Patents Examined by Mahreen Chaudhry
  • Patent number: 6730493
    Abstract: The method for recognizing damage and determining the extent of the damage to a keratin-containing material, such as hair or wool, includes subjecting a sample of it in aqueous solution to an enzymatic and/or chemical treatment for proteolytic or hydrolytic degradation of the sample, and subsequently measuring the turbidity of the resulting liquid sample to determine the extent of the damage, either by visual observation with the naked eye or by physical measurement methods. An apparatus suitable for performing the method and enzymes, such as proteases and proteinases, and chemical agents for carrying out the method are also described.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: May 4, 2004
    Assignee: Wella Aktiengesellschaft
    Inventors: Annette Schwan-Jonczyk, Lutz Haalck, Ceylan Uensal, Rainer Feldbruegge
  • Patent number: 6555698
    Abstract: The present invention discloses chemiluminescent 1,2-dioxetane substrates capable of reacting with a neuraminidase to release optically detectable energy. These 1,2-dioxetanes have the general formula: wherein Z is and the variables are selected so as to induce decomposition of said dioxetane accompanied by chemiluminescence where Z is cleaved by neuraminidase present.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: April 29, 2003
  • Patent number: 6512143
    Abstract: Novel salts of N-tert-butylhydroxylamine with lower carboxylic acids are disclosed, together with processes for their preparation. The salts possess advantageous properties that render them useful in synthesis.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: January 28, 2003
    Assignee: AstraZeneca AB
    Inventor: J├Ârgen Blixt
  • Patent number: 6492181
    Abstract: The present invention uses the principle that phosphomolybdate binds to hydrophobic surfaces to isolate the phosphomolybdate complex from other phosphate-containing molecules and further uses the SPA concept to bring a radiolabeled phosphomolybdate complex in close contact with a scintillant for measurement by scintillation counting. Generally, the present invention provides an assay for detecting and measuring the amount of orthophosphate (Pi) in an aqueous reaction mixture, wherein the amount of Pi released is separated from the reaction mixture by: adding a solution of molybdate to the reaction mixture to form a phosphomolybdate complex; and contacting the phosphomolybdate complex with a hydrophobic surface, wherein the surface is capable of being separated from the aqueous reaction mixture to allow measurement of the Pi. Particularly, this invention provides an assay for measuring the ATPase activity of enzymes, more particularly, the HPV E1 helicase.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: December 10, 2002
    Assignee: Boehringer Ingelheim (Canada) Ltd.
    Inventor: Peter White
  • Patent number: 6485924
    Abstract: Method for identifying compounds that inhibit cytokinesis, wherein the compounds are tested for their ability to modulate the formation and/or the stability of septin filaments. The compounds are useful in tumor therapy.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: November 26, 2002
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Manuel Mendoza, Michael Glotzer
  • Patent number: 6482853
    Abstract: The invention comprises a novel lactate compound for two unique purposes: (1) cardiac energy resuscitation and the treatment or prevention of reperfusion injury following ischemia, and (2) the provision of a fuel energy source to humans and other mammals during exercise and recovery. The novel lactate compound is particularly a lactate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is a lactate N-acetyl ethyl ester of the cysteine or methionine amino acid. The most preferred compound is lactate N-acetyl cysteine thiolester (LNACE): Further, the invention involves use of mixtures of lactate- and pyruvate compounds as well as hexoses (glucose and fructose), maltodextrins and electrolytes as adjutants to support LNACE in its specific purposes.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: November 19, 2002
    Inventor: George A. Brooks
  • Patent number: 6482653
    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: November 19, 2002
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael Kraus, Carsten Schelp, Andreas Wiegand
  • Patent number: 6479251
    Abstract: Test agents are screened for their effects on mitochondria using a bioassay. Mutant cells with mutations in their mitochondria are readily detectable. Agents which induce such mutations are thereby identified as potential disease causing agents.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: November 12, 2002
    Assignee: The Johns Hopkins University
    Inventor: Keshav K. Singh
  • Patent number: 6479296
    Abstract: A new method, solid phase precipitation and extraction (SPPE), is disclosed and is particularly advantageous for purifying mixtures of synthetic peptides directly from a cleavage/deprotection mixture.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: November 12, 2002
    Inventors: Alex G. Bonner, Lawrence S. Udell, William A. Creasey, Stephen Duly, Richard A. Laursen
  • Patent number: 6465677
    Abstract: The synthesis of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester via conversion under reducing conditions of novel imidazolidinone(s) is disclosed.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: October 15, 2002
    Assignee: The NutraSweet Company
    Inventors: Vladislav Orlovski, Indra Prakash, Mike G. Scaros, Christine M. V. Moore
  • Patent number: 6461830
    Abstract: The present invention relates generally to methods for detecting preeclampsia in pregnancies. The present invention comprises the steps of obtaining a sample specimen from a patient, assaying the specimen to determine the level of glycerophosphatidyl compounds, glycerophosphatidylcholine, lysophospholipids and/or lysophosphatidylcholine in the sample, comparing levels in the sample to levels in normal samples, and correlating significant decreases as compared to normal samples as a positive indicator of preeclampsia.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: October 8, 2002
    Assignee: Atairgin Technologies, Inc.
