Patents Examined by Lawrence Crane
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Patent number: 6911435Abstract: Adenosine and active agent which interact with the adenosine system are used to treat conditions of weakened, immune system, as an anti-cancer therapy and for improving the therapeutic index of a variety of therapeutic drugs.Type: GrantFiled: July 10, 1998Date of Patent: June 28, 2005Assignee: Can-Fite Biopharma Ltd.Inventors: Ilan Cohn, Pnina Fishman
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Patent number: 6822089Abstract: Methods for preparing deoxynucleosides from their corresponding ribonucleosides by forming 3-tert-butylphenoxythiocarbonylderivatives of the ribonucleosides and subsequently effecting radical deoxygenation reactions at the carbon atoms to be deoxygenated.Type: GrantFiled: March 29, 2000Date of Patent: November 23, 2004Assignee: ISIS Pharmaceuticals, Inc.Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
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Patent number: 6797521Abstract: The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.Type: GrantFiled: March 15, 2002Date of Patent: September 28, 2004Assignee: University of Utah Research FoundationInventors: Charles B. Grissom, Frederick G. West, James McGreevy, Joel S. Bentz, Michelle J. Cannon
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Patent number: 6765089Abstract: This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.Type: GrantFiled: March 20, 2000Date of Patent: July 20, 2004Assignee: Alchemia Pty LtdInventors: Istvan Toth, Gyula Dekany, Barry Kellam
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Patent number: 6706691Abstract: The present invention is directed to immunosupportive, drug sparing diets and methods of using these diets. The compositions and methods disclosed herein increase the bioavailability of pharmaceutical compositions metabolized by the gut P450 isozymes.Type: GrantFiled: July 15, 1998Date of Patent: March 16, 2004Assignees: Board of Regents, The University of Texas System, Rice UniversityInventors: Charles T. Van Buren, Fred Rudolph
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Patent number: 6680302Abstract: The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes the step of determining the level of one or more 6-mercaptopurine metabolites in the patient having an immune-mediated gastrointestinal disorder.Type: GrantFiled: December 27, 2001Date of Patent: January 20, 2004Assignee: Hospital Sainte-JustineInventors: Ernest G. Seidman, Yves Théorêt
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Patent number: 6602990Abstract: A process for the production of a porous cross-linked polysaccharide gel and a gel obtainable by the following steps: a) preparing a solution or dispersion of the polysaccharide; b) adding a bifunctional cross-linking agent having one active site and one inactive site to the solution or dispersion from step a); c) reacting hydroxylgroups of the polysaccharide with the active site of the cross-linking agent; d) forming a polysaccharide gel; e) activating the inactive site of the cross-linking agent; f) reacting the activated site from step e) with hydroxylgroups of the polysaccharide gel, whereby cross-linking of the gel takes place. The cross-linked polysaccharide gel obtained can further be cross-linked by conventional methods, one or several times.Type: GrantFiled: May 11, 1999Date of Patent: August 5, 2003Assignee: Amersham Biosciences ABInventor: Hans Berg
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Patent number: 6600028Abstract: Nucleoside analogues have structure (2) wherein Q is H or a sugar moiety or sugar analogue or a modified sugar or a nucleic backbone or backbone analogue, W is an alkylene or alkenylene chain of 0-5 carbon atoms, any of which may carry a substituent R8, X is O or N or NR12 or CR10, X′ is O or S or N, provided that when X′ is O or S, then X is C, Y is CH or N, R6 is NH2 or SMe or SO2Me or NHNH2, each of R7 and R8 is independently H or F or alkyl or alkenyl or aryl or acyl or a reporter moiety, R12 is independently H or alkyl or alkenyl or aryl or acyl or a reporter moiety, and R10 is H or ═O or F or alkyl or aryl or a reporter moiety.Type: GrantFiled: February 1, 2000Date of Patent: July 29, 2003Assignee: Amersham Pharmacia Biotech UK LimitedInventors: Daniel Brown, David Loakes, David Williams, Fergal Hill, Shiv Kumar, Satyam Nampalli, Mark McDougall, Alan Hamilton, Clifford Smith, Adrian Christopher Simmonds, William Jonathan Cummins, Patrick Finn
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Patent number: 6455506Abstract: The present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds. In one embodiment, the present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds selected from the group consisting of compounds having a formula selected from the following: wherein R2, R4, R5, R6, and R7 are independently the same or different and independently selected from the group consisting of: —H, —F, —Cl, —Br, —I, —NO2, —N(R8)2, —OR8, —SR12, and —CF3, wherein R8 is independently —H or an alkyl group having 1-6 carbon atoms and wherein R12 is independently —H or a hydrocarbyl group having 1-10 carbon atoms; and, R9, R10 and R11 are independently the same or different and are H or a hydroxyl protecting group; anomeric and optical isomers thereof; and, pharmaceutically acceptable salts and prodrug derivatives thereof.Type: GrantFiled: July 29, 1998Date of Patent: September 24, 2002Assignee: SmithKline Beecham CorporationInventors: Leroy B. Townsend, John C. Drach