Patents Examined by Louise Humphrey
  • Patent number: 10227559
    Abstract: The present invention provides a compounded cell culture medium powder formulation comprising: a basal medium powder and a cell culture media supplement, wherein the cell culture media supplement comprises and one or more salts; one or more growth factors; one or more inorganic ions; an amino acid supplement comprising one or more of asparagine, glutamine, histidine, and serine; one or more buffers; and one or more anti-foaming agents. The invention further provides methods of making a compounded cell culture medium powder formulation methods of making a cell culture medium for growing mammalian cells and methods of producing a protein of interest by culturing cells in the cell culture medium and isolating the protein of interest.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 12, 2019
    Assignee: Bayer HealthCare LLC
    Inventors: Yuval Shimoni, Volker Möhrle
  • Patent number: 10201514
    Abstract: There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid particles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there are provided lipid particles encapsulating a lipid containing unsaturated fatty acids, and foods, cosmetics, and animal feeds comprising said lipid particles added thereto. Artificially treated microorganisms or microorganisms collected from nature are grown on a solid medium, and microbial strains that form lipid particles at the periphery of the colonies and/or microbial strains that, when cultured in a transparent liquid medium, make the culture liquid cloudy are selected.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: February 12, 2019
    Inventors: Kengo Akimoto, Hiroshi Kawashima, Sakayu Shimizu
  • Patent number: 10179163
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: January 15, 2019
    Inventor: F. Nicholas Franano
  • Patent number: 10151185
    Abstract: The use of coal fields as subsurface bioreactors for producing sustainable methane gas from terrestrial sources of biomass is described. Microbial presence is determined for a target coal formation, and tracers are injected to determine permeability, porosity, volume, and minimum and a maximum material injection rates. At least one injection well and at least one circulation well effective for generating an injection rate between the minimum and maximum injection rates are provided for injecting a solution of biodegradable materials into the coal seam. A chosen quantity of biodegradable materials is allowed to be digested, fermented and converted by microbial action within the coal seam. Methane gas is extracted through producing and injecting wells, although pumping will enhance gas recovery.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: December 11, 2018
    Assignee: University of Wyoming
    Inventors: Michael A. Urynowicz, Song Jin
  • Patent number: 10131928
    Abstract: Disclosed is a method of preparing pure or substantially pure D-myo-inositol-3-phosphate from glucose-6-phosphate and/or fructose-6-phosphate. The method may also be applied to protected and/or derivative forms of glucose-6-phosphate and/or fructose-6-phosphate so as to form protected/derivative forms of D-myo-inositol-3-phosphate, for use in further chemical reactions. The enzyme D-myo-inositol-3-phosphate synthase (INO1) is contacted with the glucose-6-phosphate and/or fructose-6-phosphate to generate labeled or unlabeled, protected or unprotected D-myo-inositol-3-phosphate, which may be further reacted and/or purified.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: November 20, 2018
    Inventor: Terry K. Smith
  • Patent number: 10123965
    Abstract: The present disclosure provides formulations, methods and devices for periorbital skin rejuvenation. A periorbital skin serum in accordance with the present disclosure comprises squalane (sugarcane derived), vitamin E (tocopheryl acetate), vitamin C (tetrahexyldecyl ascorbate), and ubiquinone (coenzyme Q10, oxidized form).
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: November 13, 2018
    Assignee: YOUNIQUE, LLC
    Inventor: Mukhtar Siddiqui
  • Patent number: 10125340
    Abstract: Certain embodiments and aspects relate to a photobioreactor including encapsulating photobioreactor units (EPU) within which a liquid medium and a gas are encapsulated. The liquid medium comprises at least one species of phototrophic or mixotrophic organism therein. The gas comprises a high concentration of carbon dioxide. Certain methods of using the EPUs for algal biomass production use automated function units.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: November 13, 2018
    Inventor: Xiaoxi Wu
  • Patent number: 10094816
    Abstract: Provided is a means for evaluating the wetting characteristic of an object such as a cell sheet and a culture dish in a non-contact fashion. The wetting characteristic of an object is evaluated by a method comprising the steps of: (1) removing a liquid by jetting a gas at a surface of the object covered with the liquid, (2) measuring a dimension of a region in which the liquid is removed after the completion of the gas jetting and (3) evaluating the wetting characteristic of the object using the measured dimension as an index.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: October 9, 2018
    Inventors: Nobuyuki Tanaka, Ryohei Uchida, Makoto Kondo, Masayuki Yamato, Teruo Okano, Makoto Kaneko
  • Patent number: 10092606
    Abstract: This invention relates to a preparation comprising a probiotic bacterial strain and a prebiotic mixture comprising 5-70 wt % of at least one N-acetylated oligosaccharide selected from the group consisting of Ga1NAc?1-3Ga1?1-4G1c, Ga1?1-6Ga1Nac?1-3Ga1?1-4G1c and combinations thereof, 20-95 wt % of at least one neutral oligosaccharide selected from the group consisting of Gal?1-6Gal, Gal?1-6Gal?1-4Glc, Gal?1-6Gal?1-6Glc, Gal?1-3Gal?1-3Glc, Gal?1-3Gal?1-4Glc, Gal?1-6Gal?1-6Gal?1-4Glc, Gal?1-6Gal?1-3Gal?1-4Glc, Gal?1-3Gal?1-6Gal?1-4Glc, Gal?1-3Gal?1-3Gal?1-4Glc and combinations thereof and 2-50 wt % of at least one sialylated oligosaccharide selected from the group consisting of NeuAc?2-3Gal?1-4Glc, NeuAc?2-6Ga1?1-4G1c and combinations thereof. The invention extends to food products comprising said preparation and to the use of the preparation in the prevention and treatment of infections.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 9, 2018
    Assignee: Nestec S.A.