    Inventor: Jeff A. Parrott
  • Patent number: 6462233
    Abstract: The invented process produces sorbic acid. The process includes the steps of adding a crude sorbic acid to a hot water having a temperature exceeding 100° C., which crude sorbic acid is obtained by the decomposition of a polyester formed through a reaction of ketene with crotonaldehyde, and performing at least one treatment selected from (A) a hot water extraction treatment for extracting sorbic acid with the hot water, and (B) a treatment with an activated carbon in the hot water. The temperature of the hot water is, for example, 120° C. or lower. The amount of sorbic acid to be treated is, for example, equal to or less than the saturated dissolution amount of sorbic acid with respect to the hot water at a treating temperature. The invented process can easily and efficiently remove tar substances and other impurities by-produced in the decomposition of the polyester and can produce a highly purified sorbic acid with a high productivity.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: October 8, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Akira Yamashita, Mitsuhiro Kouno
  • Patent number: 6461831
    Abstract: A method for the diagnosis of Alzheimer's disease (AD) in a patient, comprising the steps of: (1) providing a sample of an appropriate body fluid from said patient; (2) detecting the presence of acetylcholinesterase (AChE) with an altered glycosylation pattern in said sample. It has been established that approximately 75-95% of the AChE in the CSF of AD patients binds to Concanavalin (Con A) or wheat germ agglutinin (WGA) but with different specificity to each. Accordingly, in order to identify the glycosylation pattern of AChE in the sample, the binding to Con A is determined, then the binding to WGA is determined, and a ratio calculated. The ratio is characteristic of the glycosylation pattern. In alternative embodiment of the invention a monoclonal antibody specific for AChE with an altered glycosylation pattern is used to detect its presence.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: October 8, 2002
    Inventors: David Henry Small, Javier Saez-Valero, Gian Sberna
  • Patent number: 6458596
    Abstract: In a method for recognizing the faulty positioning of an optically evaluatable test strip in a device for measuring a substance in a liquid, especially for blood sugar determination, the fluid to be investigated is applied to a test field (24) of a test strip (20) and the change in the reflection or transmission ability of the test field (24) thereby effected is captured and evaluated. A measuring field (16) of the measuring device associated with the test field of the test strip is divided into at least two measuring areas which, with respect to the insertion direction of the test strip, are arranged behind one another and are separately sensed. The test strip (20) has at least in the area lying in front of the test field (24), with respect to the insertion direction zones (28, 29) arranged behind one another and of different reflection or transmission abilities.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: October 1, 2002
    Assignee: LRE Technology Partner GmbH
    Inventor: Norbert Poellmann
  • Patent number: 6458322
    Abstract: A method for shipping clinical specimens lawfully, safely, cheaply, and easily without regard to some or all of the laws, rules, and regulations regarding samples that may contain infectious and/or etiologic agents. Optional method of direct analysis of shipped samples.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: October 1, 2002
    Assignee: Bioavailability Systems, LLC
    Inventor: James W. Harris
  • Patent number: 6458998
    Abstract: Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: October 1, 2002
    Assignee: Telik, Inc.
    Inventors: Wayne R. Spevak, Songyuan Shi, Prasad V. V. S. V. Manchem, Michael R. Kozlowski, Steven R. Schow, Robert T. Lum
  • Patent number: 6451550
    Abstract: The present invention relates to a haptoglobin assay of the type wherein the level of haptoglobin in a sample to be tested is determined by measuring the peroxidase activity of haptoglobin/haemoglobin complex. The assay employs at least one reagent for reducing a peroxidase effect due to any albumin or any other protein(s) present in the sample. The reagent may be selected from a) a reducing agent effective against disulphide bonds; b) a protein binding inhibitor and/or c) a chaotropic agent. The present invention also relates to kits suitable for use in such an asay.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: September 17, 2002
    Assignee: The University Court of the University of Glasgow
    Inventor: Peter David Eckersall
  • Patent number: 6448027
    Abstract: A method for measuring activity of osteoclast-derived acid phosphatase located at Band 5b of Band 5 in polyacrylamide gel electrophoresis of a sample which is characterized by using an inhibitor to acid phosphatases located at Band 5 other than Band 5b; and a composition and a kit for using in the method.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: September 10, 2002
    Assignee: FALCO biosystems Ltd.
    Inventors: Mamoru Nakanishi, Kagehiro Uchida
  • Patent number: 6444839
    Abstract: Rosemarinic acid or its concentrate is made from seeds of lamiaceous plants in a predetermined period of germination. The method makes it possible to make the rosemarinic acid in any period through the year. High productivity can be achieved by small production facility since high-density cultivation of germinated seed is possible and a cultivation period is short. An amount of rosemarinic acid is rapidly increased after start of germination, and an increasing amount usually becomes maximum five to eight days after start of cultivation. Power obtained by pulverizing dry germinated seeds contains 3 to 5% of rosemarinic acid and can be used for various purposes. An extract obtained by water soluble alcohol from the powder and a fraction obtained by fractioning the extract by an organic solvent are concentrated containing about 15% and 30% of rosemarinic acid respectively. When each concentrate is processed by column chromatography, isolated 99%-rosemarinic acid is obtained.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: September 3, 2002
    Assignee: Salad Cosmo Co., Ltd.
    Inventor: Takeo Murui
  • Patent number: 6444435
    Abstract: A test strip for confirming a desired proportion of components in dialysate, including a first medium capable of indicating the concentration of bicarbonate ion, and a second medium capable of indicating the concentration of glucose. The test strip defines a first region impregnated with the first medium, and a second region impregnated with the second medium. The test strip optionally includes a third medium capable of indicating the pH of the dialysate. The third medium is impregnated at a third region on the test strip. Alternatively, the test strip comprises a bicarbonate test pad attached to the first region, a glucose test pad attached to the second region, and optionally a pH test pad attached to the third region. The glucose test pad is impregnated with the first medium, the glucose test pad is impregnated with the second medium, and the pH test pad is impregnated with the third medium.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: September 3, 2002
    Assignee: Serim Research Corporation
    Inventors: James E. Christner, Linda S. Hout