Patents Examined by Paul C. Martin
  • Patent number: 10479969
    Abstract: Bioreactors and methods for cultivating microalgae under heterotrophic growth conditions using fruit wastewater as a carbon source are provided herein. The heterotrophic growth conditions include low irradiance of light sufficient to initiate light-activated metabolism, but not photosynthesis. The methods provide a cost effective and environmentally friendly solution for converting wastewater from dried fruit and wine industries into products like biofuels.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: November 19, 2019
    Assignee: PHYCOIL BIOTECHNOLOGY INTERNATIONAL. INC.
    Inventors: Jane Kim, Chung-Soon Im
  • Patent number: 10450237
    Abstract: The present invention relates to a novel phosphate solubilizing strain of Penicillium bilaiae, which is a hybrid of Penicillium bilaiae ATCC 22348 and Penicillium bilaiae V08/021001, as well as compositions and methods for using the novel phosphate solubilizing strain to increase the availability of phosphorous for plant uptake from soil.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: October 22, 2019
    Assignee: NOVOZYMES BIOAG A/S
    Inventors: David Greenshields, Shelagh Steckler, Kari Priest, Caressa Caldwell, Michael Frodyma
  • Patent number: 10421949
    Abstract: Provided herein are methods of culturing an adherent mammalian cell in a shake tube using a plurality of microcarriers and batch re-feed perfusion, and various methods that utilize these culturing methods.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: September 24, 2019
    Assignee: Genzyme Corporation
    Inventors: Jianguo Yang, Yang Yang
  • Patent number: 10364447
    Abstract: The present invention provides a method for producing ?-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: July 30, 2019
    Assignee: Universitat Des Saarlandes
    Inventors: Ernst Roemer, Rolf Müller, Ronald O. Garcia, Mark Stadler, Dominik Pistorius, Alexander Brachmann
  • Patent number: 10350248
    Abstract: Provided are uses of Bacteroides in preparation of a medicament. The medicament is for use in treatment or prevention of obesity and obesity-related diseases. Also provided are a pharmaceutical composition, a medicament, a food product, and an animal feed that comprise Bacteroides, uses thereof in treatment or prevention of obesity and obesity-related diseases, and a method for treatment or prevention of obesity and obesity-related diseases.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: July 16, 2019
    Assignee: RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Guang Ning, Jie Hong, Weiqing Wang, Ruixin Liu, Jiqiu Wang
  • Patent number: 10330688
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present or secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provides metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: June 25, 2019
    Assignees: Wisconsin Alumni Research Foundation, Stemina Biomarker Discovery, Inc.
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Patent number: 10323217
    Abstract: The disclosure concerns a detergent composition comprising one or more anionic surfactants; an enzyme selected from the group consisting of: a protease, a lipase, a cutinase, an amylase, a carbohydrase, a cellulase, a pectinase, a mannanase, an arabinase, a galactanase, a xylanase, and an oxidase; and a deoxyribonuclease (DNase), as well as methods for washing a textile.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: June 18, 2019
    Assignee: Novozymes A/S
    Inventors: Klaus Gori, Lilian Eva Tang Baltsen, Marie Allesen-Holm
  • Patent number: 10323226
    Abstract: A bacteria starter material for use in biomass generators without causing jamming of the feeder mechanism, particularly under high temperature and/or high humidity conditions, the starter material comprising one or more species of waste-decomposing bacteria, sucrose, and a soy based protein. Preferably, DI-PAC® sugar (sucrose and maltodextrin) and powdered KIKKOMAN® Soy Sauce are used as the sugar and protein ingredients. The starter material may also comprise a dried bran culture comprising Pseudomonas. The starter material ingredients are blended together and formed into a tablet or pellet having a particular shape, size, and hardness characteristics suitable for use in the feeder mechanism of a biomass generator.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: June 18, 2019
    Assignee: NCH Corporation
    Inventors: Judith G. Pruitt, Robert C. Pearce, III, Daniel Aberle, Charles J. Greenwald, Gabriel F. K. Everett
  • Patent number: 10323264
    Abstract: The invention provides a method for producing methacrylyl-CoA that converts 3-hydroxyisobutyryl-CoA into methacrylyl-CoA using an enzyme having dehydratase activity as a method for producing methacrylyl-CoA using an enzyme catalyst. In this production method, conversion rate of 3-hydroxyisobutyryl-CoA into methacrylyl-CoA by the enzyme having dehydratase activity is 50% or higher. In this production method, furthermore, the enzyme having dehydratase activity derives from a microorganism belonging to the genus Pseudomonas or Rhodococcus.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: June 18, 2019
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Eiji Sato, Fujio Yu, Eiji Nakajima, Michiko Yamazaki, Wataru Mizunashi
  • Patent number: 10324100
    Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: June 18, 2019
    Assignee: Institute of Rheological Functions of Food
    Inventors: Takehiko Fujino, Shiro Mawatari
  • Patent number: 10324036
    Abstract: The invention relates to a porous planar cell capture system for use in determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using such a cell capture system. The cell capture system contains a fluid permeable, planar membrane adopted to retain cells thereon, a fluid permeable support member that supports the membrane, and an optional register associated with the membrane.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: June 18, 2019
    Assignees: Charles River Laboratories, Inc., ReaMetrix Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia
  • Patent number: 10316347
