Patents Examined by Micah-Paul Young
  • Patent number: 11684580
    Abstract: The present disclosure provides extended release trihexyphenidyl compositions suitable for once- or twice-daily administration. The compositions comprise a core comprising at least one organic acid; at least one drug layer comprising trihexyphenidyl or a pharmaceutically acceptable salt thereof over the core; and a functional coat over the drug-layered core. The compositions of the disclosure provide extended release with reduced Cmax, a Cmin:Cmax ratio of ?0.4, Fluctuation Index of ?1, while providing and maintaining at least a minimum therapeutically effective plasma concentration, of the trihexyphenidyl or the pharmaceutically acceptable salt thereof for at least about 10 hours. The compositions of the disclosure improve solubility of the trihexyphenidyl or the pharmaceutically acceptable salt thereof at a pH of greater than or equal to 5, to provide and maintain at least a minimum effective concentration of the drug at such pH.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: June 27, 2023
    Inventors: Siva Ram Kiran Vaka, Namdev B. Shelke, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit
  • Patent number: 11666652
    Abstract: Methods for the generation of electrochemical plasma activated aqueous chemotherapeutics (EPAAC) solutions are described. These solutions have been found to selectively reduce the proliferation of human pancreatic cancer cells, with no toxic effects for healthy cells.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: June 6, 2023
    Assignee: Symbios Technologies, Inc.
    Inventors: Brooks M. Hybertson, Jessica M. Joslin, Justin P. Bzdek, Derek C. Johnson
  • Patent number: 11654115
    Abstract: According to the invention there is provided a pharmaceutical composition comprising N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, in which composition the C21 or salt thereof is protected by the presence of a coating comprising an enteric substance. Preferred dosage forms comprise capsules in which C21 or salt thereof is presented in the form of a dry powder mixture or a suspension of particles of C21 in a solvent in which it is insoluble. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: May 23, 2023
    Assignee: VICORE PHARMA AB
    Inventors: Ola Camber, Christina Johansson
  • Patent number: 11648556
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: May 16, 2023
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Patent number: 11633389
    Abstract: An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated methylphenidate-ion exchange resin complex, a barrier coated methylphenidate-ion exchange resin complex-matrix, and an uncomplexed methylphenidate active component. Following administration of a single dose of the extended release methylphenidate chewable tablet, a therapeutically effective amount of methylphenidate is reached in less than about 20 minutes and the composition provides a twelve-hour extended release profile.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: April 25, 2023
    Assignee: TRIS PHARMA, INC
    Inventors: Yu-Hsing Tu, Ashok Perumal, Kalyan Kathala
  • Patent number: 11628143
    Abstract: Disclosed herein is a tablet for oral suspension comprising carglumic acid and its use.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: April 18, 2023
    Assignee: Novitium Pharma LLC
    Inventors: Muthusamy Shanmugam, Shivanand Premanand Puthli
  • Patent number: 11628219
    Abstract: This invention provides methods and systems for achieving high-specificity killing of targeted cells using Magneto-Electric Nano-Particles (MENPs) and functional or diagnostic imaging that detects changes at the cellular level. Embodiments comprise injecting into a patient's body manufactured MENPs that have a higher tendency to accumulate near or attach to targeted cells through one or more physical forces and/or biological mechanisms; and applying a magnetic field to the MENPs to generate an action that is sufficient to cause death of the targeted cells, and using an imaging apparatus to image or detect a specific property of the MENPs or changes in a property of the MENPs due to the coupling of the MENPs with their surrounding environment.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 18, 2023
    Inventor: Ping Liang
  • Patent number: 11617730
    Abstract: The present invention concerns a pharmaceutical formulation for administering paracetamol by buccal/gingival route consisting of a hydroalcoholic solution comprising dissolved paracetamol, characterised in that: #the mass of paracetamol is between 95 mg and 190 mg, #the volume of said hydroalcoholic solution is between 1.0 ml and 2.0 ml, #the degree of alcohol of said hydroalcoholic solution is between 48.5° and 52.5°, and #the concentration of paracetamol in said hydroalcoholic solution is between 85 mg/ml and 110 mg/ml. The present invention also concerns said pharmaceutical formulation for the use of same for accelerating the speed at which paracetamol passes through the blood-brain barrier, and the use thereof as a drug, in particular for the symptomatic treatment of pain or fever.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: April 4, 2023
    Inventor: Eric Goupil
  • Patent number: 11612564
    Abstract: An oral adhering lozenge is provided which delivers to the mouth a component with an undesirable flavor and a component for delivering a masking flavor. The oral adhering lozenge comprises a first, adherent layer and a second layer. The first, adherent layer includes a flavor-masking component, and the second layer includes both an active component and a flavor-masking component. In another configuration, the first, adherent layer includes both an active component and a flavor-masking component. In use, the second layer of the lozenge generally finishes dissolving and/or eroding in the mouth before the first layer finishes dissolving and/or eroding. The later eroding adherent layer will continue to release the flavor-masking component after all of the active component has been released into the mouth, thereby providing increased masking of any bitter aftertaste of the active.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: March 28, 2023
    Assignee: Quest Products, LLC
    Inventor: Jeffrey Haley
  • Patent number: 11607420
    Abstract: The present invention relates to a new formulation of specific nutritional ingredients (nutraceuticals) and/or pharmaceutical compounds.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: March 21, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Elger Funda, Odile Krainz
  • Patent number: 11590067
    Abstract: An anhydrous topical composition provides a water repellent surface. The anhydrous topical composition has at least one film former with surface tension lower than 35 dynes/cm, at least one particle having a hydrophobic surface or a hydrophobic surface treatment, and a volatile topical carrier.
