Abstract: The present disclosure relates to a cardiorespiratory analysis system that includes, in at least one embodiment, a conformal patch with a compressible viscoelastic interface and an array of sensors, including, but not limited to a photoplethysmography (PPG) sensor, a 3-axis accelerometer, and an electrocardiogram (ECG) sensor. In at least one embodiment, the system includes a microcontroller wired to the array of sensors. According to at least one embodiment, the system uses computing techniques to derive features from the array of sensors and determines one or cardiorespiratory characteristics of a patient based on the derived features.

Abstract: Systems and methods for treating sexual dysfunction using transcranial photobiomodulation (t-PBM) with near infrared light (NIR) are provided. In particular, a device configured for treating a disorder of a subject, the device can have a power source and a light source configured to receive power from the power source to cause the light source to emit near infrared light, wherein the near-infrared light has a wavelength of 600 nm to 1400 nm. The device has a processor and a housing configured to position the light source to deliver the near infrared light to a region of interest of the subject via transcranial photobiomodulation in a dosimetry and duration sufficient to treat the disorder.

Abstract: The present disclosure relates to a system for generating a predefined electrical signal in an MR scanner for use in electrical stimulation of a subject during MRI or functional MRI of said subject, wherein said MR scanner is located inside a shielded MRI room. The system comprises a control unit to be located outside the MRI room for generating an electrical signal and an electrical to optical converter to be located outside the MRI room for converting said electrical signal to a corresponding optical signal. An optical transmitting element, such as an optical fiber, is used for transmitting the optical signal into the MRI room, and an optical to electrical converter is used for converting the optical signal to said predefined electrical signal for electrical stimulation of the subject during magnetic resonance imaging. The optical to electrical converter is configured for being located inside the MRI room and for operation during magnetic resonance imaging.

Abstract: A lead fixation device for securing a first portion of a lead relative to a hole formed through a skull includes a skull attachment member having an upper surface and a lower surface and a bore extending through and between the upper surface and the lower surface. The lead fixation device also includes a lead compression mechanism integral with the skull attachment member and aligned with the bore of the skull attachment member. The lead compression mechanism defines a passageway through the lead fixation device, which passageway is characterized by a diameter that is defined by the lead compression mechanism. The lead compression mechanism is configured to transition the diameter from a first size to a second size greater than the first size upon insertion of an implant tool through the passageway, and from the second size to the first size upon removal of the implant tool from the passageway.

Abstract: A medical device with closed-loop responsive stimulation may include techniques to mitigate the impact on the therapy output of noise coupled into the medical device. A medical device according to this disclosure may determine the presence of noise and alter the closed loop policy to provide the necessary therapy to the patient and avoid prolonged under stimulation caused by the noise. The medical device may continue therapy, while testing for noise. When the device determines the noise level no longer affects the output therapy, the device may return the closed loop policy to a no-noise mode of operation. The medical device may also include techniques to mitigate the impact of manual adjustment while the medical device is subject to noise or is responding to changes in the patient's physiological signals.

Abstract: A method of localizing brain regions for the purpose of guiding placement of electrodes and related implants is disclosed. The inventive method involves effecting a pulse in a patient's brain, temporally aligning readings taken from an electrode at various depths, measuring local field potentials at each depth during interstimulus intervals, performing a coherence analysis comparing the local field potential measurements of the different depths, and determining a corresponding brain region for the depths compared.

Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

Abstract: A lead fixation device for attaching a deep brain stimulation lead within in a burr hole in a human skull. The lead fixation device may comprise a mounting plate having first and second arms. The first arm may comprise a first flange, a first mounting hole, and a first inner wall. The second arm may comprise a second flange, a second mounting hole, and a second inner wall. The first and second arms may comprise first and second arcuate grooves located on the first and second inner walls. When the lead device is in a closed position the first and second arcuate grooves form a guide channel and the first and second inner walls form an exit channel to receive the lead when the lead fixation device is in a closed position.

Abstract: A ring has an open top side and side walls that circumscribe a central region for receiving a phototherapy subject. The side walls include a work surface that is configured to receive visible light through the open top side and reflect the visible light toward the central region for phototherapy. The work surface includes a first surface that is a diffuse reflector and a second surface that is a specular reflector.

