Patents Examined by Lance Rider
  • Patent number: 8933290
    Abstract: A mesh implant is disclosed which may be utilized for treating urinary incontinence, hernias, uterovaginal prolapses and other related injuries.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: January 13, 2015
    Assignee: Sofradim Production SAS
    Inventors: Olivier Lefranc, Philippe Gravagna, Yves Bayon, Michel Therin
  • Patent number: 8916197
    Abstract: The present invention pertains to a bone marrow-directing drug delivery material that includes at least one fine particle, wherein the fine particle includes an anionic moiety on a surface of the particle. Also disclosed are uses of the material set forth herein for the prevention, treatment, or diagnosis of a disease of bone, cartilage, bone marrow, or a joint. Also disclosed are methods of preventing, treating, or diagnosing a disease of bone, cartilage, bone marrow, or a joint in a subject, involving administering to the subject a pharmaceutically effective amount of the material of the present invention.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: December 23, 2014
    Assignees: The Board of Regents of the University of Texas System, Waseda University
    Inventors: Keitaro Sou, Shinji Takeoka, Eishun Tsuchida, Beth A. Goins, William T. Phillips
  • Patent number: 8916136
    Abstract: Disclosed are apparatuses for detecting glucose levels in a subject. The apparatuses include a glucose sensor coupled with an anti-inflammatory module. The apparatus is configured to monitor blood glucose by detecting the fluorescence generated by the sensor and simultaneously reduce the tissue inflammation reaction. Also disclosed are biosensor systems including the apparatuses and methods of using the biosensor systems.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: December 23, 2014
    Assignee: Indian Institute of Technology Bombay
    Inventors: Rohit Srivastava, Ayesha Chaudhary, Rahul Dev Jayant
  • Patent number: 8889163
    Abstract: Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polmers to a solid support. Utility as a contact disinfectant is disclosed.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: November 18, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein
  • Patent number: 8883133
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 11, 2014
    Assignee: Valorisation-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8877158
    Abstract: It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent to accumulate in the neovascular site. The present invention provides a targeting agent to a neovascular site, which comprises a gelatin-like protein.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: November 4, 2014
    Assignees: FUJIFILM Corporation, Kyoto University
    Inventors: Kentaro Nakamura, Yasuhiko Tabata
  • Patent number: 8877163
    Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: November 4, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Chih-Wei Chiu, Gin-Chung Liu
  • Patent number: 8871180
    Abstract: This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO43?) or carbonate ion (CO32?), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: October 28, 2014
    Assignee: Japan Science and Technology Agency
    Inventors: Kazunori Kataoka, Michiaki Kumagai, Keisuke Aikawa
  • Patent number: 8871182
    Abstract: The invention relates to nanocrystals, containing one or more metals as defined in the specification; having a size of 2 to 200 nm; having a defined, three-dimensional polyhedral structure, optionally functionalized by ligands and/or embedded crystals. The invention further relates to monodisperse assemblies of such nanocrystals, to formulations and devices comprising such nanocrystals as well as to the manufacture and use thereof.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: October 28, 2014
    Assignee: Eth Zurich
    Inventors: Christophe Jan Lacroix, Christophe Chassard, Marcus Yaffee
  • Patent number: 8809283
    Abstract: The invention relates to methods and compositions for inhibiting proteasome activity using cinnamate compounds. These cinnamate compounds can be formulated for topical or systemic use for skin disorders such as psoriasis.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: August 19, 2014
    Assignee: Natuderm, LLC
    Inventor: Jack Arbiser
  • Patent number: 8784846
