Patents Examined by Michael A Marcheschi
  • Patent number: 9012208
    Abstract: A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a macrofluidic component, including a chamber for receiving an unprocessed sample from a collection device and at least one filled liquid purification reagent storage reservoir; and (ii) a microfluidic component in communication with the macrofluidic component through at least one microfluidic element, the microfluidic component further comprising at least one nucleic acid purification matrix; and (iii) at least one interface port to a drive mechanism on the instrument for driving said liquid purification reagent, through the microfluidic element and the nucleic acid purification matrix, wherein the only inputs to the apparatus are through the chamber and the interface port to the drive mechanism.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: April 21, 2015
    Assignee: NetBio, Inc.
    Inventors: Richard F. Selden, Eugene Tan
  • Patent number: 8969072
    Abstract: The present invention is directed to a method and automated unloading means for unloading a container from an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: March 3, 2015
    Assignee: bioMerieux, Inc.
    Inventors: Ronnie J. Robinson, Mark Joseph Fanning, Stanley Michael Philipak, Anthony Valentino, Mike Ammerman
  • Patent number: 8951783
    Abstract: Systems and methods to analyze contaminants including a plurality of stages configured to detect contaminants in a sample, wherein the plurality of stages are configured to detect a plurality of contaminants at substantially the same time.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: February 10, 2015
    Inventor: Jaydeep Bhattacharya
  • Patent number: 8945917
    Abstract: A novel enhanced surface area conico-cylindrical flask (ES-CCF) providing increased surface area by virtue of its' inner arrangement and useful in routine small-scale studies of bioactives production by any biofilm-forming marine as well as terrestrial microorganisms. Compared to corresponding Erlenmeyer flask of similar volume the ES-CCF provides more than 80% additional surface for biofilm attachment and growth. The ES-CCF does not require steam sterilization and is durable as the device is constructed of polymethyl methacrylate or any other such hydrophobic material and offers possibility of altering the nature of the growth surface (hydrophilic and hydrophobic). The ES-CCF also provides external aeration like a bioreactor, thus increasing the versatility of applications. Further, the device can be operated as a cylindrical flask, that is without the inner arrangement.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: February 3, 2015
    Assignee: Counci of Scientific & Industrial Research and School of Environmental Studies
    Inventors: Sreyashi Sarkar, Debashis Roy, Joydeep Mukherjee
  • Patent number: 8921094
    Abstract: A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: December 30, 2014
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Reto Keller, Thomas Meyer
  • Patent number: 8900853
    Abstract: A thermocycling device includes a sample holder, a thermal reference and a heating and cooling device which is arranged between the sample holder and thermal reference. The heating and cooling device is in thermally conductive contact with the sample holder and with the thermal reference. The thermocycling device further includes a reference heating and cooling device for maintaining the temperature of the thermal reference at a predetermined temperature level during cycling, and a heat sink which is in thermally conductive contact with the reference heating and/or cooling device.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: December 2, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Boudewijn Theodorus Verhaar, Jacobus Frederik Molenaar, Martijn Cornelis Franciscus Vervoorn
  • Patent number: 8889406
    Abstract: An apparatus for cultivating cells utilizing wave motion comprising a container, a retaining member configured to retain the container, a drive assembly for swiveling the container with respect to the substantially horizontal pivot axis and to swivel, such that during swiveling the pivot axis follows a cyclical closed-loop path.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: November 18, 2014
    Assignee: Strix Beheer B.V.
