Patents Examined by Michael B. Hydorn
  • Patent number: 5869523
    Abstract: Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolinProcess for the manufacture of 6.beta.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: February 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Noel John de Souza, Adolf D'Sa, Samba Laxminarayan Kattige, Gulab Bajirao Padwal, Jurgen Blumbach
  • Patent number: 5670701
    Abstract: The alkyl adipates are prepared by reacting admixture consisting essentially of alkyl 3-pentenoate and alkyl 2-pentenoate with carbon monoxide and an alcohol, at elevated temperature, under superatmospheric pressure and in the presence of a catalytically effective amount of cobalt or a cobalt compound and a nitrogenous heterocyclic base.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: September 23, 1997
    Assignee: Rhone-Poulenc Chimie
    Inventors: Philippe Denis, Jean-Michel Grosselin, Jean Jenck, Francois Metz, Paul Rouyer
  • Patent number: 5488171
    Abstract: A compound of formula ##STR1## where R.sup.1 and R.sup.2 are independently a C.sub.1 -C.sub.10 aliphatic radical, or R.sup.1 is a C.sub.1 -C.sub.10 aliphatic radical and R.sup.2 is a C.sub.6 -C.sub.10 aromatic radical, and R.sup.3 is a C.sub.1 -C.sub.8 aliphatic radical, a C.sub.3 -C.sub.8 cycloaliphatic radical, a C.sub.6 -C.sub.15 aromatic radical or a C.sub.7 -C.sub.13 araliphatic radical, provided that R.sup.3 is not methyl when R.sup.1 and R.sup.2 are each methyl, that R.sup.3 is not ethyl when R.sup.1 and R.sup.2 are each methyl and that R.sup.2 is not p-aminophenyl when R.sup.1 is methyl and R.sup.3 is ethyl.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: January 30, 1996
    Assignee: Ciba-Geigy Corporation
    Inventor: Eric K. Baylis
  • Patent number: 5455243
    Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: October 3, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Mark E. Duggan, Melissa S. Egbertson, Nathan Ihle, George D. Hartman, Laura M. Turchi, William F. Hoffman
  • Patent number: 5455266
    Abstract: The invention relates to enhanced chemotherapeutic compositions against microbial infections in fish, containing a benzylamine derivative of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, or a physiologically acceptable acid addition salt thereof and an effective amount of an antimicrobially active substance or a combination of such substances, preferably incorporated in feed, the preparation and the use thereof.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: October 3, 1995
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Riichi Kusuda, Ulrich Hamel
  • Patent number: 5449510
    Abstract: A stable cosmetic emulsion of the oil-in-water type contains an aqueous phase, an oily phase, and an emulsifier, with the oily phase containing at least one silicone oil and the emulsifier being a polyoxyethylenated polyorganosiloxane with the following formula: ##STR1## The stable emulsion is especially desirable in the fields of cosmetics and dermatology, particularly in creams, lotions, and makeup products.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: September 12, 1995
    Assignee: L'Oreal
    Inventors: Nathalie Gregoire, Anne Boelle
  • Patent number: 5447959
    Abstract: Derivatives of long-chain fatty alcohols, and methods of obtaining them, are provided, as well as pharmaceutical compositions containing derivatives and their uses, in particular in treating or preventing neuro-degenerative illnesses, conditions linked to skin ageing, the phenomena of thrombosis and atherosclerosis, and immune deficiencies.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: September 5, 1995
    Assignee: Medafor
    Inventor: Jacques Borg
  • Patent number: 5446068
    Abstract: This invention relates to 1-phenyl-3-phenyl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: August 29, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Dinerstein, Jeffrey S. Sabol, Keith A. Diekema
  • Patent number: 5439758
    Abstract: An electrochemical power generating system has a base unit and a replaceable fuel unit. The base unit comprises controller for controlling operation of the pump. The fuel unit comprises a second housing releasably connectable to the first housing and a row of metal-air cells in the second housing electrically inter-connected together. Each cell includes a casing, a metal anode within the casing, an air cathode, a spacer between the cathode and anode for preventing the anode from contacting the cathode, an electrolyte intake port and an electrolyte discharge port in the casing for passage of electrolyte through the casing and between the anode and cathode. The fuel unit further comprises a manifold, an electrolyte reservoir, and a fluid line. The manifold has an intake port and a plurality of discharge ports in fluid communication with the electrolyte intake ports of the cells so that electrolyte flowing through the manifold is directed through the intake ports of the cells.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: August 8, 1995
    Assignee: Voltek, Inc.
    Inventors: Gordon R. Stone, Richard L. McGee, Douglas J. Amick
  • Patent number: 5440044
    Abstract: The present invention relates to a leukotriene-B.sub.4 analog according to formula I ##STR1## in which R.sup.1 is a COOR.sup.2 group, wherein R.sup.2 is a C.sub.2-4 -alkyl group;B is a C.sub.1-3 -alkylene group, a radical ##STR2## wherein R.sup.3 is a hydrogen atom or a carboxy or methoxycarbonyl group; ##STR3## . . . is a single or double bond; or optionally, their salts with physiologically compatible bases. The present invention also relates to the production of the latter leukotriene-B.sub.4 analogs and their use as pharmacological agents.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: August 8, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Josef Heindl, Werner Skuballa, Bernd Buchmann, Wolfgang Frohlich, Roland Ekerdt, Claudia Giesen
  • Patent number: 5439924
    Abstract: The present invention is a method for controlling ectoparasites. More particularly, the invention relates to a method of treatment in which the warm blooded animal is dosed with an ovicidally effective amount of a heterocyclic nitrogen compound selected from the group represented by the formula: ##STR1## wherein R.sub.1, is either one of the following groups: ##STR2## R.sub.2 and R.sub.3 are the same or different, each a hydrogen atom, a halogen atom or a methyl group; R.sub.4 is a halogen atom or a methyl group; R.sub.5 and R.sub.6 are the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 haloalkyl group or a C.sub.1 -C.sub.4 haloalkoxy group; X, Y and Z are the same or different, each an oxygen atom, a sulfur atom or a methylene group, which is transmitted to the ectoparasite by the animal's blood. In a further embodiment, a compound selected from the group consisting of ivermectin, milbemycin, milbemycin oxime, moxidectin and avermectin and avermectin derivatives.
