Patents Examined by Ponnathapu Achutamurthy
  • Patent number: 7374921
    Abstract: Disclosed is a novel cellulase having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulase NCE5 are substituted. Further, a polynucleotide encoding the novel cellulase, an expression vector containing the polynucleotide, a host cell transformed with the expression vector, and a cellulase preparation and a washing composition containing the cellulase are disclosed. The cellulase of the present invention is resistant to surfactants, and maintains a high activity even under alkaline conditions.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: May 20, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kaoru Okakura, Koji Yanai
  • Patent number: 7371552
    Abstract: We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: G121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 13, 2008
    Assignee: Danisco A/S
    Inventors: Karsten Matthias Kragh, Bo Spange Sørensen
  • Patent number: 7371560
    Abstract: A process for the production of hydrogen, comprising the steps of: (i) providing a photosynthetic microorganism having electron transfer capability through a photosynthetic light reaction pathway and through a respiratory electron transfer chain involving an oxidative phosphorylation pathway, and which expresses a hydrogenase, wherein regulation of the oxidative phosphorylation pathway is disrupted with the result that electron flow along the respiratory electron transfer chain toward cytochrome oxidase (complex IV) is reduced; ii) culturing the microorganism under microoxic and illuminated conditions; and (iii) collecting evolved hydrogen.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 13, 2008
    Assignee: University of Queensland
    Inventors: Ben Hankamer, Olaf Kruse
  • Patent number: 7371555
    Abstract: The invention relates to isolated polypeptides having ?-H-?-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising the nucleic acids according to the invention. The invention also relates to methods of producing and using the polypeptides according to the invention. The invention also relates to a method for isolating polypeptides having ?-H-?-amino acid amide racemase activity, for isolating nucleic acids encoding the same and for isolating microorganisms comprising polypeptides having ?-H-?-amino acid amide racemase activity. The invention also relates to new microorganisms comprising polypeptides having ?-H-?-amino acid amide racemase activity.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: May 13, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Wilhelmus Hubertus Joseph Boesten, Petronella Catharina Raemakers-Franken, Theodorus Sonke, Gerrit Jan Willem Euverink, Pieter Grijpstra
  • Patent number: 7368268
    Abstract: The present invention provides an aerobic coryneform bacterium transformant in which a lactate dehydrogenase gene is disrupted, and a pyruvate carboxylase gene is recombined so as to be highly expressed by a genetic engineering method. The aerobic coryneform bacterium transformant of the present invention can produce dicarboxylic acids from saccharides at a high production rate.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: May 6, 2008
    Assignee: Research Institute of Innovative Technology for the Earth
    Inventors: Shikiko Murakami, Kaori Nakata, Shohei Okino, Yuko Ikenaga, Masayuki Inui, Hideaki Yukawa
  • Patent number: 7354751
    Abstract: A novel gene having a function of improving acetic acid fermentation in practical level was cloned from a practical acetic acid bacterium belonging to the genus Gluconacetobacter by a method for obtaining a gene having a growth-promoting function in acetic acid-containing medium from the chromosomal DNA library of the acetic acid bacterium. It was made possible to significantly shorten the growth induction period and significantly improve the acetic acid fermentation rate of transformants obtained by introducing the gene into acetic acid bacteria, when such transformants are cultured in the presence of ethanol.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: April 8, 2008
    Assignee: Mitsukan Group Corporation
    Inventor: Shigeru Nakano
  • Patent number: 7335502
    Abstract: The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from Enterobacter sp. DS-S-75 strain (FERM BP-5494) which is bacteria belonging to the genus Enterobacter, a EnHCH gene shown by base sequence of SEQ. ID. NO: 1, a gene encoding a protein having an amino acid sequence of SEQ. ID. NO: 2, and E. coli DH5? (pKK-EnHCH) deposited to International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology as a deposition No. FERM BP-08466.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: February 26, 2008
    Assignee: Daiso Co., Ltd.
    Inventors: Atsushi Nakagawa, Toshio Suzuki, Atsuhiko Shinmyo, Ko Kato, Hideaki Idogaki
  • Patent number: 7326551
    Abstract: The invention provides isolated nucleic acids molecules which encode pyruvate decarboxylase enzymes having improved decarboxylase activity, substrate affinity, thermostability, and activity at different pH. The nucleic acids of the invention also have a codon usage which allows for high expression in a variety of host cells. Accordingly, the invention provides recombinant expression vectors containing such nucleic acid molecules, recombinant host cells comprising the expression vectors, host cells further comprising other ethanologenic enzymes, and methods for producing useful substances, e.g., acetaldehyde and ethanol, using such host cells.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: February 5, 2008
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Julie A. Maupin-Furlow, Lee Ann Talarico, Krishnan Chandra Raj, Lonnie O. Ingram
  • Patent number: 7303901
    Abstract: An RNA ligase derived from bacteriophage TS2126 which infects Thermus scotoductus, nucleic acids comprising nucleotide sequences of open reading frame (ORF) and polypeptides encoded by the nucleic acids, are described.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: December 4, 2007
    Assignee: Prokaria Ehf.
