Patents Examined by Patricia C. Mallari
  • Patent number: 7878975
    Abstract: An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biologic
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: February 1, 2011
    Assignee: Diabetes Tools Sweden AB
    Inventors: Lars Gustaf Liljeryd, Ulf Frederik Magnusson
  • Patent number: 7874985
    Abstract: A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of severe hypoglycemia in diabetics, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting both HbA1c and periods of increased risk of hypoglycemia, and to the enhancement of emerging continuous monitoring devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia and hypoglycemia.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: January 25, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Boris P. Kovatchev, Daniel J. Cox
  • Patent number: 7871382
    Abstract: The preferred embodiment of the present invention comprises a single microprocessor-based interface that connects between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor or module. The interface effectively emulates an IBP transducer in such a way that the IBP monitor sees the interface as if it were a regular IBP transducer from a fluid-filled blood pressure monitoring line. It receives the signal from an NIBP sensor and determines the blood pressure corresponding to the signal. It accepts the excitation voltage provided by the IBP monitor. From the excitation voltage and a known transducer sensitivity which the IBP monitor is configured to work with, the interface emulates the IBP transducer output signal corresponding to the blood pressure. The interface also emulates the input and output impedances of the IBP transducer which the IBP monitor is configured to work with.
    Type: Grant
    Filed: November 16, 2006
    Date of Patent: January 18, 2011
    Assignee: Healthstats International Pte Ltd
    Inventor: Kim-Gau Ng
  • Patent number: 7871381
    Abstract: The preferred embodiment of the present invention comprises a single microprocessor-based interface that connects between a noninvasive blood pressure (NIBP) sensor and an invasive blood pressure (IBP) monitor or module. The interface effectively emulates an IBP transducer in such a way that the IBP monitor sees the interface as if it were a regular IBP transducer from a fluid-filled blood pressure monitoring line. It receives the signal from an NIBP sensor and determines the blood pressure corresponding to the signal. It accepts the excitation voltage provided by the IBP monitor. From the excitation voltage and a known transducer sensitivity which the IBP monitor is configured to work with, the interface emulates the IBP transducer output signal corresponding to the blood pressure. The interface also emulates the input and output impedances of the IBP transducer which the IBP monitor is configured to work with.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: January 18, 2011
    Assignee: Healthstats International Pte Ltd
    Inventors: Kim-Gau Ng, Wee Leng Peh, Ngak Kwong Chua
  • Patent number: 7862513
    Abstract: This invention relates generally to apparatus and methods for the calibration of implanted pressure transducers. It is an object of several embodiments of the present invention to provide apparatus and methods for the calibration of one or more implanted pressure transducers implanted in the body of medical patients. Various embodiments of the present invention are particularly advantageous because they offer a calibration system that is less invasive than the systems currently available.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: January 4, 2011
    Assignee: Pacesetter, Inc.
    Inventors: Neal Eigler, James Whiting, Brian Mann
  • Patent number: 7865235
    Abstract: A method of detecting and classifying mental states, comprising the steps of: detecting bio-signals from one or more than one bio-signal detector; transforming the bio-signals into one or more than one different representations; detecting values of one or more than one property of the transformed bio-signal representations; and applying one or more than one mental state detection algorithm to the detected properties in order to classify whether the bio-signals indicate the presence of a predetermined response by a subject.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: January 4, 2011
    Inventors: Tan Thi Thai Le, Nam Hoai Do, William Andrew King, Hai Ha Pham, Johnson Thie, Emir Delic
  • Patent number: 7857761
    Abstract: An acoustic blood analyzer with a transducer section of acoustic biosensors for measurement of blood properties including, but not limited to blood coagulation, platelet function and various blood disorders in a blood sample is provided. Methods for use of the blood analyzer in measurement of blood properties are also provided.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: December 28, 2010
    Assignee: Drexel University
    Inventors: Ryszard M. Lec, J. Yasha Kresh, David M. Wootton
  • Patent number: 7860561
    Abstract: The present invention relates to a method of quantifying a subject's wake or sleep state, and more particularly to a higher resolution method of determining when a subject is awake or asleep. The present invention additionally relates more specific applications of this method, and a system for making these quantitative measurements. There are numerous embodiments of the present invention, which are envisioned, with a few of those listed below. The present invention relates to a method of analyzing a subject, and preferably a human subject to determine quantitatively when the subject is awake and when the subject is sleeping. The present invention has application for use with alertness devices, for use to better analyze sleeping disorders, anesthesia monitors, psychiatric and hypnosis medication monitoring, and for looking at the effect of various other therapies.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: December 28, 2010
    Assignee: Cleveland Medical Devices Inc.
    Inventor: Mohammad Modarres
  • Patent number: 7857760
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: December 28, 2010
    Assignee: DexCom, Inc.
    Inventors: Mark Brister, James Brauker, J. Michael Dobbles
  • Patent number: 7857759
    Abstract: Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm2; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: December 28, 2010
    Assignee: Sysmex Corporation
    Inventors: Kaoru Asano, Yasunori Maekawa, Kennichi Sawa, Toshiyuki Sato, Seiki Okada
  • Patent number: 7850615
    Abstract: A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: December 14, 2010
    Assignee: Medtronic, Inc.
