Patents Examined by Michelle F. Paguio Frising
  • Patent number: 12029817
    Abstract: The present invention provides a method for manufacturing a water-in-oil-in-water multiple emulsion, comprising: (a) mixing an active component with an internal aqueous phase to form a homogenized mixture; (b) mixing the homogenized mixture with an oleaginous phase to form a water-in-oil emulsion; and (c) mixing the water-in-oil emulsion with an external aqueous phase to form the water-in-oil-in-water multiple emulsion, wherein the external aqueous phase comprises water and an excipient, and wherein the excipient comprises a whey protein concentrate and a modified starch.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: July 9, 2024
    Assignee: FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE
    Inventors: Chia-Chen Hsu, Nai-Yi Wang, Yu-Chen Cheng, Jinn-Tsyy Lai
  • Patent number: 12013318
    Abstract: The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: June 18, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Carolin Bier, Stefan Lange, Pirmin Hans Loetscher
  • Patent number: 12005158
    Abstract: Provided are methods for preparing sterilized, gelled, solubilized extracellular matrix (ECM) compositions useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the gelled, solubilized ECM is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: June 11, 2024
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Stephen F. Badylak, Timothy Joseph Keane, Jr., Neill Jordon Turner, Christopher Lee Dearth
  • Patent number: 12004513
    Abstract: The invention concerns a method for prophylaxis of infections by fungi, particularly by oomycetes, and of bacterial infections in crop and ornamental plants. Areas of application are vine, fruit, vegetable and ornamental plant growing. The method of the invention is characterized in that an aqueous solution of a protease, alone or in combination with ?-glucanases and/or chitinases, is prepared, stabilizers, stickers and wetters are added, and the additized solution is applied by conventional techniques to the plants a number of times within the vegetation period, preferably ahead of weather-related phases of high infection threat.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: June 11, 2024
    Assignee: BIOPRACT GMBH
    Inventors: Matthias Gerhardt, Joachim Pheiffer, Hanns-Heinz Kassemeyer, Rene Fuchs, Sophie Jacobs
  • Patent number: 11988675
    Abstract: The present disclosure provides methods, compositions and kits for measuring activity of a frataxin (FXN) protein, e.g., an FXN fusion protein. The present invention also provides methods for identifying compounds capable of modulating activity of an FXN protein, e.g., an FXN fusion protein.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: May 21, 2024
    Assignee: Larimar Therapeutics, Inc.
    Inventor: Joan David Bettoun
  • Patent number: 11980645
    Abstract: Compositions and methods of use for modulating bile acids, including phenylalanocholic acid, tyrosocholic acid and leucocholic acid, to treat diseases, such as inflammatory bowel disease. In embodiments, the invention provides pharmaceutical compositions that modulate levels of a bile acid conjugate in a subject. In embodiments, the invention provides pharmaceutical compositions that modulate levels of a bile acid conjugate in a particular organ or bodily region of the subject.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: May 14, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Pieter Dorrestein, Alexey Melnik, Alexander Aksenov, Robert Quinn
  • Patent number: 11976107
    Abstract: The invention comprises several embodiments of a multi-step method for processing hard tissues, including bone, teeth, tooth enamel and dentin, mollusk shells, crustacean shells, deep sea sponge, coral, radiolarians, diatoms, antler bone, and other naturally occurring mineralized biocomposites, and soft tissues, including connective tissue, cartilage, tendon, ligament, vertebral discs, pathological mineralized soft tissues and other soft tissues, including at least processing a portion of tissue by one or more of contacting, immersing, adding and mixing a portion of tissue with a first solution, obtaining a first material, derived from processing the portion of tissue with the first solution, processing the first material using one or more alkali metal and ammonium salts of citrate, acetate, phosphate, sulfate, tartarate and chloride, and obtaining a resulting material, derived from processing the first material with the one or more salts.
    Type: Grant
    Filed: January 10, 2021
    Date of Patent: May 7, 2024
    Assignee: ORTHOGRAFT PRIVATE LIMITED
    Inventor: Atharva Poundarik
  • Patent number: 11969446
    Abstract: The disclosure relates generally to bacterial strains of the genus Christensenella, e.g., Christensenella sp. P152-H6d bacterial strains, and compositions comprising such bacterial strains. The disclosure further relates to methods of using such bacterial strains and compositions for preventing or treating a disorder, e.g., an inflammatory disorder, a gastrointestinal disorder, a metabolic disorder, and/or dysbiosis.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: April 30, 2024
    Assignee: XBIOME INC.
