Patents Examined by Lara E. Chapman
  • Patent number: 5310539
    Abstract: The present invention involves an image-enhancing agent comprising melanin combined with an essentially non-dissociable signal-inducing metal. The signal-inducing metal has an association constant for its melanin combination of at least about 10.sup.20. Upon suspension or dissolution in water the metal remains undissociated. A preferred signal-inducing metal is paramagnetic or superparamagnetic, of course for magnetic resonance imaging. A preferred paramagnetic or superparamagnetic metals are gadolinium, iron, nickel, copper, erbium, europium, praseodymium, dysprosium, holmium, chromium or manganese. Gadolinium is the most effective metal. The metal is incorporated into the melanin in an ionic or particulate form. Metals may be utilized which are particularly useful to modify ultrasound images by the enhancement of the image obtained from emission and detection of high-frequency soundwaves. Metals emitting gamma particles may also be utilized to enhance images resulting from gamma particle emission scanning.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: May 10, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventor: Robert F. Williams
  • Patent number: 5310535
    Abstract: A group of functionalized polyaminocarboxamide modified chelators that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: May 10, 1994
    Assignees: The Dow Chemical Company, The University of Texas
    Inventors: William J. Kruper, Jr., William A. Fordyce, A. Dean Sherry
  • Patent number: 5310912
    Abstract: An iodinated neuroprobe is provided for mapping monoamine reuptake sites. The iodinated neuroprobe is of the formula: ##STR1## wherein R=a C.sub.n H.sub.2n+1 group where n=0-6, an alkenyl group, a monofluoroalkyl group including .sup.n F where n=18 or 19, or a .sup.m C.sub.n H.sub.2n+1 group where n=1-6 and where m=11 or 14 for at least one .sup.m C;R'=a C.sub.n H.sub.2n+1 group where n=0-6, a p-iodophenylmethyl group, a p-iodophenylethyl group, a phenylmethyl group, or a phenylethyl group;X=an isotope of F, an isotope of Cl, an isotope of Br, an isotope of I, CH.sub.3, or Sn(R".sub.1 R".sub.2 R".sub.3);R".sub.1 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.2 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group;R".sub.3 =a C.sub.n H.sub.2n+1 group where n=1-6, or an aryl group; andY=H only if X is an isotope of I, or R' is a p-iodophenylmethyl group, or R' is a p-iodophenylethyl group, else Y=an isotope of I.Related analogs are also provided.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: May 10, 1994
    Assignee: Research Biochemicals Limited Partnership
    Inventors: John L. Neumeyer, Richard A. Milius, Robert B. Innis
  • Patent number: 5308605
    Abstract: A method or the treatment and diagnosis of tumors is disclosed. This method comprises the administration of an effective amount of a radiohalogenated pyrimidine nucleoside to the tumor affected site.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: May 3, 1994
    Assignee: The President and Fellows of Harvard College
    Inventors: Amin I. Kassis, S. James Adelstein
  • Patent number: 5300281
    Abstract: Radioactive compositions containing a calcific matrix and methods for using the compositions for therapeutic radiation treatment including rheumatoid arthritis are disclosed.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: April 5, 1994
    Assignee: The Dow Chemical Company
    Inventors: Kenneth McMillan, Jaime Simon
  • Patent number: 5290937
    Abstract: Novel compounds, useful as radiolabeling reagents, including an alkoxy group on the phenyl ring and having the formula ##STR1## wherein X is a radionuclide are disclosed. The invention further includes novel radiohalogenated proteins as well as processes for preparing such reagents and radiohalogenated proteins.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Frank P. Tomasella
  • Patent number: 5290537
    Abstract: Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: March 1, 1994
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Dennis A. Moore, Rebecca A. Wallace
  • Patent number: 5286853
    Abstract: A gadolinium (3.sup.+) complex of polyamine polyacetate, comprising a polyamine nucleus having a pendant boron-containing substituent on one of the nitrogen or carbon atoms of the polyamine nucleus. The boron-gadolinium compound may suitably be of the formula: ##STR1## wherein: is a polyamine coordination structure capable of covalently bonding the substitutents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and of complexing with Gd;R.sub.1, R.sub.2, and R.sub.3 are independently selected from carboxyl, carboxylic salt groups, carboxylic ester groups, and carboxylate anion;R.sub.4 is a boron-containing group; andx is a number from zero to 4.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: February 15, 1994
    Assignee: Boron Biologicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood
  • Patent number: 5277894
    Abstract: The invention relates to a method of detecting an Fc receptor-expressing tumor site in an individual by administering to the individual a diagnostically effective amount of detectably-labeled non-specific immunoglobulin or Fc or Fc' fragment thereof, wherein the immunoprotein substantially accumulates at the site when the site bears such a tumor. By using a therapeutically-labeled specific or non-specific immunoglobulin or Fc or Fc' fragment thereof, the tumor may be treated therapeutically.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: January 11, 1994
    Assignee: The General Hospital Corporation
    Inventors: H. William Strauss, Robert H. Rubin, Ban A. Khaw, Faina Shtern
  • Patent number: 5273738
    Abstract: A method of selectively delivering radiation homogeneously to lymphoid and marrow tissues in vivo including the step of administering an effective dose of a radiolabeled immunological binding partner of a T-200 antigen to a patient is disclosed. Also disclosed are immunological binding partners and compositions based thereon for carrying out the method.
    Type: Grant
    Filed: March 3, 1990
    Date of Patent: December 28, 1993
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Dana C. Matthews, Irwin D. Bernstein, John A. Hansen, Fred R. Appelbaum, Claudio Anasetti, Paul J. Martin