Patents Examined by Nasir Shahrestani
  • Patent number: 8280482
    Abstract: Methods for measuring atrophy in a brain region occupied by the hippocampus and entorhinal cortex. In one example, MRI scans and a computational formula are used to measure the medial-temporal lobe region of the brain over a time interval. This region contains the hippocampus and the entorhinal cortex, structures allied with learning and memory. Each year this region of the brain shrank in people who developed memory problems up to six years after their first MRI scan. The method is also applicable for measuring the progression rate of atrophy in the region in an instance where the onset of Alzheimer's disease has already been established.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: October 2, 2012
    Assignee: New York University
    Inventors: Henry Rusinek, Mony J. De Leon
  • Patent number: 8147408
    Abstract: Systems and methods are shown which provide feedback with respect to the desired or proper placement of a medical device guide without introducing protuberances or other perturbations to the surface of devices used in medical procedures. Embodiments provide a biopsy needle guide bracket for use with an ultrasound transducer assembly, wherein the biopsy needle guide bracket and ultrasound transducer assembly are adapted to detect when the biopsy needle guide bracket is properly located on the ultrasound transducer assembly using one or more sensors. Embodiments may implement various sensor technology, such as Hall effect sensors, optical sensors, capacitive coupled sensors, inductive coupled sensors, and/or the like to provide feedback with respect to placement of a medical device guide.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: April 3, 2012
    Assignee: Sonosite, Inc.
    Inventors: Steven M. Bunce, Blake W. Little
  • Patent number: 8145292
    Abstract: A method and system are provided for effecting interactive, three-dimensional renderings of selected body organs for purposes of medical observation and diagnosis. A series of CT images of the selected body organs are acquired. The series of CT images is stacked to form a three-dimensional volume file. To facilitate interactive three-dimensional rendering, the three-dimensional volume file may be subjected to an optional dataset reduction procedure to reduce pixel resolution and/or to divide the three-dimensional volume file into selected subvolumes. From a selected volume or subvolume, the image of a selected body organ is segmented or isolated. A wireframe model of the segmented organ image is then generated to enable interactive, three-dimensional rendering of the selected organ.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: March 27, 2012
    Assignee: Wake Forest University Health Sciences
    Inventor: David J. Vining
  • Patent number: 8131337
    Abstract: Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the endomembranes of the cancerous tissue before and after treatment; the treatment comprises administration of a cytotoxic therapy, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cytotoxic treatment of cancer. In addition, a method for monitoring protein translation related to the cytotoxic treatment of cancer is disclosed.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: March 6, 2012
    Assignee: Receptomon, LLC
    Inventor: Joseph F. Norfray
  • Patent number: 8121665
    Abstract: The invention relates to a method and furthermore a device from the examination of cavities, in particular an eye, by means of laser scanning. The aim of the invention is to carry out further investigations, above all with respect to possible diseases. Said aim is achieved, whereby the determination of the cavity wall thickness, in particular of retinal cavities is carried out. The external diameter and the internal diameter are determined by scanning doppler laser and the wall thickness determined from the data recorded thus.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 21, 2012
    Assignee: Heidelberg Engineering Optische Messsysteme GmbH
    Inventor: Georg Michelson
  • Patent number: 8105248
    Abstract: A piezoelectric unit (4), preferably a piezoelectric foil, is arranged in a medical plaster unit (13) for therapeutic or stimulating influence of body tissue in an area underneath the plaster unit. The plaster unit may be equipped with a battery (11) and a microcircuit (2) for delivering voltage pulses or oscillations to the piezo unit (4). The plaster unit (13) can possibly be used as part of a system of several plaster units (13) that are activated synchronously to influence one and the same tissues area.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: January 31, 2012
    Assignee: Orga Sense AS
    Inventor: Birger Orten
  • Patent number: 8078263
    Abstract: An imaging system illuminates an object with infrared light to enhance visibility of buried structure beneath the surface of the object, and projects a visible light image of the buried structure onto the surface of the object. The system may include an infrared light source for generating the infrared light and a structure for diffusing the infrared light. The diffusing structure may include one or more layers of diffusing material for diffusing the light. The system further includes a video imaging device for receiving the infrared light reflected from the object and for generating a video image of the buried structure based on the reflected infrared light. The buried structure may be a subcutaneous blood vessel. A calibration procedure is described as well as embodiments for ensuring that the object is maintained in focus at the correct distance.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: December 13, 2011
    Assignee: Christie Medical Holdings, Inc.