    Abstract: In situ optical analysis of bacterial endospores can be inhibited when the endospores are present within an optically active carrier medium. To help isolate the endospores from the carrier medium, in some examples, the carrier medium is passed through a hydrophobic material that captures the endospores via hydrophobic attraction. Subsequently, a germination fluid and lanthanide source, such as terbium, can be added to the bacterial endospores captured on the hydrophobic material to form a lanthanide-dipicolinic acid complex in the germination fluid. The germination fluid can then be optically analyzed by measuring the fluorometric response of the lanthanide-dipicolinic acid complex to determine a concentration of the bacterial endospores in the carrier medium.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: June 11, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Anthony Wayne Erickson, Elaine Patricia Black, Nathan Richard Ortmann, Rodney H. Banks
  • Patent number: 10316336
    Abstract: This invention provides optimized fermentation of cellulosic and hemicellulosic sugars. Biomass-derived hemicellulosic and cellulosic sugars are independently conditioned and separately fermented, utilizing reuse and recycle of microorganisms, metabolic intermediates, and nutrients. Conditioned sugars can be fermented in separate vessels, where excess cells from glucose fermentation are conveyed to hemicellulose sugar fermentation along with raffinate from solvent recovery, to enhance productivity and product yield.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: June 11, 2019
    Assignee: API Intellectual Property Holdings, LLC
    Inventors: Shrikant Survase, Ryan Zebroski, Georgios Adamos, Vesa Pylkkanen
  • Patent number: 10314868
    Abstract: Suppository compositions are provided combining a pharmaceutically acceptable matrix material that is solid outside of the human body and in a dry environment, but which melts at body temperature; and apple cider vinegar and one or more species of probiotic bacteria dispersed within the matrix material; wherein the matrix material contains a mixture of fatty acids that are solid at room temperature. Methods for supplementing and nourishing the microbiome of the rectum of a male or female and the microbiome of the vagina of a female are also disclosed. Oral dosage forms of the compositions of the present invention are also provided.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: June 11, 2019
    Inventor: Deborah L. Lynch
  • Patent number: 10203330
    Abstract: This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ASCL1 and RET expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: February 12, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Farhad Kosari, George Vasmatzis, Marie-Christine Aubry, Cristiane M. Ida
  • Patent number: 10196602
    Abstract: The present invention relates to a biomaterial for cell or tissue culture, based on a polymeric carrier, which contains at least one crosslinkable hydrophilic polymer. The polymer is functionalized with groups that are selected from maleimide, vinylsulfonic, acrylate, alkyl halide, azirine, pyridyl, thionitrobenzene acid groups, or arylating groups. The invention relates further to a method of production of said biomaterial, and the use of particular functionalizing groups for the production of a biomaterial for the cultivation of tissue and/or cells. The biomaterial can have biofactors that exert a particular action on cells.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: February 5, 2019
    Assignee: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
    Inventor: Helmut Wurst
  • Patent number: 10188965
    Abstract: The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) in a solution comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and von Willebrand factor (VWF), the method comprising: (i) passing a feedstock comprising at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF through a hydrophobic charge-induction chromatographic resin under conditions selected such that at least one protein selected from the group consisting of plasminogen, tissue plasminogen activator and other protease(s) present in the feedstock is bound to the resin; and (ii) recovering a solution comprising the at least one protein selected from the group consisting of fibrinogen, Factor VIII and VWF which passes through the resin, wherein the concentration of the at least one protein selected from the group consisting of plasm
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: January 29, 2019
    Assignee: CSL BEHRING GMBH
    Inventors: Hung Pham, Jeffrey Michael Hey, Darren Nguy
  • Patent number: 10173913
    Abstract: A process of growing a culture of cyanobacteria or algae using chitin or chitosan as a source of nitrogen for photosynthetic growth is described. This process can be used to remove pollutants from nitrogen-deficient natural waters or wastewaters including buchu mercaptan production wastewater. Biomass that results from photosynthetic growth on chitin can be used, either as whole cells or the isolated components of the cells, for a large variety of commercial purposes.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 8, 2019
    Inventors: Carrine Blank, Nancy W. Hinman
  • Patent number: 10167576
    Abstract: A method of producing a fine fiber, including treating a cellulose raw material with an enzyme; and fibrillating the treated cellulose raw material; treating with the enzyme under a condition where at least a ratio of endo-glucanase activity to cellobiohydrolase activity that is 0.06 or greater. The cellulose raw material may be a plant fiber. The method efficiently produces a fine fiber from a cellulose raw material at low cost and with a low environmental burden, a fine fiber, and a non-woven fabric.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: January 1, 2019
    Assignee: OJI Holdings Corporation
    Inventors: Yaping Chao, Yasutomo Noishiki
  • Patent number: 10157734
    Abstract: Methods and systems for identification of microorganisms either after isolation from a culture or directly from a sample. The methods and systems are configured to identify microorganisms based on the characterization of proteins of the microorganisms via high-resolution/mass accuracy single-stage (MS) or multi-stage (MSn) mass spectrometry. Included herein are also discussion of targeted detection and evaluation of virulence factors, antibiotic resistance markers, antibiotic susceptibility markers, typing, or other characteristics using a method applicable to substantially all microorganisms and high-resolution/mass accuracy single-stage (MS) or multi-stage (MSn) mass spectrometry.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: December 18, 2018
    Assignee: OXIOD LIMITED
    Inventors: James L. Stephenson, Jr., Oksana Gvozdyak, Roger Grist, Clay Campbell, Iain C. Mylchreest, Ian D. Jardine