    Inventors: Pieter van der Heiden, Marc Buevink, Nicolaas Marius Gerard Oosterhuis
  • Patent number: 8889403
    Abstract: A system for generating a tissue construct includes a mixing chamber, a piston chamber, a reaction chamber, and a pump. The mixing chamber is configured to receive a hydrogel solution and a cell suspension solution. The piston chamber includes a first piston and is configured to receive a mixture of the hydrogel solution and the cell suspension solution from the mixing chamber. The first piston is configured to push the mixture through one or more capillaries into the reaction chamber. The reaction is configured to receive the mixture and a cross-linking initiator. The pump is configured to move the mixture through the reaction chamber such that the mixture and the cross-linking initiator combine to form an encapsulated cell material.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: November 18, 2014
    Assignee: Empire Technology Development LLC
    Inventors: Marvi A. Matos, William B. Carlson, Ivan Vesely, Yansong Gu
  • Patent number: 8871502
    Abstract: The present invention discloses a culture medium device, which comprises a plate containing a solid-state or gel-state culture medium layer; a shield layer covering the culture medium layer; and a lid covering the plate. The shield layer is in a solid, gel or liquid state and contains sugar at a concentration of greater than 0% (w/w) and less than or equal to 0.1% (w/w). Via the shield layer containing a select composition, the present invention can reduce the affection of microbiological contamination and promote the yield and productivity of biomass in the process of inoculating and cultivating Polyporales.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: October 28, 2014
    Assignee: Balay Biotechnology Corporation
    Inventors: Wen-Huang Liu, Chien-Liang Kuo
  • Patent number: 8846377
    Abstract: A process for capturing CO2 includes contacting a CO2-containing gas with an absorption mixture optionally within a packed reactor is provided. The absorption mixture includes a liquid solution and micro-particles. The micro-particles include a support material and biocatalyst supported by the support material and are sized and provided in a concentration such that the absorption mixture flows through the packed reactor and that the micro-particles are carried with the liquid solution to promote dissolution and transformation of CO2 into bicarbonate and hydrogen ions. The absorption mixture and micro-particles may be provided in an absorption reactor so as to be pumpable. Furthermore, a process for desorbing CO2 gas from an ion-rich aqueous mixture includes providing biocatalytic micro-particles and feeding the mixture to a desorption reactor, to promote transformation of the bicarbonate and hydrogen ions into CO2 gas and water.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: September 30, 2014
    Assignee: CO2 Solutions Inc.
    Inventors: Sylvie Fradette, Julie Gingras, Normand Voyer, Jonathan Carley, Glenn R. Kelly, Olivera Ceperkovic
  • Patent number: 8828692
    Abstract: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components into contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microorganisms that converted the syngas to desired liquid products. The system can sustain production with a variety of microorganisms and membrane configurations.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: September 9, 2014
    Assignee: Coskata, Inc.
    Inventors: Robert Hickey, Rathin Datta, Shih-Perng Tsai, Rahul Basu
  • Patent number: 8822208
    Abstract: The bioreactor is for use in performing biological and/or biochemical reactions and includes a vessel, an agitator, a reaction assembly, and a harvesting outlet. The vessel of the bioreactor includes several ports including a mixing port, a reaction port, and a harvesting port. The agitator extends through the mixing port into the vessel while the harvesting outlet extends through the harvesting port and permits the withdrawal of reaction medium to another vessel. The reaction assembly extends through the reaction port into the vessel and has multiple components including a gas conduit adapted to introduce gas into a reaction medium in the vessel, a sampling device adapted to remove a portion of the reaction medium from the vessel without contamination of the remaining reaction medium, and an introduction conduit permitting the introduction of at least the reaction medium into the vessel.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: September 2, 2014
    Assignee: Becton, Dickinson and Company
    Inventor: Bunkim Chokshi
  • Patent number: 8815572
    Abstract: The present invention relates to a nucleic acid extracting apparatus, and the nucleic acid extracting apparatus can include a pipe-shaped tube having an open outlet at one side thereof, and a hydrogel supporting member that is provided inside the tube and filters impurities excluding an extraction target material.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: August 26, 2014
    Assignee: Postech Academy-Industry Foundation
    Inventors: Geun-Bae Lim, Ji-Min Kahng, Jin-Hwa Jung, Ho-Taik Kwon
  • Patent number: 8809041
    Abstract: The invention provides a photo bioreactor comprising an aqueous liquid comprising a photosynthetic culture and light distributors (30). Each light distributor has a surface arranged to receive light and a tapered surface arranged to emit at least part of the received light. At least part of the tapered surface is submerged in the aqueous liquid comprising the photosynthetic culture. Light may be distributed efficiently in the aqueous liquid comprising the photosynthetic culture by relatively simple and cheap means. The reactor allows a high illuminated volume fraction.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: August 19, 2014
    Assignee: Feyecon B.V.
