Patents Examined by Mary Vaughn
  • Patent number: 4067871
    Abstract: This invention relates to N-nitroso compounds having the formula ##STR1## wherein R and R' each are selected from hydrogen and alkyl, Z is --CN or --COOR" wherein R" is alkyl and n is a positive integer from 1 to 7. These compounds are useful as intermediates in the preparation of photographic silver halide developing agents.
    Type: Grant
    Filed: September 9, 1976
    Date of Patent: January 10, 1978
    Assignee: Polaroid Corporation
    Inventors: James R. Bartles-Keith, Mary T. Burgess, Jean B. Rogers
  • Patent number: 4066652
    Abstract: A class of hydrocarbyl substituted 8-hydroxyquinolines wherein the indicated substituent arises through the indirect alkylation of said quinolinol with a hindered aldehyde. These alkylates are useful metal collectors in hydrometallurgical extraction processes designed for the recovery of metal values from dilute aqueous solutions thereof.
    Type: Grant
    Filed: September 12, 1973
    Date of Patent: January 3, 1978
    Assignee: Ashland Oil, Inc.
    Inventor: James A. Hartlage
  • Patent number: 4066662
    Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
    Type: Grant
    Filed: December 30, 1976
    Date of Patent: January 3, 1978
    Assignee: Science Union et Cie., Societe Francaise de Recherche Medicale
    Inventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
  • Patent number: 4064249
    Abstract: New compounds of the formula ##STR1## wherein R is hydrogen or methyl group,X y is a group of the formula ##STR2## and N IS AN INTEGER OF FROM 4 TO 10, ARE PREPARED BY ACYLATING THE APPROPRIATE LYSERGIC ACID-(3'-ALLYLOXY-2'-OXY-PROPYL)-AMIDE COMPOUNDS WITH CARBOXYLIC ACIDS OF 6 TO 12 CARBON ATOMS OR WITH THEIR REACTIVE DERIVATIVES. If desired, the new compounds can be converted into their pharmaceutically acceptable acid addition salts.The above compounds possess prolonged antidepressive activities.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: December 20, 1977
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Erzsebet Mago nee Karacsony, Jozsef Borsi, Endre Csanyi, Katalin Pik, Lajos Wolf
  • Patent number: 4056535
    Abstract: The compounds 3-(N-diethylcarbamyl)amino-1-methyl pyrrolidine, 3-(N-carbethoxy-N-methyl)amino-1-methyl pyrrolidine, 1-diethylcarbamyl-3-(N-methyl)amino pyrrolidine and 1-diethylcarbamyl-3-dimethylamino pyrrolidine, said compounds having utility as antifilarial agents.
    Type: Grant
    Filed: April 23, 1976
    Date of Patent: November 1, 1977
    Assignee: Stanford Research Institute
    Inventors: David W. Henry, Priscilla A. Sturm
  • Patent number: 4039558
    Abstract: The invention is dealing with compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which X represents oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --,R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, an alkyl, alkoxy or alkylthio group or a trifluoromethyl group,R.sub.5 and R.sub.6 represent hydrogen, an alkyl group or an aralkyl group,R.sub.7 represents hydrogen or alkyl (1-4 C),R.sub.8, r.sub.9 represent hydrogen or methyl, andQ represents hydrogen (2H) or oxygen,Having valuable antihistamine, sedative and antidepressive properties.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: August 2, 1977
    Assignee: Akzona Incorporated
    Inventors: Willem Jacob van der Burg, Robert Raymond Malvine Salsmans
  • Patent number: 4026897
    Abstract: 5-[1-Hydroxy-2-(substituted-amino)]alkyl -8-hydroxy-carbostyril derivatives represented by the formula (I) ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms and R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.2 and R.sup.3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the same.
