Patents Examined by Paul C. Martin
  • Patent number: 11883428
    Abstract: Agents, kits, and methods that utilize oxygenation to prevent and/or treat infections caused by anaerobic microorganisms are provided. The agents, kits, and methods according to several embodiments utilize oxygenation in the intestinal lumen to prevent and/or treat infections caused by anaerobic bacteria. The agents, kits, and methods can be utilized to prevent and/or treat anaerobic bacterial infections of the intestinal lumen by enteric aerobization therapy.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: January 30, 2024
    Assignee: LPOXY THERAPEUTICS, INC.
    Inventor: Larry D. Sutton
  • Patent number: 11873474
    Abstract: Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: January 16, 2024
    Assignee: Wilson Wolf Manufacturing
    Inventors: Daniel P. Welch, John R. Wilson
  • Patent number: 11857626
    Abstract: Biochemical scaffolds for regulating mammalian cell function. The biochemical scaffolds include a base liquid medium, a bioenergetic platform and a vibrational platform. The bioenergetic platform includes at least one Krebs cycle modulator and/or neurotransmitter modulator. The vibrational platform includes at least one energy signature component, e.g., an herb. The biochemical scaffold is subjected to harmonic oscillation for a defined, predetermined period of time, wherein the energy signature of the energy signature component is imparted to, captured, replicated, and retained by the liquid medium, and, when the biochemical scaffolds are delivered to and, thus, in communication with biological tissue, the biochemical scaffolds induce specific biochemical activities via the resonant transfer of the retained energy signature to the biological tissue and, hence, endogenous cells thereof.
    Type: Grant
    Filed: February 20, 2023
    Date of Patent: January 2, 2024
    Assignee: Next2Me, LLC
    Inventors: Ralph L Peterson, Renee D Williman
  • Patent number: 11849721
    Abstract: An organ preservation and/or perfusion solution for an isolated tissue or organ is provided. The solution comprises dextran, glucose, calcium ions, a buffer, and water, has a pH of 6.6 to 7.8, and is sterile based on having been subjected to heat sterilization. A method of preparing the solution also is provided. The method comprises combining dextran, glucose, calcium ions, buffer, and water to obtain an initial solution, adjusting the pH of the initial solution to 7.0 to 7.8 if needed, and subjecting the initial solution to heat sterilization, thereby obtaining the organ preservation and/or perfusion solution. A method of preserving and/or perfusing an isolated tissue or organ also is provided. A method for flushing, storage, and/or transportation of an isolated lung after removal from a donor in preparation for eventual transplantation into a recipient also is provided.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 26, 2023
    Assignee: XVIVO PERFUSION AB
    Inventors: Anne-Li Sigvardsson, Elin Sjöqvist
  • Patent number: 11846631
    Abstract: The present invention provides a method for determining the effect of a drug on a mature cardiomyocyte. In some embodiments, the method comprises using transmembrane voltage and/or intracellular calcium data obtained from control immature cardiomyocytes and those that have been contacted with the drug to parameterize models of immature cardiomyocytes, then applying a maturation matrix to generate a mature cardiomyocyte model. The method is useful for, among other things, predicting whether a drug may have proarrhythmic properties and for determining whether a particular drug should be administered to a patient.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: December 19, 2023
    Assignee: ORGANOS, INC.
    Inventors: Aslak Tveito, Samuel Wall, Karoline Horgmo Jaeger
  • Patent number: 11834673
    Abstract: The invention relates to methods for generating multipotent mammary stern cells from isolated and cultured human breast luminal cells. The method comprises the steps: 1. isolating and growing normal differentiated cells in vitro; 2. treating the differentiated cells with either a conditioned medium from active fibroblasts or cytokine. The invention also relates to multipotent mammary stem cells, cultures of the multipotent stem cells, differentiated cells, tissues, organs derived from the culture multipotent stem cells isolated by the methods disclosed and therapeutic and other uses for those cells thereof.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: December 5, 2023
    Assignee: KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE
    Inventors: Abdelilah Aboussekhra, Huda H. Al-Khalaf, Hazem Ghebeh
  • Patent number: 11827907
    Abstract: The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a bioreactor. The invention provides a reproducible and robust method and system of determining and controlling the optimal time of infection of host cells using a correlation of process air parameters including Air flow, O2 flow, and respective trends thereof resulting in increased virus yield.