Abstract: Systems and methods for managing machine-generated alert notifications of medical events detected from one or more patients are described herein. An embodiment of a data management system may receive an adjudication of a medical event episode including an episode characterization. A storage unit stores an association between one or more episode characterizations and corresponding detection algorithms for detecting a medical event having respective episode characterizations. An episode management circuit may detect from a subsequent episode, using the stored association, a medical event having an episode characterization of at least one medical event episode presented for adjudication, and schedule presenting at least a portion of the subsequent episode based on the detection.

Abstract: An example system for exciting a selected set of motor neurons of a patient comprises one or more signal generators configured for generating a first electrical signal and a second electrical signal; a first set of wires configured to provide the first electrical signal to a first set of electrodes, wherein the first set of electrodes are configured for being secured to a first set of positions on the patient; a second set of wires configured to provide the second electrical signal to a second set of electrodes, wherein the second set of electrodes are configured for being secured to a second set of positions on the patient; and a controller configured to control operation of the one or more signal generators. The first electrical signal is a periodic signal of a first frequency. The second electrical signal is a periodic signal of a second frequency. The first frequency and the second frequency differ by a non-zero frequency difference.

Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

Abstract: Disclosed are: a skin care device which determines whether, on the basis of a voltage fluctuation according to contact with the skin, the skin care device has been rubbed, and which blocks the output of current through an electrode when rubbing does not occur for at least a set time; and a control method therefor. The disclosed skin care device determines the state of the skin care device on the basis of sensing voltage corresponding to a change in current of a transformation module according to the outputting of alternating current into the skin through contact electrodes, and blocks the output of current of an electrode module if the skin care device is in a fixed state.

Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: Systems and methods for His bundle pacing and classifying response to pacing impulses include applying, using a pulse generator, an impulse through a stimulating electrode to induce a response from a patient heart. A response to the impulse is measured using at least one sensing electrode and time-domain based characteristics of the response are analyzed to determine whether His bundle capture has occurred and, if so, what type of capture has occurred.

Abstract: The present application discloses a method for identifying arrhythmia, a device for identifying arrhythmia, and a computer readable medium. The method includes: acquiring a type of arrhythmia to be identified; acquiring an ECG signal collected by an ECG acquisition device; detecting feature wave information in the ECG signal according to the type of arrhythmia to be identified; extracting a feature parameter from the denoised ECG signal and the feature wave information according to the type of arrhythmia to be identified; and identifying, by a classifier, an occurrence of the type of arrhythmia to be identified according to the feature parameter.

Abstract: Systems and techniques are disclosed for improvement of machine learning systems based on enhanced training data. An example method includes accessing a database storing associations between objects included in medical images and classifications of the objects. A risk assessment model adapted to determine a risk condition for an object is accessed, the assessment based on features of the object. Risk conditions associated with respective objects are determined based on the risk assessment model. A group of objects associated with a first risk condition is identified. An interactive user interface is generated for display, the user interface concurrently displaying images of the group of objects. The interactive user interface enables a user to select subsets of images to be concurrently assigned a user-selected classification. User selected classifications are provided to a machine learning system adapted to update the risk assessment model based on the classifications to increase accuracy of the model.

Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.

Abstract: A neural stimulation and recording electrode assembly includes a selectively deformable guide tube. The guide tube includes a plurality of sequentially coupled connecting structures, wherein each connecting structure of the plurality of connecting structures has a respective central axis, and wherein at least one of the plurality of connecting structures is selectively deformable relative to the central axis of a sequential connecting structure of the plurality of connecting structures such that the central axis of the selectively deformable connecting structure is angularly oriented relative to the central axis of the sequential connecting structure.

Abstract: A method of cataract surgery in an eye of a patient includes identifying a feature selected from the group consisting of an axis, a meridian, and a structure of an eye by corneal topography and forming fiducial mark incisions with a laser beam along the axis, meridian or structure in the cornea outside the optical zone of the eye. A laser cataract surgery system a laser source, a topography measurement system, an integrated optical subsystem, and a processor in operable communication with the laser source, corneal topography subsystem and the integrated optical system. The processor includes a tangible non-volatile computer readable medium comprising instructions to determine one of an axis, meridian and structure of an eye of the patient based on the measurements received from topography measurement system, and direct the treatment beam so as to incise radial fiducial mark incisions.