Patents Examined by Michael Borin
  • Patent number: 9563266
    Abstract: The present technology relates to systems, methods and devices for haptically-enabled virtual reality simulation of cerebral aneurysm clipping, wherein a user uses two physical stations during the simulation. The first station is a haptic and augmented reality station, and the second station is a haptic and virtual reality station.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: February 7, 2017
    Assignees: IMMERSIVETOUCH, INC., THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: P. Pat Banerjee, Cristian J. Luciano
  • Patent number: 9552457
    Abstract: Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: January 24, 2017
    Assignee: BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Steven J. M. Jones, Oleksandr Yakovenko, Silvia Thoene, Pierre Yulmin Cheung, Jianghong An
  • Patent number: 9495517
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 15, 2016
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Patent number: 9454642
    Abstract: The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention 10 includes an input unit 11, a calculation unit 12, and a prediction unit 13. The input unit 11 is a unit through which sequence information on a target aptamer sequence group including selected aptamers in a target pool and a reference aptamer sequence group including reference aptamer sequences are inputted. The calculation unit 12 calculates the free energy of the target aptamer sequence group and the free energy of the reference aptamer sequence group. The prediction unit 13 compares the free energy of these sequence groups, and predicts that the target pool is an enriched pool when the free energy of the target aptamer sequence group is lower than the free energy of the reference aptamer sequence group.
    Type: Grant
    Filed: July 2, 2011
    Date of Patent: September 27, 2016
    Assignees: NEC Solution Innovators, Ltd., KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION
    Inventors: Jou Akitomi, Shintarou Katou, Shotaro Tsuji, Iwao Waga
  • Patent number: 9451886
    Abstract: A probabilistic digital signal processor using data from multiple instruments is described. In one example, an analyzer is configured to: receive discrete first and second input data, related to a first and second sub-system of the system, from a first and second instrument, respectively. A system processor is used to fuse the first and second input data into fused data. The system processor optionally includes: (1) a probabilistic processor configured to convert the fused data into at least two probability distribution functions and (2) a dynamic state-space model, the dynamic state-space model including at least one probabilistic model configured to operate on the at least two probability distribution functions. The system processor iteratively circulates the at least two probability distribution functions in the dynamic state-space model in synchronization with receipt of updated input data, processes the probability distribution functions, and generates an output related to the state of the system.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: September 27, 2016
    Inventor: Rodrigo E. Teixeira
  • Patent number: 9345418
    Abstract: An electroencephalography system is provided. The electroencephalography system includes a support structure that covers at least predetermined areas on a patient's head, a plurality of electrodes mounted on the support structure so that, the electrodes are distributed around the patient's head and measure usable electrical signals that are representative of electrical activity or activity in a patient's head, a plurality of transmitting wires incorporated into the support structure, a multi-pin connector having an output and an input, each of the plurality of transmitting wires directly connected between a respective one of each of the plurality of electrodes and a corresponding pin of the multi-pin connector so that, electrical signals are sent to the output of the connector and a first transmitter that is capable of being operatively coupled to the output of the connector.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: May 24, 2016
    Assignee: Dignity Health
    Inventor: Brian Alkire
  • Patent number: 9334494
    Abstract: The present invention provides a method of selecting a mRNA for production of a polypeptide of interest comprising: a) producing an array of individual mRNA sequences comprising different nucleotide sequences encoding the polypeptide of interest; b) determining one or more or two or more of the following parameters for each individual mRNA sequence of (a): (i) minimum free energy (MFE) RNA secondary structure; (ii) ensemble free energy (EFE); (iii) frequency of the minimum free energy (FMFE) RNA secondary structure in a thermodynamic ensemble; and (iv) ensemble diversity (ED); c) ranking the individual mRNA sequences of the array according the parameters determined in step (b); and d) selecting a mRNA sequence from the ranked array of step (c), wherein the selected mRNA produces the polypeptide of interest. The present invention further provides a method of selecting a mRNA for enhanced and reduced production of a polypeptide of interest.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 10, 2016
