Abstract: A trigger arrangement for an infusion device is disclosed, the trigger arrangement being configured to trigger a bolus injection of the infusion device and including: a body having an outside surface, a haptic structure arranged on the outside surface or integrated into the outside surface, wherein the haptic structure includes a first end section and a second end section and wherein the haptic structure includes a haptic track extending from the first end section to the second end section, a touch sensitive sensor arrangement extending along the haptic track and configured to detect a sliding motion of an object along the haptic track.

Abstract: The present invention includes the provision and use of a novel method and apparatus for anchoring a catheter line to the tissue of a patient (e.g., the internal fascia of a patient) for pain pump drug delivery. In one preferred form of the invention, the invention includes the provision and use of a catheter line fixation device including a housing and a collet assembly. The catheter line fixation device is intended to be adjustably secured to a catheter line, and the catheter line fixation device is intended to be secured to the tissue of a patient (e.g., the internal fascia of a patient), so as to secure the catheter line to the tissue of the patient.

Abstract: The present invention provides a lamprey lock device configured to provide a fluid transfer between two devices or objects. In one embodiment, lamprey lock device of the present invention improves fluid transfer by maximizing the inner diameter of connections between two objects including but not limited to a catheter, tubing, veress needles, trocars, syringes, or gas/fluid delivery systems.

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Abstract: An integrated vascular delivery system and method of use, the system including: a frame having a catheter hub that provides a first anchoring point on the patient and receives a catheter insertable in the patient to transfer fluid at an insertion site, a stabilization hub that provides a second anchoring point on the patient, at least one lateral member extending between the catheter and stabilization hubs, and a fluidic channel. The frame operates in a folded configuration in which the hubs are coupleable and an unfolded configuration in which the anchoring points are distributed around the insertion site to anchor the frame to the patient, thereby stabilizing the catheter. In some embodiments, the system further includes a septum that helps prevent fluid leakage from the catheter hub, or a needle shield that covers the distal end of a needle used during catheter insertion.

Abstract: In various embodiments, a device is provided comprising a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being the same or greater than the first pressure. In various embodiments, a method comprising fabricating a balloon configured to expand to an expanded state in response to introduction of a fluid at a first pressure, wherein the fluid perfuses through the balloon above a second pressure, the second pressure being at or greater than the first pressure, disposing the balloon on an elongate member having a lumen, placing the lumen in fluid communication with an interior volume of the balloon.

Abstract: A needle assembly for use with a drug delivery device comprises a cap releasably secured to the drug delivery device and a blocking member. The blocking member comprises a disinfectant swab and a user graspable portion. The blocking member is configured to be physically moved with respect to the needle assembly by a user. The needle assembly is configured such that in an initial position, the blocking member blocks the cap from being removed from the drug delivery device and movement of the blocking member from the initial position causes the disinfectant swab to contact a septum of a cartridge retained within the drug delivery device.

Abstract: A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. The limit of use is reached when at least one of a first criterion and a second criterion is met, wherein the first criterion is that the timer reaches or exceeds a time limit and wherein the second criterion is that at least one operation of a drive train of said medical device reaches or exceeds a limit.

Abstract: Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.

Abstract: A catheter insertion system includes a housing extending along a longitudinal axis. A needle extends distally from a distal end of the housing. The needle has a longitudinal passage coaxially aligned with the housing. A catheter has a length and is sized and shaped to be advanced from a retracted position within the longitudinal passage of the needle to an extended position with at least a portion of the catheter length extending beyond a distal tip of the needle. The needle is typically configured to be retracted back into the housing after the catheter has been advanced, thus providing an integrated catheter and catheter insertion apparatus. After needle retraction, the housing may be taped to the patient's skin while the needle remains protected within the housing. A luer on the catheter may then be connected to a fluid or other source in an otherwise conventional manner.

