Patents Examined by Michael A Marcheschi
  • Patent number: 8748186
    Abstract: A method for counting blood cells in a sample of whole blood. The method comprises the steps of: (a) providing a sample of whole blood; (b) depositing the sample of whole blood onto a slide, e.g., a microscope slide; (c) employing a spreader to create a blood smear; (d) allowing the blood smear to dry on the slide; (e) measuring absorption or reflectance of light attributable to the hemoglobin in the red blood cells in the blood smear on the slide; (f) recording a magnified two-dimensional digital image of the area of analysis identified by the measurement in step (e) as being of suitable thickness for analysis; and (g) collecting, analyzing, and storing data from the magnified two-dimensional digital image. Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: June 10, 2014
    Assignee: Abbott Laboratories
    Inventors: Richard Kendall, John W. Roche
  • Patent number: 8748167
    Abstract: An air purifier with a tub capable of containing a liquid. Reactor plates are in the tub wherein the reactor plates provide a curvilinear path for air flow with abrupt directional change. A pump is situated to distribute the liquid onto the reactor plates to form a moist surface. An air inlet brings contaminated air into contact with biocatalyst on the moist surface thereby forming purified air. An air outlet discharges said purified air from the air purifier.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: June 10, 2014
    Assignee: SGBlue, Inc.
    Inventors: Wesley O. Greene, Brian D. Summers, Roy D. Crowninshield
  • Patent number: 8735143
    Abstract: The present invention provides a hepatic lobule-like bioreactor. The bioreactor includes a nanofiber scaffold enclosed within a housing. An intrahepatic fibrous vascular network, a bile capillary network, upper hepatic bile ducts, lower hepatic bile ducts, a common bile duct connecting the upper and the lower hepatic bile ducts, and collagen fibrous microchannels for hepatocytes surrounded by the bile capillary network are distributed throughout the nanofiber scaffold. Bile capillaries in the bile capillary network are provided with two or more inlet ports for biliary epithelial cells. The collagen fibrous microchannels for hepatocytes are provided with two or more inlet ports for hepatocytes. The intrahepatic vascular network is provided with a liquid inlet port and a liquid outlet port. These ports extend through the housing.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: May 27, 2014
    Assignee: Zhejiang University
    Inventors: Lanjuan Li, Chengbo Yu, Yiming Zhang, Xiaoping Pan, Weibo Du, Hongcui Cao, Guoliang Lv, Jianrong Huang
  • Patent number: 8691561
    Abstract: A thermal treatment apparatus includes a fluidic device including at least one channel, a first temperature-changing unit that changes the temperature of a fluid in part of the channel, and a second temperature-changing unit that changes the temperature of the fluid in another part of the channel. The temperature changes by the first and second temperature-changing units cause at least any one of the expansion and contraction of the fluid in the respective parts of the channel, and the at least any one of the expansion and contraction of the fluid due to the first temperature-changing unit is offset by the at least any one of the expansion and contraction of the fluid due to the second temperature-changing unit.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: April 8, 2014
    Assignee: Canon Kabushiki Kaisha
    Inventor: Eishi Igata
  • Patent number: 8586353
    Abstract: The invention provides a device for growing genetically enhanced aquatic photoautotrophic organisms in a stable culture, causing the organisms to produce ethanol, and then separating, collecting, and removing the ethanol in situ.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: November 19, 2013
    Assignee: Algenol Biofuels Switzerland GmbH
    Inventors: Robert Paul Woods, Edwin Malkiel, Benjamin Moll, Edward Legere
  • Patent number: 8563299
    Abstract: A process for converting a feed gas containing at least one of CO, CO2, and/or H2 to a liquid product using biomass that grow on the surface of carriers suspended in a fermentation broth within the vessel of a moving bed bioreactor (MMBR). An injector is used to at least partially dissolved the feed gas in the fermentation broth, at least partially entrain the gas in the broth as microbubbles and to introduce the mixture of the entrained gas and broth into the vessel in a substantially horizontal direction. The injection of the mixture creates eddy current in the surrounding liquid for thoroughly mixing the fermentation broth in the vessel and for keeping the biomass carrier moving to provide sufficient shear so as to maintain a biofilm thickness on the carrier in a desirable range.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: October 22, 2013
    Assignee: Coskata, Inc.
