Abstract: An apparatus for equipment monitoring includes an input unit, a processing unit, and an output unit. The input unit is configured to provide the processing unit with batches of temporal sensor data for an item of equipment. Each batch of temporal sensor data includes temporal sensor values as a function of time. The processing unit is configured to process the batches of temporal sensor data to determine batches of spectral sensor data. Each batch of spectral sensor data includes spectral sensor values as a function of frequency. The processing unit is configured to implement at least one statistical process algorithm to process the spectral sensor values for the batches of spectral sensor data to determine index values. For each batch of spectral sensor data there is an index value determined by each of the statistical process algorithms.

Abstract: Isolated antigen binding molecules that specifically binds to a molecule comprising an amino acid sequence selected from the group consisting of GGGS (SEQ ID NO: 1), GGGGS (SEQ ID NO: 46) and related sequences are provided. The antigen binding molecules may be used in the methods provided herein.

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

Abstract: A method for correlating data from sensors includes receiving sensor information from a plurality of sensors of an industrial operation. Sensor information from component sensors is used for functionality of a component of the industrial operation and sensor information from additional sensors monitor conditions of a portion of the industrial operation different from the component. The method includes deriving, using the sensor information, correlations between component sensors and additional sensors and deriving a baseline signature from the sensor information and the correlations. The baseline signature encompasses a range of normal operating conditions. The method includes identifying an abnormal operating condition based on a comparison between additional sensor information and the baseline signature. The sensor information is used differently for functionality of the component than for deriving the correlations and baseline signature and identifying the abnormal operating condition.

Abstract: The present disclosure relates to a linker molecule for targeting molecule-drug conjugate, and the corresponding conjugate, the preparation and use thereof.

Abstract: The present disclosure provides a method and apparatus for processing astronomical survey data. The method comprises: a data distribution step: delivering a spectral data file to be processed to a distributed file system, dividing the spectral data file into a plurality of data blocks, and distributing the data blocks to computing nodes; a data computing step: performing a spectral classification of spectra to be measured in the data blocks, with a template matching method; the data computing step comprises: reading template spectra, and extracting template universal operators; reading the spectra to be measured; performing spectral matching, and computing Chi-square error values for flow rate values of the template spectra multiplied by the polynomial and flow rate values of the spectra to be measured; and finding corresponding minimum Chi-square error and corresponding redshift for each of the template spectra, so as to determine classifications of the spectra to be measured.

Abstract: Isolated antigen binding molecules that specifically bind to a polypeptide comprising the alpha chain of the constant region of a T cell receptor (TCR) are provided. The antigen binding molecules may be used in the methods provided herein.

Abstract: A device for monitoring state of apparatus projects a plurality of pieces of measured data to a dimensionless space in which a plurality of display shapes of a plurality of pieces of normal information are represented by a common shape on the basis of a positional relationship between the plurality of display shapes of the plurality of pieces of normal information and the plurality of pieces of measured data, and estimates a distribution of the state of the apparatus on the basis of the plurality of pieces of measured data projected to the dimensionless space.

Abstract: A method for identifying a flow parameter in a wellbore may comprise identifying a state vector at a moment t, performing a flow simulation using a flow model, predicting the state vector and a covariance matrix at the moment t, updating the state vector with an EnKF algorithm, correcting the state vector at the moment t, and updating the flow simulation model. A system for identifying a flow parameter in a wellbore may comprise a distributed acoustic system into a wellbore and an information handling system. The distributed acoustic system may comprise a fiber optic cable and at least one measurement device.

Abstract: The present disclosure provides antibody-drug conjugates comprising anti-PTCRA antibodies and methods of using the same. The ADCs of the disclosure are useful for the treatment of T-ALL and other disorders related to elevated expression of PTCRA.

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccines and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract: A method and system of fault prediction in a packaging machine is disclosed. The method comprises registering data values associated with the motion of independently movable objects along a track in the packaging machine; determining a distribution of the data values; calculating a measure of central tendency of the data values in the distribution; calculating a quantified measure of a shape of the distribution; associating the measure of central tendency with said quantified measure of the shape as a coupled set of condition parameters; determining a degree of dispersion of a plurality of coupled sets of condition parameters associated with a plurality of motion cycles of the independently movable objects; and comparing the degree of dispersion with a dispersion threshold value, or determining a trend of the degree of dispersion over time, for said fault prediction.

Abstract: Provided are binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof, comprising a CH1 domain (e.g., a human IgG1 CH1 domain), wherein the CH1 domain has an engineered N-linked glycosylation site at amino acid position 114, according to Kabat numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

Abstract: A reservoir bank landslide susceptibility evaluation method. The method includes the following steps: S1, acquiring geophysical parameters; S2, calculating stability of a reservoir bank after impoundment through a static geological evaluation model according to the geophysical parameters; S3, obtaining an average displacement velocity in a geographic coordinate system according to single look complex (SLC) images after impoundment; and S4, according to the average displacement velocity in the geographic coordinate system and the stability of the reservoir bank after impoundment of the reservoir, obtaining a reservoir bank landslide susceptibility grade. According to the method, a problem that present landslide susceptibility evaluation methods all adopt a single model to evaluate landslide susceptibility, which has low evaluation accuracy of the landslide susceptibility is solved.

Abstract: A method for determining a usability of a household appliance includes scanning operating information of the household appliance, determining stresses of different components of the household appliance on the basis of the operating information, and of determining the usability of the household appliance on the basis of the stresses determined and of predetermined stress functions for the components. Wherein a stress function maps a stress determined to a remaining stress capacity.

Abstract: Techniques regarding determining the operating condition of one or more mechanical parts are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a status component that can update a predictive failure algorithm by altering a vibration threshold based on a measured temperature of a mechanical part. Also, the vibration threshold can characterize an amount of vibration associated with a standard operating condition of the mechanical part.

Abstract: The present disclosure provides for antibody-oligonucleotide conjugates, methods of preparation thereof, and methods of use thereof. Also provided are related compounds, compositions and kits.

Abstract: A monitoring method includes monitoring variables that change over time and are continuously measured during repeated executions of a dynamic process. The measurement data include training data in a training period and monitoring data measured subsequently to the training period. Vectors are continuously determined based on the measurement data, the vector components of which comprise respective rates of change of the measured values of the individual measured variables determined for a series of successive points in time on the basis of the measurement data, wherein the points in time of each series cover a time window of a duration and the time windows of successive vectors are shifted. The vectors are stored as a reference cluster. The vectors are compared with the reference cluster. An anomaly is determined when a vector is outside the reference cluster.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.