    Inventors: Peyman Akbari, Ali Akin, Rounak Feigelman, Wayne Herber, Jason Hudak, Jun Ma, Jackie Papkoff, Lauren Wong
  • Patent number: 11963989
    Abstract: The present invention discloses an application of a medical cell CMU-pb-7 in preparation of blood lipid-lowering drugs, which belongs to the technical field of biology. The medical cell CMU-pb-7 disclosed by the present invention is a newly discovered strain of Lactobacillus rhamnosus, having a collection number of CCTCC NO: M 2022220. The medical cell CMU-pb-7 of the present invention can relieve impaired glucose tolerance caused by a high-fat diet in mice with hyperlipidemia, reduce the blood lipid level, enhance the antioxidant capacity of the liver tissue, and regulate the expression of key proteins of liver lipid metabolism to relieve fatty change caused by a high-fat diet. The medical cell CMU-pb-7 disclosed by the present invention has a great potential application prospect in preparation of blood lipid-lowering drugs.
    Type: Grant
    Filed: June 17, 2023
    Date of Patent: April 23, 2024
    Assignees: GUANGDONG XINGHAI BIOTECHNOLOGY CO., LTD., GUANGDONG XINGHAI INSTITUTE OF CELL
    Inventors: Jincheng Zeng, Shaobing Zhang
  • Patent number: 11957721
    Abstract: The present invention relates to edible plant parts or tissues comprising probiotic bacteria and use thereof for oral delivery of the probiotic bacteria to an organism and enriching and/or improving the organism gastrointestinal tract microbiome. The present invention further relates to methods for selecting and/or producing probiotic bacteria capable of colonizing a plant tissue.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: April 16, 2024
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., OFEK—ESHKOLOT RESEARCH AND DEVELOPMENT LTD.
    Inventors: Oded Shoseyov, Sigal Baruch-Sharon, Betty Schwartz, Lilach Iasur Kruh, Roni Almon, Alaa Naama-Amar
  • Patent number: 11944652
    Abstract: The present invention relates to vesicles derived from bacteria of the genus Sphingomonas and a use thereof. These vesicles were significantly decreased in clinical samples of patients with hepatic cirrhosis, liver cancer, myocardial infarction, renal insufficiency, diabetes, brain tumors, mild cognitive impairment, dementia, depression, autism, and atopic dermatitis as compared to normal individuals. Administration of isolated vesicles suppressed secretion of inflammatory mediators by pathogenic vesicles such as E. coli-derived vesicles. Upon oral administration, the vesicles were distributed in the brain tissue. Vesicles derived from bacteria of the genus Sphingomonas are envisioned for use in methods of diagnosis, as well as compositions and methods for treating, hepatic cirrhosis, liver cancer, myocardial infarction, renal insufficiency, diabetes, brain tumors, mild cognitive impairment, dementia, depression, autism, and atopic dermatitis.
    Type: Grant
    Filed: October 26, 2022
    Date of Patent: April 2, 2024
    Assignee: MD HEALTHCARE INC.
    Inventor: Yoon-Keun Kim
  • Patent number: 11944670
    Abstract: The present invention provides a therapeutic agent for disc herniation, which has extremely few adverse side effects, can achieve a prolonged pain-ameliorating effect when administered in only a single dose, and can exhibit a high therapeutic effect and high safety in clinical applications. The present invention relates to a therapeutic agent for disc herniation, which is characterized by containing chondroitinase ABC as an active ingredient and being administered in such a manner that the ingredient can be administered into a human disk in an amount of 1-8 units per disk.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: April 2, 2024
    Assignee: SEIKAGAKU CORPORATION
    Inventors: Taiichi Sirogane, Takao Murayama, Masafumi Yaguchi
  • Patent number: 11944653
    Abstract: Methods and compositions diagnose and treat degenerative mitral valve disease in a canine. A method of treating or slowing progression of degenerative mitral valve disease in a canine can include administering a composition to the canine, and the composition contains at least one probiotic that is Butyricicoccus and/or Faecalibacterium The composition can be a pet food or administered in conjunction with a pet food.
