Patents Examined by Lisa Cook
  • Patent number: 9952229
    Abstract: Subject of the present invention are assays and in vitro methods for the prediction of the risk of a subject for contracting metabolic syndrome and/or diabetes mellitus and for diagnosing metabolic syndrome, comprising determining the level of arginine vasopressin pro-hormone or fragments thereof in a sample of a subject.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: April 24, 2018
    Assignees: B.R.A.H.M.S. GmbH, The General Hospital Corporation
    Inventors: Joachim Struck, Andreas Bergmann, Olle Melander, Christopher Newton-Cheh, Thomas Wang
  • Patent number: 9910052
    Abstract: Markers useful in diagnosing disseminated intravascular coagulation (DIC) or infectious DIC are provided. In a method for detecting DIC of the present invention, sCD14-ST in a sample is measured. In a method of detecting infectious DIC of the present invention, sCD14-ST and a coagulation-related marker in a sample are measured.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 6, 2018
    Assignees: LSI MEDIENCE CORPORATION, FUKUOKA UNIVERSITY
    Inventor: Hiroyasu Ishikura
  • Patent number: 9851357
    Abstract: The present invention relates to an in vitro method for the prognosis of survival of a patient suffering from a solid cancer, comprising the quantification of the cell density of CD8+ cells and DC-LAMP+ dendritic cells present in a tumor tissue sample from said patient, wherein a high density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has a favorable prognosis, a high density of CD8+ cells and a low density of DC-LAMP+ dendritic cells indicates that the patient has a poor prognosis, and a low density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has the worst prognosis.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 26, 2017
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS6), ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
    Inventors: Catherine Sautes-Fridman, Wolf-Herve Fridman, Marie-Caroline Dieu-Nosjean, Jeremy Goc
  • Patent number: 9835528
    Abstract: A sample preparation device and associated method is provided for preparing samples according to an assay protocol. A cell deposition module deposits a sample on each of a plurality of assay devices supported by a support device. An epitope retrieval module deposits a reagent on each of the samples. Each of the samples is brought to a selected temperature. A heating device, corresponding to each of the assay devices, directly interacts with the corresponding assay device and may be used to heat each assay device to the selected temperature, in conjunction with the epitope retrieval module depositing the reagent on each of the samples. A staining module deposits a staining reagent on each of the samples, and removes excess staining reagent. The staining, epitope retrieval, and cell deposition modules cooperate with the support device and heating devices to form a unitary sample preparation device.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: December 5, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: William Alan Fox, Ryan Carl Williams, Brian Reuben Langhoff
  • Patent number: 9823258
    Abstract: Method of diagnosis and prognosis of contrast media induced nephropathy (CIN) including the steps of i) taking a urine sample from a patient exposed to the application of contrast media, notably patients subjected to coronary angiography; ii) assessing the level of vitamin D binding protein (VDBP) in the urine sample obtained in step (i); iii) relating the urinary vitamin D binding protein level determined in step (ii) to a pre-selected threshold level. A urinary vitamin D binding protein level higher than the pre-selected threshold level indicates that the patient is at risk of renal failure and in need of a dialysis treatment.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: November 21, 2017
    Assignee: Immundiagnostik AG
    Inventors: Franz Paul Armbruster, Berthold Hocher
  • Patent number: 9823239
    Abstract: The invention relates to a process for determining the susceptibility to nosocomical infections in a patient, comprising the measurement of the expression of sCD127 in a biological sample.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: November 21, 2017
    Assignees: HOSPICES CIVILS DE LYON, BIOMERIEUX
    Inventors: Alain Lepape, Fabienne Venet, Astrid Villars, Guillaume Monneret
  • Patent number: 9810697
    Abstract: The invention relates to biomarkers associated with Diabetes, including protein and lipid metabolite biomarkers, methods of using the biomarkers to determine the risk that an individual will develop Diabetes, and methods of screening a population to identify persons at risk for developing Diabetes and other pre-diabetic conditions.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: November 7, 2017
    Assignee: True Health IP, LLC
    Inventors: Michael P. McKenna, Steve M. Watkins
  • Patent number: 9804160
    Abstract: The subject invention pertains to materials and methods for the classification of cancers as sensitive or resistant to treatments based on protein-protein interactions, treatment of cancer, identification of biomarkers, identification of protein-protein interaction modulators, and selection of cancer treatments.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: October 31, 2017
    Assignee: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
    Inventor: Eric B. Haura
  • Patent number: 9802193
    Abstract: A system and method for capturing and analyzing cells comprising: a fluid delivery module; a reservoir configured to receive a biological sample including a target cell population and at least one fluid from the fluid delivery module; a manifold configured to receive and distribute the biological sample and at least one fluid from the reservoir into a cell capture device; a waste chamber configured to couple to the manifold; and a pump configured to couple to the waste chamber. In embodiments of the system configured to promote further purification of captured cells, the system can further comprise a magnet that enables further separation of captured cells from undesired sample materials. The system can additionally further comprise a heater configured to heat at least one fluid and/or biological sample, and a cell capture device configured to couple to the manifold, in order to facilitate capture of the target cell population.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: October 31, 2017
    Assignee: DeNovo Sciences, Inc.
