Patents Examined by Lynn Y Fan
  • Patent number: 11453900
    Abstract: The invention relates to methods and compositions for the production of fucosylated oligosaccharides.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: September 27, 2022
    Assignee: GLYCOSYN LLC
    Inventors: Matthew Ian Heidtman, Massimo Merighi, John M. McCoy
  • Patent number: 11448653
    Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: September 20, 2022
    Assignee: Inguran, LLC
    Inventors: Kenneth Michael Evans, Thomas Boyd Gilligan, Richard W. Lenz, Ramakrishnan Vishwanath, Clara Gonzalez-Marin
  • Patent number: 11447742
    Abstract: Methods and compositions herein provide non-naturally occurring ?-butyrolactones (GBLs) in racemic mixtures that increase efficiency and effectiveness of screening for production of antibiotics, and enhance yields and express silent pathways. Non-naturally occurring GBLs were synthesized and found to stimulate antibiotic production in several different streptomycete strains. Antibiotic production by Streptomyces coelicolor was induced by a racemic mixture of non-cognate stereoisomers of VB-D, seven of which are non-naturally occurring. Further, novel A-factor-type GBL analogs stimulated antibiotic production in S. coelicolor. Synthesis in response to the treatment with the non-cognates GBL was observed for known compounds including undecylprodigiosin, desferrioxamine and streptorubin B, as was synthesis of a compound of unknown structure.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: September 20, 2022
    Assignee: Prospective Research, Inc.
    Inventors: Dakota Benjamin Hamill, Jake J. Cotter
  • Patent number: 11439926
    Abstract: The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid. The invention also relates to use of the separation medium for purification of large molecules, which do not enter the separation medium, as well as small molecules, which enter the separation medium and are eluted from there.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: September 13, 2022
    Assignee: Cytiva BioProcess R&D AB
    Inventors: Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Jean-Luc Maloisel, Nils Norrman, Tobias E. Soderman
  • Patent number: 11415494
    Abstract: A method of rapidly and completely rendering a tissue (11) rich in lipid droplets (12) transparent. The method comprises the following steps: providing a tissue sample (11) rich in lipid droplets (12) and immobilized with a hydrogel; performing a pre-transparency-rendering process on the tissue sample (11) to obtain a pre-processed sample; performing a transparency-rendering process on the pre-processed sample to obtain a transparency-rendered sample; and performing a post-transparency-rendering process on the transparency-rendered sample to obtain a final transparency-rendered sample (31). The method does not damage the fine structure of a biological tissue (11) and can significantly increase a depth of an optical image of the biological tissue (11). The method does not damage the fine structure of a biological tissue (11) and can significantly increase a depth of an optical image of the biological tissue (11).
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: August 16, 2022
    Assignee: SHANGHAI JIAOTONG UNIVERSITY
    Inventors: Xiaowei Li, Zhifeng Shao, Mengjie Lai, Jun Li, Daniel Czajkowsky
  • Patent number: 11406650
    Abstract: The invention proposes a nutritional composition comprising selected oligosaccharides that reduces the abundance of Streptococcus bacteria in the gut of infants or young mammals. The infants are preferably infants in needs presenting a relatively high count of Streptococcus. Ultimately the reduction of streptococcus and the related microbiota balance affects and lowers the risk of adiposity or obesity later in life.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: August 9, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Olga Sakwinska, Bernard Berger, Irma Silva Zolezzi, Joanna Holbrook
  • Patent number: 11378580
    Abstract: The present invention provides: a method of pretreating a serum or plasma sample for detection of a protein or a plurality of proteins of interest in a serum or plasma sample via mass spectrometry and a method of detecting such a protein or proteins, wherein proteins such as albumin present in abundance in a sample are removed in a convenient manner, thereby making it possible to collect digested peptides from the protein of interest. Specifically, the present invention provides a method of pretreating a sample for detecting proteins in a serum or plasma sample via mass spectrometry, comprising a step of adding a protease to the sample under non-denaturing conditions to digest proteins and a step of separating the obtained peptides from undigested proteins, and a method of detecting proteins, comprising subjecting the obtained peptides to mass spectrometry.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: July 5, 2022
    Assignee: Shimadzu Corporation
    Inventors: Atsuhiko Toyama, Taka-Aki Sato
  • Patent number: 11365374
    Abstract: Composition for the removal of biofilms present on a substrate, characterized in that it comprises at least one detergent component comprising a sequestrant and also a wetting agent and a dispersant and at least one enzymatic component containing at least one protease, at least one laccase and at least one polysaccharidase, method of implementation thereof and uses thereof.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: June 21, 2022
    Assignees: S.A. REALCO, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Gauthier Boels, Gordon Blackman, Christine Faille, Yannick Lequette, Martine Clarisse
  • Patent number: 11359074
    Abstract: A mycological biopolymer material is subjected to treatment in one or more solutions that work to enhance and/or retain the inherent material properties of the material. In one embodiment, the solution is an organic solution; in another embodiment, the solution is an organic solvent with a salt; in another embodiment, the solution is an organic solvent phenol and/or polyphenol; and in another embodiment, a series of such solutions is used.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 14, 2022
    Assignee: ECOVATIVE DESIGN LLC
    Inventors: Jessica Kaplan-Bie, Gavin R. McIntyre, Lucy Greetham, Ian Bonesteel, Alex Carlton, Eben Bayer
  • Patent number: 11344561
    Abstract: This disclosure relates to compositions, kits and methods for non-surgical reduction of localized subcutaneous fat such as that associated with a cosmetic fat accumulation. The methods employ compositions having specific concentrations of a salt of deoxycholic acid which provides a superior fat cell necrosis with modest adverse effects. Examples of localized subcutaneous fat are found in the submental area, in particular under the chin.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: May 31, 2022
    Assignee: Allergan Sales, LLC
    Inventor: Patricia Walker
  • Patent number: 11339300
    Abstract: Disclosed herein are methods for preventing biofilm formation on a surface. The present disclosure also relates to anti-biofilm forming agents, to methods of producing and using them, and to anti-fouling coatings produced therefrom.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: May 24, 2022
    Assignee: Aequor, Inc.
