Abstract: This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula I, salts, derivatives, and prodrugs thereof wherein, A is an bridging aryl or heterocyclyl and R1 and R2 are further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.
Type:
Grant
Filed:
June 18, 2020
Date of Patent:
December 6, 2022
Assignees:
Emory University, Georgia State University Research Foundation, Inc.
Inventors:
Hyunsuk Shim, Suazette Reid Mooring, Renren Bai
Abstract: The present invention discloses a compound of anilino polyethylene glycol ether cycloquinazoline substituted with a substituted arylmethyl heteroatomic group having the structure of formula (I) below, or a pharmaceutically acceptable salt, ester or solvate thereof, and a pharmaceutical composition comprising the same. The compound and pharmaceutical composition disclosed herein can be used in tumor targeted therapy and in the regulation of tumors and related diseases.
Abstract: This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of a ?5-containing GABAA receptor agonist (e.g.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
November 22, 2022
Assignee:
AGENEBIO, INC.
Inventors:
Belew Mekonnen, John A. Butera, Jianxing Huang, Hemantbhai Patel
Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of USP7 polypeptide to increase the sensitivity of cancer cells (e.g., CD340+ cancer cells such as HER2+ cancer cells) to treatment with an inhibitor of a CD340 polypeptide (e.g., an inhibitor of a HER2 polypeptide) are provided. Methods and materials for using USP7 polypeptide inhibitors in combination with CD340 polypeptide inhibitors to treat cancer (e.g., HER2+ breast cancer that was refractory to trastuzumab alone treatment) are provided.
Type:
Grant
Filed:
July 7, 2017
Date of Patent:
November 15, 2022
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Liewei Wang, Matthew P. Goetz, Judy C. Boughey, Jia Yu, Bo Qin
Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including metabolic disorders such as obesity, cancer, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD) wherein the compound is according to Formula (I).
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
November 15, 2022
Assignee:
FGH BIOTECH, INC.
Inventors:
Joel Huff, Motonari Uesugi, John Kincaid
Abstract: The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of proliferative diseases, such as cancer.
Type:
Grant
Filed:
March 16, 2018
Date of Patent:
November 1, 2022
Assignee:
ARGONAUT THERAPEUTICS LIMITED
Inventors:
Andrew Morley, Rebecca Miller, Nicholas La Thangue
Abstract: The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII, formula VIII, formula IX or Formula X and, the methods for the treatment of fungal infections may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of fungal infections.
Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
Type:
Grant
Filed:
August 18, 2020
Date of Patent:
October 25, 2022
Assignees:
CASE WESTERN RESERVE UNIVERSITY, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE UNIVERSITY OF IOWA
Inventors:
Sanford Markowitz, Joseph Ready, Andrew Pieper
Abstract: It is an object of the present invention to provide a method for modifying an antibody in a specific and simple manner, and others. The present invention relates to: an IgG-binding peptide, an IgG-binding peptide modified with a crosslinking agent, a complex of an IgG-binding peptide modified with the crosslinking agent and IgG, a method for producing the complex, and others.
Abstract: Disclosed herein are phthalocyanine dyes, and conjugates thereof, useful as fluorescent reporters for bioassays, for optical imaging and as therapeutic conjugates as the photosensitizing agents in light-based therapies including photoimmuno therapy (PIT). Certain phthalocyanine dyes disclosed herein are water soluble, and possess photophysical and photochemical profiles useful for use in imaging or therapy.
Type:
Grant
Filed:
September 22, 2021
Date of Patent:
October 11, 2022
Assignee:
RAKUTEN MEDICAL, INC.
Inventors:
Juan Betancort, Lew Makings, Torsten Wiemann
Abstract: The methods and compositions described herein relate to methods of immunization or stimulating an immune response, e.g., using agonists of TLR7 and/or TLR8 as antigens. The methods and compositions described herein have particular relevance to use in infants.
Type:
Grant
Filed:
March 23, 2018
Date of Patent:
October 11, 2022
Assignees:
Children's Medical Center Corporation, University of Montana
Inventors:
Ofer Levy, David Dowling, Helene Bazin-Lee, David Burkhart, Jay Evans, Alyson Jessica Smith
Abstract: A carcinogenesis inhibitor having no side effect and having an excellent effect by oral administration. A carcinogenesis inhibitor containing a hydantoin derivative or a pharmaceutically acceptable salt thereof as an active ingredient shows an inhibiting action for polyp formation and for cell proliferation, and has no side effect and highly safe whereby it is very highly useful as a pharmaceutical agent and a food such as supplement which prevent the occurrence and progress of cancer, inhibits the recurrence and metastasis of cancer and further achieves the therapeutic effect.
Type:
Grant
Filed:
June 12, 2018
Date of Patent:
October 11, 2022
Assignees:
NATIONAL CANCER CENTER, NIPPON ZOKI PHARMACEUTICAL CO., LTD.
Inventors:
Michihiro Mutoh, Yurie Kurokawa, Gen Fujii, Shingo Miyamoto
Abstract: Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
Abstract: A composition contains a phthalocyanine derivative represented by the following formula: where R1 to R8 are independently an alkyl group, M is Si, each of R9 and R10 is any one of substituents represented by the following formulas, R11 to R13 are independently an alkyl group, and R14 to R18 are independently an alkyl group or an aryl group:
Abstract: The present invention is directed to therapeutic compounds capable of targeting cancer cells and cancer stem cells. The present invention is further directed to compositions comprising these therapeutic compounds and methods of treating cancer comprising administering these therapeutic compounds.
Type:
Grant
Filed:
February 12, 2018
Date of Patent:
September 13, 2022
Assignee:
Cellectar Biosciences, Inc.
Inventors:
Jamey P. Weichert, Anatoly Pinchuk, Kevin Kozak, Marc Longino, Joseph Grudzinski, Benjamin Titz, Chorom Pak, Nathan Stehle
Abstract: Disclosed herein are a method for improving cognition in an individual having findings consistent with a cognitive impairment, and a method of enhancing cognition in an individual. The methods include administering a therapeutically effective amount of (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane or a metabolite or a pharmaceutically acceptable salt thereof to the individual.
Abstract: The invention provides compounds of formula (I) and compositions comprising compounds of formula (I). The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease or corticobasal degeneration, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease or corticobasal degeneration.
Abstract: Compounds of formula I (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as pesticides and can be prepared in a manner known per se.
Type:
Grant
Filed:
September 14, 2018
Date of Patent:
August 16, 2022
Assignee:
SYNGENTA PARTICIPATIONS AG
Inventors:
Sebastian Rendler, Andrew Edmunds, Michel Muehlebach, Girish Rawal, Indira Sen, Vikas Sikervar, Daniel Emery