    Type: Grant
    Filed: January 22, 2017
    Date of Patent: February 28, 2023
    Inventors: James SaNogueira, Tao Zheng
  • Patent number: 11583487
    Abstract: A method for producing a coating on skin, the method comprising: A) a step of electrostatically spraying a composition X comprising the following component (a) and the following component (b) directly on the skin to thereby form a coating on a skin surface: (a) one or more volatile substances selected from the group consisting of water, an alcohol, and a ketone, and (b) a polymer having a coating forming ability; and B) a step of applying a composition Y, other than the composition X, containing the following component (c) and the following component (d) to the skin: (c) 5% by mass or more and 20% by mass or less of an adhesive polymer, and (d) 1% by mass or more and 40% by mass or less of a polyol, in this order or in reverse order.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: February 21, 2023
    Inventors: Asuka Imai, Nobuyuki Asami
  • Patent number: 11571498
    Abstract: The present disclosure relates to medical devices, and methods for producing and using the devices. In embodiments, the medical device may be a buttress including a porous substrate possessing a therapeutic layer of a chemotherapeutic agent and optional excipient(s) thereon. By varying the form of chemotherapeutic agents and excipients, the medical devices may be used to treat both the area to which the medical device is attached as well as tissue at a distance therefrom.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: February 7, 2023
    Assignee: Covidien LP
    Inventors: Terry Morgan, Beth Sersen, Daniel Schulz-Jander, Joseph Traina, Brian Graham, Carol Sullivan, Gerald Hodgkinson
  • Patent number: 11571442
    Abstract: A seal formulation for forming a physical barrier in the teat canal of a non-human animal for prophylactically controlling infection of a mammary gland by a mastitis-causing organism comprises a polymer in a gel base wherein the polymer is a lower alkyl vinyl ether-maleic anhydride copolymer or a salt derivative thereof. The lower alkyl vinyl ether-maleic anhydride copolymer salt derivative may comprise at least one cationic ion including monovalent, bivalent or trivalent cations and mixtures thereof.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: February 7, 2023
    Assignee: Zoetis Broomhill IP Limited
    Inventors: Francisco Javier Molins Albanell, Brendan Gerard Smith, James Kennedy, Fiona Ní Chearúil
  • Patent number: 11564872
    Abstract: The present invention relates to a cosmetic composition in the form of an oil-in-water emulsion comprising: (i) at least one C16-C30 fatty alcohol; (ii) at least one anionic surfactant of general formula (I): RCOY(CH2)nSO3M; (iii) at least one oil; (iv) at least one wax, and (v) at least one hydrophilic solvent, the weight ratio of anionic surfactant(s) of general formula (I)/fatty alcohol(s) ranging from 1/5 to 1/3, said composition comprising from 1% to 10% by weight of wax(es) relative to the total weight of the composition. The present invention also relates to a process for preparing said composition and a cosmetic makeup and/or care process.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: January 31, 2023
    Assignee: L'OREAL
    Inventors: Odile Aubrun, Arno Wahler
  • Patent number: 11565979
    Abstract: Methods and systems are provided for generating and utilizing a bacterial composition that comprises at least one genetically engineered bacterial strain that fixes atmospheric nitrogen in an agricultural system that has been fertilized with more than 20 lbs of Nitrogen per acre.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: January 31, 2023
    Assignee: Pivot Bio, Inc.
    Inventors: Karsten Temme, Alvin Tamsir, Sarah Bloch, Rosemary Clark, Emily Tung, Kevin Hammill, Douglas Higgins, Austin Davis-Richardson
  • Patent number: 11547678
    Abstract: An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: January 10, 2023
    Assignee: Gruenenthal GmbH
    Inventors: Ulrich Reinhold, Marc Schiller, Eva Wulsten, Sabine Karine Katrien Inghelbrecht, Roger Carolus Augusta Embrechts, Ulrich Feil
  • Patent number: 11529313
    Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: December 20, 2022
    Assignees: R.P. Scherer Technologies, LLC, UNIVERSITY OF MISSISSIPPI
    Inventors: Sampada Bhaskar Upadhye, Ronald S. Vladyka, Michael Andrew Repka, Jun-Bom Park, Roshan Vijay Tiwari, Hemlata Gunga Patil, Joseph Thomas Morott, Jr., Wenli Lu
  • Patent number: 11517531
    Abstract: Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NO3? and Cl? ions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: December 6, 2022
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Sudipta Seal, Swetha Barkam, Amitava Adhikary
  • Patent number: 11510996
    Abstract: The present invention provides compositions comprising tolerizing immune modified particles (TIMPs) and methods for using and making said TIMPs. In particular, carrier polymer is covalently conjugated with antigenic peptide before particle formation, which allows for exquisite control of particle size and antigen encapsulation (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 29, 2022
    Inventors: Ryan Pearson, Daniel Getts, John Puisis, James Herrmann, Lonnie D. Shea