Abstract: The present disclosure relates to a process for preparing arimoclomol, arimoclomol citrate and key intermediates, such as ORZY-01, thereof. The disclosure further relates to a process for preparing high purity arimoclomol citrate and methods of using the same.
Type:
Grant
Filed:
March 10, 2022
Date of Patent:
July 25, 2023
Inventors:
Zhe Zhang, Mark Read, Elisabeth Vang Carstensen, Marco Poppe, Andreas Pelz
Abstract: Disclosed is a method for filling a root canal in a tooth. The method includes positioning a fiber in the root canal of the tooth, filling at least a portion of the root canal with an unset hydrogel composition, such that the unset hydrogel composition contacts at least a portion of the fiber, setting the hydrogel composition, thereby forming a set hydrogel, and removing the fiber from the set hydrogel, thereby leaving a channel in the set hydrogel. Methods and kits for repairing teeth are also described.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
July 18, 2023
Assignee:
Oregon Health & Science University
Inventors:
Luiz Bertassoni, Anthony Tahayeri, Avathamsa Athirasala, Jack L. Ferracane
Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.
Abstract: A dissolvable fibrous solid shampoo article containing fibrous elements. The fibrous elements can contain a polymeric structurant, a surfactant, and optionally a cationic polymer. The fibrous article is substantially free of lamellar structures and can have a hand dissolution of less than 15 strokes.
Type:
Grant
Filed:
June 26, 2020
Date of Patent:
June 20, 2023
Assignee:
The Procter & Gamble Company
Inventors:
Brian Xiaoqing Song, Jennifer Elaine Hilvert, Min Mao, Dinah Achola Nyangiro, Brandon Michael Taylor, Mark William Hamersky
Abstract: The present invention is related to a composition comprising at least one bile acid; at least one fatty acid or salt thereof, calcium, and vitamin D, for use as a medicament, and especially in inducing expression of vitamin D-receptor co-activator Hsp90? for increasing vitamin D-induced calcium uptake in a mammal. The invention is also related to a dietary or nutritional supplement comprising a composition as described above and comprising additionally conventional components for dietary or nutritional supplements.
Abstract: A glycophospholipid polymer is disclosed. The glycophospholipid polymer comprises a reaction product of one or more glycosaminoglycans and one or more phospholipids. Also disclosed is a glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans, one or more phospholipids and, one or more crosslinking agents.
Type:
Grant
Filed:
March 11, 2020
Date of Patent:
June 13, 2023
Assignee:
BAUSCH & LOMB INCORPORATED
Inventors:
Alok Kumar Awasthi, James Anthony DiBella, Jr., Mark R. Mis, Alai Musleh, George L. Grobe, III
Abstract: The present invention is directed to a method of replacing collagen broken down during physical activity using a novel dietary supplement. The supplement composition of the present invention comprises collagen, glutamine, taurine, and, optionally, the nine essential amino acids. The uptake of collagen is enhanced using this combination of components to levels substantially near the pre-workout levels.
Type:
Grant
Filed:
June 3, 2020
Date of Patent:
June 6, 2023
Assignee:
Societe des Produits Nestle S.A.
Inventors:
Kurt Seidensticker, Matt Aporta, Corey Friese, Angela Skubal
Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).
Type:
Grant
Filed:
November 28, 2017
Date of Patent:
June 6, 2023
Assignees:
INSERM, INTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG
Inventors:
Sébastien Roux, Thierry Plouvier, Julie Le Merrer, Jérôme Becker
Abstract: The present specification relates to a composition for external application to skin with improved solubility and feeling during use, comprising a benzoic acid amide compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solute that is a solvate thereof, and a first cyclodextrin solubilizing agent.
Type:
Grant
Filed:
March 26, 2018
Date of Patent:
May 23, 2023
Assignee:
AMOREPACIFIC CORPORATION
Inventors:
Chang-geun Yi, Suil Kim, Sung Il Park, Hong-ju Shin
Abstract: The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process.
Type:
Grant
Filed:
October 27, 2017
Date of Patent:
May 16, 2023
Assignee:
Cellink Bioprinting AB
Inventors:
Paul Gatenholm, Hector Martinez, Michela Schettino, Erik Gatenholm
Abstract: The present invention relates to a process for the production of a homogenous mixture of two or more branched chain keto acids wherein in a first step, two or more free keto acids are mixed, and in a second step, the mixed keto acids are co-crystallized with one or more alkaline earth metal salts, and foodstuff, food supplement or pharmaceutical products containing a mixture of branched-chain keto acids for supporting muscle structure, increasing muscle performance and improving general wellbeing with simultaneous relief of nitrogen detoxification metabolism by reduced nitrogen supply compared to the intake of the corresponding amino acids and an improved nitrogen metabolism in the body.
Abstract: The present invention aims to provide a warming composition showing a favorable dispersion stability after long-term storage, a high warming impact, and improvement of zeolite-specific deterioration of feeling of use, and to provide an aerosol formulation containing the warming composition. This object is achieved with a warming composition containing zeolite nanoparticles having an average particle size of not more than 500 nm, wherein the temperature of the composition is rapidly increased by heat generated by hydration reaction between the zeolite and water.
Type:
Grant
Filed:
September 13, 2019
Date of Patent:
May 9, 2023
Assignees:
Toyo Aerosol Industry Co., Ltd., The University of Tokyo
Abstract: Non-invasive Ocular Drug Delivery Insert Technology. The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a “Fickian” or a linear profile according to the intend purpose or pathology.
Type:
Grant
Filed:
February 10, 2017
Date of Patent:
May 9, 2023
Assignee:
UNIVERSIDADE DE COIMBRA
Inventors:
Marcos João Mota Leite Machado Mariz, Paula Cristina Nunes Ferreira Calvinho, Maria Helena Mendes Gil, Joaquim Carlos Neto Murta
Abstract: A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
May 2, 2023
Assignee:
SYK TECHNOLOGIES, LLC
Inventors:
Christian S. Minton, Stephen D. Minton, J. W. Randolph Miller
Abstract: A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.
Type:
Grant
Filed:
February 16, 2022
Date of Patent:
April 18, 2023
Assignee:
OXION DENTAL, LLC
Inventors:
Ali Razavi, Farid Razavi, Anthony Andrew Prousi
Abstract: A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
April 11, 2023
Assignee:
SYK TECHNOLOGIES LLC
Inventors:
Christian S. Minton, Stephen D. Minton, J. W. Randolph Miller
Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
Type:
Grant
Filed:
January 27, 2020
Date of Patent:
April 11, 2023
Assignee:
THERAPEUTICSMD, INC.
Inventors:
Brian A. Bernick, Julia M. Amadio, Peter H. R. Persicaner, Thorsteinn Thorsteinsson, Janice Louise Cacace, Frederick D. Sancilio, Neda Irani
Abstract: A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.
Type:
Grant
Filed:
May 26, 2022
Date of Patent:
April 11, 2023
Assignee:
SYK TECHNOLOGIES LLC
Inventors:
Christian S. Minton, Stephen D. Minton, J. W. Randolph Miller
Abstract: The present invention provides a composition for preventing, ameliorating, alleviating or treating dermatitis comprising exosomes derived from adipose-derived stem cells as an active ingredient. The composition of the present invention is able to act against dermatitis-inducing multiple cytokine targets, and thus be widely applied against dermatitis caused by various factors and effectively suppress and alleviate dermatitis.