Patents Examined by Liban M Hassan
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Patent number: 10407653Abstract: A photobioreactor system includes vessel for containing a biomass and a plurality of illuminators which may have solid state devices embedded therein or coupled thereto. The light energy is distributed in the vessel volume by the illuminators so as to reach substantially all of the biomass being circulated in the vessel. Biomass may exit the top of the vessel and be refreshed with nutrients and liquid before being reintroduced at the bottom of the vessel. Carbon dioxide is introduced at the bottom of the vessel. The biomass may be agitated either ultrasonically or by motion of the illuminators. A source of energy for the light sources may be solar panels with battery storage and the carbon dioxide may be a byproduct of thermal power generation.Type: GrantFiled: January 30, 2014Date of Patent: September 10, 2019Assignee: Wayne State UniversityInventors: Gregory Auner, Michelle A. Brusatori, Joseph M. Smolinski, David J. Sant
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Patent number: 10306882Abstract: A biological sample vitrification carrier and a method for freezing a biological sample are provided. Specifically, the carrier comprises a main body and a sealing cap that form a sealed frozen sample placing region. Frozen liquid circulating in a liquid circulating channel in the main body contacts with an outer surface of the frozen sample placing region and cools a biological sample in the frozen sample placing region. The biological sample vitrification carrier and the method in the present invention have the advantages of safety, nontoxicity and high vitrification and rewarming operation efficiency and have wide application prospects in the field of biological sample freezing.Type: GrantFiled: April 9, 2014Date of Patent: June 4, 2019Inventors: Wei Lou, Yanping Kuang
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Patent number: 10301584Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.Type: GrantFiled: April 17, 2014Date of Patent: May 28, 2019Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Gordana Vunjak-Novakovic, Sarindr Bhumiratana, Keith Yeager
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Patent number: 10286397Abstract: The invention relates to a pressing arrangement for a cover, in particular in a laboratory thermostat, having at least: a first component disposed to exert an excitation force, a second component, in particular a plate component disposed to exert a pressing force Fz in at least one target position, a transmission device disposed for transmitting force from the first component to the second component, characterized in that the transmission device comprises a transmission component disposed to be driven by the first component and to drive the second component, and the transmission device comprises at least one elastic tensioning member disposed to be driven by the first component so as to change its tension and to drive the transmission component, and the transmission device or the transmission component causes the setting of the pressing force Fz in dependence on the target position. The invention further relates to a corresponding method for pressuring.Type: GrantFiled: February 21, 2012Date of Patent: May 14, 2019Inventors: Gregor Bechmann, Lutz Timmann, Manuel Petzold, Stefan Roth, Arne Schafrinski
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Patent number: 10245368Abstract: The present invention relates to the field of bio-artificial liver technology. Particularly, the invention provides an integrated hybrid bio-artificial liver support system that provides the features of artificial liver assist devices with that of bio-artificial liver support systems.Type: GrantFiled: July 29, 2016Date of Patent: April 2, 2019Assignee: INDIAN INSTITUTE OF TECHNOLOGY, KANPURInventors: Ashok Kumar, Apeksha Damania
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Patent number: 10214712Abstract: An apparatus for receiving and processing organic waste by anaerobic bioconversion comprising a closed tank which is the bioconversion site, provided in the top portion thereof with a gasometric bell for storing and pressurizing the biogas produced, around which the external members of the apparatus are distributed on a pod which also forms the support for a body of the digester. The tank, in a preferred embodiment, comprises a main enclosure which is the bioconversion site, and a secondary central enclosure called the crop, intended to receive and store the organic waste to be processed before the dosing of same into the main enclosure to complete the bioconversion. The crop forms a removable subassembly that can be configured in different ways, with a circulation and distribution block on which it is secured and with a liquid-solid phase separator which is mounted over same.Type: GrantFiled: July 30, 2013Date of Patent: February 26, 2019Inventor: Francois-Regis Mahrer
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Patent number: 10150973Abstract: The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism. The apparatus and the method for fermenting, separating, and refining, of the present invention, can separate and refine the product that is produced by microbial fermentation in a simple, continuous manner and with high efficiency.Type: GrantFiled: April 13, 2012Date of Patent: December 11, 2018Assignee: GS CALTEX CORPORATIONInventors: Sang-Hyun Lee, Moon-Ho Eom, Julia Lee, Sang-Jun Jeon, Jung-Hee Cho, Jin Dal Rae Choi
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Patent number: 10130748Abstract: This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.Type: GrantFiled: March 12, 2010Date of Patent: November 20, 2018Assignee: Mayo Foundation for Medical Education and ResearchInventors: Scott L. Nyberg, Stephen M. Corner, Bruce Amiot