    Inventors: Herbert D. Zeman, Gunnar Lovhoiden, Carlos Vrancken, John Snodgrass, James A. DeLong
  • Patent number: 8064984
    Abstract: A magnetic resonance imaging apparatus includes a magnet having a two poles and a wall connecting the poles; the poles delimiting a patient-imaging space; and a table which is slidably connected to one of the two poles between the two poles and which table extends substantially parallel to the two poles; a drive for displacing the table relative to the magnet; a lock for locking the table in a selected position relative to the magnet; a drive for rotating the magnet about the axis; the table connected to the magnet such that the table rotates with the magnet when the magnet rotates about the axis; the magnet and the table being rotatable from a position in which the poles and the table are horizontal to a position in which the table and the poles are vertical.
    Type: Grant
    Filed: March 18, 2003
    Date of Patent: November 22, 2011
    Assignee: Esaote S.p.A.
    Inventors: Luigi Satragno, Eugenio Biglieri, Fabio Rezzonico, Osvaldo Pugliese, Orfeo Contrada, Trequattrini Alessandro
  • Patent number: 8055329
    Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. Specifically, the ingestible device may be arranged to perform a diagnostic image of nuclear radiation of a radiophamaceutical, scintillation of a scintillation liquid, responsive to nuclear radiation of a radiophamaceutical, optical fluorescence of a fluorescing-pharmaceutical or of bare gastrointestinal-tract tissue, infrared radiation of the gastrointestinal-tract tissue, temperature-differences along the gastrointestinal-tract, impedance, ultrasound reflection, magnetic resonance, and a combination thereof. The ingestible device may be adapted for general screening of a large population, on the one hand, and for specific diagnoses of suspected pathologies, on the other.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: November 8, 2011
    Assignee: Spectrum Dynamics LLC
    Inventors: Yoav Kimchy, Roni Amrami, Yona Bouskila, Udi Antebi
  • Patent number: 8050734
    Abstract: A method for performing patient specific analysis of disease relevant changes of a disease in an anatomical structure of interest is provided. The method comprises determining a percentage of the anatomical structure that is encompassed by a diseased tissue region using a patient specific healthy tissue model. The method then comprises determining the amount or spatial distribution or a combination thereof of tissue volume variation due to the disease in the anatomical structure based on the percentage of the anatomical structure encompassed by the diseased tissue region and an estimated original amount of tissue.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: November 1, 2011
    Assignee: General Electric Company
    Inventors: James Vradenburg Miller, Paulo Ricardo dos Santos Mendonca
  • Patent number: 8046044
    Abstract: The disclosure describes a technique for medical imaging, referred to herein as the Rapid Interleave Overlap Technique (RIOT), wherein image data is acquired as a plurality of series sequences in a manner that allows for unlimited overlap. RIOT involves interleaving and overlapping 2D image slices of multiple series of image data of the same ROI into a composite data set from which MPR and 3D reconstructions exhibiting excellent resolution properties and crisp image quality can be generated.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: October 25, 2011
    Assignee: Washington University
    Inventors: Madelyn Milagros Stazzone, Omar G. El-Ghazzawy, Fred William Prior
  • Patent number: 8033997
    Abstract: The invention relates to an ultrasonic transducer comprising a plurality of micro-cells, arranged in an array having M rows and N columns, and driving electronic means apt to connect in parallel to each other said micro-cells so as to form at least two sub-groups of said micro-cells, the micro-cells of each sub-group being connected in parallel to each other, at least one column of said array comprising micro-cells belonging to at least two different adjacent sub-groups, so that a radiation emitted in a direction perpendicular to the array columns by said at least one column has a phase that is intermediate between the phases of said at least two different adjacent sub-groups.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: October 11, 2011
    Assignee: Esaote S.p.A,
    Inventors: Danilo Fiasca, Giosuè Caliano, Alessandro Caronti, Vittorio Foglietti, Elena Cianci, Massimo Pappalardo
  • Patent number: 8002704
    Abstract: A method and system for determining contact along a surface of an ultrasound probe are provided. The method includes frequency analyzing ultrasound signals received by the ultrasound probe and displaying indicators of acoustic contact of the ultrasound probe with an object based on the frequency analysis.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: August 23, 2011
    Assignee: General Electric Company
    Inventors: Hans Garmann Torp, Fredrik Orderud, Lasse Lovstakken
  • Patent number: 8000774
    Abstract: A method for detecting a complete or partial obstruction in a vessel through an intervening fluid includes receiving spectroscopic responses at different locations of a vessel wall, e.g., a vein or artery, through an intervening fluid, preferably blood. Spectroscopic responses are generated by irradiating the vessel wall at different locations and detecting spectra at those locations. In preferred embodiments, the radiation used is in the near infrared (NIR) region of the electromagnetic spectrum. The thrombus is located by determining whether fluctuations, spatial and/or spectral, of the spectral responses are indicative of thrombus.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: August 16, 2011
    Assignee: Infraredx, Inc.