    Inventor: Robert Hickey
  • Patent number: 8557588
    Abstract: Methods and apparatus are described for sampling and diluting concentrated emulsions, which may be oil-in-water emulsions, water-in-oil emulsions, or other concentrated emulsions. One method embodiment of the invention comprises obtaining a sample of a concentrated emulsion comprising a dispersed phase and a continuous phase fluid; measuring droplet concentration of the dispersed phase in the sample; and for droplet concentration of the sample greater than about 1000 ppm, diluting the sample with substantially pure continuous phase fluid, forming a first diluted emulsion. Methods of the invention include those wherein the obtaining of a sample comprises opening a fluid connection to a flowing stream comprising the concentrated emulsion, wherein the obtaining and diluting steps occur in real time.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: October 15, 2013
    Assignees: Schlumberger Technology Corporation, Total S.A.
    Inventor: Gary Martin Oddie
  • Patent number: 8557571
    Abstract: A reactor has a reactor unit with a first chamber and a second chamber, with the first chamber being formed by the interior of a housing and the second chamber being formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm2, based on the cross-sectional area of the first chamber. The reactor unit can include two casting compounds, in which a portion of the hollow fibers are embedded and between which another portion of the hollow fibers extends. The length of at least some or all of the hollow fibers is at least 0.5% greater than the distance of the casting compounds.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: October 15, 2013
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Franz Kugelmann, Paul Hengster, Raimund Margreiter, Bernd Nederlof, Massimo Fini, Ciro Tetta, Thomas Wild, Micaela Yakubovich, Michael Paul, Marco Caronna
  • Patent number: 8541214
    Abstract: A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a hydrophilic membrane under anaerobic conditions and transfers these components into contact with microorganisms contained as a biofilm on the membrane. Maintaining the microorganisms as a biolayer on the surface of the membrane facilitates cleaning of the membrane surface that retains the biofilm. In addition the shell gas space that surrounds the membranes may be flooded to reduce or remove the biofilm. Agitation of the liquid, by for example the bubbling of gas in the surrounding shell space, can fully or partially remove the biofilm from the membrane.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: September 24, 2013
    Assignee: Coskata, Inc.
    Inventors: Robert Hickey, Rahul Basu, Rathin Datta, Shih-Perng Tsai
  • Patent number: 8507261
    Abstract: A laboratory dish comprises an incubation container, containing cultured cells, for observation through a microscope, in which a partitioning member partitions an interior of the incubation container into a plurality of incubation chambers by substantially perpendicular walls. The partitioning member tightly fits to a bottom portion of the incubation container, thereby capable of retaining in separation a liquid inputted in each of the incubation chambers from liquids in the other incubation chambers. A cover member covers an upper portion of each of the incubation chambers partitioned by the partitioning member and tightly fitted to the partitioning member. A whole or part of the cover member is formed of a transparent member, and the upper portion of each incubation chamber is formed with an opening via which to input the liquid.
    Type: Grant
    Filed: November 29, 2009
    Date of Patent: August 13, 2013
    Assignee: Nikon Corporation
    Inventors: Yasushi Ogihara, Ichiro Sase, Roman Zantl
  • Patent number: 8507263
    Abstract: Articles and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. In some embodiments, a bioreactor is configured to provide a first and second chamber, such as an inner and an outer chamber, respectively. The chambers may be co-axially arranged with respect to each other. A wall of the bioreactor defining the two chambers may be formed at least in part from a scaffold derived from a length of a hollow or tubular tissue or organ. Such a bioreactor can be used to form biocompatible structures for tissue engineering and organ replacement, such as cellular tissues, organ-like structures, and/or complete organs, within the bioreactor.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: August 13, 2013
    Inventors: Maria Adelaide Asnaghi, Sara Mantero
  • Patent number: 8501090
    Abstract: An apparatus and method administering nitric oxide at very high concentrations to healthy skin, tools, implements, support surfaces, and sterile fields to provide sterilization. The apparatus and method providing sterilization in a dry environment lacking the common undesirable effects of anti-microbial soaps and antiseptics.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: August 6, 2013
    Inventors: Christian S. Minton, Stephen Minton, John William Randolph Miller
  • Patent number: 8501091
    Abstract: The invention relates to a method for sterilizing a cosmetic product, in which said product consists of a fluid circulating under regulated pressure in a sterilization circuit (1), according to the viscosity of said fluid. The invention also relates to the device for implementing such a method.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: August 6, 2013