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Patent number: 10119965Abstract: The present invention relates to devices for conducting microorganism or toxin detection. More particularly, the invention relates to portable, pre-packaged devices that are suitable for culturing microorganisms, aliquoting predetermined volumes of testing samples, and conducting microorganism or toxin detection based on immunological reactions using samples of considerable size collected at remote sites away from testing laboratories.Type: GrantFiled: September 28, 2010Date of Patent: November 6, 2018Assignee: FUNDACION GAIKERInventors: Jose Luis Gondra Zubieta, Paloma Aldamiz-Echebarria Zulueta, Javier Escobal Gonzalo, Miren Garbine Olabarria De Pablo, Armando Cruz Llosa, Jesus Berganza Granda, Brigitte Michele Jacqueline Sauvage
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Patent number: 10119151Abstract: Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.Type: GrantFiled: December 11, 2013Date of Patent: November 6, 2018Assignee: Brigham Young UniversityInventors: Quentin T. Aten, Larry L. Howell, Brian D. Jensen, Sandra Burnett
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Patent number: 10114020Abstract: A device for analyzing an analyte in a sample includes a first substrate, a second substrate, a fluidic channel, an inlet port and an outlet port. Each of the first substrate and the second substrate has an inner surface and an outer surface, the inner surface of the first substrate forming, at least in part, the lower wall of the fluidic channel, and the inner surface of the second substrate forming, at least in part, the upper wall of the fluidic channel. The fluidic channel is connected to the inlet port and the outlet port. The fluidic channel includes a reagent region and a detection region, at least a portion of the reagent region being coated with one or more dried reagents. The device further includes a wicking pad located on the outer surface of the second substrate, the wicking pad being positioned at a pre-determined distance from the outlet port.Type: GrantFiled: March 15, 2013Date of Patent: October 30, 2018Assignee: MBio Diagnostics, Inc.Inventors: John S. Dunn, Jeffrey T. Ives, Michael J. Lochhead, Kurt R. Vogel, Keagan B. Rowley
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Patent number: 10106766Abstract: The present invention provides a microfluidic bio-reactor device, which comprises: a first cell culture layer; a microfluidic base, which is located on the top of the first cell culture layer; a microfluidic layer, which is located on the top of the microfluidic base and have an air-bubble removal device; a microfluidic roof, which is located on the top of the microfluidic layer; the present invention also provides a method for culturing cells by the microfluidic bio-reactor device of the present invention and the kit with a cell-loading device and present microfluidic bio-reactor device.Type: GrantFiled: April 8, 2015Date of Patent: October 23, 2018Assignee: NATIONAL YANG-MING UNIVERSITYInventors: Oscar Kuang-Sheng Lee, Meng-Hua Yen, Shu-Wen Kuo
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Patent number: 10023897Abstract: A biosensor chip is placed in a biosensor device and is rotated while a biochemical analysis specimen is measured, the biosensor chip comprising a main body, a holding chamber, a dispensing chamber, a plurality of quantification chambers, and a plurality of measurement chambers. The main body has an inlet into which the specimen is poured. The holding chamber holds the poured specimen inside the main body. The dispensing chamber is connected to the holding chamber via a first channel and dispenses the specimen. The quantification chambers are connected to the dispensing chamber, hold a specific amount of the dispensed specimen, and are disposed at positions located away from a rotational center of a rotary motion according to a distance from the first channel. The measurement chambers are connected to the quantification chambers via a second channel and react the specimen with a biochemical analysis reagent.Type: GrantFiled: September 30, 2014Date of Patent: July 17, 2018Assignee: PHC HOLDINGS CORPORATIONInventors: Kazuyoshi Mori, Masahiro Kouge, Fumihisa Kitawaki, Takako Matsumura, Seiji Onishi
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Patent number: 9885729Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.Type: GrantFiled: September 4, 2015Date of Patent: February 6, 2018Assignee: Theranos IP Company, LLCInventors: Alexander Loo, Elizabeth A. Holmes
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Patent number: 9868095Abstract: A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.Type: GrantFiled: January 10, 2008Date of Patent: January 16, 2018Assignee: Finesse Solutions, Inc.Inventors: Mark Selker, Barbara Paldus
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Patent number: 9850458Abstract: There is provided a bioreactor which is provided with a lid (13) that facilitates access to the incubation cavity. Specifically the end wall of the incubation cavity is constituted by the lid (13) so that removal of the cap renders the incubation cavity fully accessible.Type: GrantFiled: December 7, 2011Date of Patent: December 26, 2017Assignee: DRUGMODE APSInventors: Stephen John Fey, Krzysztof Wrzesinski
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Patent number: 9834806Abstract: A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.Type: GrantFiled: June 25, 2009Date of Patent: December 5, 2017Assignee: HITACHI PLANT SERVICES CO., LTD.Inventors: Hideyuki Noda, Masahiro Okanojo, Kenko Uchida, Norihito Kuno