    Inventors: Geert Feye Woerlee, Steven Elmore, Frank Emile Wubbolts
  • Patent number: 8772019
    Abstract: The proposed invention is an in-situ system for aerobic heat treatment of biodegradable organic waste, comprising a bioreactor made up of a dish-shaped decomposition chamber. The decomposition chamber has a lid at the top through which an air extraction device is connected. The air extraction device enables fresh air to enter the decomposition chamber and a preparation for a device supplies the biodegradable organic waste. The decomposition chamber is also connected to a system of pipes which convey a hot fluid from the supply tank into a plurality of minitubes located longitudinally on the inner perimeter of the decomposition chamber, and into a shaft that forms part of the mixing mechanism. A centrifugal pump conveys the same fluid, which is now “cold”, from inside the minitubes and shaft to a solar collector, to heat it, before delivering it to a storage tank for subsequent recirculation.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 8, 2014
    Assignee: Instituto Tecnologico y de Estudios Superiores de Monterrey
    Inventor: Miguel Angel Lopez Zavala
  • Patent number: 8765460
    Abstract: A photobioreactor system for mass production of microorganisms is disclosed. Water with microorganisms suspended therein is sprayed through a nozzle to create droplets. These droplets have a high surface area to volume ratio enabling efficient light transfer and gas diffusion. The water may also be passed through channels between two transparent plates, wherein superior mixing is achieved along with a high surface to volume ratio. The water is preferably circulated through a dark holding tank Active and passive flashing lights of different wavelengths are used to promote growth of the microorganisms when the water is sprayed and/or passing through the transparent plates.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: July 1, 2014
    Inventors: Atle B. Nordvik, George Berliner
  • Patent number: 8759047
    Abstract: Ethanol and other liquid products are produced from biomass using indirect gasification of the biomass to produce a syngas containing CO2, CO, H2 and methane that passes the syngas without substantial removal of the methane to a fermentation zone for the conversion of the CO and CO2 and H2 to ethanol and the production of a methane rich stream followed by the methane reforming of the methane rich stream to produce additional CO and CO2 and H2 that passes to the fermentation zone.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: June 24, 2014
    Assignee: Coskata, Inc.
    Inventors: Rathin Datta, Ralph Corley
  • Patent number: 8753876
    Abstract: An apparatus and method for recovering thermal energy from boiler stack exhaust gases and using the thermal energy in biomaterial processing. The apparatus and method include means to improve the boiler's operation and reduce emission of certain regulated compounds.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: June 17, 2014
    Inventor: Andrew K. Schwartz, Jr.
  • Patent number: 8748165
    Abstract: This invention provides a method for generating short tandem repeat (STR) profiles on each of a plurality of samples comprising, for each sample: a) isolating DNA from the sample; b) amplifying STR markers in the isolated DNA and c) analyzing the amplification product by electrophoresis.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: June 10, 2014
    Assignee: IntegenX Inc.
    Inventors: Mattias Vangbo, William D. Nielsen, Iuliu I. Blaga, Michael Van Nguyen, Steven B. Jovanovich
  • Patent number: 8747740
    Abstract: Haloamine biocides are prepared via multi-step processes in an integrated apparatus comprising an electrochemical cell and a mixing chamber, wherein active halogen donor species are electrochemically generated and subsequently reacted with amine-containing compositions to form haloamine biocide. Haloamine biocides prepared according to such processes are used to treat liquids in order to inhibit, reduce, and/or control microorganism growth therein.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: June 10, 2014
    Assignee: Hercules Incorporated
    Inventors: David E. Sharoyan, Huai N. Cheng, Michael J. Mayer, Freddie L. Singleton