    Assignee: CL Tech (Societe par Actions Simplifiee)
    Inventors: Didier Lopez, Christophe Lopez
  • Patent number: 8492137
    Abstract: The present invention relates to a cover for covering one or more sample(s) that are suitable to avoid or minimize evaporation and/or condensation of any vaporizable substance that may be present in the sample(s) or reaction mixture(s), in particular evaporation of substance at the fringes of a vessel or an array of vessels or condensation of a substance on the lid of a reaction vessel or a plate/block containing the sample(s) and/or a cover. This is achieved by providing a device comprising, among others, a force distribution unit that comprises at least one medium or material that is unable to withstand a static shear stress and deforms continuously under the action of a shear force.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: July 23, 2013
    Assignee: Eppendorf AG
    Inventors: Holger Link, Jens Peter Kroog, Lutz Timmann, Henner Tasch, Cordula Kroll, Stefan Roth, Ruediger Huhn, Reinhold Goetz, Helmut Knofe, Arne Schafrinski
  • Patent number: 8491179
    Abstract: A food mixing machine (20) has an agitator (25) to mix food in a cup (C). A cup holder (31) is provided with a flexible boot (32) which receives the cup (C). The cup holder (31) is moveable through an opening (90) in the machine (20) and carries a gripping assembly (33) and an actuator assembly (34). The actuator assembly (34) is moveable relative to the gripping assembly (33) and is biased by springs (35) to maintain fingers (56) of the gripping assembly (33) in engagement with the cup (C). When it is desired to release the cup (C), a release assembly (80) overcomes the bias of the springs (35). As the cup holder (31) moves through the opening (90), the area between the cup holder (31) and the opening (90) is sealed by a seal assembly (91) so that food materials cannot go through the opening (90).
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: July 23, 2013
    Assignee: Vita-Mix Corporation
    Inventors: Eugene J. Kozlowski, John K. Barnard
  • Patent number: 8491454
    Abstract: A spinning force system and methods of operation are provided for measuring a characteristic of a sample. The system includes a detection module having a light source for illuminating the sample and an objective being aligned to the light source to define a light path for producing an image of the sample. A rotor is mechanically coupled to the detection module and configured to rotate the light path for applying a force to the sample. The force may include a centrifugal force and other forms of force (such as a viscous drag force) resulted from the rotation. In some examples, the force is applied in a direction that is not parallel to a surface of the sample.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: July 23, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: Wesley P. Wong, Kenneth A. Halvorsen
  • Patent number: 8485958
    Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: July 16, 2013
    Assignee: Kensey Nash Corporation
    Inventors: John E. Nash, William T. Fisher
  • Patent number: 8486710
    Abstract: A method for measuring a lower heating value of a gaseous fuel. The method includes mixing a gaseous fuel with air to provide a combustible air-fuel mixture. The air-fuel mixture is directed to flow across a flow surface of a first micro-hotplate maintained at a constant temperature. A change in power required to maintain a constant temperature of the first micro-hotplate flow surface due to a convective and conductive heat transfer from the first micro-hotplate flow surface to the air-fuel mixture is measured. The air-fuel mixture is directed to flow across a flow surface of a second micro-hotplate maintained at a constant temperature. The air-fuel mixture is combusted as the air-fuel mixture flows across the second micro-hotplate flow surface. A change in power required to maintain a constant temperature of the second micro-hotplate flow surface due to the combustion of the air-fuel mixture is measured.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: July 16, 2013
    Assignee: General Electric Company
    Inventors: William Joseph Antel, Nirm Velumylum Nirmalan, Stephen Adam Solovitz, Nishant Vats, Subhrajit Dey, Robert Michael Orenstein, Matthew Moorman, Ronald P. Manginell
  • Patent number: 8480954
    Abstract: An apparatus and methods for dispensing sample holders for use in an automated sample analyzer is disclosed herein. The apparatus for dispensing sample holders includes a rotating carousel for housing stack of sample holders. Stacks of sample holders from the rotating carousel are fed into a chute where sample holders contact a set of rotating members having helical threads thereon. The helically threaded rotating members engage the sample containers and separate each sample holder from the remaining sample holders in the stack by rotation of the helically threaded rotating members. The sample holder can then be transferred for use in an automated sample analyzer.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: July 9, 2013
    Assignee: Biokit, S.A.
    Inventors: Mark Talmer, Paul Dahlstrom
  • Patent number: 8480976
    Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: July 9, 2013
    Assignees: Gen-Probe Incorporated, Qualigen, Inc.
    Inventors: Scott S. Breidenthal, Sara H. Fan, Richard S. Lee, Norman C. Nelson, Matthew J. Scott, Jason A. Taylor