Abstract: 2,4-Diaminoquinazolines are employed as antithrombotic agents and have the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are monovalent groups independently selected from the group consisting ofA. ##STR2## wherein R.sub.4 and R.sub.5 independently are selected from the group consisting of hydrogen, alkyl, and cycloalkyl, with the proviso that both R.sub.4 and R.sub.5 cannot be cycloalkyl,B. ##STR3## wherein R.sub.6, R.sub.7, and R.sub.8 independently are selected from the group consisting of hydrogen and alkyl, and A is a divalent organic group having from two to about six carbon atoms such that the two nitrogen atoms are separated by at least two carbon atoms, andC. heterocyclic-amino, andR.sub.3 is a monovalent group selected from the group consisting of hydrogen, halogen, and alkyl.

Abstract: A method of inhibiting histamine activity, in particular inhibiting H-2 histamine receptors, by administering heterocyclicalkylguanidines.

Abstract: The invention is based on the discovery, after long study and many test operations, that the combination of five chemical elements, towit 5-hydroxymethylcytosine, thymine, nicotamide, pyridoxal, and thiamine, is effective in antagonizing the narcotic effects of barbiturates, and that each one is essential, in the combination, for positive result. Although thymine per se long has been known as increasing the action of barbiturates, tests of the said composition established that thymine has an unexpected and essential function therein, its omission rendering the composition ineffective. These tests were directly made by the present applicant, with corroboration as to every detail thereof by the Chief of the Section of Neurochemistry, New York State Institute of Neurochemistry and Drug Addiction, established by the State of New York, and operating under its control.

Abstract: .alpha.-[4-(5-Mono-substituted or 3,5-di-substituted-pyridyl-2-oxy)phenoxy]alkanecarboxylic acids and derivatives thereof useful as a herbicide; a herbicidal composition containing the compound; methods of controlling weeds using such materials and production of such materials.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 6 to 19 carbon atoms, andR.sub.2 is methyl or ethyl,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as the salts are useful as pharmaceuticals for the treatment of cardiac and circulatory insufficiencies.

Abstract: Novel preparations of triazolobenzodiazepines are disclosed. Novel 6-pyridyl-4H-triazolo[4,3-a]-1,4-benzodiazepines and novel intermediates are also disclosed which are useful as anticonvulsants, muscle relaxants and sedative agents.

Abstract: Cyclic and acyclic amides, substituted ureas and sulphonamides are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations and in tobacco.

Abstract: Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.

Abstract: The preparation of novel N-(acyl)-p-amino-N'-(monosubstituted) benzamides by modified Schotten-Baumann reaction of the corresponding p-aminobenzamides is described. These compounds are effective anti-ulcer agents.

Abstract: Anti-allergic agents of N-aromatic and N-heterocyclic 1H-(or 2H) tetrazole-5-carboxamide derivation present the following formulae: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2, 3, 4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)alkoxy, 2-(lower alkoxy oxalyloxy)ethoxy, N-mono- and di-lower alkylamino(lower)-alkoxy, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, mono- and di- lower alkylamino, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals;And pharmaceutically acceptable salts thereof.

Abstract: Novel pharmaceutical compositions containing as the active ingredient the compound 5-methyl-1-phenyl-2-(1H)-pyridone are described. Such compositions have been found to have a metabolic property which causes significant lowering of serum glucose levels in humans and other mammals. The compositions containing 5-methyl-1-phenyl-2-(1H)-pyridone caused no irritation on oral administration or when applied to specific target tissues showed no significant irritation or other sequelae.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen or lower alkyl,R.sub.3 is hydrogen or hydroxyl, andZ is alkylene of 2 to 6 carbon atoms,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as sympathomimetics.

Abstract: Novel pharmaceutical compositions containing 1:1 zinc methionine complex salts having the formula:[CH.sub.3 SCH.sub.2 CH.sub.2 CH(NH.sub.2)COO.sup.. Zn.sup.+.sup.+].sub.w Xwherein X is an anion and w is an integer equal to the anionic charge of X. These compounds when administered in dosage form have been found to have therapeutic effect in the treatment of certain epidermal disorders such as acne.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy,R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy,X is carbonyl or sulfonyl, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.

Abstract: Novel compounds of (I) ##STR1## are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. The compounds are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.

Abstract: 3-Carboxyisocoumarins, 2-thiaisocoumarins and related isocarbostyrils are useful anti-allergic agents. Several of these compounds are novel, and a process for their preparation is provided.

Abstract: 5-Sulfinyl-2-pyridinecarboxylic acids, e.g. those of the formula ##STR1## OR FUNCTIONAL DERIVATIVES THEREOF, ARE HYPOTENSIVE AGENTS.

Abstract: Dermal protective compositions are disclosed which comprise a pharmaceutical extending medium having incorporated therein a substantive, dermally non-irritating compound which is a polyfunctional organic molecule containing one or more fluorocarbon-containing groups joined by one or more polar linking groups to a polyvalent organic radical. When applied to skin, these compositions provide repellency against a wide variety of dermal irritants and are resistant to removal by mild abrasion and/or detergent solutions.

Abstract: Preventive as well as therapeutic treatment of acne vulgaris (hereafter referred to as acne) consisting of the topical application of a solution, lotion or cream containing N-methyldiethanolamine is disclosed. Topical application to uninvolved or involved skin has been found to achieve respectively a complete prevention or a substantial remission of acne.

Abstract: Novel berbine derivatives of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each methoxy or jointly a methylenedioxy, R.sub.3 is methyl, 4-methoxyphenyl or phenylvinyl, and X is a pharmaceutically acceptable anion. They inhibit the growth of transplanted sarcoma strain in mice.