    Type: Grant
    Filed: December 26, 1974
    Date of Patent: May 31, 1977
    Assignee: Otsuka Pharmaceutical Company
    Inventors: Kazuyuki Nakagawa, Shiro Yoshizaki, Kaoru Tanimura, Shigeharu Tamada
  • Patent number: 4022766
    Abstract: Compounds of the following formula ##STR1## wherein R is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.1 is hydrogen, methyl, ethyl or phenyl; R.sub.2 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.3 is hydrogen, methoxy, trifluoromethyl, chloro, bromo or fluoro; and R.sub.4 is methyl. The new compounds are useful as CNS depressants, anticonvulsants, anti-inflammatories and inhibitors of the enzymes which promote the synthesis of prostaglandins.
    Type: Grant
    Filed: March 17, 1975
    Date of Patent: May 10, 1977
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Luigi Fontanella, Luigi Mariani, Giorgio Tarzia
  • Patent number: 4013665
    Abstract: Compounds of the formula ##SPC1##Where A is selected from the group consisting of hydrogen, halogen, lower alkoxy, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower diakylaminoalkyl, amino, lower alkylamino and lower dialkylamino,Where B is selected from the group consisting of hydrogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxyl, amino, lower alkylamino, and lower dialkylamino,Where C is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxyl, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxy, amino, lower alkylamino and lower dialkylamino,Where D is selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, hydroxyl, thio, trifluoromethyl, lower dialkylaminoalkoxyl, amino, lower alkylamino and lower diaklamino,Where n is an integer from 2 to 12 inclusive,And Y is selected from the group consisting of amino, lower alkylamino, lower dialkylamino, and
    Type: Grant
    Filed: October 1, 1973
    Date of Patent: March 22, 1977
    Assignee: Bristol-Myers Company
    Inventors: Ronnie Ray Crenshaw, George Michael Luke, Paul Siminoff
  • Patent number: 4006164
    Abstract: 2-Substituted-4-aryl-1,2,3,4-tetrahydropyrrolo[3,4-b]-indoles, their use as tranquilizing agents and their preparation from 4-aryl-1,2,3,4-tetrahydropyrrolo[3,4-b]indoles.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: February 1, 1977
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert
  • Patent number: 3991065
    Abstract: The invention provides 5,6,7,8-tetrahydroquinoline derivatives which are substituted at the 8-position by an amino group or the group NHCSNHR.sup.5 where R.sup.5 is hydrogen, alkyl of 1 - 3 carbon atoms which may be substituted by dialkylamino; lower alkanoyl or aroyl. The 8-amino cmpounds and those where R.sup.5 is lower alkanoyl or aroyl are intermediates. The other compounds are anti-ulcer agents.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: November 9, 1976
    Assignee: John Wyeth & Brother Limited
    Inventors: Adrian Charles Ward Curran, Roger Crossley, David George Hill
  • Patent number: 3980655
    Abstract: 1,4-Dihydro-2H-isoquinoline derivatives of the general formula I ##SPC1##in whichR.sup.1 represents hydrogen or straight chain or branched alkyl of 1 to 6 carbon atoms,R.sup.2 represents low molecular dialkylaminoalkyl, in which both alkyl groups of the dialkylamino group together with the nitrogen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substituted by hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl, or R.sup.1 and R.sup.2 together may form a 5- or 6-membered saturated ring containing 1 nitrogen atom,R.sup.3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino or sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridylR.sup.4 andR.sup.5, which may identical or different, represent hydrogen or alkoxy of 1 to 4 carbon atoms, andX represent oxygen or sulfur,Their physiologically tolerated salts, process for preparing them.
    Type: Grant
    Filed: October 17, 1974
    Date of Patent: September 14, 1976
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rudolf Kunstmann, Joachim Kaiser
  • Patent number: 3976649
    Abstract: High tinctorial strength, easily dispersible perylene-3,4,9,10-tetracarboximides and N,N'-dialkylperylene-3,4,9,10-tetracarboximides are produced by introducing a finely ground crude pigment whose primary particle size is not more than 0.05 micron into a primary aliphatic or aromatic amine, into a heterocyclic base, into an aliphatic carboxamide, into a mixture thereof, or into from 75 to 84% by weight sulfuric acid and converting it into pigmentary form at a temperature of from ambient temperature to 160.degree.C. The products are easily dispersible pigments of high tinctorial strength.