    Type: Grant
    Filed: March 17, 1994
    Date of Patent: August 8, 1995
    Assignee: Virbac, Inc.
    Inventor: Thomas A. Miller
  • Patent number: 5430191
    Abstract: Novel racemic and optically active phosphorus compounds of the formula ##STR1## wherein R signifies hydroxy or a protected hydroxy group, R.sup.1 represents hydroxy, a protected hydroxy group or lower alkoxy and R.sup.2 represents lower alkyl, cycloalkyl, aryl or together with the phosphorus atom a group of the formula are described. The compounds of formula I are useful in the form of complexes with a metal of Group VIII as catalysts for asymmetric hydrogenations and for enantioselective hydrogen displacements in parochial, allylic systems.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: July 4, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joseph Foricher, Rudolf Schmid
  • Patent number: 5428040
    Abstract: This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.
    Type: Grant
    Filed: August 31, 1993
    Date of Patent: June 27, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Ronald L. Magolda, William J. Pitts, Irina C. Jacobson, Carl H. Behrens, Michael J. Orwat, Douglas G. Batt
  • Patent number: 5426109
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: June 20, 1995
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Girard, Pierre Hamel
  • Patent number: 5426120
    Abstract: .gamma.-Hydroxybutyric acid and its physiologically equivalent forms are useful in the treatment of the syndromes of abstinence, craving and dependence on drugs, drugs of abuse, psychotropics, stupefacient and/or psychoactive substances, nicotine, or nutritional disorders.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: June 20, 1995
    Inventors: Gaetano Crepaldi, Santo Ferrara, Luigi Gallimberti, Gian L. Gessa
  • Patent number: 5420355
    Abstract: A highly pure borate complex of a trialkylborane with an alkylated or arylated alkali metal is obtained by reacting an aryl magnesium halide with a boron trihalide to produce a triarylborane product. The triarylborane product is then subjected to thorough removal of magnesium salts produced as by-products and removal of unreacted aryl magnesium halide. A solution of alkylated or arylated alkali metal in a hydrocarbon solvent, a straight chain ether solvent or a mixed solvent thereof is then added dropwise to the solution of triarylborane product in a hydrocarbon solvent, straight chain ether solvent or mixed solvent thereof, while keeping the temperature range from -80.degree. to 25.degree. C.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: May 30, 1995
    Assignee: Tosoh Akzo Corporation
    Inventors: Yoshihiko Ikeda, Takeo Yamane, Eiichi Kaji, Kenji Ishimaru
  • Patent number: 5420359
    Abstract: Normally liquid chlorofluoroether compositions consisting or consisting essentially of one or a selected mixture of perhalogenated chlorofluoroether compounds are provided by direct fluorination of the corresponding chloroether or chlorofluoroether precursors. The compositions are useful, for example, as heat transfer agents, blood substitutes, and solvents.
    Type: Grant
    Filed: October 7, 1993
    Date of Patent: May 30, 1995
    Assignees: Minnesota Mining and Manufacturing Company, HemaGen/PFC
    Inventors: George G. I. Moore, Richard M. Flynn, Robert J. Kaufman, Thomas J. Richard
  • Patent number: 5415949
    Abstract: A metal air cell comprising a flexible, recloseable, pouch made of a gas-permeable, electrolyte-impermeable, material forming the cathode of the cell, a metal plate anode in the pouch, and spacers physically isolating the anode from the interior of the flexible pouch cathode, the spacers separating the anode and the cathode by a predetermined spacing. A plurality of such cells are preferably stacked into a multicell battery, and compressed in a harness to maintain proper anode-cathode spacing as the anode is consumed. The stack can be incorporated as a replaceable part of a larger power system including a circulatory system for circulating an electrolyte solution through the cells in the stack. A controller controls the circulatory system, particularly during start-up and shut-down, to achieve a fast start up, and an efficient shut down.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: May 16, 1995
    Assignee: Voltek, Inc.
    Inventors: Gordon R. Stone, Richard L. McGee, Douglas J. Amick
  • Patent number: 5416216
    Abstract: Novel piperidine compounds of the formula (I) ##STR1## in which R.sub.1 is e.g. hydrogen or methyl, n is e.g. 1 and A is e.g. --COR.sub.2 with R.sub.2 being C.sub.1 -C.sub.18 alkyl.The said compounds are effective as light stabilisers, heat stabilizers and oxidation stabilisers for organic materials.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: May 16, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Roberto Scrima, Graziano Zagnoni
  • Patent number: 5416245
    Abstract: A synergistic process for the production of methanol comprises electrolysing water to produce hydrogen and oxygen; providing a feed stream of an organic combustible fuel; feeding at least a portion of the oxygen together with a stoichiometric amount of the organic combustible fuel to a partial oxidation reactor to produce off gases including carbon monoxide and hydrogen; feeding a stoichiometric amount of carbon monoxide and hydrogen to a methanol synthesizer to produce methanol. Further, the process utilizes the methanol and off gases and supplies of hydrocarbons and ethanol to produce MTBE and/or ETBE.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: May 16, 1995
    Assignee: Integrated Energy Development Corp.
    Inventors: Norman J. MacGregor, Gerry Shessel