    Inventor: Cynthia K. Burzell
  • Patent number: 11332707
    Abstract: An endophytic fungus from gingko, that is, Fusarium proliferatum DZHQ1 having antitumor activity and antibacterial activity, is isolated from the ginkgo bark. The species of the strain is determined by the combination of colonial morphology and 18 sRNA sequencing, and then the anti-cervical cancer activity of a crude extract of the strain is detected by MTT. Finally, a secondary metabolite of the strain with an inhibition rate of more than 50% is isolated by semi-preparative HPLC, which promotes the further screening of individual compounds with anti-tumor activity. Moreover, the metabolite of the endophytic fungus from gingko shows a more pronounced inhibition in the detection of activity against E. coli and/or S. aureus, and has potential use in the preparation of new antibacterial products.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 17, 2022
    Assignee: DEZHOU UNIVERSITY
    Inventors: Qing He, Qiangcheng Zeng, Lianying Zhang, Zhongmin Dai, Haixia Zhou, Mingyou Wang, Jianzhou Meng
  • Patent number: 11324780
    Abstract: A composition for treating a patient with a tissue disease or malformity has a composition containing amniotic fluid. The amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source. A method of treating a patient with a tissue disease or malformity comprises the steps of: identifying the tissue region to be treated and selecting a location to apply either topically or by injection or inhalation a composition containing amniotic fluid; selecting the composition containing amniotic fluid wherein the amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source allowing more specific targeted growth factors to be used for specific disease processes; and applying or injecting the composition at or into the selected location.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: May 10, 2022
    Inventor: Michael P. Zahalsky
  • Patent number: 11319574
    Abstract: A method of rapidly evaluating the susceptibility of a strain of bacteria to a cell wall synthesis inhibiting antibiotic based on an assessment of cell enlargement in response to doses of the cell wall synthesis inhibiting antibiotic which are correlated to breakpoints of bacterial susceptibility.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: May 3, 2022
    Assignee: ABM Technologies, LLC
    Inventors: Jose Luis Fernandez Garcia, Jaime Gosalvez Berenguer, Rebeca Santiso Brandariz, Maria Tamayo Novas, German Bou Arevalo
  • Patent number: 11285125
    Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 29, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 11248212
    Abstract: The present disclosure provides a method of fabricating cell, such as stem cell, arrays on a carrier where the surface energy of the carrier has been modified and patterned so that only areas of low contact angle are wetted by a water based cell solution. The patterned cell solution when applied to the carrier surface then self assembles into a 3 dimensional micro pattern on the carrier that mimics the surface topography of mammalian organs.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: February 15, 2022
    Assignee: StemoniX Inc.
    Inventor: Robert John Petcavich
  • Patent number: 11249098
    Abstract: The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method using magnetic beads containing negatively charged carboxyl groups extending from the surface of the magnetic beads.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: February 15, 2022
    Assignee: Beckman Coulter, Inc.
    Inventors: Andras Guttman, Clarence Lew, Marton Szigeti, Csaba Varadi
  • Patent number: 11241409
    Abstract: Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: February 8, 2022
    Assignee: Retrotope, Inc.
    Inventor: Mikhail S. Shchepinov
  • Patent number: 11235007
    Abstract: Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: February 1, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
  • Patent number: 11225681
    Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: January 18, 2022
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Susan M. Kircher, Vanda White, William B. Brasso, Dyan Luper, James Y. Zhou, Julie L. Rosales, Jeffery H. Bruton, John D. Mantlo, Adrien P. Malick, Donald R. Callihan, Ben Turng, Liping Feng, Curtis M. Gosnell, Patrick Shawn Beaty, John P. Douglass