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: November 28, 2023
    Assignee: RESILIENCE GOVERNMENT SERVICES, INC.
    Inventors: Perry Newton, Dalton Berrie, Tyler Grow, Sheldon Doxilly, Christopher J. Montoya, Sara Jane Terpening, Eric Vela
  • Patent number: 11761948
    Abstract: The present invention provides methods, compositions, kits, and devices for detecting heavy metals in dried blood (e.g., dried blood spots). For example, the present invention provides: 1) dried blood spot paper that is detectably free of heavy metals and methods of preparing such paper using organic acid; 2) dried blood extraction solutions optimized for heavy metal detection (e.g., extraction solutions containing acetic acid and/or gold); 3) methods for estimating venous blood volume from dried blood mass; and 4) kits and kit components optimized for heavy metal detection in dried blood (e.g., kits with paper detectably free of heavy metals, heavy metal free skin wipes, metal free collection case, etc.).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 19, 2023
    Assignee: Northwestern University
    Inventors: William E Funk, Thomas McDade
  • Patent number: 11753666
    Abstract: The present invention relates to a system for production of ATP. This system is comprised of a support and one or more enzymes coupled to that support which are capable of collectively producing ATP from glucose or fructose metabolism. The present invention is additionally directed to a device, which includes the system, and to a method for carrying out a reaction involving the conversion of ATP to ADP using the system.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: September 12, 2023
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventor: Alexander Travis
  • Patent number: 11739083
    Abstract: A disposable sensor chip for biological component concentration measurement includes: a chip main body defining a cavity through which a body fluid is flowable; and a reagent located in the cavity such that the body fluid flowing through the cavity comes into contact with the reagent. The reagent comprises a 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: August 29, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Hiroya Sato
  • Patent number: 11702621
    Abstract: Provided are a multilayer film having excellent gas permeability and excellent handling properties and hence is suited for forming a cell culture container, and a cell culture container formed by using the same. A multilayer film used for forming a cell culture container, comprising: a base material composed of a polyethylene-based resin having a density of 0.87 g/cm3 to 0.90 g/cm3; and an inner layer composed of a polyethylene-based resin having a density of 0.896 g/cm3 to 0.93 g/cm3 and forming a cell culture icy surface. A cell culture container is formed by using this multilayer film.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: July 18, 2023
    Assignee: TOYO SEIKAN GROUP HOLDINGS, LTD.
    Inventors: Satoshi Tanaka, Takahiko Totani, Yoichi Ishizaki, Kyohei Ota, Ryo Suenaga, Masahiro Kuninori
  • Patent number: 11698368
    Abstract: This disclosure provides a method for determining male fertility status. The method comprises determining GM1 distribution patterns following induced sperm capacitation, identifying the frequency of distribution of various patterns, and determining if the frequency distribution of certain GM1 patterns in response to induced capacitation is altered. Based on the change in the frequency distribution patterns of certain patterns in response to induced capacitation, alone or in combination with other sperm attributes, male fertility status can be identified.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: July 11, 2023
    Assignee: Cornell University
    Inventors: Alexander J. Travis, Gianpiero Palermo
  • Patent number: 11685763
    Abstract: Embodiments of the invention relate generally to protein extraction and, more generally, to bone protein extraction methods that do not require demineralization. In one embodiment, the invention provides a method comprising: mixing a bone sample and a quantity of an extraction buffer comprising: ammonium phosphate dibasic; or ammonium phosphate dibasic and ammonium bicarbonate; or ammonium phosphate dibasic, ammonium bicarbonate, and guanidine HCl; or sodium phosphate dibasic and sodium bicarbonate; or sodium phosphate dibasic, sodium bicarbonate, and guanidine HCl; or potassium phosphate dibasic and potassium bicarbonate; or potassium phosphate dibasic, potassium bicarbonate, and guanidine HCl; and incubating the bone sample/extraction buffer mixture.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: June 27, 2023
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Timothy Paul Cleland, Deepak Vashishth
  • Patent number: 11667939