    Type: Grant
    Filed: April 1, 1974
    Date of Patent: August 24, 1976
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Fabian, Klaus Schrempp
  • Patent number: 3975391
    Abstract: 5-[1-HYDROXY-2-SUBSTITUTED-AMINO)]ETHYL-8-HYDROXY-3,4-DIHYDROCARBOSTYRIL DERIVATIVES REPRESENTED BY THE FORMULA (I) ##SPC1##wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R.sup.1 and R.sup.2 may, when taken together with the nitrogen atom to which they are attached, form a 5 or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the above compounds.
    Type: Grant
    Filed: December 26, 1974
    Date of Patent: August 17, 1976
    Assignee: Otsuka Pharmaceutical Company Limited
    Inventors: Kazuyuki Nakagawa, Shiro Yoshizaki, Kaoru Tanimura, Shigeharu Tamada
  • Patent number: 3974154
    Abstract: 3-BENZYL-7-AMINO-3-CEPHEM-4-CARBOXYLIC ACID AND ESTERS AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
    Type: Grant
    Filed: April 24, 1974
    Date of Patent: August 10, 1976
    Assignee: Beecham Group Limited
    Inventors: John Herbert Charles Nayler, Michael John Pearson, Robert Southgate
  • Patent number: 3968111
    Abstract: 8,8-Disubstituted-6-methylergolines and 9-ergolenes, prepared by alkylation of lysergic, isolysergic or their 9,10-dihydro analogues, optionally followed by chemical modification of an 8-substituent.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: July 6, 1976
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmund C. Kornfeld
  • Patent number: 3966724
    Abstract: Compounds having the structure: ##SPC1##In which R.sub.1 and R.sub.2 are alkoxy groups of one to four carbon atoms, R.sub.3 and R.sub.4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R.sub.5 and R.sub.6 each is an alkyl group of one to four carbon atoms or an arylalkyl group such as benzyl or R.sub.5 taken with R.sub.6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof and processes for preparing these compounds. These compounds are useful as vasodilators.
    Type: Grant
    Filed: December 20, 1974
    Date of Patent: June 29, 1976
    Assignee: Armour Pharmaceutical Company
    Inventors: John Lawrence Hughes, Jay Kenneth Seyler, Carroll M. Smith
  • Patent number: 3966763
    Abstract: A process for producing 2-pyrrolidone by the simultaneous hydrolysis and hydrogenation of succinonitrile at elevated temperatures and pressures in the presence of a hydrogenation catalyst and a reaction promoter selected from the group consisting of 2-pyrrolidone and N-alkyl-2-pyrrolidone wherein the alkyl group contains from 1 to 6 carbon atoms.
    Type: Grant
    Filed: June 30, 1975
    Date of Patent: June 29, 1976
    Assignee: Standard Oil Company
    Inventor: Janice L. Greene
  • Patent number: 3963716
    Abstract: A pharmaceutically active phthalzone derivative of the following formula ##SPC1##Wherein each of R.sub.1 and R.sub.2 is a member selected from the group consiting of alkyl of from 1 to 3 carbon atoms; R.sub.3 is a member selected from the group consiting of alkyl of from 1 to 5 carbon atoms with the proviso that R.sub.3 can form together with R.sub.2 a member selected from the group consiting of methylene, methyl-substituted and ethyl-substituted methylene. This compound is effectie for treating hypertension, thrombosis and athroscllerosis. A process for its preparation and a pharmaceutical composition containing it are also provided.
    Type: Grant
    Filed: September 10, 1974
    Date of Patent: June 15, 1976
    Inventors: Michiro Inoue, Masayuki Ishikawa, Takashi Tsuchiya, Takio Shimamoto
  • Patent number: 3963722
    Abstract: The invention relates to magnesium halide derivatives of tetrahydroquinolines and related compounds. These are intermediates useful in the preparation of anti-ulcer agents.
    Type: Grant
    Filed: November 22, 1974
    Date of Patent: June 15, 1976
    Assignee: John Wyeth & Brother Limited
    Inventor: Adrian Charles Ward Curran