    Inventors: Sigridur Hjorleifsdottir, Audur Thorisdottir, Arnthor Aevarsson, Gudmundur Oli Hreggvidsson, Thorarinn Blondal
  • Patent number: 7300782
    Abstract: The invention relates to a new glycosyl hydrolases with an amyloltic activity and nucleic acids coding for said gylcosyl hydrolases, A PCR-based method for identifying and preparing new gylcosyl hydrolases from metagenome DNA and several possible technical uses for such glycosyl hydrolases with an amylolytic activity. Washing and cleaning products containing such enzymes, and methods and possible uses corresponding thereto are particularly interesting.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: November 27, 2007
    Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
    Inventors: Roland Breves, Karl-Heinz Maurer, Jürgen Eck, Patrick Lorenz, Holger Zinke
  • Patent number: 7288407
    Abstract: The invention relates to a stable recombinant host cell comprising a CYP24 nucleic acid. The host cell is preferably a mammalian cell or an insect cell. The cell is useful for identifying modulators of CYP24 that can be used in the treatment of CYP24 expression-related medical conditions.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: October 30, 2007
    Assignee: Cytochroma, Inc.
    Inventors: Anqi Zhang, Mian Gao
  • Patent number: 7285403
    Abstract: Disclosed are xylose-fermenting recombinant yeast strains expressing xylose reductase, xylitol dehydrogenase, and xylulokinase and having reduced expression of PHO13 or a PHO13 ortholog, as well as methods of fermenting xylose to obtain ethanol using the recombinant yeast strains.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: October 23, 2007
    Assignees: Wisconsin Alumni Research Foundation, United States as Represented by the Secretary of Agriculture
    Inventors: Thomas W. Jeffries, Haiying Ni, Jose Miguel Laplaza
  • Patent number: 7279321
    Abstract: The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: October 9, 2007
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Fateme Sima Sariaslani, Tina K. Van Dyk
  • Patent number: 7267972
    Abstract: The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol dehydratase whereof the catalytic activity is independent of the presence of coenzyme B12 or one of its precursors and a nucleic acid coding for a 1,3-propanol dehydrogenase intervening in the synthesis of 1,3-propanediol. The invention further concerns recombinant vectors and host cells comprising said nucleic acids and the polypeptides coded by the latter.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: September 11, 2007
    Assignee: Institut National de la Recherche
    Inventors: Patricia Sarcabal, Christian Croux, Philippe Soucaille
  • Patent number: 7232678
    Abstract: The present invention relates to compositions and methods for modulating conception in animals. More particularly, the composition modulates mRNA degradation during gametogenesis and early development. Yet further, the present invention relates to pharmaceutical compositions and methods for modulating diseases of the reproductive organs, such as hyperproliferative diseases.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: June 19, 2007
    Assignees: Wyeth, Baylor College of Medicine
    Inventors: Martin M. Matzuk, Yuchen Bai, Wei Yan
  • Patent number: 7226767
    Abstract: A substantially pure culture of a microorganism having enzyme activities of pyrG and CCT and carrying a recombinant DNA composed of a DNA fragment containing genes encoding pryG and CCT and a vector.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: June 5, 2007
    Assignee: Kyowa Hakko Food Specialities Co., Ltd.
    Inventors: Akihiko Maruyama, Tatsuro Fujio, Sadao Teshiba
  • Patent number: 7226768
    Abstract: Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: June 5, 2007
    Assignee: The California Institute of Technology
    Inventors: Edgardo T. Farinas, Frances H. Arnold, Ulrich Schwaneberg, Anton Glieder
  • Patent number: 7217559
    Abstract: The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to a new cyclododecanone monooxygenase and to a method of use of the cyclododecanone monooxygenase-encoding gene.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: May 15, 2007
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Patent number: 7208300
    Abstract: The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay system to identify compounds that selectively modulate EER-7 protein activity by interaction with estrogen receptors.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: April 24, 2007
    Assignee: Wyeth
    Inventors: Mark J. Evans, Marshall S. Scicchitano, Ashok R. Bapat, Ramesh A. Bhat, Robert Mastroeni, Sotirios K. Karathanasis
  • Patent number: 7208310
    Abstract: The present invention relates to proteases of high specific activity homologous to proteases derived from Nocardiopsis, and the production thereof by the wild-type, and in recombinant host cells including transgenic plants and non-human transgenic animals. The proteases are effective in animal feed, and detergents. Characteristic structural features of relevance for the specific activity of these proteases of peptidase family S2A or S1E are disclosed.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: April 24, 2007
    Assignee: Novozymes A/S
    Inventors: Soeren Flensted Lassen, Carsten Sjoholm, Peter Rahbek Ostergaard