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Shib Sankar Basu, Kristen Kamerath Dang, Kasimalai Azhakanandam, Thomas Z. McNeill, Sheng Guo
  • Patent number: 9316636
    Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: April 19, 2016
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Robert Karlsson, Karl Andersson, Christina Wass
  • Patent number: 9289144
    Abstract: A method includes storing in memory preoperative brain atlas data. Neurophysiological data is obtained intra-operatively for a plurality of known sites in a brain of a given patient to provide corresponding intra-operative neurophysiological data for at least a portion of the sites. A constrained optimization is performed to fit the pre-operative brain atlas data based at least in part on the intra-operative neurophysiological data.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: March 22, 2016
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: J. Luis Lujan, Cameron C. McIntyre
  • Patent number: 9278159
    Abstract: The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: March 8, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Edward S. Boyden
  • Patent number: 9262582
    Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: February 16, 2016
    Assignee: University College Cork, National University of Ireland, Cork
    Inventors: Louise Kenny, Philip Newton Baker, David Broadhurst
  • Patent number: 9195795
    Abstract: A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in chemical, biochemical, pharmaceutical, and other purposes. The method identifies key protein vibration modes that control the chemical reaction rate of the protein-mediated reaction, providing identification of the factors that enable the enzymes to achieve the high rate of reaction enhancement. By controlling these factors, the function of enzymes may be modulated, i.e., the activity can either be increased for faster enzyme reaction or it can be decreased when a slower enzyme is desired.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: November 24, 2015
    Assignee: UT-BATTELLE, LLC
    Inventor: Pratul K. Agarwal
  • Patent number: 9140699
    Abstract: The invention relates to an analytical measuring and evaluation method for determining the interaction parameters between an analyte and a ligand, preferably in a biosensor. According to the inventive method, the concentration of the analyte is gradually changed at defined intervals ti and the initial association or dissociation rates or association and dissociation rate constants are determined. The invention further relates to a device for carrying out the inventive method.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: September 22, 2015
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Hans-Heinrich Trutnau
  • Patent number: 9081736
    Abstract: This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by binding to the substrate binding domain.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: July 14, 2015
    Assignee: The University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Xiaoqin Huang, Adel Hamza
  • Patent number: 9002656
    Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: April 7, 2015
    Assignee: Daxor Corporation
    Inventors: Joseph Feldschuh, Jonathan Feldschuh
  • Patent number: 9002657
    Abstract: A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: April 7, 2015
    Assignee: Daxor Corporation
    Inventors: Joseph Feldschuh, Jonathan Feldschuh
  • Patent number: 8972198
    Abstract: Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: March 3, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Ting Chen, Benjamin J. Feldman
  • Patent number: 8972196
    Abstract: Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: March 3, 2015
    Assignee: Medtronic Minimed, Inc.
    Inventors: Thomas A. Peyser, Soya Gamsey, Matthew A. Romey, David R. Markle
  • Patent number: 8898047
    Abstract: The invention concerns the generation of a three dimensional model of the six helix bundle (6HB) complexed with an inhibitor and the use of that model to identify, screen and/or develop inhibitors against viruses that use a class I fusion protein. Such inhibitors of viruses that use a class I fusion protein may be effective for treating, for example, respiratory infections by Respiratory Syncytial Virus (RSV).
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: November 25, 2014
    Assignee: Janssen Pharmaceuticals NV
    Inventors: Dirk André Emmy Roymans, Hendrik Leon Augusta Jozef De Bondt, Eric Pierre Alexandre Arnoult, Herman Van Vlijmen, Jean-François Bonfanti
  • Patent number: 8892364
    Abstract: The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: November 18, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Scott Glaser, Stephen Demarest, Brian Robert Miller, William B. Snyder, Xiufeng Wu, Norman Wang, Lisa J. Croner, Alexey Alexandrovich Lugovskoy