Patents Examined by Michael A Marcheschi
  • Patent number: 8187866
    Abstract: An optical scanning system including a switchable light source, a detector, a substrate and a plurality of optical sensing sites, as well s methods and kits for use thereof are provided. The substrate is coupled to and in optical communication with the switchable light source and the detector. Additionally, the substrate includes a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing. The plurality of optical sensing sites are each in optical communication with an intersection region.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: May 29, 2012
    Assignee: PLC Diagnostics, Inc.
    Inventor: Reuven Duer
  • Patent number: 8178343
    Abstract: A diagnosis apparatus is provided. A gene chip having a target gene cluster is used with the apparatus. The target gene cluster comprises a plurality of target genes related to a cancer. Thus, a fast, accurate, sensitive and cheap WEnCA-Chipball platform is provided for mass analysis and automatic operation while human error and time for diagnosis are both reduced.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: May 15, 2012
    Assignee: Fooyin University Hospital
    Inventors: Shiu-Ru Lin, Hui-Jen Chang, Der-An Tsao
  • Patent number: 8173415
    Abstract: A microinjection device for injecting a target cell with a reagent. The microinjection device includes a flexible substrate; a target supply channel formed in the flexible substrate for receiving the target cell; a reagent supply channel formed in the flexible substrate for receiving the reagent; a suction capillary mounted within a suction channel formed in the flexible substrate, the suction capillary providing suction to the target supply channel for immobilizing the target cell within the target supply channel; an injection needle mounted within a needle channel formed in the flexible substrate, the injection needle being movable between injected and un-injected positions by deforming at least a part of the flexible substrate; and a plurality of electrodes embedded in the flexible substrate, the plurality of electrodes creating a voltage potential across the injection needle to move the reagent into the target when the injection needle is in the injected position.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: May 8, 2012
    Assignee: McMaster University
    Inventors: Arash Noori, Ponnambalam R. Selvaganapathy
  • Patent number: 8163043
    Abstract: Palm-based biodiesel formulations with enhanced cold flow properties are provided including the following: (I) A biodiesel formulation comprising not more than 40 vol % palm-based biodiesel and not less than 60 vol % petroleum-based file 1 oil; (II) A biodiesel formulation comprising not more than 20 wt % palm-based biodiesel and not less than 80 wt % alkyl ester of C6-C18 saturated or unsaturated fatty acid, or a mixture thereof; (III) A biodiesel formulation comprising approximately 0.1-1.0% (wt/vol) of a polyalkyl methacrylate (PAMA) additive and a palm-based biodiesel blend comprising i) not more than 40 vol % palm-based biodiesel; and ii) not less than 60 vol % petroleum-based fuel oil; (IV) A biodiesel formulation comprising approximately 0.1-5.0% (wt/vol) of a polyalkyl methacrylate (PAMA) additive and a palm-based biodiesel having unsaturation level of not less than 60%.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: April 24, 2012
    Assignee: Malaysian Palm Oil Board
    Inventors: Yuen May Choo, Ah Ngan Ma, Yusof Basiron, Chee Liang Yung, Sit Foon Cheng
  • Patent number: 8148142
    Abstract: A system and methods for processing organic waste material for residential type environments includes a reactor tank dimensioned to receive a predetermined amount of organic material therein. The amount of organic material is selected based upon the size of the residential service area the system is servicing. The system includes homogenizing the volume of organic waste materials and selectively introducing the homogenized organic material into a reaction tank. A system for selectively removing gaseous by-products from the anaerobic digestion of organic material within the reactor tank is provided, along with a system for selective removal of waste solids from the reactor tank to provide for substantially continuous processing of materials and production of usable gases.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: April 3, 2012
    Inventors: Michael R. Sapp, Rudy J. Wojtecki
  • Patent number: 8133722
    Abstract: Provided are a cell culture compartment unit and an array including the same. The cell culture compartment unit includes: a cell culture region and a bio material emission region including a cell culture fluid, which are separated with a porous membrane therebetween; a piezoelectric device on the porous membrane of the cell culture region; a thin layer for cell attachment being on the piezoelectric device and having at least one surface on which cells are attachable; and a first power supply applying a first electric field to the piezoelectric device.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: March 13, 2012
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sanghee Kim, Chul Am Kim, Chang-Geun Ahn, Moon Youn Jung
  • Patent number: 8124572
    Abstract: The present invention is directed to methods and systems for processing triglyceride-containing, biologically-derived oils, wherein such processing comprises conversion of triglycerides to free fatty acids and the separation of these fatty acids by saturation type. Such separation by type enables the efficient preparation of both lubricants and transportation fuels from a common source using a single integrated method and/or system.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: February 28, 2012
    Assignee: Chevron U.S.A. Inc.