    Abstract: Systems and methods for enhancing the selective targeting of agents for preferential action at a target with reduced action with healthy tissue distal the target tissue. One or more agents can be combined with nano scale structures/particles for delivery to the target tissue. Appropriate bombardment with accelerated particle radiation, such as proton radiation, induces the release of the agents at the target site. Nano carriers can be combined with therapeutic and/or imaging enhancement agents. Imaging of the target tissue can provide a verification of the delivered dose of particle radiation. Nanocarriers can be provided with an outer shell selected for biocompatibility and durability in the in vivo environment and further selected to provide a feedback mechanism in the treatment environment to accelerate the release of the agent and reduce a total radiation dose needed for that release.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: July 22, 2014
    Assignee: Loma Linda University Medical Center
    Inventors: Reinhard Schulte, Gilmer Valdes-Diaz
  • Patent number: 8784792
    Abstract: A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: July 22, 2014
    Assignee: Valorization-Recherche Limited Partnership
    Inventors: Jean-Christophe Leroux, Mohamad Nasser Eddine
  • Patent number: 8771642
    Abstract: Nanoparticles, which are luminescent and/or electroactive and/or suitable for MRI (magnetic resonance imaging and/or PET (positron emission tomography) applications, comprise a micelle, which has a hydrophilic shell and an hydrophobic central portion, and a polysilicate core; the micelle comprises a plurality of molecules of a functionalized surfactant having the following structure: M1-Hydro1-Lipo-Hydro2-M2 wherein Lipo indicates a hydrophobic chain; Hydro1 ed Hydro2 indicate, each, a respective hydrophilic chain; M1 ed M2 represent respective recognition functionalities.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: July 8, 2014
    Assignee: Alma Mater Studiorum—Universita' Di Bologna
    Inventors: Sara Bonacchi, Riccardo Juris, Marco Montalti, Luca Prodi, Enrico Rampazzo, Nelsi Zaccheroni
  • Patent number: 8758778
    Abstract: The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nano-carriers that are degraded by lower pH and/or ROS.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: June 24, 2014
    Assignee: The Regents of the University of California
    Inventors: Adah Almutairi, Jagadis Sankaranarayanan, Enas Mahmoud, Eric Schopf
  • Patent number: 8715737
    Abstract: The present invention relates a method to make porous materials which are useful in pharmaceutical, medicine, industry, and agriculture. The most advantage of the porous materials is to provide extremely large surface area for further modification and to incorporate a bioactive reagent in a mild condition to make the porous materials bioactive, biocompatible and biodegradable.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: May 6, 2014
    Inventor: Zhuo Joe Zhang
  • Patent number: 8586062
    Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more taxane derivative, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: November 19, 2013
    Assignee: Sun Pharma Advanced Research Company Ltd.
    Inventors: Ajay Jaysingh Khopade, Subhas Balaram Bhowmick, Natarajan Arulsudar
  • Patent number: 8535644
    Abstract: Techniques are provided to produce and use non-spherical colloidal particles with independently tuned size, shape, flexibility, and chemical properties. A pre-polymer mixture for forming hydrogel particles includes a percentage of PEGDA selected to impart a target stiffness to the particles and includes, a percentage of acrylic acid selected to impart an independent target chemical function to the particles. The mixture also includes a percentage of photo-initiator to polymerize PEGDA upon exposure to a light source to impart an independently selected target size or shape or both to the particles.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: September 17, 2013
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Ramin Haghgooie, Patrick Seamus Doyle, Mehmet Toner, Daniel Colin Pregibon
  • Patent number: 8530526
    Abstract: A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, a method of coating the device with the composition, and an implantable device coated with the composition are provided.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: September 10, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Stephen D. Pacetti
  • Patent number: 8512755
    Abstract: A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: August 20, 2013
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Kimihiro Susumu, Michael H. Stewart
  • Patent number: 8501201
    Abstract: Disclosed is a topical powder composition useful for improving rough or hard feet on the human skin comprising magnesium sulfate, vitamins, melaleuca alternifolia, biodegradable surfactants, sodium carbonate, water, fragrance, propylparaben, propylene glycol, may also contain one or more FD&C colors.
    Type: Grant
    Filed: March 3, 2012
    Date of Patent: August 6, 2013
    Inventor: Tami Dion Harrison