspension while maintaining temperature conditions that do not cause significant gelatinization of the starch; c. subjecting the decoction suspension to a first heat treatment at 60-85° C. to simultaneously partially gelatinize and enzymatically degrade the starch; d. subjecting the decoction suspension to a second heat treatment at a higher temperature than the first heat treatment to gelatinize the starch at an increased rate and to a higher extent; e. combining the heated decoction suspension obtained from the second heat treatment with the aqueous malt enzyme suspension from step a. to obtain a mash; f. maintaining the mash at 35-85° C. for at least minutes; and g.
    Type: Grant
    Filed: May 14, 2007
    Date of Patent: June 19, 2012
    Assignee: Heineken Supply Chain B.V.
    Inventor: Hendrikus Mulder
  • Patent number: 8197808
    Abstract: The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: June 12, 2012
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Amihay Freeman, Noa Hadar
  • Patent number: 8198230
    Abstract: The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell via receptor-mediated endocytosis. According to the invention, novel synthetic mimics of cell surface receptors have been designed and methods for use of the same are disclosed.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: June 12, 2012
    Assignee: The Penn State Research Foundation
    Inventor: Blake R. Peterson
  • Patent number: 8198409
    Abstract: A mutant of the polypeptide Protein A, wherein immunoglobulin binding properties can be altered by changing temperature under the conditions of pH 5-9, below 60° C. The use of the mutant Protein A include the use thereof as a ligand coupled to an affinity chromatography support for the purification of immunoglobulins by affinity chromatography, wherein the immunoglobulins is eluted by changing temperature and thereby the conformation of the mutant Protein A.
    Type: Grant
    Filed: May 18, 2008
    Date of Patent: June 12, 2012
    Assignee: Nomadic Bioscience Co., Ltd.
    Inventor: Satoshi Sato
  • Patent number: 8198047
    Abstract: The invention concerns recombinant gelatins with unevenly distributed RGD motifs that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: June 12, 2012
    Assignee: Fujifilm Manufacturing Europe B.V.
    Inventors: Arjo Lysander De Boer, Hendrik Van Urk, Jan Bastiaan Bouwstra, Peter Franciscus Theresius Maria Van Asten
  • Patent number: 8193314
    Abstract: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes and methods for evaluating phenotypic diversity.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: June 5, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Daniel Klein-Marcuschamer
  • Patent number: 8193160
    Abstract: In Magnaporthe species and other plant pathogenic fungal species, the appressoriu, (infection structure) is responsible for breaching the host plant cell wall and gaining entry into the host tissues. Magnaporthe ABC3 protein is an MDR transporter that plays an important role during host penetration and also is involved in regulating fungal response to intracellular oxidative stress. The insertional mutant abc3?, in which the ABC3 efflux pump function is blocked, lacks functional appressoria and is therefore incapable of causing disease in host plants. This invention provides the abc3 nucleic acid (gene) and ABC3 protein from Magnaporthe or from Aspergillus, Ustilago or Fusarium and describes methods for reducing plant pathogenicity for important rice pathogens.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: June 5, 2012
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Naweed Isaak Naqvi, Chuan Bao Sun
  • Patent number: 8183022
    Abstract: Embodiments of the invention relate, for example, to methods for reducing the load of organic acids and glycerol in water recycled to the fermentation process. Organic acids and glycerol produced during ethanol fermentation are used as a replacement for carbohydrates for propagation of yeast. The yeast may be sold as a feed product or used in subsequent fermentation.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: May 22, 2012
    Assignee: Archer Daniels Midland Company
    Inventor: Gadi Steiner