    Inventor: Stephen Joseph Miller
  • Patent number: 8123930
    Abstract: The invention thus provides crude oils and products which have been produced therefrom and comprise distillation residues, comprising at least one alkylphenol-aldehyde resin having a repeat structural unit of the formula where R1 is a branched alkyl or alkenyl radical which has from 10 to 40 carbon atoms and bears at least one carboxyl, carboxylate and/or ester group, R2 is hydrogen or R1 R3 is hydrogen or an alkoxy group of the formula -(A-O)m—H, A is a C2- to C4-alkylene group, m is from 1 to 100, R4 is hydrogen, a C1- to C11-alkyl radical or a carboxyl group, R5 is C1-C200-alkyl or -alkenyl, O—R6 or O—C(O)—R6, R6 is C1-C200-alkyl or -alkenyl, n is from 1 to 100 and k is 1 or 2, the use of the alkylphenol-aldehyde resin for splitting emulsions of water and crude oils or products derived therefrom, the use of the alkylphenol-aldehyde resin for improving the cold flowability of crude oils and products derived therefrom, and the use of the alkylphenol-aldehyde resin as an asphaltene dispersant in crude
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: February 28, 2012
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Carsten Cohrs, Matthias Krull, Michael Feustel, Heidi Rausch
  • Patent number: 8114659
    Abstract: This apparatus introduces catalysts and fluids into a media to effect remediation of contaminants, improve soil fertility and permeability, control undesirable pests, or create useful chemicals or food. The apparatus generates and releases enzymes, metabolites, and biologically active organisms. Aerobic metabolism of compounds in a media is facilitated through the transfer of fluids, such as air. The apparatus and methods provide an environment for select organisms, including refugia and nutrient substrate. The biodegradable composition of the apparatus is partially transformed by catalytic treatment. Catalysts or remediation agents are produced in-situ, for specific applications that provide a range of retention, activation, activity, and release profiles. The apparatus is placed in contact with media. Catalytic infusion of media by biological consortia, such as fungi, releases exudates that transform or biodegrade materials.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: February 14, 2012
    Inventors: Robert William Rawson, Mia Rose Maltz
  • Patent number: 8114663
    Abstract: A waste management and resource recovery system that uses the different waste streams from typical waste sources as fuel or feedstock for its subsystems that, in turn, produce fuel, feedstock or energy for other subsystems such that all the different waste streams are effectively managed. The subsystems include a gas burner for solid and fuel wastes that supplies heat to a hydrothermal processor for saccharification of paper and cardboard. The resulting saccharification broth, along with kitchen wastes and blackwater, are supplied to a bioreactor using dark fermentation to produce hydrogen and volatile fatty acids. The hydrogen and volatile fatty acids are supplied to hydrogen and microbial fuel cells to produce electrical energy for operating the system and potable water. A steam accumulator is added to provide sufficient temperatures and pressures to reach the necessary thermodynamic states for the saccharification process.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: February 14, 2012
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Michael V. Henley, Lixiong Li, Theodore V. Marolla, William Wallace, Seth M. Foulkes
  • Patent number: 8110397
    Abstract: A reconfigurable sample preparation device includes a rotary plunger device having a hollow body and a coupling device, provided above one end of the rotary plunger, and accommodating a sample. The device also includes at least one sealed reagent module. When the rotary plunger is rotated on the coupling device, a film of the reagent module is pierced, mixing the sample with a substance from the reagent module.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: February 7, 2012
    Assignee: Smiths Detection Inc.
    Inventor: Douglas Jason Green
  • Patent number: 8105824
    Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: January 31, 2012
    Assignee: Fluidigm Corporation
    Inventors: Geoffrey Facer, Robert Grossman, Marc Unger, Phillip Lam, Hou-Pu Chou, Jake Kimball, Martin Pieprzyk, Antoine Daridon
  • Patent number: 8105398
    Abstract: Production of ester-based fuels such as biodiesel or jet fuel from renewable starting materials such as lignocellulosic material or algae is disclosed. Pulping and saccharification of the renewable starting materials produces carboxylic acids such as fatty acids or rosin acids, which are esterified via a gas sparged, slurry form of heterogeneous reactive distillation to yield ester-based fuels.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: January 31, 2012
    Assignee: Endicott Biofuels II, LLC
    Inventor: William Douglas Morgan
  • Patent number: 8105537
    Abstract: A fuel quality evaluation apparatus and evaluation method enable a reliable evaluation at a low cost. The apparatus includes a combustion chamber which causes an injected fuel to combust, temperature control means which adjusts an interior temperature of the combustion chamber before injection, injection control means which controls the injection, light intensity measurement means which measures flame combustion light intensity, and analysis means which analyzes the measurement result and evaluates a fuel quality. The analysis means causes the fuel to combust a plurality of times, identifies a transformation of a flame light intensity, and evaluates the quality of the fuel based on a variation in the light intensity transformations for each combustion.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: January 31, 2012