    Inventors: Kalyan Handique, Kyle Gleason, Austin Payne, Priyadarshini Gogoi, Saedeh Sepehri Javdani, Christopher Siemer, Yi Zhou
  • Patent number: 9797902
    Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: October 24, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: David King, William F. Link, Renato del Rosario, Michael Leos
  • Patent number: 9797900
    Abstract: Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (CICs) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which the drug had been administered at least once for determining the weight/size of the immune complexes, optionally a second non-SEC chromatography, and at least one immunoassay, whereby the immune complex is characterized by the correlation of the immune complex size and the immunoassay result/read-out. Also reported herein is the use of a method as reported herein for determining a correlation to altered pharmacokinetics, for determining loss or reduction of efficacy, for determining neutralization of natural counterparts of the drug, for determining immune and hypersensitivity reactions, including serum sickness/type III hypersensitivity reaction/immune complex-mediated disease.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: October 24, 2017
    Assignee: F. HOFFMAN-LA ROCHE AG
    Inventors: Uwe Dahl, Gregor Jordan, Roland Staack
  • Patent number: 9784750
    Abstract: The present invention relates to using 72 kDa type IV collagenase:Metalloproteinase inhibitor 2 complex as a prognostic biomarker in renal injuries.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: October 10, 2017
    Assignee: ASTUTE MEDICAL, INC.
    Inventors: Joseph Anderberg, Jeff Gray, Paul Mcpherson, Kevin Nakamura, James Patrick Kampf
  • Patent number: 9766165
    Abstract: An automated microscope slide staining system and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments or a pressurizable common chamber for individually and independently processing a plurality of microscope slides. The apparatus preferably features independently movable slide support elements each having an individually operable heating element.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 19, 2017
    Inventor: Lee H. Angros
  • Patent number: 9753039
    Abstract: The present invention is in the field of clinical diagnostics. Particularly the present invention relates to the prognosis of adverse events in patients with stable chronic heart failure or being suspected of having stable chronic heart failure by determination of the level of Procalcitonin (PCT).
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: September 5, 2017
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Joachim Struck, John GF Cleland
  • Patent number: 9739785
    Abstract: A method of analyzing protein-protein interactions at a single molecular level is disclosed.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: August 22, 2017
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventor: Tae-Young Yoon
  • Patent number: 9733255
    Abstract: A method of analyzing protein-protein interactions includes binding the first proteins to the substrate where the first proteins are tagged with the first markers which bind specifically to the biomolecules immobilized on the substrate or the first proteins bind specifically to the biomolecules immobilized on the substrate; incubating the substrate bound first proteins with cell lysate containing the second proteins which are tagged with second markers; analyzing the interactions between the first proteins and the second proteins in the cell lysate, and obtaining the first analytic value representing the kinetic picture of the interactions; incubating the substrate bound first proteins with cell lysate mixture of a cell lysate consisting of the second markers-tagged second proteins and another cell lysate comprising other proteins including unlabelled second proteins and obtaining the second analytic value; comparing and analyzing the first and the second analytic values.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: August 15, 2017
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventor: Tae-Young Yoon
  • Patent number: 9726605
    Abstract: The invention is directed to a fluorescence immunochromatography method carried out by illuminating a fluorescent substance in a membrane with excitation light and detecting fluorescence emitted from the fluorescent substance, by applying a sample to a test strip having a membrane and a transparent film attached to the surface of the membrane, wherein the transparent film satisfies Formula (1) Formula (1) nFf>nWf (nFf: refractive index of transparent film at wavelength ?f of the fluorescence) (nWf: refractive index of analyte liquid at wavelength ?f of the fluorescence), and wherein the membrane contains a fluorescent labeling reagent which binds to target substance contained in the sample; binding the fluorescent labeling reagent to the target substance; immobilizing the fluorescent labeling reagent bound to the target substance in the membrane; detecting the presence of target substance.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 8, 2017
    Assignee: FURUKAWA ELECTRIC CO., LTD.
    Inventors: Hideki Aizawa, Michio Ohkubo
  • Patent number: 9724262
    Abstract: This invention provides methods of diagnosing and treating syndromes of reversion to fetal consciousness in a neonate.
    Type: Grant
    Filed: May 1, 2016
    Date of Patent: August 8, 2017
    Assignee: The Regents of the University of California
    Inventors: John E. Madigan, Monica R. Aleman
  • Patent number: 9719988
    Abstract: Methods and compositions are provided for detection of biological substances in nasal specimen.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: August 1, 2017
    Assignee: Cyrano Therapeutics, Inc.
    Inventor: Robert I. Henkin
  • Patent number: 9708661
    Abstract: The present invention relates to methods, monitors and systems, useful, for example, for advanced detection of sepsis in a subject.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: July 18, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Song Shi, Richard L. Moore, James Garrett