Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: Glucose prediction using machine learning (ML) and time series glucose measurements is described. Given the number of people that wear glucose monitoring devices and because some wearable glucose monitoring devices can produce measurements continuously, a platform providing such devices may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process and covers a robust number of state spaces unlikely to be covered without the enormous amount of data. In implementations, a glucose monitoring platform includes an ML model trained using historical time series glucose measurements of a user population. The ML model predicts upcoming glucose measurements for a particular user by receiving a time series of glucose measurements up to a time and determining the upcoming glucose measurements of the particular user for an interval subsequent to the time based on patterns learned from the historical time series glucose measurements.

Abstract: An apparatus for inserting a continuous analyte monitoring transmitter that includes an outer member, an inner member configured to telescope relative to the outer member, a transmitter, a bias member, an insertion device, and a pivot member. Force is applied to press the outer member toward an insertion site over the duration of a stroke. During a first portion of the stroke, the pivot member cannot pivot and the motion of the outer member translates to the insertion device until the biosensor is inserted at the insertion site. Over a second portion of the stroke, the continued motion causes a first pivot window in the outer member to overlap with a second pivot window in the inner member, allowing the pivot member to pivot and retract the insertion device from the insertion site, leaving the implanted biosensor.

Abstract: A method of treatment of a type 2 diabetic patient includes selecting a type 2 diabetic patient having a predetermined comorbidity for treatment, initiating a continuous glucose monitor regimen for the selected type 2 diabetic patient, wherein after six months of initiation of the continuous glucose monitor regimen, a rate of hospitalization for a predetermined diagnostic category of the selected patient having the predetermined comorbidity is reduced by at least 12% relative to an average rate of hospitalization for the predetermined diagnostic category of selected patients having the predetermined comorbidity without the continuous glucose monitor regimen.

Abstract: A method of filtering a signal in a continuous analyte monitoring system (CAM) includes applying adaptive filtering to the signal using an adaptive filter to generate a filtered continuous analyte monitoring signal during an analyte monitoring period, and increasing the adaptive filtering applied to the signal as a function of increasing noise on the signal. Other methods, apparatus, continuous analyte monitoring devices, and continuous glucose monitoring devices are also disclosed.

Abstract: An eyewear device, method for use with an eyewear device, and a non-transient computer readable medium for detecting blood sugar levels are disclosed. The eyewear device has a frame including a first rim configured to support a first lens, a second rim configured to support a second lens, and a bridge connecting the first rim to the second rim. The bridge is configured to receive a nose of a user when the eyewear device is worn by the user. Blood sugar levels are detected by monitoring behavior of a pupil of an eye of the user with a sensor, comparing the monitored behavior with known blood sugar level behaviors, identifying a match responsive to the comparison between the monitored behavior and one of the known blood sugar level behaviors corresponding to a particular blood sugar level, and selecting the particular blood sugar level as a blood sugar level of the user.

Abstract: N-type polymer based electrochemical devices include one or more source electrodes, one or more drain electrodes, one or more channels, a gate electrode, and an electrolyte solution are disclosed. The channels include one or more n-type polymers and one or more enzymes. The gate electrode includes one or more n-type polymers and one or more enzymes. The source and the drain electrodes are electrically connected by the corresponding channel. The electrolyte solution contains one or more metabolites capable of reacting with the one or more enzymes in the channel and the gate electrode and is in electrical contact with the channel and the gate electrode. Saturation current that flows through the channel increases when the metabolites react with the enzymes to produce electrons, which are directly transferred to the n-type polymers at the gate electrode and the channel. Methods of making and using the n-type electrochemical device are also disclosed.

Abstract: A medical temperature monitoring system includes an electrical wire set having a thermistor at a distal end of the wire set configured to sense temperatures to which the thermistor is exposed; an electronic circuit in electrical communication with the wire set and the thermistor and configured to convert the temperatures sensed by the thermistor to temperature display signals; a display in electrical communication with the electronic circuit for receiving the temperature display signals and displaying temperatures corresponding to the temperature display signals; and a bead of cured protective material encapsulating the thermistor. The protective material is a radiation curable adhesive applied to the thermistor in an uncured state and then cured to encapsulate the thermistor. The bead of cured protective material electrically isolates the conductor sufficient to pass a Hi-Pot test at 500 VAC, <0.1 mA.