    Type: Grant
    Filed: February 22, 2023
    Date of Patent: April 2, 2024
    Assignee: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
    Inventor: Qinghong Li
  • Patent number: 11944656
    Abstract: The invention relates to direct-fed microbials for use in E. coli, Salmonella, and/or Campylobacter inhibition in animals. More particularly, the invention relates to isolated Bacillus strains A12, 54, 681, 101, 235, and 721, and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention also relates to the use of isolated Bacillus strains 681,721, A12, 54, 86, 300, 101, 102, 235, and 177, and strains having all of the identifying characteristics of these strains, to prevent or reduce prolapse in an animal.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: April 2, 2024
    Assignees: MICROBIAL DISCOVERY GROUP, LLC, UNITED ANIMAL HEALTH, INC.
    Inventors: Michael R. King, Sona Son, Kyle Leistikow, Joel D. Spencer
  • Patent number: 11939568
    Abstract: A novel method of growing fungi is disclosed which uses an engineered artificial media and produces high density filamentous fungi biomats that can be harvested with a minimum of processing and from which fungal products such as antibiotics, proteins, and lipids can be isolated, the method resulting in lowered fungus cultivation costs for energy usage, oxygenation, water usage and waste stream production.
    Type: Grant
    Filed: October 4, 2022
    Date of Patent: March 26, 2024
    Assignee: The Fynder Group, Inc.
    Inventors: Mark A. Kozubal, Richard E. Macur, Yuval C. Avniel
  • Patent number: 11931385
    Abstract: A feed additive composition comprising a direct fed microbial (DFM), in combination with a xylanase (e.g. endo-1,4-?-d-xylanase) and a ?-glucanase (and optionally a further fibre degrading enzyme).
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: March 19, 2024
    Assignee: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Mai Faurschou Isaksen, Marion Bernardeau, Luis Fernando Romero Millan, Elijah G. Kiarie, Susan Lund Arent, Päivi Nurminen, Sofia Forssten, Daniel Petri, Elizabeth Ann Galbraith, Mari Ellen Davis
  • Patent number: 11917999
    Abstract: Provided is the use of or compositions or formulations comprising Burkholderia species, filtrate, supernatant, extract, pesticidally active compound or metabolite derived therefrom as an insecticide, particularly against infestation of Corn Rootworm larvae, and/or as crop yield enhancer.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: March 5, 2024
    Assignee: Pro Farm Group, Inc.
    Inventors: Ratnakar Asolkar, Marja Koivunen, Pamela G. Marrone, Ana Lucia Cordova-Kreylos, Huazhang Huang
  • Patent number: 11919231
    Abstract: In an aspect, the present disclosure provides a method for printing an object, comprising: directing at least one energy beam from an energy source into a media chamber comprising at least one polymeric precursor to generate said object at a fine resolution within a certain time period.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: March 5, 2024
    Assignee: Prellis Biologics, Inc.
    Inventors: Melanie P. Matheu, Kathryn J. Parkinson, Emma R. Moulton
  • Patent number: 11912980
    Abstract: The present invention relates to the field of microbiology, specifically the field of production of a dairy food product using fermentation and the field of gene transfer by conjugation.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: February 27, 2024
    Assignee: DSM IP Assets B.V.
    Inventors: Mariya Alexeevna Tarazanova, Thom Huppertz, Herwig Bachmann, Jan Kok, Marke Beerthuyzen
  • Patent number: 11913057
    Abstract: A method for determining whether a test sample contains a phytopathogenic fungus selectively from two kinds of fungi of a phytopathogenic fungus and a non-phytopathogenic fungus. The method comprises: (a) putting the test sample on a front surface of a substrate comprising a through hole; wherein the substrate comprises a cellulose film on a back surface thereof; the cellulose film has no through hole; the cellulose film has a thickness of more than 2 micrometers and not more than 3.7 micrometers; and the through hole has a cross-sectional area of not less than 7.065 square micrometers and not more than 19.625 square micrometers; (b) leaving the test sample at rest; (c) observing a back surface of the cellulose film; and (d) determining that the test sample contains the phytopathogenic fungus, if a fungus which has penetrated the cellulose film is found on the back surface of the cellulose film.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: February 27, 2024
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventor: Yoshitsugu Uriu