    Abstract: The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus Pseudomonas or Rhodococcus.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: June 6, 2023
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Eiji Sato, Fujio Yu, Eiji Nakajima, Michiko Yamazaki, Wataru Mizunashi
  • Patent number: 11639941
    Abstract: The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: May 2, 2023
    Assignee: Icagen, LLC
    Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L. E. Miller
  • Patent number: 11618861
    Abstract: This disclosure describes processes for using a single cellulosic feedstock or a combination of two or more different cellulosic feedstocks with a starch component to produce a fermented product. The process includes separating the components of the cellulosic feedstocks with fractionation, pretreating a component with wet fractionation with chemicals, hydrolysis and fermentation of the pretreated feedstock(s) to produce cellulosic biofuel. The process may include combining the cellulosic feedstock(s) with other components to a cook and/or a fermentation process, distilling and dehydrating the combined components to produce the bio fuel. The process may also include producing a whole stillage stream from the feedstock(s) and mechanically processing the whole stillage stream to produce a high-value protein animal feed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 4, 2023
    Assignee: ICM, Inc.
    Inventors: Jeremy Edward Javers, Christopher Riley William Gerken, Charles C. Gallop, Samuel Vander Griend, Jesse Spooner, Jonathon Phillip Licklider, Laercio Malburg, Ryan Edward Hoefling, Douglas Bernard Rivers, Kurt A. Dieker
  • Patent number: 11612630
    Abstract: A biochemical scaffold for regulating mammalian cell function. The biochemical scaffold includes a base liquid medium, a bioenergetic platform and a vibrational platform. The bioenergetic platform includes at least one Krebs cycle modulator and the vibrational platform includes at least one energy signature component, e.g., an herb. The biochemical scaffold is subjected to sequential harmonic oscillation at defined frequency ranges for a defined, predetermined period of time, wherein the energy signature of the energy signature component is imparted to, captured, replicated, and retained by liquid medium, and, when the biochemical scaffold is delivered to and, thus, in communication with biological tissue, the biochemical scaffold induces specific biochemical activities via the resonant transfer of the retained energy signature to the biological tissue and, hence, endogenous cells thereof, the biochemical activities including increased bioavailability of ATP.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: March 28, 2023
    Assignee: Next2Me, LLC
    Inventors: Ralph L Peterson, Renee D Williman
  • Patent number: 11613743
    Abstract: The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacterium Vibrio alginolyticus chemovar. iophagus (NCIMB Number: 11038, synonym LMG 3418, hereinafter called Vibrio alginolyticus), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced from Vibrio alginolyticus according to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: March 28, 2023
    Assignee: FIDIA FARMACEUTICI S.p.A.
    Inventors: Susanna Vaccaro, Michele Caputo, Christian Cuppari, Giovanni Gennari
  • Patent number: 11592453
    Abstract: Disclosed herein is a method of providing a metabololipidomic profile and SPM signature on the progress of the innate host defense response following blood clotting. The method can include the step of taking one or more measurements in a patient's blood sample, wherein the sample is obtained during the time-course of clotting or coagulation or following clotting or coagulation, of pro-thrombotic and pro-inflammatory mediators (eicosanoids) and specialized pro-resolving mediators SPMs. From these measurements, a personalized metabololipidomic profile can be obtained. By comparing the measurement to that taken from normal or reference blood, a comparison profile can be developed. The profile comparison profile can then be used to make a medical or therapeutic decision.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: February 28, 2023
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Nan Chiang, Paul Norris
  • Patent number: 11584946
    Abstract: The present disclosure relates to testing, analysis and treatment of an environment, wherein one or more baseline(s) is established for the environment. Systems and methods for detecting, treating, comparing and testing for mold, mold spores and mold fragments physically present or in the air of an environment are disclosed herein, as well as methods for remediating the effects of mold in the environment.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 21, 2023
    Inventor: Gregory M. Gandee