Abstract: A removal tool uses magnetic attraction to guide the removal tool toward an implantable device subcutaneously implanted in subcutaneous tissue of a host and to remove the implantable device from the host. The removal tool may include first and second lever members that are pivotably connected together, and the first and second lever members include a pair of jaw members configured to move between open and closed positions to grasp the implantable device. The first jaw member may include a magnet to magnetically attract and couple to an implantable device implanted subcutaneously below a skin surface of a host.

Abstract: A system and method for personalized calibration for glucose sensing. In some embodiments, the method includes obtaining a plurality of first glucose measurements from a subject, at a plurality of first sampling times during a time interval, using a first glucose sensor; obtaining a plurality of second glucose measurements from the subject, at a plurality of second sampling times during the time interval, using a second glucose sensor; and estimating a first in-vivo calibration parameter for the first glucose sensor and the second glucose sensor, based on the first glucose measurements and the second glucose measurements, wherein a first in-vivo time-constant, relating blood glucose to an output of the first glucose sensor, is different from a second in-vivo time-constant, relating blood glucose to an output of the second glucose sensor.

Abstract: The present invention provides a measuring method for prolonging a usage lifetime of a biosensor to measure a physiological signal representative of a physiological parameter associated with an analyte in a biofluid. The biosensor includes two working electrodes at least partially covered by a chemical reagent and two counter electrodes having silver and a silver halide, and each silver halide has an initial amount.

Abstract: In one embodiment, a system for finger-to-thumb crease testing includes a patient interface configured to attach to a thumb of a patient, the patient interface including a touch sensor configured to sense contact between a finger of the patient and the touch sensor, the touch sensor being positioned on the patient interface in a location at which it overlies a distalmost thumb crease of the thumb when the patient interface is attached, and a control module in electrical communication with the patient interface, the control module being configured to count a number of times the patient successfully taps the touch sensor with the finger.

Abstract: A glucose monitoring system includes a sensor control device comprising an analyte sensor coupled with sensor electronics, the sensor control device configured to transmit data indicative of an analyte level, and a reader device comprising a wireless communication circuitry configured to receive the data indicative of the analyte level, and one or more processors coupled with a memory.

Abstract: A insertion module includes a main body, an auxiliary insertion seat, an insertion needle assembly and a sensor assembly. The main body has a plurality of slide grooves. The auxiliary insertion seat has a base portion, and a plurality of wing portions. The insertion needle assembly is fixed through the interference between the wing portions and wall surfaces of the slide grooves, such that the insertion needle is prevented from being oblique to an insertion direction before the insertion needle is inserted into a host.

Abstract: A physiological signal monitoring device includes a biosensor, and a transmitter including a bottom casing, a processing unit and a battery. The bottom casing has a first stepped section, a second stepped section, and a riser section interconnecting the first stepped section and the second stepped section. The processing unit corresponds in position to the first stepped section. The battery corresponds in position to the first stepped section, and is configured not to overlap the processing unit in a direction of a first axis so as to reduce a thickness of the transmitter.

Abstract: The present invention relates to a continuous glucose monitoring system that is capable of continuously monitoring blood glucose levels. According to the present invention, the continuous glucose monitoring system includes: a body (A) attached to a given region of a user's body having less pain; a glucose sensor (B) having a micro needle (B1) protruding from one surface of the body (A) to be inserted into the epidermis of the user's body; and a glucose monitoring module (C) for monitoring the glucose from the glucose sensor (B).

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a measured probing potential modulation current signal; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection functio

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value.

Abstract: A method of filtering a signal in a continuous analyte monitoring (CAM) system includes applying time-varying filtering to the signal using a time-varying filter to generate a filtered continuous analyte monitoring signal during an analyte monitoring period. Other methods, apparatus, continuous analyte monitoring devices, and continuous glucose monitoring devices are also disclosed.

Abstract: A method for controlling sub-acute ruminal acidosis (SARA) in a dairy cow. The method includes placing a pH sensor in a rumen of the dairy cow, obtaining pH data of the rumen utilizing the pH sensor, receiving the pH data by one or more processors, calculating a first average of the pH data and a second average of the pH data utilizing the one or more processors, generating a plurality of pH classes based on a plurality of predefined pH ranges, generating a plurality of sodium bicarbonate classes based on a plurality of predefined sodium bicarbonate mass ranges, designing a fuzzy control system based on a set of rules, and determining an amount of sodium bicarbonate to add to a water supply of the dairy cow utilizing the fuzzy control system based on the first average and the second average.