Abstract: The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
Type:
Grant
Filed:
September 27, 2000
Date of Patent:
March 4, 2003
Assignee:
Genset, S.A.
Inventors:
Marta Blumenfeld, Ilya Chumakov, Lydie Bougueleret, Annick Cohen