Abstract: Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.

Abstract: Described herein is a cosmetic composition comprising a mixture of metal oxide pigments having different shapes and sizes which provides high coverage and a natural look upon application.

Abstract: The present invention provides a variable color transparent lip balm, consisting of following components by weight percent: 4.0 to 5.0% by weight of dibutyl lauroyl glutamide, 2.0 to 3.0% by weight of polyamide-3, 15.0 to 20.0% by weight of bis-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimer dilinoleate copolymer, 46.65 to 49.60% by weight of C12-15 alkyl benzoate, 1.0 to 3.0% by weight of heptyl undecylenate, 9.0 to 11.0% by weight of C10-30 cholesterol/lanosterol esters, 10.0 to 15.0% by weight of hydrogenated C6-20 polyolefin, 1.5 to 2.5% by weight of dextrin isostearate, 0.05 to 0.1% by weight of eosin yellowish and 0 to 0.8% by weight of excipient. The transparent lip balm of the present invention has good transparency, and excellent variable color effect.

Abstract: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C?C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C?C—. The variables j, R3, and R4 are as defined herein.

Abstract: Methods of preparing a dentifrice comprising polymer matrix film with menthol therein are disclosed. The methods comprise combining a polymer matrix film that comprises hydrophobic additives and is free of a low solubility flavorant such as menthol with a dentifrice base comprising a low solubility flavorant such as menthol and maintaining the combined polymer matrix film with the dentifrice base comprising low solubility flavorant for an amount of time sufficient for an amount of a low solubility flavorant to transfer from the dentifrice base comprising low solubility flavorant to the polymer matrix film and establish an equilibrium of menthol concentration between the polymer matrix film and the dentifrice base. Products comprising low solubility flavorant-free polymer matrix film in a dentifrice base comprising low solubility flavorant are also disclosed.

Abstract: The present invention relates to novel glycerin ether ethoxylate solfactant compounds, compositions employing the same, and methods of using these compounds. Beneficially the compounds have efficacy as both solvents and surfactants with low foam and low viscosity. The compounds of the present invention can be used as antimicrobials and/or sanitizing agents in various formulations. The compounds of the present invention are also suitable for use as solvents and/or hydrotropes.

Abstract: An aqueous hair cleansing agent containing the following components (A), (B) and (C) and water: (A) an anionic surfactant; (B) a specific organo polysiloxane; and (C) one or more of cationized polymer(s) selected from (c-1) and (c-2): (c-1) a cationized polymer having cellulose skeleton or galactomannan skeleton; and (c-2) a cationic polymer having diallyl dimethylammonium salt skeleton.

Abstract: The invention provides a composition for topical treatment of hair loss/alopecia including three natural, active ingredients, caffeine, saw palmetto berry extract, and epigallocatechin-3-gallate (EGCG). The invention also provides methods for using this composition to treat hair loss.

Abstract: The present invention relates to a composition comprising, in a cosmetically acceptable carrier, at least one UV screening system, characterized in that it comprises: (i) at least one screening agent of lipophilic hydroxybenzophenone type; and (ii) at least one silicon-comprising s-triazine of formula (III) substituted by at least two alkylaminobenzoate groups. In some embodiments, the composition also includes: (iii) a dibenzoylmethane derivative.

Abstract: The present invention is related to a seamless capsule which easily dissolves in the oral cavity etc. The present invention provides a seamless capsule comprising a capsule content solution, and a capsule shell enclosing the capsule content solution, wherein the capsule shell comprises a gelatin having a bloom value of 50 to 190 and wherein the seamless capsule has a capsule shell-dissolution time of 60 seconds or less when the dissolution time is determined by a disintegration test using water as a test solution.

Abstract: A bi-phasic, non-emulsion cosmetic composition for application to skin includes a hydrophobic liquid phase and a hydrophilic liquid phase separate from but in contact with the hydrophobic liquid phase. Either or both phases may include active ingredients useful for cosmetic applications. When the composition is agitated, a temporary mixture of the two phases results, wherein the mixture contains globules of one of the phases suspended in the other. The mixture containing globules is applied to skin as a cosmetic.

Abstract: Provided is an antimalarial drug which is useful for prevention and treatment of infectious diseases caused by malaria parasites. A preventive and/or therapeutic agent for malaria, which contains, as an active ingredient, 5-aminolevulinic acid (ALA), a derivative thereof, or a pharmacologically acceptable salt thereof, is used.

Abstract: A bi-phasic, non-emulsion cosmetic composition for application to skin includes a hydrophobic liquid phase and a hydrophilic liquid phase separate from but in contact with the hydrophobic liquid phase. Either or both phases may include active ingredients useful for cosmetic applications. When the composition is agitated, a temporary mixture of the two phases results, wherein the mixture contains globules of one of the phases suspended in the other. The mixture containing globules is applied to skin as a cosmetic.

Abstract: A process for preparing particles having a hydrophobic material therein is disclosed. The process comprises providing a multiple emulsion comprising a first emulsion dispersed in a hydrophobic medium, said first emulsion comprising a hydrophobic phase dispersed in a hydrophilic phase, wherein the hydrophobic phase comprises the hydrophobic material and the hydrophilic phase comprises a precursor which is capable of reacting to form a non-fluid matrix and reacting the precursor in the multiple emulsion to form the matrix in the form of the particles having the hydrophobic material therein wherein the precursor is added prior to formation of the multiple emulsion. Also disclosed are particles having a hydrophobic material therein, which may be releasable, as well as particles having a hydrophobic material therein, which may be releasable, made by the process and methods of using the particles.

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

Abstract: The present invention provides a reduced dose oral pharmaceutical composition comprising mixture of nanoparticulate fenofibrate and micronized fenofibrate and one or more pharmaceutically acceptable excipients.

Abstract: The invention relates to percutaneous administration of drugs and vaccines in form of solid penetrating needles, “injectable needles”, comprising a polymeric matrix resulting from the polymerization of a polymerizable paste or mixture. The injectable needles are hard enough to penetrate the skin and can be administered percutaneously by simple pusher or injector delivery devices. The manufacturing procedure of the injectable needles allows for the incorporation of the drug as preformulated stable microparticles and incorporation of modifying agents to modulate stiffness, solubility and drug release. Drugs formulated in these injectable needles offer a safe, simple and effective alternative to conventional percutaneous drug delivery systems based on hypodermic needles and syringes that require refrigerated storage and reconstitution prior to administration.

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.

Abstract: A pigmented skin care composition including a dermatologically acceptable carrier and at least a first and second interference pigment. The composition according to the invention is useful in improving the appearance of the skin and in particular in reducing the appearance of skin discontinuities.