    Inventors: Stephen Thomas Sum, Jennifer Blanche Lisauskas, Thomas M. Meese
  • Patent number: 8000767
    Abstract: A detector uses the magneto-optical Kerr effect and exploits the transition region between two magnetization states of a magneto-optical film to detect magnetic fields of less than 100 pT. The magnetic field of a subject is determined by examining the polarization of light reflected from the magneto-optical film. A several ?m thick, bismuth doped, YIG film is used for detection as the transition regions are steep, providing large changes in the polarization rotation angle for small variations in the applied magnetic field. The apparatus may be used in the functional imaging of various organs and systems in humans and animals or for the spatial and temporal tracking of nano or micro magnetic particles intentionally introduced into the circulatory or intestinal systems for diagnostic or research purposes.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: August 16, 2011
    Assignee: Board of Trustees of the University of Illinois
    Inventors: J. Gary Eden, Ju Gao
  • Patent number: 7991454
    Abstract: Images of blood vessels of a body are obtained by injecting a refraction enhancement contrast agent into the blood vessels to increase a difference in refractive indices of the blood vessels and surrounding material. The blood vessels are irradiated with a penetrating radiation, and an image of the blood vessels is generated based on detected radiation. The image has visible edge enhancement features indicating boundaries of the blood vessels.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: August 2, 2011
    Assignee: Academia Sinica
    Inventors: Yeu-Kuang Hwu, Giorgio Margaritondo, Jung Ho Je
  • Patent number: 7983735
    Abstract: A nuclear medicine imaging simulator system is provided for simulating nuclear imaging of a target within a phantom using a selected pharmacokinetic model. The system includes a processor assembly having at least one processor receiving a digital phantom model and a digital pharmacokinetic model, and a dynamic integration module executable on the processor assembly for integrating the pharmacokinetic model with the phantom model to generate a dynamic phantom data representing activity of the pharmacokinetic model within the phantom model over simulated time.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: July 19, 2011
    Assignee: General Electric Company
    Inventor: Ravindra Mohan Manjeshwar
  • Patent number: 7955276
    Abstract: A capsule endoscope is disclosed that includes a capsule and a transparent cover having a central axis and that is located in front of an objective optical system within the capsule. The objective optical system has a depth of field, a field of view, and an image surface that has curvature of field, and is arranged on the central axis of the transparent cover and the capsule. The field of view of the objective optical system includes a spherical surface that is tangent to the transparent cover at a periphery of the field of view, and the near point of the depth of field on the optical axis of the objective optical system is positioned farther from the objective optical system than is the transparent cover. Various conditions are satisfied so as to provide high quality imaging.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: June 7, 2011
    Assignee: Olympus Corporation
    Inventor: Koichiro Yoshino
  • Patent number: 7955265
    Abstract: Methods, apparatus and systems for measuring a thickness of a portion of a multi-layer vessel based on at least one medical diagnostic image frame using an integrated ultrasound device is provided. The method includes for each x-coordinate determining a y-coordinate along an interface between each layer of the vessel including determining a Y coordinate of a center of an intima-media center (IMC) determining the adventitia-media interface Y coordinate, determining the intima-lumen interface Y coordinate, determining for each X coordinate the lumen-intima interface Y coordinate, determining media-adventitia interface Y coordinate, determining a thickness of at least one vessel layer using X and Y coordinates of respective layer interfaces, and outputting the thickness to a display.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: June 7, 2011
    Assignee: General Electric Company
    Inventors: Elina Burla, Doron Hess, Alexander Sokulin
  • Patent number: RE43901
    Abstract: A thermal treatment system including a heat applying element for generating thermal doses for ablating a target mass in a patient, a controller for controlling thermal dose properties of the heat applying element, an imager for providing preliminary images of the target mass and thermal images during the treatment, and a planner for automatically constructing a treatment plan, comprising a series of treatment sites that are each represented by a set of thermal dose properties. The planner automatically constructs the treatment plan based on input information including one or more of a volume of the target mass, a distance from a skin surface of the patient to the target mass, a set of default thermal dose prediction properties, a set of user specified thermal dose prediction properties, physical properties of the heat applying elements, and images provided by the imager.
    Type: Grant
    Filed: September 8, 2005
    Date of Patent: January 1, 2013
    Assignee: InSightec Ltd.
    Inventors: David Freundlich, Jacob Vortman, Roni Yagel, Shuki Vitek, Naama Brenner