Abstract: A nasal aspirator capable of effectively preventing backflow and a control method thereof are disclosed. The nasal aspirator includes a casing, a control board, a lower suction nozzle, an upper suction nozzle, a liquid storage cup, and an air pump unit. The control board is disposed in the casing. The lower suction nozzle is disposed on an upper end of the casing. The lower suction nozzle has a chamber and a suction passageway therein. The chamber has an opening facing upward. An upper end of the suction passageway communicates with the chamber. A detection system for detecting a liquid is provided in the chamber. The detection system is connected to the control board.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: An auto injector for administering injection of a medicament from a cartridge containing the medicament, includes a housing, a cartridge receiver with a cartridge receiver compartment configured to receive a cartridge assembly including at least one cartridge retention member when the cartridge assembly is inserted through a cartridge receiver opening along a longitudinal axis in a receiving direction, an elongated ejector including an ejector support face for supporting the cartridge or the cartridge assembly and a longitudinal ejector slot extending towards the ejector support face from an ejector rest portion, wherein the elongated ejector is suspended to move along the longitudinal direction and is spring-loaded in the direction opposite of the receiving direction, and an ejector lock supported for turning at least a fraction of a revolution and maintained in a longitudinal position relative to the housing.

Abstract: A stopper is disclosed herein. The stopper is configured to be disposed within a medical cartridge. The stopper includes a shell defining a cavity, a core arranged within the cavity, and at least one electronic device embedded within the core, wherein the at least one electronic device includes a sensor and wherein the shell is configured to pass a sensing signal therethrough.

Abstract: A precision steerable and angled medication delivery system is disclosed. The system may direct a delivery mechanism in connection with a control syringe to delivery sites within a patient's body. In this manner, therapeutic injections may be performed at precise locations as desired. The precision steerable and angled medication delivery system may have a structure configured to orient at least a portion of an elongate penetrative feature such as needle to be at least partially non-parallel to a longitudinal axis, further facilitating performance of therapeutic injections at precise locations.

Abstract: Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.

Abstract: The present invention relates to a medicament delivery device comprising a housing, an actuation mechanism (40) arranged inside said housing, the actuation mechanism comprising a plunger rod (42) arranged to act on a stopper (18) of a medicament container (16); an actuator (84) arranged slidable and connected to the plunger rod (42) for acting on the stopper (18) when said actuator (84) is operated by displacing it in a longitudinal direction of the actuation mechanism (40); an activator (104) rotatably arranged for activating said actuation mechanism and for setting a dose; said activator (104) comprising a generally tubular activator sleeve (148), said activator sleeve (148) comprises protrusions (150) arranged to interact with ledges (90) on said actuator (84) such that said activator sleeve (148) is rotated when said actuator (84) is operated.

Abstract: A device and method for monitoring the heart rate of a patient for a bradyarrhythmia event and thereafter administering medications is disclosed. The method comprises the steps of monitoring heart rate via at least one sensor secured to the neck or head of a patient; and if a bradyarrhythmia event is determined; applying an anticholinergic medication to the conjunctiva of at least one eye and releasing ammonia vapor in close proximity to the nostrils of a patient.

Abstract: An injector device includes a housing for receiving a medicament cartridge; a needle unit comprising a needle; and a first sleeve slideable along a longitudinal axis of the housing from a first position, in which the first sleeve conceals the needle, to a second position, in which the needle is exposed from an end of the first sleeve, the first sleeve configured to engage the needle unit so that, during use, movement of the first sleeve from the first position to the second position moves the needle unit from a primary position to a secondary position, in which secondary position the needle unit locates over an end of a medicament cartridge, wherein the device further comprises a second sleeve arranged to move telescopically with respect to the first sleeve, the first sleeve extending from the second sleeve when the first sleeve is in the first position.

Abstract: A catheter assembly may include an introducer needle coupled to a needle hub, an intermediate member having a contact surface, a resilient member, and a ramp member. The resilient member may be coupled to one of the needle hub and the intermediate member. The ramp member may be coupled to the other one of the needle hub and the intermediate member. The resilient member may engage a ramp surface of the ramp member and impart a force on the intermediate member in a distal direction. The contact surface of the intermediate member may engage a proximal surface of a catheter adapter body and urge the catheter adapter body in the distal direction such that a catheter projecting from the catheter adapter body may be translated in the distal direction relative to the introducer needle.