    Inventors: Douglas A. Hettrick, Todd M. Zielinski
  • Patent number: 7850618
    Abstract: The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: December 14, 2010
    Assignee: Pulmosonix Pty Ltd.
    Inventors: Malcolm Howard Wilkinson, Clive Andrew Ramsden, Philip John Berger
  • Patent number: 7848795
    Abstract: The invention relates to a mechanism for determining the depth of sleep of a subject. In order to obtain information about the continuum of the depth of sleep in a user-friendly way without a need for high computational power, EEG signal data is obtained from a subject, REM sleep periods of the subject are detected, and a measure indicative of irregularity in the EEG signal data is derived. Based on the measure and the depicted REM sleep periods, a sleep depth index and state information are produced, where the index is indicative of the depth of sleep of the subject and the state information indicates whether or not the EEG signal data is obtained during a REM sleep period. The detection of the REM periods may be based on a bioimpedance measured from EEG electrodes simultaneously with the EEG measurement or on EOG signal data measured from the subject.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: December 7, 2010
    Assignee: General Electric Company
    Inventors: Pekka Meriläinen, Markku Paloheimo, Juha Virtanen, Hanna Viertiö-Oja, Petteri Lapinlampi
  • Patent number: 7846095
    Abstract: The invention is directed to lead configurations for sensors that allow for less invasive sensor replacement procedures. In one configuration, a sensor lead assembly includes an outer lead body and an inner lead including a sensor such as an electrochemical glucose sensor. The inner lead can be positioned in an inner conduit of the outer lead body. The outer lead body may be substantially permanently implanted in the patient, and the inner lead can be implanted through the inner conduit of the outer lead body. Once the sensor of the inner lead has worn out or otherwise exhausted its useful life, the inner lead can be removed, and a new inner lead can be implanted in place of the old inner lead.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: December 7, 2010
    Assignee: Medtronic, Inc.
    Inventors: Mark A. Christopherson, Nancy Perry Pool, John L. Sommer, Eric Bonde
  • Patent number: 7841985
    Abstract: An inventive method and system are provided for identifying a compatible photoplethysmographic sensor when interconnected to a given photoplethysmographic monitor. The method and system may further provide for the identification of which of a plurality of compatible sensors is interconnected to allow for selective calibration of the photoplethysmographic monitor. In this regard, the system and method may entail provision of a predetermined drive or test signal to a light source and/or identification element (i.e., sensor elements) of a photoplethysmographic sensor, and the obtainment of a corresponding output signal for use in sensor identification. In one approach, an output signal is obtained from at least one of three sensor elements each of which is interconnected between a different pair of sensor terminals which is a unique combination of two of four sensor terminals on the sensor.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: November 30, 2010
    Assignee: Datex-Ohmeda, Inc.
    Inventor: Christopher Hicks
  • Patent number: 7841987
    Abstract: A method for improved visualization of information related to the physiology of a sleeping patient is disclosed. Physiological information from the patient is obtained by a device, converted to digital format, and transformed into physiological data of two or more types. Physiological data of two or more types are combined into a compact graphical display representing data from all physiological data types.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: November 30, 2010
    Assignee: Apneos Corporation
    Inventors: John G. Sotos, John L. Branscum, Jr.
  • Patent number: 7833157
    Abstract: A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: November 16, 2010
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rebecca Gottlieb, Rajiv Shah, Mary M. Morris, Victor Giron, Michael E. Miller, Bradley J. Enegren
  • Patent number: 7833165
    Abstract: A system and method for evaluating neural shunt functionality is provided. Accordingly, in one aspect a method for monitoring neural shunt functionality may include measuring a first intracranial pressure pulse inside the shunt, measuring a second intracranial pressure pulse outside the shunt, and comparing pulsatile characteristics from the first measurement to the second measurement in order to determine shunt functionality.
    Type: Grant
    Filed: August 15, 2006
    Date of Patent: November 16, 2010
    Inventors: Kim Manwaring, Preston Manwaring, Mark Manwaring
  • Patent number: 7833174
    Abstract: A method and apparatus (10) for advancing a device (12) underneath the skin (102) in a mammalian body comprises a casing (50) made of a magnetic material. The casing (50) has a closed tip (64) at one end and an aperture (65) in an opposite end. The casing (50) includes an annular inner surface (70) that defines a cavity (76) within the casing for receiving a device (12) that projects through the aperture (65). The casing (50) further includes structure for attaching to the device (12). The casing (50) is operable to advance the device (12) through tissue (100) underlying the skin (102) in response to movement of a magnetic field across the skin.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: November 16, 2010
    Assignee: The Cleveland Clinic Foundation
    Inventors: Ali R. Rezai, Ashwini D. Sharan
  • Patent number: 7828741
    Abstract: A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: November 9, 2010
    Assignee: The Charlotte-Mecklenburg Hospital Authority
    Inventors: Jeffrey A. Kline, Jackeline Hernandez, John Albert Watts, Jr.