    Assignee: National University Corporation Okayama University
    Inventors: Eiji Tomita, Hiroshi Morinaka
  • Patent number: 8105992
    Abstract: The invention relates to viscosity modifier polymers, concentrate and lubricant formulations utilizing a diblock polymer having one block A and one block B, block A contributing from 15 to 30% of the total chain length and block B from 70 to 85% of the total chain length, wherein block A comprises at least 93 wt % of ethylene and at least one other alpha-olefin and block B comprises an ethylene content between 40 and 75 wt % and at least one other alpha-olefin and wherein the resulting block copolymer has an average ethylene content of between about 60 wt % to 80 wt % ethylene, a fast Gaussian NMR relaxation signal between 17 and 22% and a slow exponential NMR relaxation signal between 58 and 68% of the total NMR relaxation signal, a SSI of at least 35% and a TE of at least 3.5 in order to obtain improvements in fuel economy.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: January 31, 2012
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Jean-Roch Schauder, Kirk Alan Nass, Periagaram Srinivasan Ravishankar, Karine Vincent
  • Patent number: 8097450
    Abstract: Disclosed is a thin film chemical analysis apparatus and an analysis method using the same, which can solve the sealing problem caused by environmental factors (e.g. impact, temperature) for long circulation and storage periods, as well as can detect an analyte quickly and easily. The thin film chemical analysis apparatus includes at least one chamber adapted to store a fluid necessary for biological or biochemical analysis or to conduct a biological or biochemical reaction; channels for fluid-connection of the chambers; holes arranged between or inside the channels and connected to the channels; a rotatable body having the chambers, the channels, and the holes integrated into the body; and a burst valve having a sealing means for closing the hole and sealing a fluid in the chamber, the sealing means being torn away from the hole by centrifugal force resulting from rotation of the body and opening the hole.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: January 17, 2012
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Jae-chern Yoo
  • Patent number: 8092744
    Abstract: A purge and trap concentrator system that includes a sparge vessel, and includes a variable gas flow valve for controlling the gas pressure in an analytic trap or the sparge vessel; a sensor that detects both a foaming sample state and a high liquid level in the sparge vessel, using one optical sensor; a control scheme that re-directs the purge gases to a second inlet of the sparge vessel during a foaming condition; a control scheme that uses a split flow to enhance the quantity of sample gases passed from an analytic trap; an electrically powered thermal energy source with a fan raising the sparge vessel temperature via thermal convection.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: January 10, 2012
    Assignee: EST Analytical, Inc.
    Inventor: Douglas A. Meece
  • Patent number: 8088183
    Abstract: A system and method for the conversion of free fatty acids to glycerides and the subsequent conversion of glycerides to glycerin and biodiesel includes the transesterification of a glyceride stream with an alcohol. The fatty acid alkyl esters are separated from the glycerin to produce a first liquid phase containing a fatty acid alkyl ester rich (concentrated) stream and a second liquid phase containing a glycerin rich (concentrated) stream. The fatty acid alkyl ester rich stream is then subjected to distillation, preferably reactive distillation, wherein the stream undergoes both physical separation and chemical reaction. The fatty acid alkyl ester rich stream is then purified to produce a purified biodiesel product and a glyceride rich residue stream. The glycerin rich second liquid phase stream may further be purified to produce a purified glycerin product and a (second) wet alcohol stream.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: January 3, 2012
    Assignee: Seneca Landlord, LLC
    Inventors: John P. Jackam, Joel M. Pierce, Jeffrey D. Jones
  • Patent number: 8088616
    Abstract: The present technology provides for a heater substrate that contains networks of heater elements configured to controllably and selectively deliver heat to one or more PCR reaction chambers in a microfluidic substrate with which the heater substrate makes contact. In exemplary embodiments, the heater substrate can deliver heat to 12, 24, 48, or 96 chambers independently of one another, or simultaneously. The heater substrate is located in a heater unit that may be introduced into a diagnostic apparatus that can receive and position a microfluidic substrate, such as in a cartridge, in contact with the heater unit, receive one or more polynucleotide containing samples into one or more lanes in the microfluidic substrate, and cause amplification of the polynucleotides to occur, and detect presence of absence of specified polynucleotides in the amplified samples.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: January 3, 2012
    Assignee: HandyLab, Inc.
    Inventor: Kalyan Handique
  • Patent number: 8076522
    Abstract: A fuel composition exhibiting a reduced acceleration time, the fuel composition comprising a blend comprising a non-Fischer-Tropsch derived diesel base fuel and from about 0.2 v/v % to 3 v/v % Fischer-Tropsch derived kerosene fuel product, the blend exhibiting a reduced acceleration time that is at least 0.20% less than a theoretical acceleration time.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 13, 2011
    Assignee: Shell Oil Company
    Inventors: Richard Hugh Clark, John Nicholas Davenport, Jurgen Jacobus Johannes Louis