    Inventors: Norbert Sprenger, Francois Morgan, Rafael Berrocal, Marcel Braun, Christine Cherbut, Peter Duncan
  • Patent number: 10086113
    Abstract: A porous matrix suitable for use as a tissue scaffold is described. The matrix may be shaped before insertion into or at the target tissue site, or injected via a minimally invasive method. The matrix may be pre-seeded with cells of the target tissue or may be used to support growth of the local endogenous tissue. The matrix may contain growth factors or other pharmacologically acceptable moieties such as antibiotics.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: October 2, 2018
    Inventors: Richard Melville France, Robin Andrew Quirk
  • Patent number: 10041037
    Abstract: The presently disclosed subject matter relates, in general, to the identification, isolation, and use of a population of stem cells isolated from umbilical cord blood, peripheral blood and/or other sources and that are referred to herein as Small Mobile Stem cells (short: SMS). More particularly, the presently disclosed subject matter relates to isolating said SMS stem cells and employing the same, optionally after in vitro manipulation, to treat tissue and/or organ damage in a subject in need thereof.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: August 7, 2018
    Assignee: SMSBIOTECH, INC.
    Inventor: Abdulkader Rahmo
  • Patent number: 10028980
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: July 24, 2018
    Assignee: Regents of the University of Minnesota
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
  • Patent number: 10030218
    Abstract: To provide a microorganism culture vessel that can control existence of invading foreign matters and put a large amount of sample therein, a microorganism test kit, a method for testing a dialysate, a method for culturing the microorganism, a method for testing the microorganism and a method for producing the microorganism culture vessel. The invention includes the microorganism culture vessel, including an inlet-equipped culture bag in which a sheet-like medium is put and sealed.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: July 24, 2018
    Inventors: Yuichi Onji, Masashi Ushiyama, Kongen Aoki
  • Patent number: 10017451
    Abstract: A method for recovering lactic acid from an aqueous mixture including the steps of: providing an aqueous mixture including lactic acid and at least 5 wt. % dissolved magnesium chloride, based on the total weight of water and dissolved material in the aqueous mixture; extracting the lactic acid from the aqueous mixture into a first organic liquid including an organic solvent selected from the group consisting of C5+ ketones, diethylether and methyl-tertiary-butyl-ether, thereby obtaining an organic lactic acid solution and an aqueous waste liquid including magnesium chloride; and extracting the lactic acid from the organic lactic acid solution into an aqueous liquid, thereby obtaining an aqueous lactic acid solution and a second organic liquid. The method according to the invention allows a combined purification and concentration step for feed solutions of lactic acid.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: July 10, 2018
    Assignee: PURAC BIOCHEM B.V.
    Inventors: André Banier De Haan, Jan Van Krieken, Tanja Ðekic {hacek over (Z)}ivkovic
  • Patent number: 10018534
    Abstract: The present invention refers to articles for collecting samples from a surface, articles for microbiological analyses of said samples, and methods of use of said articles. The articles include sample collectors, sample housings with optional barrier layers, and sample-ready reagent strips comprising hydrophilic agents to grow and detect microorganisms. The disclosure includes methods to collect, detect, and quantify microorganisms in a surface sample.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: July 10, 2018
    Assignee: 3M Innovative Properties Company
    Inventors: Cynthia D. Zook, Robert H. Silbernagel, Barbara L. Horter, Henry J. Lubrant, Robert E. Koeritzer
  • Patent number: 10006071
    Abstract: Methods are provided to control the harvesting of desired metabolic byproducts from hypersaline photosynthetic algae. Methods are presented to control secretion of said metabolic products in monocultures and co-cultures after accumulation of byproducts. The metabolic byproduct secretion is controlled by controlling caspase activity.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 26, 2018
    Assignee: Institute for System Biology
    Inventors: Nitin S. Baliga, Monica V. Orellana, Kenia Whitehead, W. Lee Pang
  • Patent number: 10000778
    Abstract: The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with gasoline and decreasing the United States' dependence on foreign oil. For example, to reduce the cost of transporting biomass to ethanol production facilities, mobile systems for producing ethanol from biomass are provided. Also provided are small-scale ethanol production facilities. For example, instead of transporting biomass to the production facility, the facility is transported to the biomass or is located nearby the source of the biomass. The ethanol production facilities or components thereof may be transported via land, water, or air. Production of other products, such as hydrocarbons, natural gas, hydrogen gas, plastics, polymers, and proteins, can also be made by the methods and facilities. Any product described herein can be made in finished form or un-finished form and moved, e.g., to a fixed facility, e.g.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: June 19, 2018
    Assignee: XYLECO, INC.
    Inventor: Marshall Medoff
  • Patent number: 9993527
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: June 12, 2018
    Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Patent number: 9987336
    Abstract: Methods for attenuating or treating, or reducing the mortality of sepsis or septic shock using an ectonucleotidase such as CD39 or CD73 are provided.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: June 5, 2018
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Gyorgy Hasko, Zoltan Nemeth
  • Patent number: 9968638
    Abstract: The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: May 15, 2018
    Inventors: Michael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton